Standout Papers
Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube
2011
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning
2007
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
2004
Small-molecule modulators of the Sonic Hedgehog signaling pathway
2009
The Caenorhabditis elegans rop-1 gene encodes the homologue of the human 60-kDa Ro autoantigen
1995
1 Developmental roles and clinical significance of Hedgehog signaling
2003
Distinct fibroblast lineages determine dermal architecture in skin development and repair
2013 StandoutNature
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
2017 Standout
Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
2002
A Role for Runx Transcription Factor Signaling in Dorsal Root Ganglion Sensory Neuron Diversification
2006
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
2014 StandoutNatureNobel
The Gli code: an information nexus regulating cell fate, stemness and cancer
2007
Targeted Expression of GLI1 in the Mammary Gland Disrupts Pregnancy-induced Maturation and Causes Lactation Failure
2007
Wound repair: a showcase for cell plasticity and migration
2016
The complexities of skeletal biology
2003 StandoutNature
Hedgehog: functions and mechanisms
2008 Standout
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
Some distal limb structures develop in mice lacking Sonic hedgehog signaling
2001
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
2002
In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog
2005 Nature
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
2003 StandoutNature
Epithelial stem cells, wound healing and cancer
2012
Mechanisms and Functional Implications of Adult Neurogenesis
2008 Standout
Long non-coding RNAs in nervous system function and disease
2010
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
2003 Nature
Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification
2002
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
2005
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche
2013
Emerging interactions between skin stem cells and their niches
2014
Mechanistic Differences in the Transcriptional Interpretation of Local and Long-Range Shh Morphogen Signaling
2012
Hedgehog signalling in the mouse requires intraflagellar transport proteins
2003 StandoutNature
Control of Shh activity and signaling in the neural tube
2000
Dynamics of Lgr6 + Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis
2015
Cancer Metastasis: Building a Framework
2006 Standout
Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
2000
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord
2003
Hairy tale of signaling in hair follicle development and cycling
2012
The Graded Response to Sonic Hedgehog Depends on Cilia Architecture
2007
The hedgehog signaling network
2003
Ro’s Role in RNA Reconnaissance
2005 StandoutNobel
Communicating with Hedgehogs
2005
Neural-Tube Defects
1999 Standout
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
Sonic hedgehog in CNS development: one signal, multiple outputs
2002
Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade
2002 StandoutScience
Vertebrate Smoothened functions at the primary cilium
2005 StandoutNature
Ribonucleoprotein complexes as autoantigens
1995
Inactivation of a Gαs–PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis
2015
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
2005
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms
2007
Pancreatic Adenocarcinoma
2014 Standout
The single-cell transcriptional landscape of mammalian organogenesis
2019 StandoutNature
A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA
2011 Standout
Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract
2007
Dynamic Changes in the Response of Cells to Positive Hedgehog Signaling during Mouse Limb Patterning
2004
Wnt/β-Catenin Signaling and Disease
2012 Standout
The Sonic Hedgehog–Patched–Gli Pathway in Human Development and Disease
2000
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
2012
Neural Stem Cells and the Origin of Gliomas
2005
Mosaic Removal of Hedgehog Signaling in the Adult SVZ Reveals That the Residual Wild-Type Stem Cells Have a Limited Capacity for Self-Renewal
2007
Several PATCHED1 Missense Mutations Display Activity in patched1-Deficient Fibroblasts
2002
SUMOylation by Pias1 Regulates the Activity of the Hedgehog Dependent Gli Transcription Factors
2010
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
2008
C. elegans patched-3 is an essential gene implicated in osmoregulation and requiring an intact permease transporter domain
2011
Malignant Gliomas in Adults
2008 Standout
Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification
2003
Building strong bones: molecular regulation of the osteoblast lineage
2011
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
2010 StandoutNature
Gli and hedgehog in cancer: tumours, embryos and stem cells
2002
EMT: 2016
2016 Standout
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling
2013
iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
2004
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3
2002
Scarless Wound Healing
2015
Hedgehog beyond medulloblastoma and basal cell carcinoma
2010
Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches
2003
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Cyclopamine Inhibition of Sonic Hedgehog Signal Transduction Is Not Mediated through Effects on Cholesterol Transport
2000
Hedgehog Signaling in Mouse Ovary: Indian Hedgehog and Desert Hedgehog from Granulosa Cells Induce Target Gene Expression in Developing Theca Cells
2005
Mechanisms and functions of Hedgehog signalling across the metazoa
2011
Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
2014 Standout
Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function
2005
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
2004 Nature
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex
2010 Nature
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
2011 Nature
Pattern formation: old models out on a limb
2003
Hedgehog signalling in foregut malignancy
2004
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
2009
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Wnt signalling in stem cells and cancer
2005 StandoutNature
MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans
2002 StandoutNobel
Genetic Elimination of Suppressor of Fused Reveals an Essential Repressor Function in the Mammalian Hedgehog Signaling Pathway
2006
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
2007 StandoutNobel
Hedgehog Signaling in Development and Cancer
2008 Standout
Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning
2012
Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities
2004 Standout
Regulation and Function of the Sonic Hedgehog Signal Transduction Pathway in Isolated Gastric Parietal Cells
2005
The Epidermis Comprises Autonomous Compartments Maintained by Distinct Stem Cell Populations
2013
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations
2011
Patched1 Haploinsufficiency Increases Adult Bone Mass and Modulates Gli3 Repressor Activity
2008
Hedgehog Signaling in Mature Osteoblasts Regulates Bone Formation and Resorption by Controlling PTHrP and RANKL Expression
2008
Tetrahymena proteins p80 and p95 are not core telomerase components
2001 StandoutNobel
Recognition of Nascent RNA by the Human La Antigen: Conserved and Divergent Features of Structure and Function
2001
Gli1can rescue the in vivo function ofGli2
2001
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development
2005
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
2005
Gli proteins and the control of spinal‐cord patterning
2003
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling
2007
Advances in skin grafting and treatment of cutaneous wounds
2014 StandoutScience
Excitatory glutamate is essential for development and maintenance of the piloneural mechanoreceptor
2012
Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities
2000
Gene Regulatory Networks and the Evolution of Animal Body Plans
2006 StandoutScience
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
2007 StandoutScience
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
Hedgehog signaling is required for pituitary gland development
2001
Genomewide Expression Profiling in the Zebrafish Embryo Identifies Target Genes Regulated by Hedgehog Signaling During Vertebrate Development
2006
Hedgehog Signaling and Human Disease
2002
Gli Proteins in Development and Disease
2011
GLI3-dependent transcriptional repression ofGli1, Gli2and kidney patterning genes disrupts renal morphogenesis
2006
The Hedgehog Response Network: Sensors, Switches, and Routers
2004 Science
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways fromDrosophilato vertebrates
2005
Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
2009
Wound Healing: A Cellular Perspective
2018 Standout
The La Autoantigen Contains a Dimerization Domain That Is Essential for Enhancing Translation
1997
Nuclear Import and the Evolution of a Multifunctional RNA-binding Protein
1998 StandoutNobel
Gli2 functions in FGF signaling during antero-posterior patterning
2000
Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
2006
Sonic hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing Its Processing and Degradation
2006
Genetic analysis of zebrafishgli1andgli2reveals divergent requirements forgligenes in vertebrate development
2003
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
2008
Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis
2010
Autoproteolysis in nucleoporin biogenesis
1999 StandoutNobel
Loss of the Serine/Threonine Kinase Fused Results in Postnatal Growth Defects and Lethality Due to Progressive Hydrocephalus
2005
The Levels of the RoRNP-Associated Y RNA Are Dependent Upon the Presence of ROP-1, the Caenorhabditis elegans Ro60 Protein
1999
Launching the germline in Caenorhabditis elegans: regulation of gene expression in early germ cells
1999
Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents
2009
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
2001 Standout
Sonic hedgehog Promotes G1Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors
2000
Cilia and Hedgehog responsiveness in the mouse
2005
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
2014
Plasticity of epithelial stem cells in tissue regeneration
2014 Science
Works of Chen Bai being referenced
Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner
2008
Genetic analysis of a La homolog in Drosophila melanogaster
2000
Drosophila clipper/CPSF 30K is a post-transcriptionally regulated nuclear protein that binds RNA containing GC clusters
1998
All Mouse Ventral Spinal Cord Patterning by Hedgehog Is Gli Dependent and Involves an Activator Function of Gli3
2004
Direct and indirect requirements of Shh/Gli signaling in early pituitary development
2010
Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells
2011
Patterning of ventral telencephalon requires positive function of Gli transcription factors
2009
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
2000 Standout
Gli2, but notGli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
2002
Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen.
1994