Citation Impact
Citing Papers
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
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Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis
1985
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2008
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2001
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2000
Predictive motifs derived from cytosine methyltransferases
1989 StandoutNobel
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2010
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1995
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2007 StandoutNatureNobel
Crystal Structure of Calf Spleen Purine Nucleoside Phosphorylase with Two Full Trimers in the Asymmetric Unit: Important Implications for the Mechanism of Catalysis
2004 StandoutNobel
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2013
Purine nucleoside phosphorylase: A target for drug design
1993
Computational Enzyme Design
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Metabolism and action of amino acid analog anti-cancer agents
1990
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2007
CpG motifs in bacterial DNA trigger direct B-cell activation
1995 StandoutNature
N‐Methyl‐d ‐Aspartate Receptor Excitotoxicity Involves Activation of Polyamine Synthesis: Protection by α‐Difluoromethylornithine
1993
Designing the next generation of proton-exchange membrane fuel cells
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Catalysis for fluorination and trifluoromethylation
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A Strategy for Functional Proteomic Analysis of Glycosidase Activity from Cell Lysates
2004 StandoutNobel
Synthetic strategies to α-trifluoromethyl and α-difluoromethyl substituted α-amino acids
2008
Calf spleen purine-nucleoside phosphorylase: crystal structure of the binary complex with a potent multisubstrate analogue inhibitor
2004
Catalytic antibodies: hapten design strategies and screening methods
2004
Polyamines and cancer: implications for chemotherapy and chemoprevention
2013
A Distinct Translation Initiation Mechanism Generates Cryptic Peptides for Immune Surveillance
2008
New insights into copper monooxygenases and peptide amidation: structure, mechanism and function
2000
Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs
1999
Crystal structure of the Hhal DNA methyltransferase complexed with S-adenosyl-l-methionine
1993 StandoutNobel
Purification and characterization of theMspl DNA methyltransferase cloned and overexpressed inE.coli
1992 StandoutNobel
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
The double role of methyl donor and allosteric effector of S-adenosyl-methionine for Dam methylase of E. coli
1990
Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis
1990
Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with hypoxanthine at 2.15 Å resolution
1997
Binding of phosphate and sulfate anions by purine nucleoside phosphorylase from E. coli: ligand-dependent quenching of enzyme intrinsic fluorescence
1997
Chemical Approaches To Perturb, Profile, and Perceive Glycans
2009 StandoutNobel
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
1994 Standout
Polyamines and cancer: old molecules, new understanding
2004
Selective difluoromethylation and monofluoromethylation reactions
2009
N-Bromoacetyl-glycopyranosylamines as affinity labels for a β-glucosidase and a cellulase
1993
Ornithine decarboxylase inhibitors increase the cellular content of the enzyme: Implications for translational regulation
1985
Degradation of Ornithine Decarboxylase in Reticulocyte Lysate Is ATP-dependent but Ubiquitin-independent
1989 StandoutNobel
Antitumor properties of (2R,5R)-6-heptyne-2,5-diamine, a new potent enzyme-activated irreversible inhibitor of ornithine decarboxylase, in rodents.
1984
Copper-Mediated Coupling Reactions and Their Applications in Natural Products and Designed Biomolecules Synthesis
2008 Standout
Fluorine in medicinal chemistry
2007 Standout
Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis
1986 StandoutScience
Polyamine metabolism and function
1982 Standout
Role of Polyamines in the Control of Cell Proliferation and Differentiation
1981 Standout
Catalytic Enantioselective Desymmetrization Reactions to All-Carbon Quaternary Stereocenters
2016
Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism
1982
Synergistic antiproliferative activity of leukocyte interferon in combination with alpha-difluoromethylornithine against human cells in culture.
1984
Geometric and Electronic Structure/Function Correlations in Non-Heme Iron Enzymes
1999 Standout
Methylthioadenosine
1983
Solid-Phase Synthesis of a Combinatorial Array of 1,3-Bis(acylamino)-2-butanones, Inhibitors of the Cysteine Proteases Cathepsins K and L
1999
In vivo effects of α-dl-Difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei
1983
Ornithine decarboxylase from hepatoma cells and a variant cell line in which the enzyme is more stable.
1982
Plasmodium berghei: Inhibitors of ornithine decarboxylase block exoerythrocytic schizogony
1985
Trans‐N‐Deoxyribosylase: Purification by Affinity Chromatography and Characterization
1975
Design and Synthesis of Activity Probes for Glycosidases
2002
Growth of mammalian cells in the absence of the accumulation of spermine
1985
Efficient electrophilic fluorination of β-dicarbonyl compounds with the selectfluor reagent F-TEDA-BF4{1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)}
1994
Comparison of inhibitors of S-adenosylmethionine decarboxylase from different species
1983
DL-.alpha.-(Difluoromethyl)arginine: a potent enzyme-activated irreversible inhibitor of bacterial arginine decarboxylases
1981
Isolation and characterization of the mouse ornithine decarboxylase gene.
1988
Molecular Machines
1998 StandoutNobel
Ornithine Decarboxylase: Essential in Proliferation But Not Differentiation of Human Promyelocytic Leukemia Cells
1982 Science
Treatment with α‐difluoromethylornithine plus a spermidine analog leads to spermine depletion and growth inhibition in cultured L1210 leukemia cells
1984
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope
1997 StandoutScienceNobel
A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase.
1983
Assay of α-difluoromethylornithine in body fluids and tissues by automatic amino-acid analysis
1981
Aryl−Aryl Bond Formation by Transition-Metal-Catalyzed Direct Arylation
2007 Standout
Uptake of α-difluoromethylornithine by mouse fibroblasts
1982
The sequence specificity domain of cytosine-C5 methylases
1991 StandoutNobel
Stereoselective Cyclopropanation Reactions
2003 Standout
[26] Autoradiographic localization of ornithine decarboxylase
1983
Spermidine in health and disease
2018 StandoutScience
Fluorinated Ylides and Related Compounds
1996
?-Alkyl-?-aminosilanes: Synthesis via Alkylation and Hydrosilylation
1997
Transition-Metal-Catalyzed C−S, C−Se, and C−Te Bond Formation via Cross-Coupling and Atom-Economic Addition Reactions
2011 Standout
Inhibition of growth of Mycoplasma dispar by DL-α-Difluoromethyllysine, a selective irreversible inhibitor of lysine decarboxylase, and reversal by cadaverine (1,5-diaminopentane)
1984
A human neuroblastoma cell line with an altered ornithine decarboxylase.
1984
Gold Nanoparticles in Chemical and Biological Sensing
2012 Standout
The role of polyamine depletion and accumulation of decarboxylated S-adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with α-difluoromethylornithine
1984
Green and Sustainable Solvents in Chemical Processes
2018 Standout
Chemoselective Elaboration of O-Linked Glycopeptide Mimetics by Alkylation of 3-ThioGalNAc
2001 StandoutNobel
Effect of androgens on turnover of ornithine decarboxylase in mouse kidney. Studies using labeling of the enzyme by reaction with [14C] alpha-difluoromethylornithine.
1982
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
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Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Alternative Synthetic Methods through New Developments in Catalysis by Gold
2008 Standout
Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells
1984
Small-Molecule H-Bond Donors in Asymmetric Catalysis
2007 Standout
Growth-inhibitory effects of DL-alpha-difluoromethylornithine in the spectrum of human lung carcinoma cells in culture.
1982
Efficient Synthesis of Azide-Bearing Cofactor Mimics
2004
Characteristics of .beta.,.beta.-difluoroalanine and .beta.,.beta.,.beta.-trifluoroalanine as suicide substrates for E. coli B alanine racemase
1981
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Alkynyliodonium Salt Mediated Alkynylation of Azlactones: Fast Access to Cα-Tetrasubstituted α-Amino Acid Derivatives
2014
The Cyclopropyl Group in Studies of Enzyme Mechanism and Inhibition
1988
Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
2011 Standout
Tetrahedron report number 163
1984 Standout
Effects of alpha-difluoromethylornithine and recombinant interferon-alpha 2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice.
1984
Ornithine Decarboxylase Is Important in Intestinal Mucosal Maturation and Recovery from Injury in Rats
1980 Science
General approach to the synthesis of α-difluoromethyl amines as potential enzyme-activated irreversible inhibitors
1978
Polyamine biosynthetic enzymes as targets in cancer chemotherapy
1984
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
DNA N-glycosidases: properties of uracil-DNA glycosidase from Escherichia coli.
1977 StandoutNobel
Changes in mouse kidney ornithine decarboxylase activity are brought about by changes in the amount of enzyme protein as measured by radioimmunoassay.
1983
Disulfonimide-Catalyzed Asymmetric Synthesis of β3-Amino Esters Directly from N-Boc-Amino Sulfones
2013 StandoutNobel
Aromatic Trifluoromethylation with Metal Complexes
2011 Standout
Strong and Confined Acids Control Five Stereogenic Centers in Catalytic Asymmetric Diels–Alder Reactions of Cyclohexadienones with Cyclopentadiene
2020 StandoutNobel
Reconstitution of Apo-Glucose Dehydrogenase on Pyrroloquinoline Quinone-Functionalized Au Nanoparticles Yields an Electrically Contacted Biocatalyst
2005
Investigation of structure and rate of synthesis of ornithine decarboxylase protein in mouse kidney
1984
Enzymatic aminoacylation of tRNA with unnatural amino acids
2006 StandoutNobel
Trends in the biochemical pharmacology of 5′-deoxy-5′-methylthioadenosine
1982
Enantioselective Nitroaldol Reaction of α-Ketoesters Catalyzed by Cinchona Alkaloids
2005
Fluorinated organometallics: Perfluoroalkyl and functionalized perfluoroalkyl organometallic reagents in organic synthesis
1992
S‐Adenosylmethionine decarboxylase: A brief review
1984
Differential regulation of polyamine synthesis and transmethylation reactions in methylthioadenosine phosphorylase deficient mammalian cells
1985
Kinetic Analysis of the Rebek Self-Replicating System: Is There a Controversy?
1996
Ornithine decarboxylase activity from an extremely thermophilic bacterium, Clostridium thermohydrosulfuricum effect of GTP analogues on enzyme activity
1983
Suicide substrates: mechanism-based enzyme inactivators
1982
Preparation of optically active 3-substituted piperidines via ring expansion: synthesis of 4-amino- and 4-fluoro-1,4,5-trideoxy-1,5-imino-D-ribitol and 1,5-dideoxy-1,5-imino-D-ribitol
1996
Synthesis of monofluoro- and difluoro- methylenephosphonate analogues of sn-glycerol-3-phosphate as substrates for glycerol-3-phosphate dehydrogenase and the X-ray structure of the fluoromethylenephosphonate moiety
1996
Effects of (2R, 5R)‐6‐heptyne‐2,5‐diamine, a potent inhibitor of l ‐ornithine decarboxylase, on rat hepatoma cells cultured in vitro
1984
Amplification of ornithine decarboxylase gene in response to polyamine deprivation in Chinese hamster ovary cells.
1985
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
2010 StandoutScience
Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry
2008 StandoutNobel
The biosynthesis of hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). Alignment of the butylamine segment and source of the secondary amino nitrogen.
1984
Regulation of S-adenosylmethionine decarboxylase activity in rat liver and prostate.
1985
Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction
2002 Standout
An ornithine decarboxylase-deficient mutant of Chinese hamster ovary cells.
1982
Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments
2008 Standout
Kinetic and catalytic mechanism of HhaI methyltransferase.
1987
Recent advances in the biochemistry of polyamines in eukaryotes
1986 Standout
Works of Charles Danzin being referenced
2,2-Difluoro-5-hexyne-1,4-diamine. A potent enzyme-activated inhibitor of ornithine decarboxylase
1989
Irreversible inhibition of rat S-adenosylmethionine decarboxylase by 5′-{[(Z)-4-amino-2-butenyl]methylamino}-5′-deoxyadenosine
1990
Selective mechanism-based inactivation of peptidylglycine α-hydroxylating monooxygenase in serum and heart atrium vs. brain
1997
A Possible Role for Cathepsins D, E, and B in the Processing of β‐amyloid Precursor Protein in Alzheimer's Disease
1997
Biochemical and pharmacological evaluation of 2,4-difluorobenzyldimethylsilylmethanamine, a new highly selective inhibitor of monoamine oxidase-B
1994
α-monofluoromethyl and α-difluoromethyl putrescine as ornithine decarboxylase inhibitors: In vitro and in vivo biochemical properties
1982
Accumulation of Decarboxylated S‐Adenosyl‐l ‐Methionine in Mammalian Cells as a Consequence of the Inhibition of Putrescine Biosynthesis
1982
Comparison of 3-isobutyl-1-methylxanthine-induced accumulation of putrescine in rat pancreas and liver
1983
1,1-Difluoroalkyl glucosides: a new class of enzyme-activated irreversible inhibitors of .alpha.-glucosidases
1989
Effect on prostatic growth of 2-difluoromethylornithine, an effective inhibitor of ornithine decarboxylase
1982
Ortho- and para-(difluoromethyl)aryl-β-d-glucosides: A new class of enzyme-activated irreversible inhibitors of β-glucosidases
1990
Reversed-phase ion-pair liquid chromatographic procedure for the simultaneous analysis of S-adenosylmethionine, its metabolites and the natural polyamines
1982
ChemInform Abstract: 9‐(Difluorophosphonoalkyl)guanines as a New Class of Multisubstrate Analogue Inhibitors of Purine Nucleoside Phosphorylase.
1991
Synthesis and biochemical properties of chemically stable product analogs of the reaction catalyzed by S-adenosyl-L-methionine decarboxylase
1982
Effects of α-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on testosterone-induced regeneration of prostate and seminal vesicle in castrated rats
1979
(2R,5R)-6-heptyne-2,5-diamine, an extremely potent inhibitor of mammalian ornithine decarboxylase
1983
α‐DIFLUOROMETHYL DOPA, A NEW ENZYME‐ACTIVATED IRREVERSIBLE INHIBITOR OF AROMATIC L‐AMINO ACID DECARBOXYLASE
1978
α‐Allenyl putrescine, an enzyme‐activated irreversible inhibitor of bacterial and mammalian ornithine decarboxylases
1984
9-(Difluorophosphonoalkyl)guanines as a new class of multisubstrate analog inhibitors of purine nucleoside phosphorylase
1991
Deoxyribosyl Transfer Catalysis with trans‐N‐Deoxyribosylase
1974
.alpha.-Ethynyl and .alpha.-vinyl analogs of ornithine as enzyme-activated inhibitors of mammalian ornithine decarboxylase
1981
Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs
1978
Unsaturated thioacetic acids as novel mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase
1996
ChemInform Abstract: α‐(FLUOROMETHYL)DEHYDROORNITHINE AND α‐(FLUOROMETHYL)DEHYDROPUTRESCINE ANALOGS AS IRREVERSIBLE INHIBITORS OF ORNITHINE DECARBOXYLASE
1984
New Potent α-Glucohydrolase Inhibitor MDL 73945 With Long Duration of Action in Rats
1991
Fluorophosphonate derivatives of N9-benzylguanine as potent, slow-binding multisubstrate analogue inhibitors of purine nucleoside phosphorylase
1996
Analogs of ornithine as inhibitors of ornithine decarboxylase. New deductions concerning the topography of the enzyme's active site
1978
Effect of α-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on polyamine levels in rat tissues
1979
The rational design of suicide substrates of amine oxidases
1986
In vitro and in vivo effects of α-acetylenic dopa and α-vinyl dopa on aromatic l-amino acid decar☐ylase
1979
.alpha.-(Fluoromethyl)dehydroornithine and .alpha.-(fluoromethyl)dehydroputrescine analogs as irreversible inhibitors of ornithine decarboxylase
1983