Citation Impact
Citing Papers
Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice
2005 StandoutNobel
A Gene Network Regulating Lysosomal Biogenesis and Function
2009 StandoutScience
Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events
2011
Proteasome Involvement in Agonist-induced Down-regulation of μ and δ Opioid Receptors
2001
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
1997 StandoutNature
Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway
1996
Identification of a Region within the Ubiquitin-activating Enzyme Required for Nuclear Targeting and Phosphorylation
1997 StandoutNobel
Activation of Atypical Protein Kinase C ζ by Caspase Processing and Degradation by the Ubiquitin-Proteasome System
2000 StandoutNobel
Systemic inflammation in chronic obstructive pulmonary disease
2003
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
2003 StandoutNobel
Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits
1997
Proteasome inhibitors: from research tools to drug candidates
2001
Firefly luciferase mutants as sensors of proteome stress
2011
Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome
2001
Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States
1999
Structure and assembly of the 20S proteasome
1998
The Active Sites of the Eukaryotic 20 S Proteasome and Their Involvement in Subunit Precursor Processing
1997
Strategies for the inhibition of serine proteases
2001
Animal models of chronic obstructive pulmonary disease
2008
The Ubiquitin-activating Enzyme E1 Is Phosphorylated and Localized to the Nucleus in a Cell Cycle-dependent Manner
1996 StandoutNobel
The human proteasome subunit HsN3 is located inthe inner rings of the complex dimer
1995
Characterization of Recombinant REGα, REGβ, and REGγ Proteasome Activators
1997
Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants
1998 Nobel
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
The Degradation of Apolipoprotein B100 Is Mediated by the Ubiquitin-proteasome Pathway and Involves Heat Shock Protein 70
1997 StandoutNobel
Proteasome inhibitors and antigen presentation
1997
Proteasome Inhibitors: Complex Tools for a Complex Enzyme
2002
Binding of Amyloid β Protein to the 20 S Proteasome
1997
Lack of Proteasome Active Site Allostery as Revealed by Subunit-Specific Inhibitors
2001
Evidence for the Existence of a Non-catalytic Modifier Site of Peptide Hydrolysis by the 20 S Proteasome
2000
The Co-chaperone Carboxyl Terminus of Hsp70-interacting Protein (CHIP) Mediates α-Synuclein Degradation Decisions between Proteasomal and Lysosomal Pathways
2005
Active Site-directed Inhibitors of Rhodococcus 20 S Proteasome
1997
Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105
1995 StandoutNobel
A theoretical approach towards the identification of cleavage-determining amino acid motifs of the 20s proteasome 1 1Edited by R. Huber
1999
X-linked IAP is a direct inhibitor of cell-death proteases
1997 StandoutNature
Brucella requires a functional Type IV secretion system to elicit innate immune responses in mice
2007
Effects of extracellular matrix viscoelasticity on cellular behaviour
2020 StandoutNature
The Human α-Type Proteasomal Subunit HsC8 Forms a Double Ringlike Structure, but Does Not Assemble into Proteasome-like Particles with the β-Type Subunits HsDelta or HsBPROS26
1997
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection
2006 StandoutNobel
The proteasome from Thermoplasma acidophilum is neither a cysteine nor a serine protease
1995
Probing Structural Determinants Distal to the Site of Hydrolysis that Control Substrate Specificity of the 20S Proteasome
2002 Nobel
Nucleotidase Activities of the 26 S Proteasome and Its Regulatory Complex
1996
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex
1992
Constitutive and interferon-γ-induced expression of the human proteasome subunit multicatalytic endopeptidase complex-like 11EMBL accession number for MECL1 cDNA: Y13640.1
1998
Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-induced Conjugation and Subsequent Degradation of IκBα
1999 StandoutNobel
The Proteasome: Paradigm of a Self-Compartmentalizing Protease
1998
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
1996 StandoutNature
Inhibition of Ubiquitin-mediated Proteolysis by the Arabidopsis 26 S Protease Subunit S5a
1995
Protein degradation and protection against misfolded or damaged proteins
2003 StandoutNature
The 26S proteasome of the yeast Saccharomyces cerevisiae
1994 StandoutNobel
PRE3, highly homologous to the human major histocompatibility complex‐linked LMP2 (RING12) gene, codes for a yeast proteasome subunit necessary for the peptidylglutamyl‐peptide hydrolyzing activity
1994
[31] Isocoumarin inhibitors of serine peptidases
1994
The 1.9 Å Structure of a Proteasome-11S Activator Complex and Implications for Proteasome-PAN/PA700 Interactions
2005
NOD1 and NOD2 signalling links ER stress with inflammation
2016 StandoutNature
THE GENETICS OF PROTEASOMES AND ANTIGEN PROCESSING
1995
Trafficking Patterns of β-Arrestin and G Protein-coupled Receptors Determined by the Kinetics of β-Arrestin Deubiquitination
2003 StandoutNobel
Effects of Major‐Histocompatibility‐Complex‐Encoded Subunits on the Peptidase and Proteolytic Activities of Human 20S Proteasomes
1996
Degradation Process of Ligand-stimulated Platelet-derived Growth Factor β -Receptor Involves Ubiquitin-Proteasome Proteolytic Pathway
1995 StandoutNobel
Processive Degradation of Proteins and Other Catalytic Properties of the Proteasome from Thermoplasma acidophilum
1997
[24] Multicatalytic endopeptidase complex: Proteasome
1994
The Proteasome
2001
Antigen presentation by MHC class I and its regulation by interferon γ
1999
Proteasome: from structure to function
1996
Structure of 20S proteasome from yeast at 2.4Å resolution
1997 StandoutNatureNobel
Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes
1998
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Decelerated degradation of short peptides by the 20S proteasome
1998
Existence of a molecular ruler in proteasomes suggested by analysis of degradation products
1994
Degradation of the Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) by the Ubiquitin-Proteasome Pathway
2000 StandoutNobel
The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases
2014
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
2000 StandoutNature
Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System
2002 StandoutNobel
The proteasome 11S regulator subunit REGα (PA28α) is a heptamer
1997
Chapter 11 Proteinase families and their inhibitors
2001
Conformational constraints in protein degradation by the 20S proteasome
1995
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Proteasome inhibitors: fromin vitro uses to clinical trials
2000
Towards subunit-specific proteasome inhibitors: synthesis and evaluation of peptide α', β'-epoxyketones
1999
The proteasome activator 11 S REG (PA28) and Class I antigen presentation
1999
Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate
1996
Regulation of Immunoproteasome Subunit Expression In Vivo Following Pathogenic Fungal Infection
2002
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
The multicatalytic and 26 S proteases.
1993
Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation
1997
Proteasome regulation of activation-induced T cell death
1997 StandoutNobel
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
1999 Standout
Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and Nanotechnology
2003 Standout
Cytotoxic T Lymphocyte Epitopes of HIV-1 Nef
2000
Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis.
1996 Nobel
Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis
1995 StandoutScience
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome
1997
STATs and Gene Regulation
1997 StandoutScience
Proteasomes: destruction as a programme
1996
3,4-dichloroisocoumarin-induced activation of the degradation of beta-casein by the bovine pituitary multicatalytic proteinase complex.
1992
Novel dipeptide aldehydes are proteasome inhibitors and block the MHC-I antigen-processing pathway.
1995
The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides.
1996
Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides.
1994
Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution
1995 ScienceNobel
Purification of an 11 S regulator of the multicatalytic protease.
1992
Efficient Generation of a Hepatitis B Virus Cytotoxic T Lymphocyte Epitope Requires the Structural Features of Immunoproteasomes
2000
Site of catabolite inactivation
1994 StandoutNatureNobel
Subunit arrangement in the human 20S proteasome
1997
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
Reaction of proteasomes with peptidylchloromethanes and peptidyldiazomethanes
1993
Accurate protein structure modeling using sparse NMR data and homologous structure information
2012 StandoutNobel
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
Proteasomes in the archaea: from structure to function
2000
Biogenesis of eukaryotic 20S proteasomes: the complex maturation pathway of a complex enzyme
1997
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain).
1992
Adapting Proteostasis for Disease Intervention
2008 StandoutScience
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 StandoutScience
Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1
1998 Nobel
Activation of the cell death program by inhibition of proteasome function
1997
Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors
2001
Ubiquitin Aldehyde Increases Adenosine Triphosphate–Dependent Proteolysis of Hemoglobin α-Subunits in β-Thalassemic Hemolysates
1997
Single-particle selection and alignment with heavy atom cluster-antibody conjugates
1998 StandoutNobel
DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES
1999
Epoxomicin, a potent and selective proteasome inhibitor, exhibitsin vivoantiinflammatory activity
1999
Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate.
1992
PA700, an ATP-dependent activator of the 20 S proteasome, is an ATPase containing multiple members of a nucleotide-binding protein family.
1994
THE PROTEASOME
1999 Nobel
Biochemical Characterization of the 20S Proteasome from the Methanoarchaeon Methanosarcina thermophila
1998
Emerging Targets in Photopharmacology
2016 StandoutNobel
Identification, purification, and characterization of a high molecular weight, ATP-dependent activator (PA700) of the 20 S proteasome.
1994
Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2
1994 StandoutNobel
MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING
1998
Review
1997
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
In Vivo Stimulation of IκB Phosphorylation Is Not Sufficient To Activate NF-κB
1995
Selective proteasome inhibitors: modulators of antigen presentation?
1999
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
1997 StandoutScience
Molecular clutch drives cell response to surface viscosity
2018
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Ubiquitination of Protein Kinase C-α and Degradation by the Proteasome
1996
Thimet Oligopeptidase (EC 3.4.24.15), a Novel Protein on the Route of MHC Class I Antigen Presentation
1999
Immunoproteasomes Largely Replace Constitutive Proteasomes During an Antiviral and Antibacterial Immune Response in the Liver
2001
Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides.
1994
Impairment of the Ubiquitin-Proteasome System by Protein Aggregation
2001 StandoutScience
Proteasomes: multicatalytic proteinase complexes
1993
Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.
1995 StandoutNobel
Works of Christopher Cardozo being referenced
Bovine Spleen Multicatalytic Proteinase Complex (Proteasome)
1997
Focal adhesion kinase and its role in skeletal muscle
2015
Altered Properties of the Branched Chain Amino Acid-preferring Activity Contribute to Increased Cleavages after Branched Chain Residues by the “Immunoproteasome”
1998
C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation
2003
Cleavage of Pro-X and Glu-X Bonds Catalyzed by the Branched Chain Amino Acid Preferring Activity of the Bovine Pituitary Multicatalytic Proteinase Complex (20S Proteasome)
1996
Evidence That the Nature of Amino Acid Residues in the P3 Position Directs Substrates to Distinct Catalytic Sites of the Pituitary Multicatalytic Proteinase Complex (Proteasome)
1994
Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex
1991
Evidence that enzymatic conversion of N-[1(R,S)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate, a specific inhibitor of endopeptidase 24.15, to N-[1 (R,S)-carboxy-3-phenylpropyl]-Ala-Ala is necessary for inhibition of angiotensin converting enzyme
1993
Induction of Emphysema in Hamsters by Intratracheal Instillation of Cathepsin B
1992
Catalytic Components of the Bovine Pituitary Multicatalytic Proteinase Complex (Proteasome)
1993
CONTROL OF LMP7 EXPRESSION IN HUMAN ENDOTHELIAL CELLS BY CYTOKINES REGULATING CELLULAR AND HUMORAL IMMUNITY
2000
A 3,4-dichloroisocoumarin-resistant component of the multicatalytic proteinase complex
1992
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids
1993
Reactions of [14C]-3,4-Dichloroisocoumarin with Subunits of Pituitary and Spleen Multicatalytic Proteinase Complexes (Proteasomes)
1997
Lysozyme Degradation by the Bovine Multicatalytic Proteinase Complex (Proteasome): Evidence for a Nonprocessive Mode of Degradation
1999
Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes.
1994
Components of the Bovine Pituitary Multicatalytic Proteinase Complex (Proteasome) Cleaving Bonds after Hydrophobic Residues
1999