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Citing Papers
A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses
2003
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production
2005 StandoutNobel
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Function of Granulocytes with Deficient Myeloperoxidase‐Mediated Iodination in a Patient with Generalized Pustular Psoriasis
1976
Interactions of PGH Synthase Isozymes‐1 and ‐2 with NSAIDsa
1994
Rapid Secretion of Interleukin-1β by Microvesicle Shedding
2001
Prostaglandin Endoperoxide H Synthases-1 and -2
1996
Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2
1995
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Inflammation and cancer
2002 StandoutNature
COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes
1998 StandoutNobel
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
1995 StandoutNobel
Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
1993
The role of cyclooxygenases in inflammation, cancer, and development
1999
Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells
1995
Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2
1995
Pharmacology of Prostaglandin Endoperoxide Synthase Isozymes‐1 and‐2a
1994
Toll-like Receptors and Innate Immunity
2001
Cells’ Perception of Position in a Concentration Gradient
1998 StandoutNobel
NF-κB, the first quarter-century: remarkable progress and outstanding questions
2012 Standout
Binding and entry of respiratory syncytial virus into host cells and initiation of the innate immune response
2003
Selective Induction of Prostaglandin G/H Synthase I by Stem Cell Factor and Dexamethasone in Mast Cells
1995
Neutrophil priming mechanisms of sulfolipid-I and n-formyl-methionyl-leucyl-phenylalanine
1994
Signals and Receptors Involved in Recruitment of Inflammatory Cells
1995
Courtship in S. cerevisiae: Both cell types choose mating partners by responding to the strongest pheromone signal
1990 StandoutNobel
Toll-like receptors in innate immunity
2004 Standout
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
The Immunobiology of Eosinophils
1991
Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells
1989 Nature
A synaptic model of memory: long-term potentiation in the hippocampus
1993 StandoutNature
Negative regulation of inflammation by SIRT1
2012
Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part I)
1994
Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR
2003
Chemotaxis in Eukaryotic Cells: A Focus on Leukocytes and Dictyostelium
1988
A comparative analysis of cytokine production and tolerance induction by bacterial lipopeptides, lipopolysaccharides and Staphyloccocus aureus in human monocytes
1997
Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues
1993
Osteoclast differentiation and activation
2003 StandoutNature
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
HIV infection does not require endocytosis of its receptor, CD4
1988 StandoutNobel
Transcriptional control of the inflammatory response
2009
Virus-induced autoantibody response to a transgenic viral antigen
1990 StandoutNatureNobel
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
1996 Standout
FMRFamide reverses protein phosphorylation produced by 5-HT and cAMP in Aplysia sensory neurons
1989 StandoutNatureNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Origin and physiological roles of inflammation
2008 StandoutNature
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
1995 StandoutNobel
Identification of a Novel Ca2+-dependent, Phosphatidylethanolamine-hydrolyzing Phospholipase D in Yeast Bearing a Disruption in PLD1
1997
The Hallmarks of Aging
2013 Standout
Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.
1994
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
2008 Standout
Effects of Extracellular ATP on Mononuclear Phagocytes
1990
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
1994
PGH synthase isoenzyme selectivity: The potential for safer nonsteroidal antiinflammatory drugs
1993
Local and Systemic Effects of Intradermal Recombinant Interferon-γ in Patients with Lepromatous Leprosy
1986 StandoutNobel
TGF-beta1 inhibits both endotoxin-induced prostaglandin synthesis and expression of the TIS10/prostaglandin synthase 2 gene in murine macrophages
1994
Bacterial lipopolysaccharide priming of P388D1 macrophage-like cells for enhanced arachidonic acid metabolism. Platelet-activating factor receptor activation and regulation of phospholipase A2.
1990
Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells.
1994
The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its ω-metabolites
1987
THE DEVELOPMENT OF NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES IN HUMAN BONE MARROW
1971
Oxidative inactivation of leukotriene C 4 by stimulated human polymorphonuclear leukocytes
1982 StandoutNobel
Expression cloning of an ATP receptor from mouse neuroblastoma cells.
1993 StandoutNobel
Biological Defense Mechanisms THE EFFECT OF BACTERIA AND SERUM ON SUPEROXIDE PRODUCTION BY GRANULOCYTES
1974
Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin.
1996 StandoutNobel
The Role of Protein Kinase C in Transmembrane Signalling
1986
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Adults with chronic granulomatous disease of “childhood”
1977
Effect of phorbol 12-myristate 13-acetate and its analogue 4 alpha-phorbol 12,13-didecanoate on protein phosphorylation and lysosomal enzyme release in rabbit neutrophils.
1984
Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C.
1985
Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes
1976
Oxygen-Dependent Microbial Killing by Phagocytes
1978 Standout
Further characterization of NADPH oxidase activity of human polymorphonuclear leukocytes.
1976
Defect in Pyridine Nucleotide Dependent Superoxide Production by a Particulate Fraction from the Granulocytes of Patients with Chronic Granulomatous Disease
1975
Inositol trisphosphate, a novel second messenger in cellular signal transduction
1984 StandoutNature
Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.
1975
Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle
2002
Superoxide production by phagocytic leukocytes.
1975
Specific binding by human polymorphonuclear leucocytes of the immunological mediator 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine.
1983
In Vitro Activation and Nuclear Translocation of NF-κB Catalyzed by Cyclic AMP-Dependent Protein Kinase and Protein Kinase C
1989
Molecular and Cellular Mechanisms of Leukocyte Chemotaxis
1981 Science
The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum.
1994
Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes.
1983 StandoutNobel
Comparison of NADH and NADPH oxidase activities in granules isolated from human polymorphonuclear leukocytes with a fluorometric assay.
1977
Arachidonic acid metabolism in polymorphonuclear leukocytes
1979 StandoutNobel
A sulfated metabolite produced bystf3negatively regulates the virulence ofMycobacteriumtuberculosis
2006 StandoutNobel
Toxicity of β-blockers in a rat whole embryo culture: concentration-response relationships and tissue concentrations
1994
NEUTROPHIL DYSFUNCTION, CHRONIC GRANULOMATOUS DISEASE, AND NON-SPHEROCYTIC HÆMOLYTIC ANÆMIA CAUSED BY COMPLETE DEFICIENCY OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE
1973
Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils
1997 StandoutNobel
Signal transduction pathways responsible for serotonin-mediated prostaglandin G/H synthase expression in rat mesangial cells.
1994
Measuring the Accuracy of Diagnostic Systems
1988 StandoutScience
Manganese-dependent NADPH oxidation by granulocyte particles. The role of superoxide and the nonphysiological nature of the manganese requirement.
1976
Normal leukocyte glutathione peroxidase activity in patients with chronic granulomatous disease
1976
Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects.
1996 StandoutNobel
Problems of Spectrum and Bias in Evaluating the Efficacy of Diagnostic Tests
1978 Standout
1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.
1985
An early transient decrease in phosphatidylinositol 4,5-bisphosphate upon stimulation of rabbit platelets with acetylglycerylether phosphorylcholine (platelet activating factor)
1983
Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide.
1992
Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.
1983 Standout
Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?
1983 StandoutScienceNobel
H2O2 Release from Human Granulocytes during Phagocytosis
1977
Studies and Perspectives of Protein Kinase C
1986 StandoutScience
Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis.
1983 StandoutNobel
Cytoplasmic lipid bodies of neutrophils: formation induced by cis-unsaturated fatty acids and mediated by protein kinase C.
1991
Shielding the double-edged sword: negative regulation of the innate immune system
2003
Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells.
1993
Chemiluminescence as an Analytical Tool in Cell Biology and Medicine
1985
A platelet-activating factor antagonist, RP 55778, inhibits cytokine-dependent induction of human immunodeficiency virus expression in chronically infected promonocytic cells.
1993 StandoutNobel
The Application of Antibody Coated Polyacrylamide Gel (Immunobead) in the NBT Test for the Detection of Ingestion and Killing Functions of Human Neutrophils
1979
The Effects of Ascorbic Acid on Bactericidal Mechanisms of Neutrophils
1971
HIV replication in CD4+T cells of HIV-infected individuals is regulated by a balance between the viral suppressive effects of endogenous β-chemokines and the viral inductive effects of other endogenous cytokines
1996 StandoutNobel
The Biology and Detection of Immune Complexes
1980
Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.
1994
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of theMycobacterium tuberculosisvirulence factor Sulfolipid-1
2007 StandoutNobel
Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds
1981 Nature
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2
2001 StandoutNobel
A block at the toll gate
2002 Nature
SirT1 Regulates Adipose Tissue Inflammation
2011
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
Acetylglyceryl ether phosphorylcholine. A potent activator of hepatic phosphoinositide metabolism and glycogenolysis.
1983
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
2006 StandoutScienceNobel
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin
1984 StandoutNobel
ENHANCED BACTERICIDAL ACTIVITY OF PHAGOCYTES FROM PATIENTS WITH CHRONIC GRANULOMATOUS DISEASE IN THE PRESENCE OF SULPHISOXAZOLE
1975
The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.
1975
Phospholipase A2 activation in human neutrophils. Differential actions of diacylglycerols and alkylacylglycerols in priming cells for stimulation by N-formyl-Met-Leu-Phe.
1988
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
1999
Modulation of human neutrophil chemotactic responses by cyclic 3′,5′-guanosine monophosphate and cyclic 3′,5′-adenosine monophosphate
1975
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
1993
NITROBLUE-TETRAZOLIUM TESTS
1974
Familial deficiency of glutathione reductase in human blood cells
1976
Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production.
1994
Phagocytosis
1974
Works of Charles E. McCall being referenced
1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants.
1981
Lipopolysaccharide-Induced Expression of Prostaglandin H Synthase-2 in Alveolar Macrophages Is Inhibited by Dexamethasone but Not by Aspirin
1993
Epigenetic Silencing of Tumor Necrosis Factor α during Endotoxin Tolerance
2007
mRNA and Protein Stability Regulate the Differential Expression of Pro- and Anti-inflammatory Genes in Endotoxin-tolerant THP-1 Cells
2000
Dynamic and Selective Nucleosome Repositioning during Endotoxin Tolerance
2009
Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages
1992
Phospholipases and activation of the NADPH oxidase
1993
NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance
2011
Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome.
1993
NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response
2012
Characterization of Interleukin-1 Receptor-associated Kinase in Normal and Endotoxin-tolerant Cells
2000
Reduced Nicotinamide Adenine Dinucleotide and Reduced Nicotinamide Adenine Dinucleotide Phosphate Diaphorase Activity in Human Polymorphonuclear Leukocytes
1974
Nitroblue Tetrazolium Reduction: False Positive and False Negative Results
1973
LYSOSOMAL AND ULTRASTRUCTURAL CHANGES IN HUMAN "TOXIC" NEUTROPHILS DURING BACTERIAL INFECTION
1969
Diacylglycerols enhance human neutrophil degranulation responses: Relevancy to a multiple mediator hypothesis of cell function
1984
An isotopic assay for NADPH oxidase activity and some characteristics of the enzyme from human polymorphonuclear leukocytes.
1975
Phosphatidic acid and diacylglycerol synergize in a cell-free system for activation of NADPH oxidase from human neutrophils.
1993
Priming of the respiratory burst of neutrophils by diacylglycerol. Independence from activation or translocation of protein kinase C.
1987
Functional Characteristics of Human Toxic Neutrophils
1971
Dissociation by Colchicine of the Hexose Monophosphate Shunt Activation from the Bactericidal Activity of the Leukocyte
1971
Stimulation of the Hexose Monophosphate Shunt in Human Neutrophils by Ascorbic Acid: Mechanism of Action
1972
Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor.
1986
Complete Deficiency of Leukocyte Glucose-6-Phosphate Dehydrogenase with Defective Bactericidal Activity
1972
Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C.
1988
Magnesium-dependent adenosine triphosphatase as a marker enzyme for the plasma membrane of human polymorphonuclear leukocytes
1977
Propranolol, a phosphatidate phosphohydrolase inhibitor, also inhibits protein kinase C.
1992
Effects of Promethazine-Hydrochloride on Human Polymorphonuclear Leukocytes
1973
Neutrophil Aggregation: Evidence for a Different Mechanism of Action by Phorbol Myristate Acetate
1980
Induction of RelB Participates in Endotoxin Tolerance
2006
A labile transcriptional repressor modulates endotoxin tolerance.
1994
Lipopolysaccharide- and Lipoteichoic Acid-Induced Tolerance and Cross-Tolerance: Distinct Alterations in IL-1 Receptor-Associated Kinase
2002
Chemotaxin-induced changes in cyclic adenosine monophosphate levels in human neutrophils
1980
Stimulation of hexose transport by human polymorphonuclear leukocytes: A possible role for protein kinase C
1985
Regulation of IL-1 Receptor-Associated Kinases by Lipopolysaccharide
2002
Evidence for 5,12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation
1981
Endotoxin Tolerance Disrupts Chromatin Remodeling and NF-κB Transactivation at the IL-1β Promoter
2005
New biological activity following intravascular activation of the complement cascade
1974 Nature
Role of arachidonic acid in stimulation of hexose transport by human polymorphonuclear leukocytes
1980
Selective desensitization of neutrophils: further studies with 1-O-alkyl-sn-glycero-3-phosphocholine analogues.
1981
The Generation of Superoxide Anion by Various Types of Phagocyte
1975
Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase.
1992
Superoxide Dismutase Activity in Leukocytes
1974
Enhancement of hexose uptake in human polymorphonuclear leukocytes by activated complement component C5a
1979
Comparison of Human Eosinophils from Normals and Patients with Eosinophilia
1980
Independent Stimulation of Motility and the Oxidative Metabolic Burst of Human Polymorphonuclear Leukocytes
1978