Citation Impact
Citing Papers
Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization
2004 StandoutScienceNobel
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Roles of tau protein in health and disease
2017
The role of hedgehog signalling in tumorigenesis
2001
Basal cell carcinomas: attack of the hedgehog
2008 Standout
Hedgehog signalling in cancer formation and maintenance
2003 Standout
Hedgehog regulates smoothened activity by inducing a conformational switch
2007 Nature
Hedgehog: functions and mechanisms
2008 Standout
The sterol-sensing domain: multiple families, a unique role?
2002
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
2002
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
2003 StandoutNature
Forces in Tissue Morphogenesis and Patterning
2013 Standout
Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
2003
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
2009 Standout
Sensing of Cytoskeletal Forces by Asymmetric Adherens Junctions
2017
Hedgehog–GLI signaling and the growth of the brain
2002
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Multiple Muscle Cell Identities Induced by Distinct Levels and Timing of Hedgehog Activity in the Zebrafish Embryo
2003
Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways
2009 StandoutNobel
Patched acts catalytically to suppress the activity of Smoothened
2002 Nature
The hedgehog signaling network
2003
Communicating with Hedgehogs
2005
Shifted, the Drosophila Ortholog of Wnt Inhibitory Factor-1, Controls the Distribution and Movement of Hedgehog
2005
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog
2003
Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection
2016
Regulated portals of entry into the cell
2003 StandoutNature
Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling
2010
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
2002 Standout
Vertebrate Smoothened functions at the primary cilium
2005 StandoutNature
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
2005
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Targeting the Hedgehog pathway in cancer
2006 Standout
Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association
2022 Standout
Cellular Trafficking of the Glypican Dally-like Is Required for Full-Strength Hedgehog Signaling and Wingless Transcytosis
2008
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Therapeutic potential of β-arrestin- and G protein-biased agonists
2010 StandoutNobel
Polygenic control of Caenorhabditis elegans fat storage
2006 StandoutNobel
Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila
2012
A Quantification of Pathway Components Supports a Novel Model of Hedgehog Signal Transduction
2009
Morphogen gradient interpretation by a regulated trafficking step during ligand–receptor transduction
2005 StandoutNobel
Several PATCHED1 Missense Mutations Display Activity in patched1-Deficient Fibroblasts
2002
PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail
2016
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
2009 Standout
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
2013 Standout
C. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domain
2011
Multiple ligand-specific conformations of the β2-adrenergic receptor
2011 StandoutNobel
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
2004
Teaching old receptors new tricks: biasing seven-transmembrane receptors
2010 StandoutNobel
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Mechanisms of Hedgehog gradient formation and interpretation
2005
Hedgehog Signaling: Costal-2 Bridges the Transduction Gap
2004
Hedgehog beyond medulloblastoma and basal cell carcinoma
2010
Temporal modulation of the Hedgehog morphogen gradient by a patched-dependent targeting to lysosomal compartment
2004
Structural diversity of G protein-coupled receptors and significance for drug discovery
2008
Differential Regulation of Lipoprotein and Hepatitis C Virus Secretion by Rab1b
2017 StandoutNobel
Independent roles of Drosophila Moesin in imaginal disc morphogenesis and hedgehog signalling
2006
A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis
2007 Standout
Mechanisms and functions of Hedgehog signalling across the metazoa
2011
Keystone taxa as drivers of microbiome structure and functioning
2018 Standout
Adipocyte differentiation from the inside out
2006 Standout
Organizing the cell cortex: the role of ERM proteins
2010 Standout
When cell biology meets development: endocytic regulation of signaling pathways
2002
Divergence of Hedgehog Signal Transduction Mechanism between Drosophila and Mammals
2006
USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization
2012
Multidrug permeases and subcellular cholesterol transport
2001
C. elegans daf-6 Encodes a Patched-Related Protein Required for Lumen Formation
2005
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Patching the gaps in Hedgehog signalling
2007
The Long-Range Activity of Hedgehog Is Regulated in the Apical Extracellular Space by the Glypican Dally and the Hydrolase Notum
2010
Fat and Dachsous Cadherins
2013
The primary cilium: a signalling centre during vertebrate development
2010 Standout
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
2002 Standout
Atg9 Vesicles Recruit Vesicle-tethering Proteins Trs85 and Ypt1 to the Autophagosome Formation Site
2012 StandoutNobel
Multidrug efflux pumps: structure, function and regulation
2018 Standout
The role of kinases in the Hedgehog signalling pathway
2008
Hedgehog Signaling: A Tale of Two Lipids
2001 Science
Role of Rab GTPases in Membrane Traffic and Cell Physiology
2011
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Patched regulates Smoothened trafficking using lipoprotein-derived lipids
2009
Distinct roles of PTCH2 splice variants in Hedgehog signalling
2004
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
2007 StandoutScience
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis
2012 StandoutNobel
Novel Lipid Modifications of Secreted Protein Signals
2004
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
Small molecule modulation of Smoothened activity
2002 Standout
Smoothened Signal Transduction Is Promoted by G Protein-Coupled Receptor Kinase 2
2006 StandoutNobel
Patched, the receptor of Hedgehog, is a lipoprotein receptor
2008
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
2011 Standout
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Individual-, family-, and school-level interventions targeting multiple risk behaviours in young people
2018
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways fromDrosophilato vertebrates
2005
Smoothened translates Hedgehog levels into distinct responses
2003
Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes
2002
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
2018 StandoutNobel
Mice with a Targeted Mutation of Patched2 Are Viable but Develop Alopecia and Epidermal Hyperplasia
2006
GSK-3: tricks of the trade for a multi-tasking kinase
2003 Standout
Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node
2001
Emerging Targets in Photopharmacology
2016 StandoutNobel
Cellular uptake of nanoparticles: journey inside the cell
2017 Standout
Regulatory Principles of Developmental Signaling
2002 StandoutNobel
Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus
2006
Cholesterol Sensing, Trafficking, and Esterification
2006
Works of Chloe Thomas being referenced
Planar Polarity Specification through Asymmetric Subcellular Localization of Fat and Dachsous
2012
A theory-based online health behaviour intervention for new university students (U@Uni:LifeGuide): results from a repeat randomized controlled trial
2015
The cost-effectiveness of a theory-based online health behaviour intervention for new university students: an economic evaluation
2014
Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation
2001
Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila
2004
The roles of the cadherins Fat and Dachsous in planar polarity specification in Drosophila
2011
JNK signalling influences intracellular trafficking during Drosophila morphogenesis through regulation of the novel target gene Rab30
2009
Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain
2015
Hedgehog Signaling in the Drosophila Eye and Head: An Analysis of the Effects of Different patched Trans-heterozygotes
2003