Citation Impact
Citing Papers
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
2011 Standout
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Reconstituting Organ-Level Lung Functions on a Chip
2010 StandoutScience
Greater cardiac response of colloid than saline fluid loading in septic and non-septic critically ill patients with clinical hypovolaemia
2010
Antimicrobial therapy for patients with severe sepsis and septic shock: An evidence-based review
2004
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
2004 Standout
Surviving Intensive Care: a report from the 2002 Brussels Roundtable
2003
Immunomodulation in the critically ill
2009
Pro‐ versus Anti‐inflammatory Cytokine Profile in Patients with Severe Sepsis: A Marker for Prognosis and Future Therapeutic Options
2000
Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults
2009
Anti-tumor necrosis factor therapy in sepsis: Update on clinical trials and lessons learned
2001
Resistance to Acute Septic Peritonitis in Poly(ADP-ribose) Polymerase-1-Deficient Mice
2002
An evaluation of the end points of resuscitation11The opinions and assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. This article is based on a review first reported in the Journal of the US Army Medical Department 1997; PB 8-97-11/12:30-34.
1998
Pathogenetic Mechanisms of Septic Shock
1993 Standout
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
2001 Standout
Reducing Mortality in Severe Sepsis: The Surviving Sepsis Campaign
2008
Long-term health-related quality of life in survivors of sepsis. Short Form 36: A valid and reliable measure of health-related quality of life
2000
Apoptosis and caspases regulate death and inflammation in sepsis
2006
2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention
2011 Standout
Prospects for Cardiovascular Research
2001 StandoutNobel
Digestion of Streptococcus pneumoniae Cell Walls with Its Major Peptidoglycan Hydrolase Releases Branched Stem Peptides Carrying Proinflammatory Activity
1999
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
2002 StandoutNature
Cryopyrin activates the inflammasome in response to toxins and ATP
2006 StandoutNature
A Circulating Myocardial Depressant Substance is Associated with Cardiac Dysfunction and Peripheral Hypoperfusion (Lactic Acidemia) in Patients with Septic Shock
1989
Management of Sepsis
2006
Host–pathogen interactions in sepsis
2007
The Cardiovascular Response of Normal Humans to the Administration of Endotoxin
1989
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Sepsis and Septic Shock: A History
2009
Reversal of late septic shock with supraphysiologic doses of hydrocortisone
1998
Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors
2006
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
1997 Nature
Elevation of Cardiac Output and Oxygen Delivery Improves Outcome in Septic Shock
1992
Organizational Characteristics of Intensive Care Units Related to Outcomes of Abdominal Aortic Surgery
1999 Standout
Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells
2008
Outcomes Research in Critical Care
1999
Severe Sepsis and Septic Shock
2013 Standout
Protective effects of C5a blockade in sepsis
1999
Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock
2002
Inhibition of airway hyperresponsiveness and pulmonary inflammation by roflumilast and other PDE4 inhibitors
2005
A New Equation to Estimate Glomerular Filtration Rate
2009 Standout
The enigma of sepsis
2003
Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock*
2005
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
Fatal and Near-Fatal Anaphylactic Reactions to Food in Children and Adolescents
1992 Standout
A 3-Level Prognostic Classification in Septic Shock Based on Cortisol Levels and Cortisol Response to Corticotropin
2000
Inflammatory Mediators, Cytokines, and Adhesion Molecules in Pulmonary Inflammation and Injury
1996
Has the mortality of septic shock changed with time?
1998
Right Ventricular Dysfunction and Dilatation, Similar to Left Ventricular Changes, Characterize the Cardiac Depression of Septic Shock in Humans
1990
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
2000 Standout
Treating Patients with Severe Sepsis
1999
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
1995
The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.
1992 StandoutNobel
Transcriptional Instability during Evolving Sepsis May Limit Biomarker Based Risk Stratification
2013
Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis
1990
Hydrocortisone Therapy for Patients with Septic Shock
2008 Standout
Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis*
2003
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
1992 Standout
Risks and Benefits of Activated Protein C Treatment for Severe Sepsis
2002
Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin
1995
Septic shock
1998
Stress doses of hydrocortisone reverse hyperdynamic septic shock
1999
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
E5 Murine Monoclonal Antiendotoxin Antibody in Gram-Negative Sepsis<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>
2000
Cancer immunotherapy comes of age
2011 StandoutNature
Multiple Organ Dysfunction Score
1995 Standout
Atherosclerosis — An Inflammatory Disease
1999 Standout
Antibodies against CD14 protect primates from endotoxin-induced shock.
1996
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Mammalian MAP kinase signalling cascades
2001 StandoutNature
The Acute Respiratory Distress Syndrome
1995
CLINICAL TRIALS FOR SEVERE SEPSIS
1999
The Pathophysiology and Treatment of Sepsis
2003 Standout
A MODIFIED GOAL-DIRECTED PROTOCOL IMPROVES CLINICAL OUTCOMES IN INTENSIVE CARE UNIT PATIENTS WITH SEPTIC SHOCK
2006
High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: Efficacy and safety*
2006
Current treatment of severe sepsis
2006
The Effect of Tumor Necrosis Factor on Vascular Smooth Muscle
1991
Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study
2001
Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation
2000
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species
1993 StandoutScience
Hemodynamic variables related to outcome in septic shock
2005
Cardiovascular management of septic shock
2003
The inflammatory reflex
2002 StandoutNature
Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases
2008
E5531, a synthetic non‐toxic lipid A derivative blocks the immunobiological activities of lipopolysaccharide
1999
Immunonutrition in critically ill patients: a systematic review and analysis of the literature
2008
The Epidemiology of Sepsis in the United States from 1979 through 2000
2003 Standout
Selective pharmacological inhibition of distinct nitric oxide synthase isoforms
1996
Inhibition of Nitric Oxide Synthase in Experimental Gram-Negative Sepsis
1994
Monocyte deactivation in septic patients: Restoration by IFN-γ treatment
1997
Low‐dose hydrocortisone treatment for patients with septic shock: A pilot study comparing 3 days with 7 days
2011
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
2009 Standout
Laboratory models of sepsis and septic shock
1990
The immunopathogenesis of sepsis
2002 StandoutNature
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
The Effects of Ibuprofen on the Physiology and Survival of Patients with Sepsis
1997
Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock
2002 Standout
A Question of Balance
1999
Immunologic and Hemodynamic Effects of “Low-Dose” Hydrocortisone in Septic Shock
2003
Gene knockout of the KCNJ8‐encoded Kir6.1 K ATP channel imparts fatal susceptibility to endotoxemia
2006
Neutrophil Migration Mechanisms, with an Emphasis on the Pulmonary Vasculature
2000
Systemic Host Responses in Severe Sepsis Analyzed by Causative Microorganism and Treatment Effects of Drotrecogin Alfa (Activated)
2003
Cardiac-Specific Overexpression of Tumor Necrosis Factor-α Causes Oxidative Stress and Contractile Dysfunction in Mouse Diaphragm
2000
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
2016 Standout
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
1999 StandoutScience
Endotoxemia in Human Septic Shock
1991
TUMOR NECROSIS FACTOR: A Pleiotropic Cytokine and Therapuetic Target
1994
Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males
2007 StandoutNobel
Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve
1998
NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.
1990
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
2004 Standout
The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis
1988 StandoutScience
Immunology: Approaches to AIDS therapy
1986 StandoutNatureNobel
Roles of Infectious Agents in Atherosclerosis and Restenosis
1997 Standout
Platelet‐ and macrophage‐derived endogenous cannabinoids are involved in endotoxin‐induced hypotension
1998
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Disease Tolerance as a Defense Strategy
2012 StandoutScience
Multiple Roles of CLAN (Caspase-Associated Recruitment Domain, Leucine-Rich Repeat, and NAIP CIIA HET-E, and TP1-Containing Protein) in the Mammalian Innate Immune Response
2004
Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils
1997 StandoutNobel
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
1995 StandoutNobel
A Randomized Trial of Protocol-Based Care for Early Septic Shock
2014 Standout
Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome
1995
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
2011 StandoutScience
Cost-effectiveness of Monoclonal Antibodies to Gram-negative Endotoxin in the Treatment of Gram-negative Sepsis in ICU Patients
1993
Apoptosis in sepsis: a new target for therapeutic exploration
2001
Oxygen Delivery and Utilization in Sepsis
1989
Pathophysiologically Relevant Concentrations of Tumor Necrosis Factor-α Promote Progressive Left Ventricular Dysfunction and Remodeling in Rats
1998
An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality
1995
Protective effects of anti‐C5a peptide antibodies in experimental sepsis
2001
The Acquired Immunodeficiency Syndrome: An Update
1985
Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans
2001
Tumor Necrosis Factor-Dependent Adhesions as a Major Protective Mechanism Early in Septic Peritonitis in Mice
2001
2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention
2011 Standout
Epidemiology of Sepsis Syndrome in 8 Academic Medical Centers
1997
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
2003
Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding
2013
Hypotension and Resistance to Lipopolysaccharide-Induced Shock in Transgenic Mice Overexpressing Adrenomedullin in Their Vasculature
2000
Elevated blood pressures in mice lacking endothelial nitric oxide synthase
1996 StandoutNobel
Canadian Association of Radiologists consensus guidelines for the prevention of contrast-induced nephropathy: update 2012.
2007
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Charles Natanson being referenced
Systematic analysis of hydroxyethyl starch (HES) reviews: proliferation of low-quality reviews overwhelms the results of well-performed meta-analyses
2012
A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity
2007
Septic Shock in Humans
1990
Serial cardiovascular variables in survivors and nonsurvivors of human septic shock
1987
Preclinical trial of l-arginine monotherapy alone or with N-acetylcysteine in septic shock*
2006
The importance of usual care control groups for safety monitoring and validity during critical care research
2008
Surviving Sepsis — Practice Guidelines, Marketing Campaigns, and Eli Lilly
2006
Plasma exchange does not improve survival in a canine model of human septic shock
1993
Systemic Hemodynamic Abnormalities and Vasopressor Therapy in Sepsis and Septic Shock
1992
Pseudomonas aeruginosa Compared with Escherichia coli Produces Less Endotoxemia but More Cardiovascular Dysfunction and Mortality in a Canine Model of Septic Shock
1990
The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis
2009
Bundled care for septic shock: An analysis of clinical trials*
2010
Role of endotoxemia in cardiovascular dysfunction and mortality. Escherichia coli and Staphylococcus aureus challenges in a canine model of human septic shock.
1989
Depressed Left Ventricular Performance
1988
Therapeutic Trial of Lipid X in a Canine Model of Septic Shock
1993
G-CSF during Escherichia coli versus Staphylococcus aureus Pneumonia in Rats Has Fundamentally Different and Opposite Effects
1999
Meta-Analysis of Acute Lung Injury and Acute Respiratory Distress Syndrome Trials Testing Low Tidal Volumes
2002
Risk and the Efficacy of Antiinflammatory Agents
2002
Safeguarding Patients in Clinical Trials with High Mortality Rates
2001
Cardiovascular performance with E. coli challenges in a canine model of human sepsis
1988
A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.
1985
On-site physician staffing in a community hospital intensive care unit. Impact on test and procedure use and on patient outcome.
1984
Bacterial endotoxins and pathogenesis of Gram-negative infections: current status and future direction
1994
Selected Treatment Strategies for Septic Shock Based on Proposed Mechanisms of Pathogenesis
1994
The third component of complement protects against Escherichia coli endotoxin-induced shock and multiple organ failure.
1994
Controlled trials of rG-CSF and CD11b-directed MAb during hyperoxia and E. coli pneumonia in rats
1996
Factors that determine the hemodynamic response to inhalation anesthetics
1991
Tumor necrosis factor challenges in canines: patterns of cardiovascular dysfunction
1992
Anti-inflammatory therapies to treat sepsis and septic shock
1997
TNF but not IL-1 in dogs causes lethal lung injury and multiple organ dysfunction similar to human sepsis
1991
Meta-Analysis: The Effect of Steroids on Survival and Shock during Sepsis Depends on the Dose
2004
The coronary circulation in human septic shock.
1986
Cardiopulmonary effects of granulocyte colony-stimulating factor in a canine model of bacterial sepsis
1994
Hemodynamic effects of dopamine, norepinephrine, and fluids in a dog model of sepsis
1996
Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock.
1986
The sirens' songs of confirmatory sepsis trials
1998
Neutrophil aggregating activity and septic shock in humans: Neutrophil aggregation by a C5a-like material occurs more frequently than complement component depletion and correlates with depression of systemic vascular resistance
1988
Hemodynamic effects of dopamine, norepinephrine, and fluids in a dog model of sepsis
1995
Antibiotics versus cardiovascular support in a canine model of human septic shock
1990
LACK OF PROTECTION BY Nw-METHYL-L-ARGININE (NMA), A NITRIC OXIDE SYNTHASE INHIBITOR, IN ENDOTOXIN (LPS)-CHALLENGED CANINES
1993
Protection with Antibody to Tumor Necrosis Factor Differs with Similarly Lethal Escherichia coli versus Staphylococcus aureus Pneumonia in Rats
2003
Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock.
1989
Responses of left ventricular function in survivors and nonsurvivors of septic shock
1989
N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin.
1992
Persistence of Pneumocystis carinii in lung tissue of acquired immunodeficiency syndrome patients treated for pneumocystis pneumonia.
1984