Citation Impact
Citing Papers
Cap‐independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α‐estradiol
2021
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
2010
TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice
2015
The role of bile acids in functional GI disorders
2014
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Sirtuins as regulators of metabolism and healthspan
2012 Standout
Bile acid transporters
2009
The human fatty acid-binding protein family: Evolutionary divergences and functions
2011
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
2008
The circadian epigenome: how metabolism talks to chromatin remodeling
2013
Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist
2013 Standout
TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders
2009
microRNAs: Modulators of the underlying pathophysiology of sarcopenia?
2015
Beyond the Sympathetic Tone: The New Brown Fat Activators
2013
Acute kidney injury
2012 Standout
Pleiotropic Roles of Bile Acids in Metabolism
2013
Current and Future Drug Targets in Weight Management
2010
Loss of the RNA polymerase III repressor MAF1 confers obesity resistance
2015
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
The Intestinal Immune System in Obesity and Insulin Resistance
2016
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes
2014 Standout
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
2014 StandoutNature
Telomeres: history, health, and hallmarks of aging
2021
Signals from the gut microbiota to distant organs in physiology and disease
2016
Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2
2000 StandoutNobel
Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats
2015
Hallmarks of aging: An expanding universe
2023 Standout
The Human Intestinal Microbiome in Health and Disease
2016 Standout
NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function
2011
Treatment of Obesity with Celastrol
2015 Standout
NAD+ as a Signaling Molecule Modulating Metabolism
2011
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice
2012
The Human Transcription Factors
2018 Standout
The gut microbiome in cardio-metabolic health
2015
Tipping the metabolic scales towards increased longevity in mammals
2015
Sirtuins, Aging, and Metabolism
2011
Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences
2022 StandoutNobel
Bile acid sequestrants
2011
The gut as a sensory organ
2013
Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis
2015 Standout
Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1.
1997
Organization and Evolution of Brain Lipidome Revealed by Large-Scale Analysis of Human, Chimpanzee, Macaque, and Mouse Tissues
2015 StandoutNobel
Mitochondria: In Sickness and in Health
2012 Standout
Beyond intestinal soap—bile acids in metabolic control
2014
PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
2011
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
2016 Standout
Increased glycine-amidated hyocholic acid correlates to improved early weight loss after sleeve gastrectomy
2017
Acute kidney injury
2019 Standout
Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
2013
Diet–microbiota interactions as moderators of human metabolism
2016 StandoutNature
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity
2015
A within-trial cost-effectiveness analysis of primary care referral to a commercial provider for weight loss treatment, relative to standard care—an international randomised controlled trial
2012 Standout
Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice
2015
On the Dependency of Cellular Protein Levels on mRNA Abundance
2016 Standout
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
2013
A biosynthetic pathway for a prominent class of microbiota-derived bile acids
2015
Sarcopenia
2019 Standout
NAD+ homeostasis in health and disease
2020
FXR is a molecular target for the effects of vertical sleeve gastrectomy
2014 Nature
Modulating protein activity using tethered ligands with mutually exclusive binding sites
2015
The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
2012
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism
2016 Standout
Prostaglandins prevent decreased epithelial cell proliferation associated with dextran sodium sulfate injury in mice
1998
Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery
2015
What We Talk About When We Talk About Fat
2014 Standout
Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders
2009
Cellular bioenergetics as a target for obesity therapy
2010
Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans
2015 StandoutNobel
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
2011
The Hallmarks of Aging
2013 Standout
Depletion of fat-resident Treg cells prevents age-associated insulin resistance
2015 Nature
Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin
2016
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Sirtuins in neurodegenerative diseases: an update on potential mechanisms
2013
Prediabetes: a high-risk state for diabetes development
2012 Standout
Interactions Between the Intestinal Microbiome and Liver Diseases
2014
Bile acid receptors as targets for drug development
2013
Metabolic distinction between vesicular and cytosolic GABA in cultured GABAergic neurons using13C magnetic resonance spectroscopy
2001
Inflammation in obesity, diabetes, and related disorders
2022 Standout
The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice
2012
CLOCK:BMAL1 is a pioneer-like transcription factor
2014 StandoutNobel
Gut microbiota in human metabolic health and disease
2020 Standout
Novel opportunities for next-generation probiotics targeting metabolic syndrome
2014
Antibiotic effects on gut microbiota and metabolism are host dependent
2016
Deciphering the nuclear bile acid receptor FXR paradigm
2010
Intestine farnesoid X receptor agonist and the gut microbiota activate G‐protein bile acid receptor‐1 signaling to improve metabolism
2018
Advances in skin grafting and treatment of cutaneous wounds
2014 StandoutScience
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
State of the Art and Prospects in Metal–Organic Framework (MOF)-Based and MOF-Derived Nanocatalysis
2019 Standout
Dialogue between E. coli free radical pathways and the mitochondria of C. elegans
2015 StandoutNobel
ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants
2019 StandoutNobel
Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity
2011
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases
2022
Apoptotic Cells Activate the “Phoenix Rising” Pathway to Promote Wound Healing and Tissue Regeneration
2010
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1
2012 Standout
Spermidine in health and disease
2018 StandoutScience
Thyroid Hormone Regulation of Metabolism
2014 Standout
Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium
2015
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
The ecology of the microbiome: Networks, competition, and stability
2015 StandoutScience
Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation
2014
TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism
2011
Ternary MIL-100(Fe)@Fe3O4/CA magnetic nanophotocatalysts (MNPCs): Magnetically separable and Fenton-like degradation of tetracycline hydrochloride
2018
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
2022
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
The gut microbiota and metabolic disease: current understanding and future perspectives
2016
KRAB zinc finger proteins
2017
Caenorhabditis elegans responses to bacteria from its natural habitats
2016 StandoutNobel
Exploring the therapeutic space around NAD+
2012
Works of Charles Thomas being referenced
Compromised Intestinal Lipid Absorption in Mice with a Liver-Specific Deficiency of Liver Receptor Homolog 1
2007
Targeting bile-acid signalling for metabolic diseases
2008
The metabolic footprint of aging in mice
2011
PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
2011
Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea
2007
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
2009
Cholesterol dependent downregulation of mouse and human apical sodium dependent bile acid transporter (ASBT) gene expression: molecular mechanism and physiological consequences
2006
The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors
2005
TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading
2011
Effects of residual levels of tetracycline on the barrier functions of human intestinal epithelial cells
2017
Statin Induction of Liver Fatty Acid-Binding Protein (L-FABP) Gene Expression Is Peroxisome Proliferator-activated Receptor-α-dependent
2004
Liver-specific ablation of Krüppel-associated box–associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma
2012
Role of Synaptic Vesicle Proton Gradient and Protein Phosphorylation on ATP-mediated Activation of Membrane-associated Brain Glutamate Decarboxylase
1999
Bile Acids and the Membrane Bile Acid Receptor TGR5—Connecting Nutrition and Metabolism
2008
16,16-Dimethyl Prostaglandin E 2 Increases Survival of Murine Intestinal Stem Cells When Given before Photon Radiation
1983
Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity
2009
Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies
2008
Molecular Field Analysis and 3D-Quantitative Structure−Activity Relationship Study (MFA 3D-QSAR) Unveil Novel Features of Bile Acid Recognition at TGR5
2008