Standout Papers
Citation Impact
Citing Papers
Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
2009 StandoutScience
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
2023 StandoutNobel
Andrographolide Enhances Nuclear Factor-κB Subunit p65 Ser536 Dephosphorylation through Activation of Protein Phosphatase 2A in Vascular Smooth Muscle Cells
2010
Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis
2016
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts
2015
Mechanised nanoparticles for drug delivery
2009 StandoutNobel
In silico ADME/T modelling for rational drug design
2015
ADMET in silico modelling: towards prediction paradise?
2003
A Systematic Comparison of the Properties of Clinically Used Angiotensin II Type 1 Receptor Antagonists
2013
Hepatic stellate cells as key target in liver fibrosis
2017
Pharmacokinetics and Pharmacodynamics of Nonsteroidal Androgen Receptor Ligands
2006
The influence of drug-like concepts on decision-making in medicinal chemistry
2007 Standout
Differential Roles of Hyperglycemia and Hypoinsulinemia in Diabetes Induced Retinal Cell Death: Evidence for Retinal Insulin Resistance
2011
The Blood–Brain Barrier
2015 Standout
Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats
2012
Mechanisms of hepatic stellate cell activation
2017 Standout
The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
2011 Standout
A guide to immunometabolism for immunologists
2016 Standout
Prediction of drug–ABC-transporter interaction — Recent advances and future challenges
2015
Targeting Ferroptosis to Iron Out Cancer
2019 Standout
Structure and function of the blood–brain barrier
2009 Standout
DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs
2010 Standout
Macrophage polarization in response to epigenetic modifiers during infection and inflammation
2016
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
2010 Standout
Macrophages in immunoregulation and therapeutics
2023 Standout
Using the Golden Triangle to optimize clearance and oral absorption
2009
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
2021 Standout
The biology and function of fibroblasts in cancer
2016 Standout
DrugBank 4.0: shedding new light on drug metabolism
2013 Standout
Hepatocellular carcinoma
2021 Standout
Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: Regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade
2012
Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline
2016 Standout
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
2011 Nature
DrugBank: a knowledgebase for drugs, drug actions and drug targets
2007 Standout
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
Systemic Inflammation‐Associated Glucocorticoid Resistance and Outcome of ARDS
2004
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
2007 Standout
Diabetic Retinopathy
2012 Standout
Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids
2005
Designing antimicrobial peptides: form follows function
2011 Standout
Human Intestinal Transporter Database: QSAR Modeling and Virtual Profiling of Drug Uptake, Efflux and Interactions
2012
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Polyspecific Organic Cation Transporters: Structure, Function, Physiological Roles, and Biopharmaceutical Implications
2007
Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism
2015
Sarcopenia
2019 Standout
A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP
2011
4-(Anilino)pyrrole-2-carboxamides: Novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor
2008
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
2013 StandoutNobel
Effects of andrographolide on sexual functions, vascular reactivity and serum testosterone level in rodents
2010
I-TASSER: a unified platform for automated protein structure and function prediction
2010 Standout
The role of drug metabolizing enzymes in clearance
2014
The Para Substituent of S-3-(Phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides Is a Major Structural Determinant of in Vivo Disposition and Activity of Selective Androgen Receptor Modulators
2005
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer
2011 Standout
Orientational Preferences of Neighboring Helices Can Drive ER Insertion of a Marginally Hydrophobic Transmembrane Helix
2012
In silicopharmacology for drug discovery: applications to targets and beyond
2007
Defining trained immunity and its role in health and disease
2020 Standout
Live attenuated vaccines against pertussis
2014
An analysis of the attrition of drug candidates from four major pharmaceutical companies
2015 Standout
Exploring the nature of the translocon-assisted protein insertion
2012 StandoutNobel
pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
2015 Standout
TFEB at a glance
2016
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
2014 Standout
Joint preventive effects of swimming and Shenlian extract on rat atherosclerosis
2011
The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
2011 Standout
Apical Sodium Dependent Bile Acid Transporter (ASBT, SLC10A2): A Potential Prodrug Target
2006
Docking and scoring in virtual screening for drug discovery: methods and applications
2004 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles
2012 Standout
Serum Metabolomics Analysis of Asthma in Different Inflammatory Phenotypes: A Cross-Sectional Study in Northeast China
2018
Structural basis for antagonism and resistance of bicalutamide in prostate cancer
2005
Photoinduced Acceleration of the Effluent Rate of Developing Solvents in Azobenzene-Tethered Silica Gel
2008
ProTox-II: a webserver for the prediction of toxicity of chemicals
2018 Standout
Experimental and Clinical Pharmacology ofAndrographis paniculataand Its Major Bioactive Phytoconstituent Andrographolide
2013 Standout
Inflammatory Bowel Disease
2010 Standout
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
2005 Standout
Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
2008
Direct Observation of a Dark State in the Photocycle of a Light-Driven Molecular Motor
2016 StandoutNobel
Selective androgen receptor modulators in preclinical and clinical development
2008
The role of promoter hypermethylation in fibroblast activation and fibrogenesis
2012
Hypolipidemic Effects of Andrographolide and Neoandrographolide in Mice and Rats
2012
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
2009 Standout
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Design, Synthesis, Cytoselective Toxicity, Structure–Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cells
2008
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
2021 Standout
Quantitative Conformationally Sampled Pharmacophore for δ Opioid Ligands: Reevaluation of Hydrophobic Moieties Essential for Biological Activity
2007
The selective androgen receptor modulator GTx‐024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double‐blind, placebo‐controlled phase II trial
2011
TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells
2019
Impaired T cell receptor signaling and development of T cell–mediated autoimmune arthritis
2020 StandoutNobel
Macrophage plasticity, polarization, and function in health and disease
2018 Standout
MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
2021 Standout
Exploiting Nutrient Transporters at the blood–brain Barrier to Improve Brain Distribution of Small Molecules
2010
Works of Cheng Chang being referenced
DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats
2012
Molecular Determinants of Substrate/Inhibitor Binding to the Human and Rabbit Renal Organic Cation Transporters hOCT2 and rbOCT2
2005
Role of hyperglycaemia in the pathogenesis of hypotension observed in type‐1 diabetic rats
2008
Molecular Requirements of the Human Nucleoside Transporters hCNT1, hCNT2, and hENT1
2004
In silico strategies for modeling membrane transporter function
2005
Modeling of active transport systems
2002
A Novel Antiinflammatory Role for Andrographolide in Asthma via Inhibition of the Nuclear Factor-κB Pathway
2009
In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method
2013
Pharmacophore-based discovery of ligands for drug transporters
2006
SOCS1 hypermethylation mediated by DNMT1 is associated with lipopolysaccharide-induced inflammatory cytokines in macrophages
2014
Dendritic cell‐derived interferon‐γ‐induced protein mediates tumor necrosis factor‐α stimulation of human lung fibroblasts
2008
Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma
2012
Transcription factor E3, a major regulator of mast cell–mediated allergic response
2012
In Vitro and Pharmacophore-Based Discovery of Novel hPEPT1 Inhibitors
2005
Mediation of β-endorphin in andrographolide-induced plasma glucose-lowering action in type I diabetes-like animals
2007
Computational approaches to modeling drug transporters
2005
Rapid Identification of P-glycoprotein Substrates and Inhibitors
2006
Comparative Pharmacophore Modeling of Organic Anion Transporting Polypeptides: A Meta-Analysis of Rat Oatp1a1 and Human OATP1B1
2005
Metabolomics Reveals Altered Metabolic Pathways in Experimental Asthma
2012
Structural Determinants of P-Glycoprotein-Mediated Transport of Glucocorticoids
2003
A Ligand-Based Approach To Identify Quantitative Structure−Activity Relationships for the Androgen Receptor
2004
Protective Role of 14-Deoxy-11,12-didehydroandrographolide, a Noncytotoxic Analogue of Andrographolide, in Allergic Airway Inflammation
2011 Standout
Topology Scanning and Putative Three-Dimensional Structure of the Extracellular Binding Domains of the Apical Sodium-Dependent Bile Acid Transporter (SLC10A2)
2004
Site-Directed Mutagenesis and Use of Bile Acid−MTS Conjugates to Probe the Role of Cysteines in the Human Apical Sodium-Dependent Bile Acid Transporter (SLC10A2)
2005
Attenuated Bordetella pertussis BPZE 1 protects against allergic airway inflammation and contact dermatitis in mouse models
2012