Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Consistent blind protein structure generation from NMR chemical shift data
2008 StandoutNobel
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production
2005 StandoutNobel
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
2006
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
Structural Basis of Wnt Recognition by Frizzled
2012 Science
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle
2023 StandoutNobel
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels
2003 StandoutNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
The Hypoxia-Inducible Factor 2α N-Terminal and C-Terminal Transactivation Domains Cooperate To Promote Renal Tumorigenesis In Vivo
2007 StandoutNobel
Notch and Presenilin Regulate Cellular Expansion and Cytokine Secretion but Cannot Instruct Th1/Th2 Fate Acquisition
2008
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Intrinsically unstructured proteins and their functions
2005 Standout
Studies on the specificity of unprocessed and mature forms of phytanoyl-CoA 2-hydroxylase and mutation of the iron binding ligands
2005
Three-dimensional structure of human γ-secretase
2014 Nature
Many Amino Acid Substitutions in a Hypoxia-inducible Transcription Factor (HIF)-1α-like Peptide Cause Only Minor Changes in Its Hydroxylation by the HIF Prolyl 4-Hydroxylases
2004
Mitochondria in cancer: Not just innocent bystanders
2008
Active γ-Secretase Complexes Contain Only One of Each Component
2007
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
2005 StandoutNobel
The SARS coronavirus nucleocapsid protein – Forms and functions
2014
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Oxygen‐regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member
2008
Patched acts catalytically to suppress the activity of Smoothened
2002 Nature
Presenilin: Running with Scissors in the Membrane
2007
The hedgehog signaling network
2003
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
2009 StandoutNobel
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
Dynamic Regulation of Histone Lysine Methylation by Demethylases
2007
The Active Site of an Algal Prolyl 4-Hydroxylase Has a Large Structural Plasticity
2007
Glu332 in the Nicastrin Ectodomain Is Essential for γ-Secretase Complex Maturation but Not for Its Activity
2008
JmjC-domain-containing proteins and histone demethylation
2006
Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations
2006
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Wnt/β-Catenin Signaling and Disease
2012 Standout
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α
2005 StandoutNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
ECOD: An Evolutionary Classification of Protein Domains
2014
Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases
2004
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
ShapeFinder: A software system for high-throughput quantitative analysis of nucleic acid reactivity information resolved by capillary electrophoresis
2008
Coronavirus Pathogenesis
2011
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Subunit Exchange in Protein Complexes
2018
Heterotrimeric G protein activation by G-protein-coupled receptors
2007
Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6
2010
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Ligand-dependent folding of the three-way junction in the purine riboswitch
2008
An improved protein decoy set for testing energy functions for protein structure prediction
2003 StandoutNobel
Quantitative Dissection of the Notch:CSL Interaction: Insights into the Notch-mediated Transcriptional Switch
2006
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
2009
Structural studies on human 2-oxoglutarate dependent oxygenases
2010
Vascular Development in the Retina and Inner Ear
2004
Structure and function of γ-secretase
2008
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms
2006
Presenilin diversifies its portfolio
2007
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Roles of G‐protein‐coupled receptor dimerization
2004
Prolyl 4-hydroxylase-1 mediates O2 signaling during development ofDictyostelium
2007
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Multiplexed RNA structure characterization with selective 2′-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq)
2011 StandoutNobel
Toward High-Resolution de Novo Structure Prediction for Small Proteins
2005 StandoutScienceNobel
Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1
2006
Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP
2004
Leukemia-Associated Mutations within the NOTCH1 Heterodimerization Domain Fall into at Least Two Distinct Mechanistic Classes
2006
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Nuclear entry and export of FIH are mediated by HIF1α and exportin1, respectively
2018 StandoutNobel
Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level
2004 StandoutNobel
Dioxygen Activation at Mononuclear Nonheme Iron Active Sites: Enzymes, Models, and Intermediates
2004 Standout
Fluorescent Sensors for Measuring Metal Ions in Living Systems
2014 Standout
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan
2015
Protein Structure Prediction and Structural Genomics
2001 StandoutScienceNobel
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
2006 StandoutNobel
De Novo Design of an Allosteric Metalloprotein Assembly with Strained Disulfide Bonds
2016
A Novel Coronavirus from Patients with Pneumonia in China, 2019
2020 Standout
Protein structure prediction for the male-specific region of the human Y chromosome
2004 StandoutNobel
Sampling the conformational space of the catalytic subunit of human γ-secretase
2015
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity
2004 StandoutNobel
Works of Charles E. Dann being referenced
Structure and Mechanism of a Metal-Sensing Regulatory RNA
2007
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
2001 Nature
Coronavirus N Protein N-Terminal Domain (NTD) Specifically Binds the Transcriptional Regulatory Sequence (TRS) and Melts TRS-cTRS RNA Duplexes
2009
Dioxygenases as O2-dependent regulators of the hypoxic response pathway
2005
Allosteric Inhibition of a Zinc-Sensing Transcriptional Repressor: Insights into the Arsenic Repressor (ArsR) Family
2013
Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway
2002 Nobel
MotI (DgrA) acts as a molecular clutch on the flagellar stator protein MotA in Bacillus subtilis
2017