Citation Impact
Citing Papers
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR2
2004
Promoter Choice Determines Splice Site Selection in Protocadherin α and γ Pre-mRNA Splicing
2002 StandoutNobel
Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates
2000
Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay
2004 StandoutNobel
Thematic Review Series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
2008
Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells
2005
Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors
2016
Multidrug resistance in cancer: role of ATP–dependent transporters
2002 Standout
Identification of the Interaction Site within Acyl-CoA:Cholesterol Acyltransferase 2 for the Isoform-specific Inhibitor Pyripyropene A
2008 StandoutNobel
Molecular mediators of hepatic steatosis and liver injury
2004 Standout
Lineage-Specific Changes in Biomarkers in Great Apes and Humans
2015 StandoutNobel
Therapeutic elevation of HDL-cholesterol to prevent atherosclerosis and coronary heart disease
2006
Inflammation and metabolic disorders
2006 StandoutNature
Potential therapeutics for obesity and atherosclerosis: Inhibitors of neutral lipid metabolism from microorganisms
2007 StandoutNobel
The Enzymes of Neutral Lipid Synthesis
2001
Effects of Torcetrapib in Patients at High Risk for Coronary Events
2007 Standout
Selectivity of Pyripyropene Derivatives in Inhibition toward Acyl-CoA:cholesterol Acyltransferase 2 Isozyme
2008 StandoutNobel
Human Acyl-CoA:Cholesterol Acyltransferase-1 (ACAT-1) Gene Organization and Evidence That the 4.3-Kilobase ACAT-1 mRNA Is Produced from Two Different Chromosomes
1999
Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 3
2013 StandoutNobel
Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia
2000
Cancer drug resistance: an evolving paradigm
2013 Standout
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
Roles of acyl-coenzyme A : cholesterol acyltransferase-1 and -2
2001
The Active Site His-460 of Human Acyl-coenzyme A:Cholesterol Acyltransferase 1 Resides in a Hitherto Undisclosed Transmembrane Domain
2005
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Atherosclerosis: current pathogenesis and therapeutic options
2011 Standout
Very-low-density lipoprotein assembly and secretion
2001
Human Acyl-CoA:Cholesterol Acyltransferase-1 Is a Homotetrameric Enzyme in Intact Cells and in Vitro
1999
Inflammation, stress, and diabetes
2005 Standout
Immunological Quantitation and Localization of ACAT-1 and ACAT-2 in Human Liver and Small Intestine
2000
Metazoan MicroRNAs
2018 Standout
Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study
2002
Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 2
2013 StandoutNobel
Expression of Caveolin-1 Enhances Cholesterol Efflux in Hepatic Cells
2004
Synthesis and structure–activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 1
2013 StandoutNobel
Selectivity of Microbial Acyl-CoA : cholesterol Acyltransferase Inhibitors toward Isozymes
2007 StandoutNobel
Dynamics and functions of lipid droplets
2018 Standout
3 ACAT Inhibitors: The Search for a Novel and Effective Treatment of Hypercholesterolemia and Atherosclerosis
2002
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
2000
Update on strategies to increase HDL quantity and function
2009
Mammalian acyl-CoA:cholesterol acyltransferases
2000
ACAT Inhibition and Progression of Carotid Atherosclerosis in Patients With Familial Hypercholesterolemia
2009
The ins and outs of hepatitis C virus entry and assembly
2013 StandoutNobel
ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase
1998
Age-related macular degeneration
2018 Standout
The Human ATP-Binding Cassette (ABC) Transporter Superfamily
2001
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Diverse range of small peptides associated with high-density lipoprotein
2005
Lipid‐lowering therapy does not affect the postprandial drop in high density lipoprotein‐cholesterol (HDL‐c) plasma levels in obese men with metabolic syndrome: a randomized double blind crossover trial
2008
A Simple Enantioconvergent and Chemoenzymatic Synthesis of Optically Active α‐Substituted Amides
2011 StandoutNobel
Human Acyl-CoA:Cholesterol Acyltransferase-1 in the Endoplasmic Reticulum Contains Seven Transmembrane Domains
1999
Physiology of Local Renin-Angiotensin Systems
2006 Standout
Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation
2003
Increased atherosclerosis in LDL receptor–null mice lacking ACAT1 in macrophages
2001
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B–containing lipoproteins
2008 StandoutNobel
Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
2003
Current understanding of the metabolism and biological actions of HDL
2005
Atherosclerosis
2000 StandoutNature
Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis
2011 Standout
Diacylglycerol Enrichment of Endoplasmic Reticulum or Lipid Droplets Recruits Perilipin 3/TIP47 during Lipid Storage and Mobilization
2009
Perinuclear Localization and Insulin Responsiveness of GLUT4 Requires Cytoskeletal Integrity in 3T3-L1 Adipocytes
2000
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
2000
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Atherosclerosis
2001 Standout
Sequence Variations in PCSK9, Low LDL, and Protection against Coronary Heart Disease
2006 Standout
Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism
2003
Stimulation of Cholesterol Excretion by the Liver X Receptor Agonist Requires ATP-binding Cassette Transporters G5 and G8
2003
Inhibition of Acyl‐CoA Cholesterol Acyltransferase by F12511 (Eflucimibe): Could it be a New Antiatherosclerotic Therapeutic?
2008
Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice
2007
HIF-1beta determines ABCA1 expression under hypoxia in human macrophages
2009 StandoutNobel
MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 ( Srebp2 ) regulates HDL in vivo
2010
Diagnosis and Management of the Metabolic Syndrome
2005 Standout
Liver-Specific Inhibition of Acyl-Coenzyme A:Cholesterol Acyltransferase 2 With Antisense Oligonucleotides Limits Atherosclerosis Development in Apolipoprotein B100–Only Low-Density Lipoprotein Receptor −/− Mice
2006
Tumour stem cells and drug resistance
2005 Standout
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice
2003
Gene therapy for dyslipidemia: a review of gene replacement and gene inhibition strategies
2010
Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport
2011
The Nine Lives of ACAT Inhibitors
2006
Pyripyropene A, an Acyl–Coenzyme A:Cholesterol Acyltransferase 2–Selective Inhibitor, Attenuates Hypercholesterolemia and Atherosclerosis in Murine Models of Hyperlipidemia
2011 StandoutNobel
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
Regulation of ATP-Binding Cassette Transporter A1 Transcription by Thyroid Hormone Receptor
2004
ACAT2 Is Localized to Hepatocytes and Is the Major Cholesterol-Esterifying Enzyme in Human Liver
2004 StandoutNobel
Mammalian ABC Transporters in Health and Disease
2002
Isoform-Specific Inhibitors of Acats: Recent Advances and Promising Developments
2011
Thyroid Hormone Regulation of Metabolism
2014 Standout
Plasma Cholesteryl Esters Provided by Lecithin:Cholesterol Acyltransferase and Acyl-Coenzyme A:Cholesterol Acyltransferase 2 Have Opposite Atherosclerotic Potential
2004
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
2008 Standout
Interleukin‐10 overexpression in macrophages suppresses atherosclerosis in hyperlipidemic mice
2010
Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
2003
ACAT2 Is a Target for Treatment of Coronary Heart Disease Associated With Hypercholesterolemia
2005
Human Acyl-Coenzyme A:Cholesterol Acyltransferase Expressed in Chinese Hamster Ovary Cells: Membrane Topology and Active Site Location
2003
Molecular mediators of hepatic steatosis and liver injury
2004 Standout
HDL Cholesterol and Protective Factors in Atherosclerosis
2004
Total synthesis of pyripyropene A
2011 StandoutNobel
Mechanisms of Endocytosis
2009 Standout
Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
2004 StandoutScience
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Acyl coenzyme A : cholesterol acyltransferase types 1 and 2: structure and function in atherosclerosis
2001
Works of Charles Joyce being referenced
Acyl-coenzyme A
1999
ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice
2001
Comparative genome analysis of potential regulatory elements in the ABCG5–ABCG8 gene cluster
2002
ABCA1 Overexpression in the Liver of LDLr-KO Mice Leads to Accumulation of Pro-atherogenic Lipoproteins and Enhanced Atherosclerosis
2006
Identification of a Form of Acyl-CoA:Cholesterol Acyltransferase Specific to Liver and Intestine in Nonhuman Primates
1998
ACAT1 and ACAT2 Membrane Topology Segregates a Serine Residue Essential for Activity to Opposite Sides of the Endoplasmic Reticulum Membrane
2000
Study of ABCA1 Function in Transgenic Mice
2003
ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice
2001
The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice
2001
Regulation of Plasma High-Density Lipoprotein Levels by the ABCA1 Transporter and the Emerging Role of High-Density Lipoprotein in the Treatment of Cardiovascular Disease
2004