Citation Impact
Citing Papers
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Vaccine-delivered HIV envelope inhibits CD4+ T-cell activation, a mechanism for poor HIV vaccine responses
2006 StandoutNobel
Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
2005 StandoutNobel
HIV-1 gp120 Modulates the Immunological Function and Expression of Accessory and Co-Stimulatory Molecules of Monocyte-derived Dendritic Cells
2002
Regulation of Human Chemokine Receptors CXCR4
1997
Detection and Delineation of CXCR-4 (Fusin) as an Entry and Fusion Cofactor for T Cell-Tropic HIV-1 by Three Different Monoclonal Antibodies
1998
The role of chemokines in the regulation of dendritic cell trafficking
1999
The Role of the CD4 Receptor versus HIV Coreceptors in Envelope-Mediated Apoptosis in Peripheral Blood Mononuclear Cells
2002
Determinants of HIV-1 Coreceptor Function on CC Chemokine Receptor 3
1997
Virus replication begins in dendritic cells during the transmission of HIV-1 from mature dendritic cells to T cells
1999 StandoutNobel
Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4
1998
Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved?
2006
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
DC-SIGN-Mediated Internalization of HIV Is Required for Trans-Enhancement of T Cell Infection
2002
Chemokines — Chemotactic Cytokines That Mediate Inflammation
1998 Standout
Chemokines and HIV–1 second receptors
1996
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
1998 StandoutNature
Host factors and the pathogenesis of HIV-induced disease
1996 Nature
MHC-I–restricted presentation of HIV-1 virion antigens without viral replication
2001
Role of the Amino-Terminal Extracellular Domain of CXCR-4 in Human Immunodeficiency Virus Type 1 Entry
1997
Unwelcomed Guests with Master Keys: How HIV Uses Chemokine Receptors for Cellular Entry
1997
HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor
1997
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
DC-SIGN
2000 StandoutNobel
Involvement of chemokine receptors in breast cancer metastasis
2001 StandoutNature
Epitope Mapping of CCR5 Reveals Multiple Conformational States and Distinct but Overlapping Structures Involved in Chemokine and Coreceptor Function
1999
SNAREpins: Minimal Machinery for Membrane Fusion
1998 StandoutNobel
Chemokine Receptor Regulation and HIV Type 1 Tropism in Monocyte-Macrophages
1998
A CXCR4/CD4 Pseudotype Rhabdovirus That Selectively Infects HIV-1 Envelope Protein-Expressing Cells
1997
Construction of a Novel Virus That Targets HIV-1-Infected Cells and Controls HIV-1 Infection
1997
HIV-1 envelope gp41 is a potent inhibitor of chemoattractant receptor expression and function in monocytes.
1998
Trafficking of the HIV Coreceptor CXCR4
1999
CXCR4 Sequences Involved in Coreceptor Determination of Human Immunodeficiency Virus Type-1 Tropism
1998
Repertoire of Chemokine Receptor Expression in the Female Genital Tract
1998
Host Genes and HIV: The Role of the Chemokine Receptor Gene CCR5 and Its Allele (∆32 CCR5)
1997
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Cell-mediated cytotoxicity
1993 StandoutNobel
The Interaction of Immunodeficiency Viruses with Dendritic Cells
2003 StandoutNobel
HIV-1 Coreceptor Activity of CCR5 and Its Inhibition by Chemokines: Independence from G Protein Signaling and Importance of Coreceptor Downmodulation
1997
Dissociation of ligand-induced internalization of CXCR-4 from its co-receptor activity for HIV-1 Env-mediated membrane fusion
1998
Co-receptors for HIV-1 entry
1997
How Do Viruses Enter Cells? The HIV Coreceptors Teach Us a Lesson of Complexity
1997
Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor
1997
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Essential Roles for Dendritic Cells in the Pathogenesis and Potential Treatment of HIV Disease
2002
HIV fusion and its inhibition
2001
Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
1997 StandoutNatureNobel
Global quantification of mammalian gene expression control
2011 StandoutNature
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor
1998
CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4
1996
CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons
1997
CD4-Independent Infection by HIV-2 (ROD/B): Use of the 7-Transmembrane Receptors CXCR-4, CCR-3, and V28 for Entry
1997
Identification and Characterization of the CXCR4 Chemokine Receptor in Human T Cell Lines: Ligand Binding, Biological Activity, and HIV-1 Infectivity
1998
Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein–Barr virus nuclear antigen 1
1997 StandoutNobel
CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4+T Cells: Role of signal transduction
1998
gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5
1998
Degradation of Proteins with Acetylated Amino Termini by the Ubiquitin System
1989 StandoutScienceNobel
Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5
1997
Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses
1997
Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus
2004 StandoutNobel
A monoclonal antibody (12G5) directed against CXCR-4 inhibits infection with the dual-tropic human immunodeficiency virus type 1 isolate HIV-1(89.6) but not the T-tropic isolate HIV-1(HxB)
1997
CD4-Independent Binding of SIV gp120 to Rhesus CCR5
1997 Science
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages
1999 StandoutNobel
Phorbol Esters and SDF-1 Induce Rapid Endocytosis and Down Modulation of the Chemokine Receptor CXCR4
1997
Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein
1999
Functional rafts in cell membranes
1997 StandoutNature
Chemokines
1997 Standout
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection
1997
Postsynaptic Membrane Fusion and Long-Term Potentiation
1998 StandoutScienceNobel
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
2002 StandoutNobel
The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide ofStreptococcus pneumoniaein the marginal zone of mouse spleen
2003 StandoutNobel
Potential Immunocompetence of Proteolytic Fragments Produced by Proteasomes before Evolution of the Vertebrate Immune System
1997 StandoutNobel
APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection
2006 StandoutNobel
Human Immunodeficiency Virus (HIV) Envelope Binds to CXCR4 Independently of CD4, and Binding Can Be Enhanced by Interaction with Soluble CD4 or by HIV Envelope Deglycosylation
1998
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
CXCR4 is a functional coreceptor for infection of human macrophages by CXCR4-dependent primary HIV-1 isolates.
1998
Candidate Microbicides Block HIV-1 Infection of Human Immature Langerhans Cells within Epithelial Tissue Explants
2000
Lysosomes Behave as Ca2+-regulated Exocytic Vesicles in Fibroblasts and Epithelial Cells
1997
Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity
1997
Bound simian virus 40 translocates to caveolin-enriched membrane domains, and its entry is inhibited by drugs that selectively disrupt caveolae.
1996
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Expression of CCR5 Increases during Monocyte Differentiation and Directly Mediates Macrophage Susceptibility to Infection by Human Immunodeficiency Virus Type 1
1998
Cell surface receptors, virus entry and tropism of primate lentiviruses
2002
Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase
1997 StandoutNobel
Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1
1997
Detection and delineation of CXCR-4 (fusin) as an entry and fusion cofactor for T-tropic [correction of T cell-tropic] HIV-1 by three different monoclonal antibodies.
1998
Human immunodeficiency virus strains differ in their ability to infect CD4+ cells expressing the rat homolog of CXCR-4 (fusin)
1997
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Use of Murine CXCR-4 as a Second Receptor by Some T-Cell-Tropic Human Immunodeficiency Viruses
1998
Cytokine Regulation of Human Immunodeficiency Virus Type 1 Entry and Replication in Human Monocytes/Macrophages through Modulation of CCR5 Expression
1998
Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1α (SDF-1α) and SDF-1β are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage
1998 StandoutNobel
Optical trapping and manipulation of neutral particles using lasers
1997 StandoutNobel
High Levels of Viral Replication Contrast with Only Transient Changes in CD4+and CD8+Cell Numbers during the Early Phase of Experimental Infection with Simian Immunodeficiency Virus SIVmnd-1 inMandrillus sphinx
2002 StandoutNobel
CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease
1999 Standout
The Susceptibility to X4 and R5 Human Immunodeficiency Virus-1 Strains of Dendritic Cells Derived In Vitro From CD34+ Hematopoietic Progenitor Cells Is Primarily Determined by Their Maturation Stage
1999
Rapid Infection of Oral Mucosal-Associated Lymphoid Tissue with Simian Immunodeficiency Virus
1999 StandoutScienceNobel
Human Immunodeficiency Virus Fusion to Dendritic Cells Declines as Cells Mature
2006
CD4-independent infection by human immunodeficiency virus type 2 strain ROD/B: the role of the N-terminal domain of CXCR-4 in fusion and entry
1997
HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication
1997
The leukotriene B4receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells
1998
Fcγ Receptor-Mediated Suppression of Human Immunodeficiency Virus Type 1 Replication in Primary Human Macrophages
2003 StandoutNobel
Interaction of Chemokine Receptor CCR5 with its Ligands: Multiple Domains for HIV-1 gp120 Binding and a Single Domain for Chemokine Binding
1997
Cutting Edge: CXCR4 Is a Functional Coreceptor for Infection of Human Macrophages by CXCR4-Dependent Primary HIV-1 Isolates
1998
Lytic granules from cytotoxic T cells exhibit kinesin-dependent motility on microtubules in vitro
1993
Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1
1998
Altered peptidase and viral-specific T cell response in LMP2 mutant mice
1994 StandoutNobel
Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity
1997
Multiple extracellular domains of CCR-5 contribute to human immunodeficiency virus type 1 entry and fusion
1997
Mechanism by which the lectin actinohivin blocks HIV infection of target cells
2009 StandoutNobel
ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX
1996
Relationships between CD4 Independence, Neutralization Sensitivity, and Exposure of a CD4-Induced Epitope in a Human Immunodeficiency Virus Type 1 Envelope Protein
2001
Antigen Presentation and T Cell Stimulation by Dendritic Cells
2002
In Vivo Distribution of the Human Immunodeficiency Virus/Simian Immunodeficiency Virus Coreceptors: CXCR4, CCR3, and CCR5
1998
Multiple Residues Contribute to the Inability of Murine CCR-5 To Function as a Coreceptor for Macrophage-Tropic Human Immunodeficiency Virus Type 1 Isolates
1998
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor
1997
Pharmacokinetics and Safety of AMD-3100, a Novel Antagonist of the CXCR-4 Chemokine Receptor, in Human Volunteers
2000
Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains
1997
Chemokines
1997
A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains
1996
Identification of CXCR4 Domains That Support Coreceptor and Chemokine Receptor Functions
1999
Neutralizing Monoclonal Antibodies Block Human Immunodeficiency Virus Type 1 Infection of Dendritic Cells and Transmission to T Cells
1998 StandoutNobel
R5 HIV productively infects Langerhans cells, and infection levels are regulated by compoundCCR5polymorphisms
2003
The Decreased Replicative Capacity of Simian Immunodeficiency Virus SIVmac239ΔnefIs Manifest in Cultures of Immature Dendritic Cells and T Cells
2000 StandoutNobel
The Maturation of Dendritic Cells Results in Postintegration Inhibition of HIV-1 Replication
2001
Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains
1997
Prospects for the Future
2002 StandoutScienceNobel
Chemokine receptors and human immunodeficiency virus infection
1998
Works of Cheryl Lapham being referenced
Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: Implications for HIV primary infection
1997
Fusion of monocytes and macrophages with HIV-1 correlates with biochemical properties of CXCR4 and CCR5
1999
The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments.
1990
Class I molecules retained in the endoplasmic reticulum bind antigenic peptides.
1993
Evidence for Cell-Surface Association Between Fusin and the CD4-gp120 Complex in Human Cell Lines
1996 Science
Interferon γ and interleukin 6 modulate the susceptibility of macrophages to human immunodeficiency virus type 1 infection
2000
MHC-encoded proteasome subunits LMP2 and LMP7 are not required for efficient antigen presentation.
1994
Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules
1995