Standout Papers
Citation Impact
Citing Papers
The discovery and development of HMG-CoA reductase inhibitors.
1992
The effect of cholestyramine and Mevinolin on the diurnal cycle of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase
1982
Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates β-1 Adrenergic Receptor Endocytosis through Different Pathways
2003 StandoutNobel
Isoprenylated proteins in cultured cells: Subcellular distribution and changes related to altered morphology and growth arrest induced by mevalonate deprivation
1987
Proteins regulating Ras and its relatives
1993 StandoutNature
Role of cholesterol in the function and organization of G-protein coupled receptors
2006
Dynamic Covalent Chemistry
2002 StandoutNobel
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
1997 StandoutNobel
The GTPase superfamily: a conserved switch for diverse cell functions
1990 StandoutNature
The mitotic feedback control gene MAD2 encodes the α-subunit of a prenyltransferase
1993 Nature
A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
2015 Nobel
Beyond Cholesterol
1989 Standout
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis in Syrian hamster C100 cells by mevinolin, 25-hydroxycholesterol, and mevalonate: The role of posttranscriptional control
1992
The changing landscape of atherosclerosis
2021 StandoutNature
Discovery, biochemistry and biology of lovastatin
1988
Biosynthesis of Lovastatin Analogs with a Broadly Specific Acyltransferase
2006
1 The Discovery and Development of Atorvastatin, A Potent Novel Hypolipidemic Agent
2002
Degradation of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Endoplasmic Reticulum Membranes Is Accelerated as a Result of Increased Susceptibility to Proteolysis
1996 StandoutNobel
Controlling Enantioselectivity in Additions to Cyclic Oxocarbenium Ions via Transition-Metal Catalysis
2012
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
2000 StandoutNature
Regulation of the mevalonate pathway
1990 StandoutNature
Chemistry, biochemistry, and pharmacology of HMG-CoA reductase inhibitors
1988
Platforms for antibiotic discovery
2013
Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors
2003
Classification of a large microarray data set: Algorithm comparison and analysis of drug signatures
2005
Engineering the third wave of biocatalysis
2012 StandoutNature
Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans
1989 Science
Can a Ketone Be More Reactive than an Aldehyde? Catalytic Asymmetric Synthesis of Substituted Tetrahydrofurans
2018 StandoutNobel
Oxidants, antioxidants, and the degenerative diseases of aging.
1993 Standout
Cure of acromegaly by operative removal of an islet cell tumor of the pancreas
1978
Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver.
1981 StandoutNobel
Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis.
1992 StandoutNobel
Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.
1988 StandoutNobel
Post-translational modification of low molecular mass GTP-binding proteins by isoprenoid.
1990
Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: effects on cholesterol balance.
1984
Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor.
1984
3-Hydroxy-3-methylglutaryl-coenzyme A reductase of the sea urchin embryo. Deduced structure and regulatory properties.
1988
Intensive combination drug therapy of familial hypercholesterolemia with lovastatin, probucol, and colestipol hydrochloride.
1989
Molecular cloning and sequence analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase from the human parasite Schistosoma mansoni.
1989
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers.
1984
Total Synthesis of α-Pyrone Meroterpenoids, Novel Bioactive Microbial Metabolites
2005 StandoutNobel
Regulation of Plasma Cholesterol by Lipoprotein Receptors
1981 StandoutScienceNobel
The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor
1983 StandoutNobel
The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction
1998
A Receptor-Mediated Pathway for Cholesterol Homeostasis
1986 StandoutScienceNobel
Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability
1989
The LDL Receptor Defect in Familial Hypercholesterolemia: Implications for Pathogenesis and Therapy
1982 StandoutNobel
Extraction of Cholesterol with Methyl-β-Cyclodextrin Perturbs Formation of Clathrin-coated Endocytic Vesicles
1999
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight.
1982 StandoutNobel
Drug Discovery: A Historical Perspective
2000 StandoutScience
Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.
1982 StandoutNobel
Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue
2000
The role of 1,3-dithianes in natural product synthesis
2003
The lamin B receptor of the inner nuclear membrane undergoes mitosis-specific phosphorylation and is a substrate for p34cdc2-type protein kinase.
1992 StandoutNobel
Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
1988 StandoutScience
Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin.
1991
Growth Hormone-Releasing Factor from a Human Pancreatic Tumor That Caused Acromegaly
1982 StandoutScienceNobel
In vivo phosphorylation of the lamin B receptor. Binding of lamin B to its nuclear membrane receptor is affected by phosphorylation.
1990 StandoutNobel
Removal of Rab GTP-binding proteins from Golgi membranes by GDP dissociation inhibitor inhibits inter-cisternal transport in the Golgi stacks.
1994 StandoutNobel
Growth Factors and Cancer
1991 StandoutScience
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe.
1983 StandoutNobel
Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction
1992 StandoutScience
Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei.
1988
Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme
1985 StandoutNobel
Asymmetric Catalysis via Cyclic, Aliphatic Oxocarbenium Ions
2017 StandoutNobel
Modulation of human lymphocyte responses by low density lipoproteins (LDL): enhancement but not immunosuppression is mediated by LDL receptors.
1984
Emerging Targets in Photopharmacology
2016 StandoutNobel
Independent Pathways for Secretion of Cholesterol and Apolipoprotein E by Macrophages
1983 StandoutScienceNobel
Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase
1980 StandoutNobel
Reduction of Serum Cholesterol in Heterozygous Patients with Familial Hypercholesterolemia
1983
Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene.
1987 StandoutNobel
Asymmetric Enamine Catalysis
2007 StandoutNobel
Mevinolin Plus Colestipol in Therapy for Severe Heterozygous Familial Hypercholesterolemia
1984
Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows.
1981 StandoutNobel
Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension.
1995 StandoutNobel
Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia.
1981 StandoutNobel
Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.
1981 StandoutNobel
Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
2004 StandoutScience
Promotion of human T lymphocyte activation and proliferation by fatty acids in low density and high density lipoproteins.
1986
The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins.
1992
Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
2014 StandoutNobel
Endogenous hormones as a major factor in human cancer.
1982
Synthesis of Zaragozic Acid A/Squalestatin S1
1995
Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia
1984 StandoutNobel
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
2006 StandoutScience
Works of Cecilia Hoffman being referenced
Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
1980 Standout
ENDOCRINE PROFILES AND BREAST CANCER
1973
Ectopic growth hormone syndrome associated with lung cancer
1971