Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion
2008 StandoutScienceNobel
Gating the Selectivity Filter in ClC Chloride Channels
2003 StandoutScienceNobel
Developmental Differences of Cystic Fibrosis Transmembrane Conductance Regulator Functional Expression in Isolated Rat Fetal Distal Airway Epithelial Cells
1994
Extensive posttranscriptional deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manifestations of cystic fibrosis.
1992
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation
1991 Nature
Pathways through which glucose induces a rise in [Ca2+]i of polymorphonuclear leukocytes of rats
1996
Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein
1992 Nature
Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508delCFTR
2015 Standout
Influenza virus M2 protein has ion channel activity
1992
The Diversity of Volume Regulatory Mechanisms
1998
Calcium sequestration in the liver
1990
Interactions between glutamine metabolism and cell‐volume regulation in perfused rat liver
1990
Customizing model membranes and samples for NMR spectroscopic studies of complex membrane proteins11This review is dedicated to the fond memory of Professor Gitte Vold of the University of California, San Diego, CA, USA.
2000
A chloride channel widely expressed in epithelial and non-epithelial cells
1992 Nature
Generation and characterization of a ΔF508 cystic fibrosis mouse model
1995 StandoutNobel
Effects of P‐glycoprotein expression on cyclic AMP and volume‐activated ion fluxes and conductances in HT‐29 colon adenocarcinoma cells
1994
Effects of the ?F508 mutation on the structure, function, and folding of the first nucleotide-binding domain of CFTR
1993
ABC1, an ATP Binding Cassette Transporter Required for Phagocytosis of Apoptotic Cells, Generates a Regulated Anion Flux after Expression in Xenopus laevis Oocytes
1997
Physiology of Cell Volume Regulation in Vertebrates
2009
Chloride channels, Golgi pH and cystic fibrosis
1992
The C. elegans Cell Corpse Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters
1998 StandoutNobel
Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis
1991
Ion currents of Xenopus laevis oocytes: state of the art
1999
In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
1992
Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR
1992 Nature
Organoids: Modeling Development and the Stem Cell Niche in a Dish
2016
Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel
1991
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
2008 StandoutNature
Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.
1992
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive
1992 Nature
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Membrane Mechanisms and Intracellular Signalling in Cell Volume Regulation
1995
Structural determinants of water permeation through aquaporin-1
2000 StandoutNatureNobel
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans
1994 StandoutNatureNobel
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
1993
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
2002 StandoutNatureNobel
Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells
2013
Regulatory volume decrease of cultured human fibroblasts involves changes in intracellular amino-acid pool
1994
Inactivation of the murine cftr gene abolishes cAMP-mediated but not Ca2+-mediated secretagogue-induced volume decrease in small-intestinal crypts
1993 StandoutNobel
Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms
1997 Nature
Mutations in CFTR associated with mild-disease-form CI- channels with altered pore properties
1993 Nature
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
1994 StandoutNature
Salmonella typhi uses CFTR to enter intestinal epithelial cells
1998 StandoutNatureNobel
Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung afterin vivointratracheal plasmid-mediated gene transfer
1992
Antisense oligodeoxynucleotide to the cystic fibrosis transmembrane conductance regulator inhibits cyclic AMP-activated but not calcium-activated cell volume reduction in a human pancreatic duct cell line.
1993
Cotranslational Ubiquitination of Cystic Fibrosis Transmembrane Conductance Regulator in Vitro
1998
In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator
1991 Nature
DCPIB is a novel selective blocker of ICl,swell and prevents swelling‐induced shortening of guinea‐pig atrial action potential duration
2001
Chloride channels: a molecular perspective
1996
Overcoming Hysteresis to Attain Reversible Equilibrium Folding for Outer Membrane Phospholipase A in Phospholipid Bilayers
2011
Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels
1993
Redistribution of hepatocyte chloride during l-alanine uptake
1993
CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship
1993 Nature
Activation of ion transport pathways by changes in cell volume
1991
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation
2002 StandoutNatureNobel
Novel Cl--Dependent Intracellular pH Regulation in Murine MDR 1 Transfectants and Potential Implications
1994
Cystic fibrosis: molecular biology and therapeutic implications
1992 StandoutScience
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
A functional CFTR assay using primary cystic fibrosis intestinal organoids
2013
The leukotriene D4 receptor blocker, SK&F 104353, inhibits volume regulation in isolated crypts from the rat distal colon
1993
Multiple proteolytic systems, including the proteasome, contribute to CFTR processing
1995
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Hepatic Transport Systems Regulating pHi, Cell Volume, and Bile Secretion
1992
twine, a cdc25 homolog that functions in the male and female germline of drosophila
1992 StandoutNobel
Molecular physiology of anion channels
1994
Molecular genetics of cell death in the nematode Caenorhabditis elegans
1992
Volume regulation in human fibroblasts: role of Ca2+ and 5-lipoxygenase products in the activation of the Cl? efflux
1993
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
2002 StandoutNatureNobel
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
A mouse model for the delta F508 allele of cystic fibrosis.
1995 StandoutNobel
Vanadate Inhibition of Hepatocytic Autophagy
1995
Annexin VI is required for budding of clathrin-coated pits
1992 StandoutNobel
Mechanosensitive whole-cell currents in cultured rat somatosensory neurons
2000
Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
1993 StandoutNatureNobel
Role of amino acid‐induced changes in ion fluxes in the regulation of hepatic protein synthesis
1995
Amazing chloride channels: an overview
2003
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
1994 StandoutNobel
Ion-transporting activity in the murine colonic epithelium of normal animals and animals with cystic fibrosis
1994 StandoutNobel
Activation of basolateral Cl? channels in the rat colonic epithelium during regulatory volume decrease
1992
Modeling Development and Disease with Organoids
2016 Standout
Efficient generation of lung and airway epithelial cells from human pluripotent stem cells
2013
Hydroperoxide metabolism in rat liver
1993
Mechanical stretch-induced serotonin release from pulmonary neuroendocrine cells: implications for lung development
2005
An Animal Model for Cystic Fibrosis Made by Gene Targeting
1992 StandoutScienceNobel
Hypotonicity activates a native chloride current in Xenopus oocytes.
1994
Transverse relaxation-optimized NMR spectroscopy with the outer membrane protein OmpX in dihexanoyl phosphatidylcholine micelles
2001 StandoutNobel
Regulation of Plasma Membrane Recycling by CFTR
1992 Science
Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes
1991 Science
The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment.
1993
Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.
1995
Immunomodulation in Cystic Fibrosis: Why and How?
2020
Expression cloning of an ATP receptor from mouse neuroblastoma cells.
1993 StandoutNobel
Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents.
1992
Calcium-dependent chloride channels in endosomes from rabbit kidney cortex
1994
Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis
1992 StandoutScienceNobel
Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume
1997
Hypertonic stress increases the Na+ conductance of rat hepatocytes in primary culture.
1995
Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity
1991 Science
Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor
1994 StandoutScienceNobel
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans
2000 StandoutNatureNobel
Swelling-induced and depolarization-induced C1-channels in normal and cystic fibrosis epithelial cells
1991
Stretch-activated channels in airway epithelial cells
1993
Bacterial Biofilms: A Common Cause of Persistent Infections
1999 StandoutScience
Molecular Structure and Physiological Function of Chloride Channels
2002
Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches
2009
Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP.
1994
Ion permeation and selectivity in ClC-type chloride channels
2001
Abnormal regulation of ion channels in cystic fibrosis epithelia
1990
Recent advances and contraversies on the role of pulmonary neuroepithelial bodies as airway sensors
2012
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.
1993
Cystic ibrosis: Molecular Biology and Therapeutic Implications
1992 Science
Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
2013
Mouse VAP33 is associated with the endoplasmic reticulum and microtubules
2000 StandoutNobel
The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.
1992
Involvement of cell calcium and transmembrane potential in control of hepatocyte volume
1991
Stoichiometry of recombinant cystic fibrosis transmembrane conductance regulator in epithelial cells and its functional reconstitution into cells in vitro.
1994
Endogenous hydroperoxide formation, cell volume and cellular K+ balance in perfused rat liver
1993
In vitro generation of human pluripotent stem cell derived lung organoids
2015
Potential of preventing Pseudomonas aeruginosa lung infections in cystic fibrosis patients: Experimental studies in animals
1996
Volume-activated K+ and Cl- pathways of dissociated epithelial cells (MDCK): role of Ca2+
1990
Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily.
1991
Regulation of cell function by the cellular hydration state
1994
The role of cellular hydration in the regulation of cell function
1996
Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung
1997
Fluorescence Correlation Spectroscopy Reveals Highly Efficient Cytosolic Delivery of Certain Penta-Arg Proteins and Stapled Peptides
2015
Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator.
1994
Cystic Fibrosis Heterozygote Resistance to Cholera Toxin in the Cystic Fibrosis Mouse Model
1994 Science
Volume‐activated chloride currents associated with the multidrug resistance P‐glycoprotein.
1995
Regulation of Cl- channels in normal and cystic fibrosis airway epithelial cells by extracellular ATP.
1992
Functional Significance of Cell Volume Regulatory Mechanisms
1998 Standout
Very High Single Channel Water Permeability of Aquaporin-4 in Baculovirus-Infected Insect Cells and Liposomes Reconstituted with Purified Aquaporin-4
1997
Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing
2013
Channelling our thoughts
1991 Nature
Immunocytochemical localization of the cystic fibrosis gene product CFTR.
1991
Mechanism of activation of liver glycogen synthase by swelling.
1992
Role of cell volume and protein kinase C in regulation of a Cl‐ conductance in single proximal tubule cells of Rana temporaria.
1994
A C-terminal motif found in the β 2 -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na + /H + exchanger regulatory factor family of PDZ proteins
1998 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice.
1995 StandoutNobel
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
2011 StandoutNobel
Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (cftr): Detection of immunologically related proteins
1995
Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation inAplysiasensory neurons
2000 StandoutNobel
Cell volume and drug action: Some interactions and perspectives
1995
Works of Christine E. Bear being referenced
Purification and Characterization of Recombinant Cystic Fibrosis Transmembrane Conductance Regulator from Chinese Hamster Ovary and Insect Cells
1995
Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)
1992
The Chloride Channel ClC-4 Co-localizes with Cystic Fibrosis Transmembrane Conductance Regulator and May Mediate Chloride Flux across the Apical Membrane of Intestinal Epithelia
2002
ClC-2 Activation Modulates Regulatory Volume Decrease
1999
A K+-selective channel in the colonic carcinoma cell line: CaCo-2 is activated with membrane stretch
1991
Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein
2012
Drugs Transported by P-Glycoprotein Inhibit a 40pS Outwardly Rectifying Chloride Channel
1994
The cystic fibrosis mutation (ΔF508) does not influence the chloride channel activity of CFTR
1993
L-alanine evokes opening of single Ca2+-activated K+ channels in rat liver cells
1987
Phosphorylation‐activated chloride channels in human skin fibroblasts
1988
Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance
1991
ClC-2 Contributes to Native Chloride Secretion by a Human Intestinal Cell Line, Caco-2
2001
Cell Volume Changes and the Activity of the Chloride Conductance Path
1989
Intracellular pH influences the resting membrane potential of isolated rat hepatocytes
1988
A novel method for monitoring the cytosolic delivery of peptide cargo
2009
Cystic Fibrosis Transmembrane Conductance Regulator Modulates Neurosecretory Function in Pulmonary Neuroendocrine Cell-Related Tumor Cell Line Models
2002
Chloride channel activity of ClC-2 is modified by the actin cytoskeleton
2000
Novel method for evaluation of the oligomeric structure of membrane proteins
1999
The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.
1993
A novel procedure for the efficient purification of the cystic fibrosis transmembrane conductance regulator (CFTR)
1997
Purified Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Does Not Function as an ATP Channel
1996
Expression of CFTR and Cl−conductances in cells of pulmonary neuroepithelial bodies
2001
Failure of P‐glycoprotein (MDR1) expressed in Xenopus oocytes to produce swelling‐activated chloride channel activity.
1995
Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.
1991
Expression of the chloride channel ClC-2 in the murine small intestine epithelium
2000
A nonselective cation channel in rat liver cells is activated by membrane stretch
1990
Regulation of CFTR expression and function during differentiation of intestinal epithelial cells.
1992
A Therapy for Most with Cystic Fibrosis
2020
Quaternary Structure of the Chloride Channel ClC-2
2000
Evidence for a Superoxide Permeability Pathway in Endosomal Membranes
2008
Recombinant pICln Forms Highly Cation-selective Channels when Reconstituted into Artificial and Biological Membranes
1998
cAMP-inducible chloride conductance in mouse fibroblast lines stably expressing the human cystic fibrosis transmembrane conductance regulator.
1991