Citation Impact
Citing Papers
Visualizing enveloping layer glycans during zebrafish early embryogenesis
2010 StandoutNobel
Requirement of α and β subunit transmembrane helix separation for integrin outside-in signaling
2007
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open
2012 StandoutScienceNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins
2003 Science
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
The primacy of affinity over clustering in regulation of adhesiveness of the integrin αLβ2
2004
An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins
2020 StandoutNobel
Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains
2001
Rational Design of Intercellular Adhesion Molecule-1 (ICAM-1) Variants for Antagonizing Integrin Lymphocyte Function-associated Antigen-1-dependent Adhesion
2005 StandoutNobel
Intestinal MUC2 Mucin Supramolecular Topology by Packing and Release Resting on D3 Domain Assembly
2014
Rationally Designed Integrin β3 Mutants Stabilized in the High Affinity Conformation
2008 StandoutNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins
2022 StandoutNobel
Modulation of Integrin Activation by an Entropic Spring in the β-Knee
2010 StandoutNobel
Determination of the Border between the Transmembrane and Cytoplasmic Domains of Human Integrin Subunits
1999
Conformational Changes in the Integrin औA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement
2003
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation
2002
Rational design and engineering of therapeutic proteins
2003
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Structural and Functional Studies with Antibodies to the Integrin β2 Subunit
2000
The structure of an integrin/talin complex reveals the basis of inside‐out signal transduction
2009
Contextual determinants of TGFβ action in development, immunity and cancer
2018
The biology and management of non-small cell lung cancer
2018 StandoutNature
Yeast surface display for screening combinatorial polypeptide libraries
1997
Regulation of lymphocyte adhesion and migration by the small GTPase Rap1 and its effector molecule, RAPL
2004
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
Protein recognition by cell surface receptors: physiological receptors versus virus interactions
2002
Transforming Growth Factor-β Signaling in Immunity and Cancer
2019 Standout
Plant and Animal Pathogen Recognition Receptors Signal through Non-RD Kinases
2006
Computational design of an integrin I domain stabilized in the open high affinity conformation.
2000
Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation
2003
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Conversion between Three Conformational States of Integrin I Domains with a C-Terminal Pull Spring Studied with Molecular Dynamics
2004
Regulation of integrin affinity on cell surfaces
2011
Glucosylation of chimeric proteins in the cell wall of Saccharomyces cerevisiae
1994
Sweet-Heart — An integrated suite of enabling computational tools for automated MS2/MS3 sequencing and identification of glycopeptides
2013
Will the Real Integrin Please Stand Up?
2002
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
Genetic analysis of integrin function in man: LAD-1 and other syndromes
2000
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
TGF-β1 Signaling and Tissue Fibrosis
2017
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
2011 Nature
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Immunoregulation by members of the TGFβ superfamily
2016
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
2004 Standout
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Serological identification of breast cancer-related antigens from aSaccharomyces cerevisiae surface display library
2005
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Allosteric β1 Integrin Antibodies That Stabilize the Low Affinity State by Preventing the Swing-out of the Hybrid Domain
2004
Sensing the environment: a historical perspective on integrin signal transduction
2002
EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
2017
Integrin Activation Involves a Conformational Change in the α1 Helix of the β Subunit A-domain
2002
Structural Basis of Collagen Recognition by Integrin α2β1
2000
Ligand Binding to Integrins
2000
Integrin associated proteins
1998
Global analysis of protein localization in budding yeast
2003 StandoutNature
Molecular Organization of the Alkali-insoluble Fraction ofAspergillus fumigatus Cell Wall
2000
Therapeutic antagonists and conformational regulation of integrin function
2003
Small Molecule Integrin Antagonists that Bind to the β2 Subunit I-like Domain and Activate Signals in One Direction and Block Them in the Other
2003
Binding Stoichiometry and Kinetics of the Interaction of a Human Anthrax Toxin Receptor, CMG2, with Protective Antigen
2004
Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection
2017
Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces
2008
Integrins
2002 Standout
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Reconstitution of Membrane Proteins in Phospholipid Bilayer Nanodiscs
2009
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
A Structural Mechanism of Integrin αIIbβ3 “Inside-Out” Activation as Regulated by Its Cytoplasmic Face
2002
Src-family kinases: rheostats of immune cell signaling
2004
A Molecular Basis for Integrin αMβ2 Ligand Binding Promiscuity
2002
Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling
2002
EGFR endocytosis requires its kinase activity and N-terminal transmembrane dimerization motif
2013
COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast
1995 StandoutNobel
An Isoleucine-based Allosteric Switch Controls Affinity and Shape Shifting in Integrin CD11b A-domain
2000
Insights into integrin-ligand binding and activation from the first crystal structure.
2002
The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases
2014
The plant immune system
2006 StandoutNature
Regulation of Integrin Activation
2011
Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
2017 StandoutNobel
Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo
2015
An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2
2013
TGF-β Activation and Function in Immunity
2013
Integrin extension enables ultrasensitive regulation by cytoskeletal force
2017
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs
2004
Structural Basis of Integrin Regulation and Signaling
2007
Complete integrin headpiece opening in eight steps
2013
Release of Active TGF-β1 from the Latent TGF-β1/GARP Complex on T Regulatory Cells Is Mediated by Integrin β8
2014
The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane
2003 StandoutNobel
Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system
2016 StandoutNobel
Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer
2016
Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
2018 Science
Rap1 Is a Potent Activation Signal for Leukocyte Function-Associated Antigen 1 Distinct from Protein Kinase C and Phosphatidylinositol-3-OH Kinase
2000
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
2005 StandoutScience
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesion
2001
Molecular basis for multimerization in the activation of the epidermal growth factor receptor
2016
Integrin activation takes shape
2002
A model of anthrax toxin lethal factor bound to protective antigen
2005 StandoutNobel
Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand
2002 Science
Active recycling of yeast Golgi mannosyltransferase complexes through the endoplasmic reticulum
2000 StandoutNobel
Observing force-regulated conformational changes and ligand dissociation from a single integrin on cells
2012
An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin αLβ2
2005
Integrin-mediated mechanotransduction
2016
Interaction of α-Agglutinin and a -Agglutinin, Saccharomyces cerevisiae Sexual Cell Adhesion Molecules
2001
Leukocyte integrin α L β 2 headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops
2016
The Inflammasomes: Guardians of the Body
2009 Standout
A Biochemical Guide to Yeast Adhesins: Glycoproteins for Social and Antisocial Occasions
2007
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
GPI anchor attachment is required for Gas1p transport from the endoplasmic reticulum in COP II vesicles.
1996 StandoutNobel
Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8
2017
Cancer Genome Landscapes
2013 StandoutScience
A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor
2007 StandoutNobel
Platelets subvert T cell immunity against cancer via GARP-TGFβ axis
2017
Importance of Force Linkage in Mechanochemistry of Adhesion Receptors
2006
In Vitro Enzymatic Characterization of Near Full Length EGFR in Activated and Inhibited States
2009
Prediction of membrane protein structures with complex topologies using limited constraints
2009 StandoutNobel
Cell Wall and Secreted Proteins ofCandida albicans: Identification, Function, and Expression
1998
Conformational Regulation of Integrin Structure and Function
2002
Structural insight into TRPV5 channel function and modulation
2019 StandoutNobel
The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research
1999
F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse
2015
Solution structures of the cytoplasmic tail complex from platelet integrin αIIb- and β3-subunits
2002
Locking the β3 Integrin I-like Domain into High and Low Affinity Conformations with Disulfides
2004
Targeting latency-associated peptide promotes antitumor immunity
2017
Increase in chitin as an essential response to defects in assembly of cell wall polymers in the ggp1delta mutant of Saccharomyces cerevisiae
1997
Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies
2003
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Activation of integrin β-subunit I-like domains by one-turn C-terminal α-helix deletions
2004
Chemical Glycoproteomics
2016 StandoutNobel
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Chafen Lu being referenced
Conformational equilibria and intrinsic affinities define integrin activation
2017
The Structure of the β-Propeller Domain and C-terminal Region of the Integrin αM Subunit
1998
Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation
2005
Folding and Function of I Domain-deleted Mac-1 and Lymphocyte Function-associated Antigen-1
2000
Association of the Membrane Proximal Regions of the α and β Subunit Cytoplasmic Domains Constrains an Integrin in the Inactive State
2001
The Top of the Inserted-like Domain of the Integrin Lymphocyte Function-associated Antigen-1 β Subunit Contacts the α Subunit β-Propeller Domain near β-Sheet 3
2000
Force interacts with macromolecular structure in activation of TGF-β
2017 Nature
Activation-induced Conformational Changes in the I Domain Region of Lymphocyte Function-associated Antigen 1
2002
A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System
2018
A pH‐regulated dimeric bouquet in the structure of von Willebrand factor
2011
Mechanisms for Kinase-mediated Dimerization of the Epidermal Growth Factor Receptor
2012
Participation of Rip2 in Lipopolysaccharide Signaling Is Independent of Its Kinase Activity
2005
Structural determinants of integrin β-subunit specificity for latent TGF-β
2014
Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor
2011
Sequence and structure relationships within von Willebrand factor
2012
Stabilizing the integrin αM inserted domain in alternative conformations with a range of engineered disulfide bonds
2002
A pathway for cell wall anchorage of Saccharomyces cerevisiae alpha-agglutinin.
1994
Epitope Mapping of Antibodies to the C-Terminal Region of the Integrin β2 Subunit Reveals Regions that Become Exposed Upon Receptor Activation
2001
The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1.
1997
A Pathway for Cell Wall Anchorage of Saccharomyces cerevisiae α-Agglutinin
1994
Cell surface anchorage and ligand-binding domains of the Saccharomyces cerevisiae cell adhesion protein alpha-agglutinin, a member of the immunoglobulin superfamily.
1993
Fusion surface structure, function, and dynamics of gamete fusogen HAP2
2018
The Critical Cytoplasmic Regions of the αL/β2 Integrin in Rap1-induced Adhesion and Migration
2003
An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond
2001
Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor
2010
Conformational changes in tertiary structure near the ligand binding site of an integrin I domain
1999
Functional and Structural Stability of the Epidermal Growth Factor Receptor in Detergent Micelles and Phospholipid Nanodiscs
2008
Relating conformation to function in integrin α 5 β 1
2016
Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains
2001
Glycosyl phosphatidylinositol-dependent cross-linking of alpha-agglutinin and beta 1,6-glucan in the Saccharomyces cerevisiae cell wall.
1995
GARP regulates the bioavailability and activation of TGFβ
2012
The Binding Sites for Competitive Antagonistic, Allosteric Antagonistic, and Agonistic Antibodies to the I Domain of Integrin LFA-1
2004
Cell Surface Anchorage and Ligand-Binding Domains of the Saccharomyces cerevisiae Cell Adhesion Protein α-Agglutinin, a Member of the Immunoglobulin Superfamily
1993
Folding of the conserved domain but not of flanking regions in the integrin β2subunit requires association with the α subunit
1997
Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activityin vivo
2001