Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer
2008
Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1α Enhances Hypoxic Gene Expression and Tumor Growth
2009
Combinatorial Regulation of Neuroblastoma Tumor Progression by N-Myc and Hypoxia Inducible Factor HIF-1α
2010
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins
2007
Genetic and Functional Studies Implicate HIF1 α as a 14q Kidney Cancer Suppressor Gene
2011 StandoutNobel
Targeted Replacement of Hypoxia-Inducible Factor-1α by a Hypoxia-Inducible Factor-2α Knock-in Allele Promotes Tumor Growth
2005
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
2014 StandoutNobel
Role of ETS Transcription Factors in the Hypoxia-Inducible Factor-2 Target Gene Selection
2006
Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T Cells
2005
HIF isoforms in the skin differentially regulate systemic arterial pressure
2013
Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor
2015
MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1
2011 StandoutNobel
The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
2010
Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
2009
Hypoxia-Inducible Factors, Stem Cells, and Cancer
2007
The phosphorylation status of PAS‐B distinguishes HIF‐1α from HIF‐2α in NBS1 repression
2006
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
2011 StandoutNobel
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
2008
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
von Hippel–Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2α signaling and splenic erythropoiesis
2007
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis
2009 StandoutNobel
Hypoxia Increases Sirtuin 1 Expression in a Hypoxia-inducible Factor-dependent Manner
2011
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
2010
Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells
2004
Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition
2006 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms
2007 StandoutNobel
The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
2011
The interplay between MYC and HIF in cancer
2007
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis
2010 StandoutNobel
Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia
2007
Hypoxia-Inducible Factors 1α and 2α Regulate Trophoblast Differentiation
2005
Hypoxia and the HIF system in kidney disease
2007
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
The impact of O2 availability on human cancer
2008
Cardiopulmonary function in two human disorders of the hypoxia‐inducible factor (HIF) pathway: von Hippel‐Lindau disease and HIF‐2α gain‐of‐function mutation
2011 StandoutNobel
A Knock-in Mouse Model of Human PHD2 Gene-associated Erythrocytosis Establishes a Haploinsufficiency Mechanism
2013
HIF-2α, but not HIF-1α, promotes iron absorption in mice
2009
Endothelial deletion of hypoxia-inducible factor–2α (HIF-2α) alters vascular function and tumor angiogenesis
2009
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma
2005 StandoutNobel
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
The Hypoxia-Inducible Factor 2α N-Terminal and C-Terminal Transactivation Domains Cooperate To Promote Renal Tumorigenesis In Vivo
2007 StandoutNobel
Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency
2007
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance
2013 StandoutNobel
The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development
2007
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
2016 StandoutNobel
Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor–Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B
2006 StandoutNobel
Biology of hypoxia-inducible factor-2α in development and disease
2008
HIF-1α induces MXI1 by alternate promoter usage in human neuroblastoma cells
2009
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
HIF‐1α and HIF‐2α have divergent roles in colon cancer
2008
EPAS1 Promotes Adipose Differentiation in 3T3-L1 Cells
2004
A Gain-of-Function Mutation in the HIF2A Gene in Familial Erythrocytosis
2008
MYC on the Path to Cancer
2012 Standout
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
2008
The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF
2008
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
2008 StandoutNobel
HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo
2007 StandoutNobel
HIF-1 and ventilatory acclimatization to chronic hypoxia
2008
Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche
2010
The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia
2017 StandoutNobel
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype
2006
Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1α and HIF-2α Expression in Lung Epithelial Cells
2004
Transcriptional Up-regulation of Inhibitory PAS Domain Protein Gene Expression by Hypoxia-inducible Factor 1 (HIF-1)
2007
Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice
2008
Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia
2010
HIF2α cooperates with RAS to promote lung tumorigenesis in mice
2009 StandoutNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
2007 StandoutNobel
Reciprocal Regulation of HIF-1α and LincRNA-p21 Modulates the Warburg Effect
2013
The Differential Role of Hif1β/Arnt and the Hypoxic Response in Adipose Function, Fibrosis, and Inflammation
2011
Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3
2016
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
2006 StandoutNobel
Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia
2006
Transcriptional regulation by hypoxia inducible factors
2013
HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity
2007 StandoutNobel
Mechanisms of resistance to antiangiogenesis therapy
2010
Hypoxic Induction of the Regulator of G-Protein Signalling 4 Gene Is Mediated by the Hypoxia-Inducible Factor Pathway
2012
Proteomic identification of a role for the von Hippel Lindau tumour suppressor in changes in the expression of mitochondrial proteins and septin 2 in renal cell carcinoma
2006
Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction
2010
Hypoxia and Fetal Heart Development
2010
STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy
2013
Erythrocytosis and Pulmonary Hypertension in a Mouse Model of Human HIF2A Gain of Function Mutation
2013
Hypoxia inducible factor (HIF)‐2α is required for the development of the catecholaminergic phenotype of sympathoadrenal cells
2009
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth
2013
Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo
2006 StandoutNobel
Cooperativity of Stress-Responsive Transcription Factors in Core Hypoxia-Inducible Factor Binding Regions
2012
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
2012 StandoutNobel
Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism
2012
Hypoxia signalling in cancer and approaches to enforce tumour regression
2006 Nature
The Role of Hypoxia in Development of the Mammalian Embryo
2009
RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α
2007 StandoutNobel
Microarray analyses of hypoxia‐regulated genes in an aryl hydrocarbon receptor nuclear translocator (Arnt)‐dependent manner
2008
Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer
2015 StandoutNobel
HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation
2007
Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor
2007 StandoutNobel
VHL, the story of a tumour suppressor gene
2014
Hypoxia-inducible factors: central regulators of the tumor phenotype
2007
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation
2006 StandoutNobel
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
2009 StandoutNobel
Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia
2009
The von Hippel–Lindau protein, HIF hydroxylation, and oxygen sensing
2005 StandoutNobel
Signalling hypoxia by HIF hydroxylases
2005 StandoutNobel
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
2004
Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
2004
Anaemia in kidney disease: harnessing hypoxia responses for therapy
2015
Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system
2012
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
2007
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Hypoxia-inducible factor–2 (HIF-2) regulates hepatic erythropoietin in vivo
2007
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
2011
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2
2013 StandoutNobel
Hypoxia Induces Production of L-2-Hydroxyglutarate
2015
Development of novel therapeutic strategies that target HIF-1
2006 StandoutNobel
FOXO3a Is Activated in Response to Hypoxic Stress and Inhibits HIF1-Induced Apoptosis via Regulation of CITED2
2007
Brain-Specific Knock-Out of Hypoxia-Inducible Factor-1α Reduces Rather Than Increases Hypoxic-Ischemic Damage
2005
Oxygen homeostasis
2009 StandoutNobel
Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives
2014
Myc’s broad reach
2008
Molecular Mechanisms of Action and Therapeutic Uses of Pharmacological Inhibitors of HIF–Prolyl 4-Hydroxylases for Treatment of Ischemic Diseases
2013
Role of Hypoxia in the Evolution and Development of the Cardiovascular System
2007
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer
2009
Life with Oxygen
2007 StandoutScienceNobel
Hypoxia-Inducible Factor 1 (HIF-1) Pathway
2007 StandoutNobel
A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication
2013 StandoutNobel
HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
2009
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor—Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B
2007
Activation of Hypoxia‐Inducible Factor‐2 in Adipocytes Results in Pathological Cardiac Hypertrophy
2013
Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion
2014 StandoutNobel
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
The HIF Pathway and Erythrocytosis
2011
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
2004 StandoutNobel
The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1α
2006
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
2005
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1
2007 StandoutNobel
Stromal Cell–Derived Factor-1α and CXCR4 Expression in Hemangioblastoma and Clear Cell-Renal Cell Carcinoma: von Hippel-Lindau Loss-of-Function Induces Expression of a Ligand and Its Receptor
2005 StandoutNobel
Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss
2010 StandoutScienceNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
2009
Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway
2015 StandoutNobel
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue
2009
Hypoxia‐inducible factor stabilizers and other small‐molecule erythropoiesis‐stimulating agents in current and preventive doping analysis
2012
Erythrocytosis: the HIF pathway in control
2013
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
O2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3-Kinase/AKT Signaling
2011
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
2008 StandoutNobel
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
2009 StandoutNobel
A MicroRNA Signature of Hypoxia
2006
Role of Hypoxia-Inducible Factor (HIF)-1α versus HIF-2α in the Regulation of HIF Target Genes in Response to Hypoxia, Insulin-Like Growth Factor-I, or Loss of von Hippel-Lindau Function: Implications for Targeting the HIF Pathway
2006
Inactivation of the Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Suppresses von Hippel-Lindau Disease-Associated Vascular Tumors in Mice
2005
Control of Erythropoietin Gene Expression and its Use in Medicine
2007
Inhibition of Hypoxia-Inducible Factor Prolyl Hydroxylase Domain Oxygen Sensors: Tricking the Body into Mounting Orchestrated Survival and Repair Responses
2013
Works of Cheng‐Jun Hu being referenced
The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α
2007
Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells
2006
Acute postnatal ablation of Hif-2 α results in anemia
2007
HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth
2006
Upstream Stimulatory Factor 2 and Hypoxia-Inducible Factor 2α (HIF2α) Cooperatively Activate HIF2 Target Genes during Hypoxia
2012
Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response
2013
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
2003
Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate
2006
Hypoxia, HIFs, and Cardiovascular Development
2002
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells
2013
HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity
2007