Citation Impact
Citing Papers
Twist Transcriptionally Up-regulates AKT2 in Breast Cancer Cells Leading to Increased Migration, Invasion, and Resistance to Paclitaxel
2007
BRAF Inhibitors Amplify the Proapoptotic Activity of MEK Inhibitors by Inducing ER Stress in NRAS-Mutant Melanoma
2017
Combinatorial Treatments That Overcome PDGFRβ-Driven Resistance of Melanoma Cells to V600EB-RAF Inhibition
2011
Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation
2016
Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis
2009
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
2003 Standout
TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant Melanoma
2013
miR-6883 Family miRNAs Target CDK4/6 to Induce G1 Phase Cell-Cycle Arrest in Colon Cancer Cells
2017
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
2005
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.
2003
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer
2015 Standout
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
2014 StandoutNobel
Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment
2015
Akt kinases in breast cancer and the results of adjuvant therapy
2003
The hVps34‐ SGK 3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC 1 and tumour growth
2016
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
ERBB receptors and cancer: the complexity of targeted inhibitors
2005 Standout
AKT1/PKBα Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 Cells
2001
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway
2016
Direct Identification of Tyrosine 474 as a Regulatory Phosphorylation Site for the Akt Protein Kinase
2002
An Acquired and Endogenous Glycocalyx Forms a Bidirectional “Don’t Eat” and “Don’t Eat Me” Barrier to Phagocytosis
2020 StandoutNobel
Phagocytosis checkpoints as new targets for cancer immunotherapy
2019
AKT/PKB Signaling: Navigating Downstream
2007 Standout
TRAIL and Other TRAIL Receptor Agonists as Novel Cancer Therapeutics
2009
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
2007 Standout
Ovarian cancer
2014 Standout
Cancer Metastasis: Building a Framework
2006 Standout
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
2017 Standout
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment
2011
Cancer drug resistance: an evolving paradigm
2013 Standout
The resurgence of platinum-based cancer chemotherapy
2007 Standout
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
Mesenchymal stem cells in health and disease
2008 Standout
Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway
2002 StandoutNobel
Reciprocal Regulation of HIF-1α and LincRNA-p21 Modulates the Warburg Effect
2013
The biology and function of fibroblasts in cancer
2016 Standout
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Activation of AKT Kinases in Cancer: Implications for Therapeutic Targeting
2005
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
2018 Standout
Complex networks orchestrate epithelial–mesenchymal transitions
2006 Standout
Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
2004 Standout
Targeting Mutant BRAF in Melanoma
2012
Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
2015 Standout
DEVD-Based Hydrogelator Minimizes Cellular Apoptosis Induction
2013
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
2003 StandoutNobel
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
Oncogene-Induced Senescence Does Not Require the p16INK4a or p14ARF Melanoma Tumor Suppressors
2009
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
2016 Standout
Targeting apoptosis in cancer therapy
2020 Standout
Perturbations of the AKT signaling pathway in human cancer
2005
The microenvironment of the tumour–host interface
2001 StandoutNature
The essence of senescence: Figure 1.
2010 Standout
β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosis
2003 StandoutNobel
GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability
2018
Emerging Biological Principles of Metastasis
2017 Standout
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment
2021
Metastasis to bone: causes, consequences and therapeutic opportunities
2002 Standout
Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo
2003 Standout
PD-L1 expression in cancer patients receiving anti PD-1/PD-L1 antibodies: A systematic review and meta-analysis
2016
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
2004
Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity
2024 StandoutNobel
AKT/PKB Signaling: Navigating the Network
2017 Standout
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
2012 Nature
The PI3K Pathway in Human Disease
2017 Standout
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Histone deacetylase inhibition in combination with MEK or BCL-2 inhibition in multiple myeloma
2019
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
2009 Standout
Gene regulation by long non-coding RNAs and its biological functions
2020 Standout
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes
2004 StandoutNobel
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation
2008
Inferring tumour purity and stromal and immune cell admixture from expression data
2013 Standout
The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.
2001
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
2015 Standout
Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening
2014
New insights into the role of EMT in tumor immune escape
2017
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade
2018 Standout
Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.
2003
AKT plays a central role in tumorigenesis
2001
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance
2010
Ferroptosis as a target for protection against cardiomyopathy
2019 Standout
The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200
2017
Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.
2001
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.
2001
Genes regulated by hepatocyte growth factor as targets to sensitize ovarian cancer cells to cisplatin
2006
Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer
2005 Standout
Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.
2002
Activation of Antioxidant Pathways in Ras-Mediated Oncogenic Transformation of Human Surface Ovarian Epithelial Cells Revealed by Functional Proteomics and Mass Spectrometry
2004
Overexpression and overactivation of Akt in thyroid carcinoma.
2001
Works of Chen Chen Jiang being referenced
Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress
2008
RIP1 Kinase Is an Oncogenic Driver in Melanoma
2015
Inhibition of Endoplasmic Reticulum Stress–Induced Apoptosis of Melanoma Cells by the ARC Protein
2008
Regulation of PD-L1: a novel role of pro-survival signalling in cancer
2015
Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS
2010
2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2
2009
Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress
2011
Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
2000
BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma
2017
MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma
2011
Apoptosis Induction in Human Melanoma Cells by Inhibition of MEK Is Caspase-Independent and Mediated by the Bcl-2 Family Members PUMA, Bim, and Mcl-1
2007
MEK-Independent Survival of B-RAFV600E Melanoma Cells Selected for Resistance to Apoptosis Induced by the RAF Inhibitor PLX4720
2010
Tunicamycin Sensitizes Human Melanoma Cells to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis by Up-regulation of TRAIL-R2 via the Unfolded Protein Response
2007
INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas
2015