Citation Impact
Citing Papers
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
2008
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis
2009
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
2009
miR-15 and miR-16 induce apoptosis by targeting BCL2
2005 Standout
KEGG for taxonomy-based analysis of pathways and genomes
2022 Standout
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance
2013
Hallmarks of Cancer: The Next Generation
2011 Standout
Context-dependent Bcl-2/Bak Interactions Regulate Lymphoid Cell Apoptosis
2009
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
2009 StandoutNobel
To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions
2008
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
2006
BAK and NOXA Are Critical Determinants of Mitochondrial Apoptosis Induced by Bortezomib in Mesothelioma
2013
Concomitant loss of proapoptotic BH3‐only Bcl‐2 antagonists Bik and Bim arrests spermatogenesis
2005
Crystallization and preliminary X-ray characterization of Epstein–Barr virus BHRF1 in complex with a benzoylurea peptidomimetic
2012
How the Bcl-2 family of proteins interact to regulate apoptosis
2006
BH3‐ligand regulates access of MCL‐1 to its E3 ligase
2005
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Bortezomib‐induced apoptosis in mature T‐cell lymphoma cells partially depends on upregulation of Noxa and functional repression of Mcl‐1
2008
Regulation of apoptosis: uncovering the binding determinants
2005
BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX
2010
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
2008
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL
2010
A Stapled BID BH3 Helix Directly Binds and Activates BAX
2006
Multi-input chemical control of protein dimerization for programming graded cellular responses
2019 StandoutNobel
Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices
2009
Cancer drug resistance: an evolving paradigm
2013 Standout
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
2006
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
2012 Standout
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1
2008
Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival
2011
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design
2017
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy
2005
BCL-2 family antagonists for cancer therapy
2008
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
2012 StandoutNobel
Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands
2004
Proteasome Inhibitor PS-341 Induces Apoptosis in Cisplatin-resistant Squamous Cell Carcinoma Cells by Induction of Noxa
2006
Development of new fatty liver, or resolution of existing fatty liver, over five years of follow-up, and risk of incident hypertension
2014
Bcl‐xL sequesters its C‐terminal membrane anchor in soluble, cytosolic homodimers
2004
Autophagy: Renovation of Cells and Tissues
2011 Standout
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
2007
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function
2005
Endoplasmic reticulum stress: cell life and death decisions
2005 Standout
Mitochondria: In Sickness and in Health
2012 Standout
Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX
2010
The structure of Boo/Diva reveals a divergent Bcl-2 protein
2010
Cancer genes and the pathways they control
2004 Standout
Apoptosis: embedded in membranes
2010
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
Withdrawal symptoms on display: Bcl-2 members under investigation
2006
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
2011
BAX activation is initiated at a novel interaction site
2008 Nature
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Bcl‐2 changes conformation to inhibit Bax oligomerization
2006
Mcl‐1–Bim complexes accommodate surprising point mutations via minor structural changes
2010
Autophagy in the Pathogenesis of Disease
2008 Standout
Mutation to Bax beyond the BH3 Domain Disrupts Interactions with Pro-survival Proteins and Promotes Apoptosis
2011
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
2006
Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1
2010
Mitochondria: pharmacological manipulation of cell death
2005
Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist
2007
Autophagy in Human Health and Disease
2013 Standout
Programmed Anuclear Cell Death Delimits Platelet Life Span
2007
Bax Forms an Oligomer via Separate, Yet Interdependent, Surfaces
2010
Ways of dying: multiple pathways to apoptosis
2003
A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak
2007
A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria
2011
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development
2010
Functional characterization of the Bcl-2 gene family in the zebrafish
2006
Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity
2005
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Free radicals and antioxidants in normal physiological functions and human disease
2006 Standout
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
2008
Autophagy and Aging
2011 Standout
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
During Apoptosis Bcl-2 Changes Membrane Topology at Both the Endoplasmic Reticulum and Mitochondria
2004
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance
2007
Molecular mechanisms of necroptosis: an ordered cellular explosion
2010 Standout
Self-eating and self-killing: crosstalk between autophagy and apoptosis
2007 Standout
Bcl-2 family members and apoptosis, taken to heart
2006
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
2012
Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol
2011
AKT/PKB Signaling: Navigating the Network
2017 Standout
The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest
2007
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
The Bcl-2 apoptotic switch in cancer development and therapy
2007 Standout
The Hallmarks of Aging
2013 Standout
Life in the balance: how BH3-only proteins induce apoptosis
2005
Survey of the year 2005 commercial optical biosensor literature
2006
The BCL-2 protein family: opposing activities that mediate cell death
2007 Standout
BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis
2013
Mechanisms of Action of Bcl-2 Family Proteins
2013
Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1
2006
Cardiovascular Disease and Myocardial Abnormalities in Nonalcoholic Fatty Liver Disease
2016
Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands
2009
Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML
2012
Mitochondria and cell death: outer membrane permeabilization and beyond
2010 Standout
Bax dimerizes via a symmetric BH3:groove interface during apoptosis
2011
NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition
2007
Molecular Determinants of Bim(BH3) Peptide Binding to Pro-Survival Proteins
2012
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Structural insights into the degradation of Mcl-1 induced by BH3 domains
2007
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements
2007 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
The Bcl-2 family: roles in cell survival and oncogenesis
2003
Molecular biology of Bax and Bak activation and action
2010
Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease
2013
Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
2007 Science
Mcl-1 Integrates the Opposing Actions of Signaling Pathways That Mediate Survival and Apoptosis
2009
Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+
1995 Standout
Proteasome Inhibitor PS-341 Induces Apoptosis in Cisplatin-resistant Squamous Cell Carcinoma Cells by Induction of Noxa
2006
Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma
2012 StandoutNobel
An Internal EELD Domain Facilitates Mitochondrial Targeting of Mcl-1 via a Tom70-dependent Pathway
2006
α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells
2015
(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xL Recognition: Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions
2006
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
2017 Standout
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
The Sequence Read Archive: a decade more of explosive growth
2021 Standout
Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets
2006
Direct activation of full-length proapoptotic BAK
2013
BimEL up‐regulation potentiates AIF translocation and cell death in response to MPTP
2005
BIMEL, an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation
2011
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release
2008
Peptide Ligands for Pro-survival Protein Bfl-1 from Computationally Guided Library Screening
2013
Mcl-1 Down-regulation Potentiates ABT-737 Lethality by Cooperatively Inducing Bak Activation and Bax Translocation
2007
Mitochondrial Oxidative Stress: Implications for Cell Death
2006
Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance
2010
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
2008
Metabolomics: A New Tool to Reveal the Nature of Diabetic Kidney Disease
2022
Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain
2011
CASTp 3.0: computed atlas of surface topography of proteins
2018 Standout
Works of Chen Lin being referenced
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x L , but not Bcl-2, until displaced by BH3-only proteins
2005
Serum and urine metabolomics reveal potential biomarkers of T2DM patients with nephropathy
2020
Influence of Non-Alcoholic Fatty Liver Disease on Autonomic Changes Evaluated by the Time Domain, Frequency Domain, and Symbolic Dynamics of Heart Rate Variability
2013
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity
2003