Standout Papers
Citation Impact
Citing Papers
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
2011
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
2010
Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity
2009
Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome
2011
Reactive Oxygen Species in Inflammation and Tissue Injury
2013 Standout
(1,3)-β-Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages
2010
Pure Hemozoin Is Inflammatory In Vivo and Activates the NALP3 Inflammasome via Release of Uric Acid
2009
Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome
2008
Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain
2009
Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome
2009
Hallmarks of Cancer: The Next Generation
2011 Standout
Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors
2009
Metabolic regulation of NLRP 3
2017
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Dectin-1: a signalling non-TLR pattern-recognition receptor
2005
Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection
2015
Myeloid C-type lectins in innate immunity
2006
Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis
2009
Mechanisms of regulated unconventional protein secretion
2008
The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA
2009
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
2009
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Inflammasomes: guardians of cytosolic sanctity
2008
When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction
2008
Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms
2011
COPs and POPs Patrol Inflammasome Activation
2017
Autoinflammatory Disease Reloaded: A Clinical Perspective
2010 Standout
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
2011 Standout
Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System
2009
A role for mitochondria in NLRP3 inflammasome activation
2010 StandoutNature
Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation
2013
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation
2014
Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan
2016
Phagocytosis of apoptotic cells in homeostasis
2015
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
2008 Standout
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
2009 StandoutNature
Nonresolving Inflammation
2010 Standout
Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal
2009
Critical functions of priming and lysosomal damage for NLRP3 activation
2010
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Targeting the NLRP3 inflammasome in inflammatory diseases
2018
Influenza virus activates inflammasomes via its intracellular M2 ion channel
2010
Inflammasome and IL-1β-Mediated Disorders
2010
Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity
2009
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
The coming of age of de novo protein design
2016 StandoutNatureNobel
Caspase Functions in Cell Death and Disease
2013 Standout
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
2009 Standout
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
2010 Standout
Immunity, Inflammation, and Cancer
2010 Standout
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
2007
Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’
2011 Nature
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
2008
Pyroptosis: host cell death and inflammation
2009 Standout
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
2009 Standout
Superoxide dismutase 1 regulates caspase-1 and endotoxic shock
2008
Origin and physiological roles of inflammation
2008 StandoutNature
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Sterile inflammation: sensing and reacting to damage
2010 Standout
Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion
2012
The Inflammasomes
2010 Standout
The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia
2018
Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases
2009
A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response
2016 StandoutNobel
Inflammasomes as microbial sensors
2010
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
2010 Standout
Idiopathic pulmonary fibrosis
2011 Standout
Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans
2006
The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation
2013
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
2010
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
2009 Nature
The Nlrp3 inflammasome is critical for aluminium hydroxide‐mediated IL‐1β secretion but dispensable for adjuvant activity
2008
Chapter 5 Emergence of the Th17 Pathway and Its Role in Host Defense
2008
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
2008 Standout
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
The inflammasomes: mechanisms of activation and function
2010
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
The mycobacterial cord factor adjuvant analogue trehalose-6,6′-dibehenate (TDB) activates the Nlrp3 inflammasome
2012
Inflammasomes in health and disease
2012 StandoutNature
Silicosis
2012 Standout
IL‐1: Discoveries, controversies and future directions
2010
Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
2009
Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1
2012
Membrane assembly in vitro : Synthesis, glycosylatio, and asymmetric insertion of a transmembrane protein
1977 StandoutNobel
Role of Nrf2 in Oxidative Stress and Toxicity
2013 Standout
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
2011
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.
1993 StandoutNobel
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
1993 StandoutNobel
Cyclic‐di‐GMP and cyclic‐di‐AMP activate the NLRP3 inflammasome
2013
Cutting Edge: Necrosis Activates the NLRP3 Inflammasome
2009
An octamer of histones in chromatin and free in solution.
1975 StandoutNobel
The NLRP3 Inflammasome: A Sensor for Metabolic Danger?
2010 Science
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9
2002 StandoutNobel
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
2008 StandoutNature
Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux
2014
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex
2014
Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.
1988 StandoutNobel
Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
1991 StandoutNobel
A lamin B receptor in the nuclear envelope.
1988 StandoutNobel
Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis.
1980 StandoutNobel
Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice
2010
The Inflammasomes: Guardians of the Body
2009 Standout
TLRs and innate immunity
2008 StandoutNobel
Purification of the regulatory component of adenylate cyclase.
1980 StandoutNobel
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.
1991 StandoutNobel
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.
1986 StandoutNobel
Particulate Matter Air Pollution and Cardiovascular Disease
2010 Standout
Regulation of phagocytosis by Rho GTPases
2015
Multiple Cathepsins Promote Pro–IL-1β Synthesis and NLRP3-Mediated IL-1β Activation
2015
ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation.
1980 StandoutNobel
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
2009
Pyrin Critical to Macrophage IL-1β Response to Francisella Challenge
2009
Innate immunity to virus infection
2008
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway
2011
The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation
2014
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction.
1989 StandoutNobel
Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses
1999 StandoutNobel
Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.
1991 StandoutNobel
Works of Chad Steele being referenced
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
2008 StandoutScience
Dectin-1 is required for β-glucan recognition and control of fungal infection
2006
CD28 Down-Regulation on Circulating CD4 T-Cells Is Associated with Poor Prognoses of Patients with Idiopathic Pulmonary Fibrosis
2010
The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus
2005
Comparison of ribavirin and oseltamivir in reducing mortality and lung injury in mice infected with mouse adapted A/California/04/2009 (H1N1)
2012
CD36, but not G2A, modulates efferocytosis, inflammation, and fibrosis following bleomycin-induced lung injury
2013
Extrapulmonary Manifestations of Chronic Obstructive Pulmonary Disease in a Mouse Model of Chronic Cigarette Smoke Exposure
2008
Alveolar Macrophage–mediated Killing of Pneumocystis carinii f. sp. muris Involves Molecular Recognition by the Dectin-1 β-Glucan Receptor
2003
Role of IL-17A, IL-17F, and the IL-17 Receptor in Regulating Growth-Related Oncogene-α and Granulocyte Colony-Stimulating Factor in Bronchial Epithelium: Implications for Airway Inflammation in Cystic Fibrosis
2005