Citation Impact
Citing Papers
Removing T-cell epitopes with computational protein design
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Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
2005 StandoutNobel
Mouse NKR-P1B, a Novel NK1.1 Antigen with Inhibitory Function
1999
Signaling through human killer cell activating receptors triggers tyrosine phosphorylation of an associated protein complex
1998
Immunoreceptor tyrosine-based inhibition motifs
1997
Thirty years of stimulus-secretion coupling: From Ca2+ toGTP in the regulation of exocytosis
2000
Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota
2012
mTOR Signaling in Growth Control and Disease
2012 Standout
Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95
1995 StandoutScience
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Analysis of the molecular mechanism involved in 2B4-mediated NK cell activation: evidence that human 2B4 is physically and functionally associated with the linker for activation of T cells
2000
Characterization of a CD43/Leukosialin-mediated Pathway for Inducing Apoptosis in Human T-Lymphoblastoid Cells
1996
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
Cytoskeletal rearrangement during migration and activation of T lymphocytes
1999
The CD95 (APO-1/Fas) and the TRAIL (APO-2L) Apoptosis Systems
2000
Triggering of human natural killer cells through CD16 induces tyrosine phosphorylation of the p72syk kinase
1994
Tyrosine kinase activity is involved in the protein kinase C induced expression ofinterleukin‐1β gene in monocytic cells
1993
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E
1999
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
The CD94 and NKG2‐A C‐type lectins covalently assemble to form a natural killer cell inhibitory receptor for HLA class I molecules
1997
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
1998 StandoutNature
Inhibitory Pathways Triggered by ITIM-Containing Receptors
1999
ICE Family Proteases: Mediators of All Apoptotic Cell Death?
1996
X-linked IAP is a direct inhibitor of cell-death proteases
1997 StandoutNature
Inhibitory receptors, ITIM sequences and phosphatases
1997
Signaling at neuro/immune synapses
2012
SLP-76 Is a Direct Substrate of SHP-1 Recruited to Killer Cell Inhibitory Receptors
1998
Roles of the NKG2D immunoreceptor and its ligands
2003
Involvement of the Protein Tyrosine Kinase p56lck in T Cell Signaling and Thymocyte Development
1994
Natural Killer Cells: From No Receptors to Too Many
1997
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
1996 StandoutNature
Rho GTPases in cell biology
2002 StandoutNature
Signaling pathways engaged by NK cell receptors: double concerto for activating receptors, inhibitory receptors and NK cells
2000
Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors
2004
Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1
1999
RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
1995
FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway
1995
Contenders in FasL/TNF death signaling
1995
Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death
1996 Standout
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
1996 StandoutNature
Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases
1998
A Novel Phosphotyrosine Motif with a Critical Amino Acid at Position −2 for the SH2 Domain-mediated Activation of the Tyrosine Phosphatase SHP-1
1997
'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection
2010
Activation, coactivation, and costimulation of resting human natural killer cells
2006
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
1997 Standout
NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases
2003
Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases
2002
HumanKLRF1, a novel member of the killer cell lectin-like receptor gene family: molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis
2000
Atherosclerosis — An Inflammatory Disease
1999 Standout
The Fas Death Factor
1995 StandoutScience
Combined Natural Killer Cell and Dendritic Cell Functional Deficiency in KARAP/DAP12 Loss-of-Function Mutant Mice
2000
Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity
2000
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1998 StandoutNature
Deletion of SHIP or SHP-1 Reveals Two Distinct Pathways for Inhibitory Signaling
1997
Association of the p56lck protein tyrosine kinase with the FCγRIIIA/CD16 complex in human natural killer cells
1993
gp49B1-αvβ3 interaction inhibits antigen-induced mast cell activation
2001
Association of DAP12 with Activating CD94/NKG2C NK Cell Receptors
1998
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Inhibition of death receptor signals by cellular FLIP
1997 StandoutNature
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
2003 StandoutNature
A Novel Immunoglobulin Superfamily Receptor for Cellular and Viral MHC Class I Molecules
1997
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
1996 StandoutNobel
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer
1997 StandoutNobel
NK CELL RECOGNITION
2004 Standout
CD94/NKG2-A Inhibitory Complex Blocks CD16-Triggered Syk and Extracellular Regulated Kinase Activation, Leading to Cytotoxic Function of Human NK Cells
1999
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Multiplicity and plasticity of natural killer cell signaling pathways
2005
Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
2002
Cutting Edge: Differential Segregation of the Src Homology 2-Containing Protein Tyrosine Phosphatase-1 Within the Early NK Cell Immune Synapse Distinguishes Noncytolytic from Cytolytic Interactions
2002
NK CELL RECEPTORS
1998 Standout
Vav1 Phosphorylation Is Induced by β2 Integrin Engagement on Natural Killer Cells Upstream of Actin Cytoskeleton and Lipid Raft Reorganization
2003
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Regulation of the Natural Killer Cell Receptor Repertoire
2001
Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by CD94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis
1998
Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation
2000 StandoutNobel
Cutting Edge: Novel Priming of Tumor-Specific Immunity by NKG2D-Triggered NK Cell-Mediated Tumor Rejection and Th1-Independent CD4+ T Cell Pathway
2004
Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis
2001 Standout
A Balance between Positive and Negative Signals in Cytotoxic Lymphocytes Regulates the Polarization of Lipid Rafts during the Development of Cell-Mediated Killing
2000
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
1995 Standout
Ly-49W, an Activating Receptor of Nonobese Diabetic Mice With Close Homology to the Inhibitory Receptor Ly-49G, Recognizes H-2Dk and H-2Dd
2001
FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas
1995 Science
A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells
1997
A Structural Basis for the Association of DAP12 with Mouse, but Not Human, NKG2D
2004
NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation
1998 StandoutScience
Death Receptors: Signaling and Modulation
1998 StandoutScience
Conserved regulation of the lymphocyte-specific expression oflckin the Fugu and mammals
2002 StandoutNobel
SHP-1- and Phosphotyrosine-Independent Inhibitory Signaling by a Killer Cell Ig-Like Receptor Cytoplasmic Domain in Human NK Cells
2002
Natural Killer Cell Signaling Pathways
2004 Science
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Human natural killer cells with polyclonal lectin and immunoglobulinlike receptors develop from single hematopoietic stem cells with preferential expression of NKG2A and KIR2DL2/L3/S2
2001
NKG2A Complexed with CD94 Defines a Novel Inhibitory Natural Killer Cell Receptor
1997
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
1996 StandoutScienceNobel
Selective Activation of the c-Jun NH2-terminal Protein Kinase Signaling Pathway by Stimulatory KIR in the Absence of KARAP/DAP12 in CD4+ T Cells
2003
T-Independent Immune Response: New Aspects of B Cell Biology
2000 StandoutScienceNobel
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
2000 Standout
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 StandoutNobel
2B4 Is Constitutively Associated with Linker for the Activation of T Cells in Glycolipid-Enriched Microdomains: Properties Required for 2B4 Lytic Function
2002
Killer Cell Activating Receptors Function as Costimulatory Molecules on CD4+CD28null T Cells Clonally Expanded in Rheumatoid Arthritis
2000
Decoding the Patterns of Self and Nonself by the Innate Immune System
2002 StandoutScience
Human natural killer cells
2008
MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment
1999
Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants
2002 StandoutScience
The tandem Src homology 2 domain of the Syk kinase: A molecular device that adapts to interphosphotyrosine distances
2003
Association with FcRγ Is Essential for Activation Signal through NKR-P1 (CD161) in Natural Killer (NK) Cells and NK1.1+ T Cells
1997
Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires
1998
Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.
1995
Interaction of Ly-49D+ NK Cells with H-2Dd Target Cells Leads to Dap-12 Phosphorylation and IFN-γ Secretion
2000
REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS
1999
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Spatial Organization of Signal Transduction Molecules in the NK Cell Immune Synapses During MHC Class I-Regulated Noncytolytic and Cytolytic Interactions
2001
Innate or Adaptive Immunity? The Example of Natural Killer Cells
2011 StandoutScience
Immune Inhibitory Receptors
2000 Science
Mechanisms and Genes of Cellular Suicide
1995 StandoutScience
Vav1 Dephosphorylation by the Tyrosine Phosphatase SHP-1 as a Mechanism for Inhibition of Cellular Cytotoxicity
2003
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
1996 StandoutScience
Works of Christopher J. Dick being referenced
NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway
2003
Sequential Involvement of Lck and SHP-1 with MHC-Recognizing Receptors on NK Cells Inhibits FcR-Initiated Tyrosine Kinase Activation
1996
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells
2006
Interaction between lck and syk Family Tyrosine Kinases in Fcγ Receptor-initiated Activation of Natural Killer Cells
1995
Cutting Edge: A Role for the Adaptor Protein LAT in Human NK Cell-Mediated Cytotoxicity
1999
Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses.
1996
The Isoforms of Phospholipase C-γ Are Differentially Used by Distinct Human NK Activating Receptors
2005
Regulation of NK Cell-Mediated Cytotoxicity by the Adaptor Protein 3BP2
2001
Dynamin 2 Regulates Granule Exocytosis during NK Cell-Mediated Cytotoxicity
2008
Protein tyrosine phosphorylation and p56lck modification in IL-2 or phorbol ester-activated human natural killer cells.
1990
Functional Role for Syk Tyrosine Kinase in Natural Killer Cell–mediated Natural Cytotoxicity
1997
The Vav–Rac1 Pathway in Cytotoxic Lymphocytes Regulates the Generation of Cell-mediated Killing
1998
Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis.
1994