Citation Impact
Citing Papers
RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
2013
Aristolochic acid and the etiology of endemic (Balkan) nephropathy
2007 Standout
Genetic polymorphism of the Nrf2 promoter region is associated with vitiligo risk in Han Chinese populations
2016
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity
2018 StandoutNobel
The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress
2009 Standout
Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer
2019 StandoutNobel
Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor-E2–related factor-2 transcriptional pathway
2007
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
2009 Standout
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
2015
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
2009
Expression of the Aflatoxin B1-8,9-Epoxide-Metabolizing Murine Glutathione S-Transferase A3 Subunit Is Regulated by the Nrf2 Transcription Factor through an Antioxidant Response Element
2003
Coffee bean extracts rich and poor in kahweol both give rise to elevation of liver enzymes in healthy volunteers
2004
Cancer chemoprevention with dietary phytochemicals
2003 Standout
Parkinson's disease
2021 Standout
Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial
2010
Hepatocellular carcinoma
2018 Standout
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
2006 Standout
Identification of the interactive interface and phylogenic conservation of the Nrf2‐Keap1 system
2002
Bioactive composition and antioxidant potential of different commonly consumed coffee brews affected by their preparation technique and milk addition
2012
Coffee Consumption Increases the Antioxidant Capacity of Plasma and Has No Effect on the Lipid Profile or Vascular Function in Healthy Adults in a Randomized Controlled Trial
2016
The genetics of ageing
2010 StandoutNature
Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression
2003 Standout
Hormetic Dietary Phytochemicals
2008
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
NRF2 and cancer: the good, the bad and the importance of context
2012
Nrf2 Possesses a Redox-sensitive Nuclear Exporting Signal in the Neh5 Transactivation Domain
2006
Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (−/−) mice
2006
Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans
2008
Bioavailability of multiple components following acute ingestion of a polyphenol‐rich juice drink
2010
Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose–response meta-analysis
2017
The Keap1 BTB/POZ Dimerization Function Is Required to Sequester Nrf2 in Cytoplasm
2002
Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials
2016
Colonic metabolites of berry polyphenols: the missing link to biological activity?
2010
Gastrointestinal stability and bioavailability of (poly)phenolic compounds following ingestion of Concord grape juice by humans
2012
Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of phosphatidylinositol 3-kinase: The role of nitric oxide synthase in rat glutathione S-transferase A2 induction
2002
The coffee components kahweol and cafestol induce γ-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat
2001
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Intestinal transit and systemic metabolism of apple polyphenols
2010
Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles
2013
Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma
2016
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
2011 StandoutNature
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
2013
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice
2003
Chlorogenic acid (CGA): A pharmacological review and call for further research
2017 Standout
The cytoprotective role of the Keap1–Nrf2 pathway
2011
Nrf2 Mediates the Induction of Ferritin H in Response to Xenobiotics and Cancer Chemopreventive Dithiolethiones
2003
Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice
2006
Role of Nrf1 in antioxidant response element-mediated gene expression and beyond
2009
Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila
2011
Glutamate neurotoxicity and diseases of the nervous system
1988 Standout
Nrf2 Controls Constitutive and Inducible Expression of ARE-driven Genes through a Dynamic Pathway Involving Nucleocytoplasmic Shuttling by Keap1
2005
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature
2017
Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability?
2019
Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway
2003
Glycogen Synthase Kinase-3β Inhibits the Xenobiotic and Antioxidant Cell Response by Direct Phosphorylation and Nuclear Exclusion of the Transcription Factor Nrf2
2006
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
2007 Standout
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks
2012 StandoutNobel
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
Diindolylmethane Alters Gene Expression in Human Keratinocytes In Vitro
2002
Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
2011 Standout
Green Tea Flavan-3-ols: Colonic Degradation and Urinary Excretion of Catabolites by Humans
2009
Coffee and tea consumption and risk of hepatocellular carcinoma in Italy
2007
Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy
2010
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
2014 Standout
Consuming Broccoli Does Not Induce Genes Associated with Xenobiotic Metabolism and Cell Cycle Control in Human Gastric Mucosa
2007
2002
Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors
2004
Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States
2005
Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element
2003
Coffee consumption and the risk of primary liver cancer: Pooled analysis of two prospective studies in Japan
2005
Antihypertensive effects and mechanisms of chlorogenic acids
2011
Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
2001
Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber
2014
A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity
2007
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
2019 Standout
Coffee and Health: A Review of Recent Human Research
2006 Standout
Antiglycative and neuroprotective activity of colon‐derived polyphenol catabolites
2011
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism
2006
Coffee drinking and hepatocellular carcinoma risk
2007
ERRβ: A potent inhibitor of Nrf2 transcriptional activity
2007
GC/MS method to quantify bioavailable phenolic compounds and antioxidant capacity determination of plasma after acute coffee consumption in human volunteers
2016
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
2009 StandoutNobel
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
2008 Standout
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans
2006
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors
2002
Hepatocellular carcinoma
2022 Standout
Transcriptional Regulation of NF-E2 p45-related Factor (NRF2) Expression by the Aryl Hydrocarbon Receptor-Xenobiotic Response Element Signaling Pathway
2005
Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression
2010
Coffee consumption reduces the risk of hepatocellular carcinoma independently of its aetiology: a case-control study
2005
Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron
2004
TRAIL-mediated signaling in prostate, bladder and renal cancer
2011
Basic Principles and Emerging Concepts in the Redox Control of Transcription Factors
2011
Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases
2012 Standout
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
2002 Standout
Iron Catalysis in Organic Synthesis
2015 Standout
Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription
2002
Cafestol to Tricalysiolide B and Oxidized Analogues: Biosynthetic and Derivatization Studies Using Non-heme Iron Catalyst Fe(PDP)
2012
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
2003
Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity
2016
Bis- and Trisindolylmethanes (BIMs and TIMs)
2009 Standout
Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy
2010
Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women
2016
Crystal Structure of Quinone Reductase 2 in Complex with Resveratrol,
2004
Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer
2005 Standout
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
2004
Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co‐culture
2013
Nuclear Oncoprotein Prothymosin α Is a Partner of Keap1: Implications for Expression of Oxidative Stress-Protecting Genes
2005
Sesquiterpenoids Lactones: Benefits to Plants and People
2013 Standout
Coffee, Decaffeinated Coffee, Tea and Cancer of the Colon and Rectum: A Review of Epidemiological Studies, 1990-2003
2004
Identification of (Poly)phenolic Compounds in Concord Grape Juice and Their Metabolites in Human Plasma and Urine after Juice Consumption
2011
Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
2012
Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha
2007
Acute Effects of Chlorogenic Acid on Nitric Oxide Status, Endothelial Function, and Blood Pressure in Healthy Volunteers: A Randomized Trial
2012
Up-down Regulation of HO-1 and iNOS Gene Expressions by Ethyl Pyruvate via Recruiting p300 to Nrf2 and Depriving It from p65
2013
The effect of unfiltered coffee on potential biomarkers for colonic cancer risk in healthy volunteers: a randomized trial
2000
Association between the NF-E2 Related Factor 2 Gene Polymorphism and Oxidative Stress, Anti-Oxidative Status, and Newly-Diagnosed Type 2 Diabetes Mellitus in a Chinese Population
2015
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
2007 Standout
A review on protein–phenolic interactions and associated changes
2013 Standout
Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype
2005
The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation
2007
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
2002 Standout
Ferroptosis as a target for protection against cardiomyopathy
2019 Standout
Identification of Sensor Cysteines in Human Keap1 Modified by the Cancer Chemopreventive Agent Sulforaphane
2005
Emerging Role of Nrf2 in Protecting Against Hepatic and Gastrointestinal Disease
2007
Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter
2002
Effect of Milk and Brewing Method on Black Tea Catechin Bioaccessibility
2011
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
2018 Standout
The Carboxy-Terminal Neh3 Domain of Nrf2 Is Required for Transcriptional Activation
2005
Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies
2016
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
Halloysite Clay Nanotubes for Loading and Sustained Release of Functional Compounds
2015 Standout
Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease
2010
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
2002
Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex
2004
Cellular uptake of nanoparticles: journey inside the cell
2017 Standout
The association between lifestyle factors and Parkinson's disease progression and mortality
2019
Coffee Oil Consumption Increases Plasma Levels of 7α-Hydroxy-4-cholesten-3-one in Humans
2005
Polyphenols and Human Health: The Role of Bioavailability
2021 Standout
The acute effect of coffee on endothelial function and glucose metabolism following a glucose load in healthy human volunteers
2017
Antiglycative and antioxidative properties of coffee fractions
2010
Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response
2009
Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response Element
2003
Extending Healthy Life Span—From Yeast to Humans
2010 StandoutScience
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence
2003
Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.
2001
Effect of Simultaneous Consumption of Milk and Coffee on Chlorogenic Acids’ Bioavailability in Humans
2011
Works of Christophe Cavin being referenced
Quantitative analysis of plasma caffeic and ferulic acid equivalents by liquid chromatography tandem mass spectrometry
2009
Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract
2004
Nondairy Creamer, but Not Milk, Delays the Appearance of Coffee Phenolic Acid Equivalents in Human Plasma
2009
Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: Small intestine and colon are key sites for coffee metabolism
2009
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism
1998
Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells
2001
Reduction in Antioxidant Defenses may Contribute to Ochratoxin A Toxicity and Carcinogenicity
2006
Structurally Related Mycotoxins Ochratoxin A, Ochratoxin B, and Citrinin Differ in Their Genotoxic Activities and in Their Mode of Action in Human-Derived Liver (HepG2) Cells: Implications for Risk Assessment
2004
Plasma appearance and correlation between coffee and green tea metabolites in human subjects
2010
Metabolite Profiling of Hydroxycinnamate Derivatives in Plasma and Urine after the Ingestion of Coffee by Humans: Identification of Biomarkers of Coffee Consumption
2009
Impact of paper filtered coffee on oxidative DNA-damage: Results of a clinical trial
2010
Coffee diterpenes prevent the genotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and N-nitrosodimethylamine in a human derived liver cell line (HepG2)
2005
Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver
2007
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity
2002
Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol
1996
A Toxicogenomics Approach to Identify New Plausible Epigenetic Mechanisms of Ochratoxin A Carcinogenicity in Rat
2005
The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
2001