Citation Impact
Citing Papers
The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin
2015 Standout
Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O 2 activation
2019 StandoutNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Isolated pores dissected from human two-pore channel 2 are functional
2016
Small heat shock proteins: Simplicity meets complexity
2018
N- and C-terminal regions of αB-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation
2020
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Targeting hypoxia in cancer therapy
2011 Standout
Ageing and vision: structure, stability and function of lens crystallins
2003
Detection of Reactive Oxygen Species via Endogenous Oxidative Pentose Phosphate Cycle Activity in Response to Oxygen Concentration
2007
Atomic model of the type III secretion system needle
2012 StandoutNatureNobel
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3
2017 Nature
Mechanosensory hair cells express two molecularly distinct mechanotransduction channels
2016 StandoutNobel
A quantitative electrochemiluminescence assay for Clostridium perfringens alpha toxin
2006
Chronic non-spherocytic haemolytic disorders associated with glucose-6-phosphate dehydrogenase variants
2000
K2P2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site
2017 Nature
Human glucose-6-phosphate dehydrogenase: the crystal structure reveals a structural NADP + molecule and provides insights into enzyme deficiency
2000
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
Binding determinants of the small heat shock protein, αB‐crystallin: recognition of the ‘IxI’ motif
2012
The bacterial superantigen and superantigen‐like proteins
2008
Introduction of Fluorine and Fluorine‐Containing Functional Groups
2013 Standout
Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel
2019
New potential binding determinant for hERG channel inhibitors
2016
A quantitative NMR spectroscopic examination of the flexibility of the C-terminal extensions of the molecular chaperones, αA- and αB-crystallin
2010
Complement evasion by human pathogens
2008
Molecular Dynamics Simulation for All
2018 Standout
Mechanism of Clostridium perfringens Enterotoxin Interaction with Claudin-3/-4 Protein Suggests Structural Modifications of the Toxin to Target Specific Claudins
2011
Modeling the human Na<sub>v</sub>1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade
2017 StandoutNobel
Complement: a key system for immune surveillance and homeostasis
2010 Standout
Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice
2004
Mechanism of Ion Permeation in Mammalian Voltage-Gated Sodium Channels
2015
Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes
2022
The Mechanism of Na+/K+ Selectivity in Mammalian Voltage-Gated Sodium Channels Based on Molecular Dynamics Simulation
2013
A structure-based computational workflow to predict liability and binding modes of small molecules to hERG
2020 StandoutNobel
Mechanically Activated Ion Channels
2015 StandoutNobel
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Zinc coordination sphere in biochemical zinc sites
2001
MTSET modification of D4S6 cysteines stabilize the fast inactivated state of Nav1.5 sodium channels
2015
Charting the travels of copper in eukaryotes from yeast to mammals
2012
Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes
1997
Mutations in LOXHD1, an Evolutionarily Conserved Stereociliary Protein, Disrupt Hair Cell Function in Mice and Cause Progressive Hearing Loss in Humans
2009
Colocalization of ferroportin‐1 with hephaestin on the basolateral membrane of human intestinal absorptive cells
2007
Dynamics and functions of lipid droplets
2018 Standout
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels
2014
Saxitoxin
2014
The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client
2015
Molecular Basis of the Specific Subcellular Localization of the C2-like Domain of 5-Lipoxygenase
2002
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
Quaternary Dynamics of αB-Crystallin as a Direct Consequence of Localised Tertiary Fluctuations in the C-Terminus
2011
Redox Cycling in Iron Uptake, Efflux, and Trafficking
2010
A Red Carpet for Iron Metabolism
2017
Crystallin γB-I4F Mutant Protein Binds to α-Crystallin and Affects Lens Transparency
2005 StandoutNobel
Glucose-6-phosphate dehydrogenase deficiency
2000
Amino acid conservation and clinical severity of human glucose-6-phosphate dehydrogenase mutations
1999
Pore-forming toxins: ancient, but never really out of fashion
2015
The Outer Pore of the Glutamate Receptor Channel Has 2-Fold Rotational Symmetry
2004
Neither human hephaestin nor ceruloplasmin forms a stable complex with transferrin
2007
Anaphylatoxins
2007
Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers
2010
Lysine and the Na+/K+ Selectivity in Mammalian Voltage-Gated Sodium Channels
2016
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
2017 StandoutNobel
Locating the Route of Entry and Binding Sites of Benzocaine and Phenytoin in a Bacterial Voltage Gated Sodium Channel
2014
Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels
2015
Terminal Regions Confer Plasticity to the Tetrameric Assembly of Human HspB2 and HspB3
2018
The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs
2016
Slow Inactivation of Na+ Channels
2014
HIV-1 Neutralization Profile and Plant-Based Recombinant Expression of Actinohivin, an Env Glycan-Specific Lectin Devoid of T-Cell Mitogenic Activity
2010 StandoutNobel
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity
2021 StandoutNobel
Fluoxetine Blocks Nav1.5 Channels via a Mechanism Similar to That of Class 1 Antiarrhythmics
2014
Molecular Dynamics Study of Binding of µ-Conotoxin GIIIA to the Voltage-Gated Sodium Channel Nav1.4
2014
Structural Insights into Bacillus thuringiensis Cry, Cyt and Parasporin Toxins
2014
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
PROTEIN FOLDS IN THE ALL-β AND ALL-α CLASSES
1997
A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases
2016 StandoutNobel
Magnesium in Man: Implications for Health and Disease
2014 Standout
Glucose-6-phosphate dehydrogenase and xylitol production by Candida guilliermondii FTI 20037 using statistical experimental design
2005
Novel folded protein domains generated by combinatorial shuffling of polypeptide segments
2000 StandoutNobel
Copper Active Sites in Biology
2014 Standout
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
2016 Standout
Recombinant Expression and Functional Characterization of Human Hephaestin: A Multicopper Oxidase with Ferroxidase Activity
2005
Local anesthetic and antiepileptic drug access and binding to a bacterial voltage-gated sodium channel
2014
Chemical Routes for the Transformation of Biomass into Chemicals
2007 Standout
Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy
2004 Standout
The hitchhiker’s guide to the voltage-gated sodium channel galaxy
2015
Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes
2006 Standout
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
2015 StandoutNobel
Fluorescent Sensors for Measuring Metal Ions in Living Systems
2014 Standout
Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases
2015 StandoutNobel
Saxitoxin
2014
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity
2014
Ion Selectivity Strategies of Sodium Channel Selectivity Filters
2014
(α-Monofluoroalkyl)phosphonates: a class of isoacidic and “tunable” mimics of biological phosphates
2001
Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin
2015 Science
Sequence, Structure, and Dynamic Determinants of Hsp27 (HspB1) Equilibrium Dissociation Are Encoded by the N-Terminal Domain
2012
Modifying the β,γ Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic Mechanism of DNA Polymerase β
2006 StandoutNobel
Electrogenerated Chemiluminescence and Its Biorelated Applications
2008 Standout
Cryo–electron microscopy structure of the lipid droplet–formation protein seipin
2018
Pharmacology of the Na v 1.1 domain IV voltage sensor reveals coupling between inactivation gating processes
2017 StandoutNobel
C-terminal interactions mediate the quaternary dynamics of αB-crystallin
2013
Claudins and the Modulation of Tight Junction Permeability
2013 Standout
Glucose-6-phosphate dehydrogenase deficiency
2008 Standout
Emerging Targets in Photopharmacology
2016 StandoutNobel
Probing Dynamic Conformations of the High-Molecular-Weight αB-Crystallin Heat Shock Protein Ensemble by NMR Spectroscopy
2012
Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET
2017
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
2008 Standout
Works of C.E. Naylor being referenced
Role of the C-terminal domain in the structure and function of tetrameric sodium channels
2013
Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia
2014
Molecular basis of ion permeability in a voltage‐gated sodium channel
2016
Molecular Architecture and Functional Analysis of NetB, a Pore-forming Toxin from Clostridium perfringens
2012
Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein
2016
Crystal Structure of R120G Disease Mutant of Human αB-Crystallin Domain Dimer Shows Closure of a Groove
2011
Solution of the structure of tetrameric human glucose 6-phosphate dehydrogenase by molecular replacement
1999
NADP+and NAD+binding to the dual coenzyme specific enzymeLeuconostoc mesenteroidesglucose 6-phosphate dehydrogenase: different interdomain hinge angles are seen in different binary and ternary complexes
2001
Characterisation of the calcium-binding C-terminal domain of Clostridium perfringens alpha-toxin 1 1Edited by A Klug
1999
Clostridium perfringens epsilon toxin H149A mutant as a platform for receptor binding studies
2013
Structural Insights into Clostridium perfringens Delta Toxin Pore Formation
2013
Structure of the key toxin in gas gangrene
1998
Structure of the Food-Poisoning Clostridium perfringens Enterotoxin Reveals Similarity to the Aerolysin-Like Pore-Forming Toxins
2011
Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing
2012
The C-terminal domains of gammaS-crystallin pair about a distorted twofold axis
1998
Identification of Zyklopen, a New Member of the Vertebrate Multicopper Ferroxidase Family, and Characterization in Rodents and Human Cells
2010
Amino acid substitutions at the dimer interface of human glucose‐6‐phosphate dehydrogenase that increase thermostability and reduce the stabilising effect of NADP
1998
Crystal Structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20
2009
Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism
1994
Structure of a C. perfringens Enterotoxin Mutant in Complex with a Modified Claudin-2 Extracellular Loop 2
2014
Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin
2002
On the Mechanism of the Reaction Catalyzed by Glucose 6-Phosphate Dehydrogenase,
1998
Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20.
2009
Structural Relationships and Cellular Tropism of Staphylococcal Superantigen-Like Proteins
2004
Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism
2014
Identification of a Key Residue for Oligomerisation and Pore-Formation of Clostridium perfringens NetB
2014
Structural model of the open–closed–inactivated cycle of prokaryotic voltage-gated sodium channels
2014
The First Strain of Clostridium perfringens Isolated from an Avian Source Has an Alpha-Toxin with Divergent Structural and Kinetic Properties,
2002