Citation Impact
Citing Papers
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
2019 Science
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
2003 StandoutNobel
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
2005 StandoutNobel
Evolution of new nonantibody proteins via iterative somatic hypermutation
2004 StandoutNobel
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
2004 StandoutScienceNobel
AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts
2002 StandoutScienceNobel
Munc18-1 binds directly to the neuronal SNARE complex
2007 StandoutNobel
Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins
2002 StandoutNobel
Roles of tau protein in health and disease
2017
Coordinate Regulation of Motor Neuron Subtype Identity and Pan-Neuronal Properties by the bHLH Repressor Olig2
2001
Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo
2006 StandoutNobel
Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons
2003 StandoutNobel
A Role for Runx Transcription Factor Signaling in Dorsal Root Ganglion Sensory Neuron Diversification
2006
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity
2014
The Basic Helix-Loop-Helix Factor Olig2 Is Essential for the Development of Motoneuron and Oligodendrocyte Lineages
2002
Linking class-switch recombination with somatic hypermutation
2001 StandoutNobel
Immunity through DNA deamination
2003
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes
2010
The E Box Motif CAGGTG Enhances Somatic Hypermutation without Enhancing Transcription
2003
Hypermutation in antibody affinity maturation
1999
AID and mismatch repair in antibody diversification
2002
Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo
2013
Two levels of protection for the B cell genome during somatic hypermutation
2008 Nature
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
2000 Standout
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Mechanisms of chromosomal translocations in B cell lymphomas
2001
Pax6 regulates specification of ventral neurone subtypes in the hindbrain by establishing progenitor domains
2002
Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain
2018
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
2015
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Palindromic but not G-rich sequences are targets of class switch recombination
2001
Active nuclear import and cytoplasmic retention of activation-induced deaminase
2009
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
2005
Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas
2001 Nature
The generation of antibody diversity through somatic hypermutation and class switch recombination
2004
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5
2010
Towards an understanding of somatic hypermutation
2001
What role for AID: mutator, or assembler of the immunoglobulin mutasome?
2003
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
2005 StandoutNobel
Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis
2001
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube
2000
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies
2004
Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy
2013
Antibody Therapeutics Targeting Aβ and Tau
2017
Biomarker Modeling of Alzheimer’s Disease
2013
Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
2017
The specification of neuronal identity by graded sonic hedgehog signalling
1999
Requirement for the Homeobox Gene Hb9 in the Consolidation of Motor Neuron Identity
1999
Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
2014
Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
2015
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets
2004 Nature
Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc
2004
Transcriptional control of neurotransmitter phenotype
1999
Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas
2003
The Structural Mechanism of Translocation and Helicase Activity in T7 RNA Polymerase
2004 StandoutNobel
Activation-induced deaminase: controversies and open questions
2004
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
The Translesion DNA Polymerase ζ Plays a Major Role in Ig and bcl-6 Somatic Hypermutation
2001
Tau Kinetics in Neurons and the Human Central Nervous System
2018
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Induction, assembly, maturation and maintenance of a postsynaptic apparatus
2001
AID Targeting in Antibody Diversity
2011
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
The amyloid hypothesis of Alzheimer's disease at 25 years
2016 Standout
Negative regulation of activation-induced cytidine deaminase in B cells
2006 StandoutNobel
Neurodegenerative Diseases: Expanding the Prion Concept
2015
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer’s disease
2019
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs
2001 StandoutNobel
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
2002
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
2002 StandoutNobel
Expression of the AID protein in normal and neoplastic B cells
2004
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy
2017
Somatic hypermutation of the AID transgene in B and non-B cells
2002
Anti‐tau antibody reduces insoluble tau and decreases brain atrophy
2015
Longitudinal tau PET in ageing and Alzheimer’s disease
2018
A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer’s disease dementia
2019
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes
2004
Somatic motoneurone specification in the hindbrain: the influence of somite-derived signals, retinoic acid and Hoxa3
2003
Somatic mutation of bcl-6 genes can occur in the absence of VH mutations in chronic lymphocytic leukemia
2000
The connection between transcription and genomic instability
2002
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
Neural Science
2000 StandoutNobel
Generation of neurons by transient expression of neural bHLH proteins in mammalian cells
2000
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
2013
Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination
2009 StandoutNobel
Computer simulations of protein functions: Searching for the molecular origin of the replication fidelity of DNA polymerases
2005 StandoutNobel
Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback
2005
Control of hindbrain motor neuron differentiation by the homeobox genePhox2b
2000
Somatic Mutation of the Cd95 Gene in Human B Cells as a Side-Effect of the Germinal Center Reaction
2000
A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease
2014
Increased Transcription Levels Induce Higher Mutation Rates in a Hypermutating Cell Line
2001
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
DNA cleavage in immunoglobulin somatic hypermutation depends onde novoprotein synthesis but not on uracil DNA glycosylase
2005 StandoutNobel
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase
2013 StandoutNobel
Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy
2016
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation
2011 StandoutNobel
Amino-Terminal Phosphorylation of Activation-Induced Cytidine Deaminase Suppresses c-myc/IgH Translocation
2010
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas.
2004
Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination
2001 StandoutNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
Somatic hypermutation of the B cell receptor genesB29(Igβ, CD79b) andmb1(Igα, CD79a)
2003
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
2004 StandoutNobel
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Somatic mutation of bcl-6 genes can occur in the absence of VH mutations in chronic lymphocytic leukemia
2000
Morphogen gradient interpretation
2001 StandoutNatureNobel
Neuronal activity regulates extracellular tau in vivo
2014
Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice
2016
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination
2004 StandoutNobel
AID to overcome the limitations of genomic information
2005 StandoutNobel
Works of Christopher William being referenced
Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity
2015
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
2012
Beneficial effect of human anti-amyloid-β active immunization on neurite morphology and tau pathology
2010
Specification of Motor Neuron Identity by the MNR2 Homeodomain Protein
1998
Patterning of Muscle Acetylcholine Receptor Gene Expression in the Absence of Motor Innervation
2001
BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
1998
Human LilrB2 Is a β-Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer’s Model
2013 Science
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease
2015