Citation Impact
Citing Papers
p130 Is Dispensable in Peripheral T Lymphocytes: Evidence for Functional Compensation by p107 and pRB
1998
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1
1996
HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family.
1997
Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors
1996
Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis
1998
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Effects of an Rb mutation in the mouse
1992 StandoutNature
Abundance and state of phosphorylation of the retinoblastoma gene product in human pituitary tumors
1996
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
The retinoblastoma gene family in differentiation and development
1999
Requirement for a functional Rb-1 gene in murine development
1992 Nature
DP and E2F proteins: coordinating transcription with cell cycle progression
1994
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Cyclin D1 provides a link between development and oncogenesis in the retina and breast
1995
Estimating African American Admixture Proportions by Use of Population-Specific Alleles
1998
A subset of p53-deficient embryos exhibit exencephaly
1995
Tumor spectrum analysis in p53-mutant mice
1994 Standout
The ins and outs of RB: coupling gene expression to the cell cycle clock
1994
Cell Proliferation in Carcinogenesis
1990 Science
WT-1 is required for early kidney development
1993 Standout
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
1998 StandoutNobel
Induction of heat shock proteins (HSPs) by sodium arsenite in cultured astrocytes and reduction of hydrogen peroxide‐induced cell death
2002
Expression patterns of the E2F family of transcription factors during mouse nervous system development
1997
The retinoblastoma gene family: cousins with overlapping interests
1998
Telomere states and cell fates
2000 StandoutNatureNobel
Molecular characterization of the retinoblastoma susceptibility gene
1993
Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line
1995
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting
1998
Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis
2007
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
1997 StandoutNobel
The Hallmarks of Cancer
2000 Standout
The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
1994 StandoutNobel
Increased Expression of Cytochrome P450 2E1 Induces Heme Oxygenase-1 through ERK MAPK Pathway
2003
Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
1993 Standout
Role of the retinoblastoma protein in the pathogenesis of human cancer.
1997 StandoutNobel
Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice
1998
Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds
1995
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle
1993
Mechanisms of carcinogenesis and the mutant mouse
1996
Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice.
1996
Tumor suppressor genes
1994
Telomeres Do D-Loop–T-Loop
1999 StandoutNobel
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
2006 Standout
The retinoblastoma gene in human pituitary tumors.
1993
Gene targeting and development of the nervous system
1994
The regulation of E2F by pRB-family proteins
1998 Standout
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
The cell cycle and the retinoblastoma protein family
1994
DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control
1994
The Role of Hypoxia in Development of the Mammalian Embryo
2009
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.
1997
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Switching and Signaling at the Telomere
2001 StandoutNobel
Growth Regulation by the E2F and DP Transcription Factor Families
1998
Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain
1996 StandoutNobel
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
Mismatch Repair Deficiency in Phenotypically Normal Human Cells
1995 StandoutScienceNobel
Inference of Population Structure Using Multilocus Genotype Data
2000 Standout
The retinoblastoma protein as a transcriptional repressor
1993
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Role of the INK4a Locus in Tumor Suppression and Cell Mortality
1996
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Extra-embryonic function of Rb is essential for embryonic development and viability
2003 Nature
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
1994 Nature
Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.
1996
Induction of Cell Cycle Arrest and B Cell Terminal Differentiation by CDK Inhibitor p18 and IL-6
1997
Synergistic role of E1A-Binding proteins and tissue-specific transcription factors in differentiation
1997
Heme Oxygenase-1: Molecular Mechanisms of Gene Expression in Oxygen-Related Stress
2002
Heme Oxygenase-1: Redox Regulation of a Stress Protein in Lung and Cell Culture Models
2004
Mitogen Activated Protein Kinase (MAPK) Pathway Regulates Heme Oxygenase-1 Gene Expression by Hypoxia in Vascular Cells
2002
Life, death, and the pursuit of apoptosis.
1996
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
1994 StandoutScienceNobel
Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 F1 mouse.
1986
Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.
1994
In Vitro Development of Primitive and Definitive Erythrocytes from Different Precursors
1996 StandoutScienceNobel
E2F-6, a member of the E2F family that can behave as a transcriptional repressor
1998
p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
1999 Science
Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.
1994
Cancer Cell Cycles
1996 StandoutScience
Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain
2003
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase
1999
p53 and E2F-1 cooperate to mediate apoptosis.
1994
RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila.
1996
Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma.
1990
Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance.
1994 StandoutNobel
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.
1994
Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.
1994
Cells Degrade a Novel Inhibitor of Differentiation with E1A-Like Properties upon Exiting the Cell Cycle
2000 StandoutNobel
Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1.
1993
Disruption of retinoblastoma protein function by coexpression of its C pocket fragment.
1995
Reversal of Terminal Differentiation Mediated by p107 in Rb -/- Muscle Cells
1994 Science
The transcriptional control of hematopoiesis [see comments]
1996
Deregulated Expression of E2F-1 Induces S-Phase Entry and Leads to Apoptosis
1994
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
The Developmental Biology of Brain Tumors
2001
Brca2 is required for embryonic cellular proliferation in the mouse.
1997 StandoutNobel
Speculations on the roles of RB1 in tissue‐specific differentiation, tumor initiation, and tumor progression
1993
Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6.
1996
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
MyoD induced cell cycle arrest is associated with increased nuclear affinity of the Rb protein.
1993
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.
1994
Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen.
1994
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.
1997
E2F Activity Is Regulated by Cell Cycle-Dependent Changes in Subcellular Localization
1997
Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system.
1996
High levels of expression of the tumor suppressor gene APC during development of the rat central nervous system
1994
Abnormal Centrosome Amplification in the Absence of p53
1996 Science
Cyclin D1 Is Dispensable for G1 Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity
1995
Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
2002
pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis.
1996
Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.
1994
Targeted disruption of p107: functional overlap between p107 and Rb.
1996
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
An essential role in liver development for transcription factor XBP-1
2000
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle.
1996
Shared role of the pRB-related p130 and p107 proteins in limb development.
1996
Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs.
1996
Another p53 Doppelgänger?
1998 StandoutScienceNobel
E2F-1 Blocks Terminal Differentiation and Causes Proliferation in Transgenic Megakaryocytes
1996
WW6: an embryonic stem cell line with an inert genetic marker that can be traced in chimeras.
1995
Works of Chen‐Ching Lai being referenced
PCR-based detection of a polymorphic BamHI site in intron 1 of the human retinoblastoma (RB) gene
1990
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
1992 Nature
Constitutive hsp70 Attenuates Hydrogen Peroxide-Induced Membrane Lipid Peroxidation
1999
Stable Overexpression of the Constitutive Form of Heat Shock Protein 70 Confers Oxidative Protection
1998
Induction of heme oxygenase-1 by Ginkgo Biloba Extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage
2001
Regulation of endothelial heme oxygenase activity during hypoxia is dependent on chelatable iron
2000
N-Sulfoöxy-2-aminofluorene is the major ultimate electrophilic and carcinogenic metabolite of N-hydroxy-2-acetylaminofluorene in the livers of infant male C57BL/6J × C3H/HeJ F1 (B6C3F1) mice
1985