Citation Impact
Citing Papers
LIM Protein KyoT2 Negatively Regulates Transcription by Association with the RBP-J DNA-Binding Protein
1998 StandoutNobel
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation
2004
ZBTB1 is a determinant of lymphoid development
2011 StandoutNobel
Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways
2003
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Mastermind Recruits CycC:CDK8 to Phosphorylate the Notch ICD and Coordinate Activation with Turnover
2004
Notch signalling controls pancreatic cell differentiation
1999 StandoutNatureNobel
Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation
2003
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
1998 StandoutNature
Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation
1997
Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system
2000
Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
2000
The Notch 3 intracellular domain represses Notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters
1999
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.
1995
A subset of Notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex
1998
Hallmarks of Cancer: The Next Generation
2011 Standout
T‐cell fate
1998
Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears
2000
Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development
2004
Genetic determinants of pancreatic ε-cell development
2005
The Notch-Hes pathway in mammalian neural development
1999
Notch signaling is required for arterial-venous differentiation during embryonic vascular development
2001
Functional Diversity among Notch1, Notch2, and Notch3 Receptors
2002
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development
2003
Developmental restriction ofMash-2 expression in trophoblast correlates with potential activation of the Notch-2 pathway
1997
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
2014 StandoutNatureNobel
Mammalian Merkel cells are descended from the epidermal lineage
2009
Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling
2008
Hypoxia Requires Notch Signaling to Maintain the Undifferentiated Cell State
2005
Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation
1998
Arteries and veins: making a difference with zebrafish
2002
LIN-12/Notch signaling: lessons from worms and flies
1998
Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity
2005 Nature
Notch and neurogenesis
1998
Notch1 and T-cell development: insights from conditional knockout mice
2001
Delta–Notch Signaling in Odontogenesis: Correlation with Cytodifferentiation and Evidence for Feedback Regulation
1998
Notch signaling and inherited disease syndromes
2003
Notch function in the vasculature: insights from zebrafish, mouse and man
2004
Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate
2001
Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1
1999
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Notch/RBP-J Signaling Regulates Epidermis/Hair Fate Determination of Hair Follicular Stem Cells
2003 StandoutNobel
Target Selectivity of Vertebrate Notch Proteins
2005
Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways
2008
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
1997
An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages
1996
Nas transgenic mouse line allows visualization of Notch pathway activity in vivo
2006
Skeletal and CNS Defects in Presenilin-1-Deficient Mice
1997 Nobel
Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells
2000
Notch signaling: direct or what?
1998
Notch signaling targets the Wingless responsiveness of a Ubx visceral mesoderm enhancer in Drosophila
2001
Neurogenic genes and vertebrate neurogenesis
1996
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
2000 Standout
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis
2006
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Notch/LIN-12 signaling: transduction by regulated protein slicing
1998
Notch activity acts as a sensor for extracellular calcium during vertebrate left–right determination
2004 Nature
Oncogenic Forms of NOTCH1 Lacking Either the Primary Binding Site for RBP-Jκ or Nuclear Localization Sequences Retain the Ability to Associate with RBP-Jκ and Activate Transcription
1997
DNER as key molecule for cerebellar maturation
2006
Notch Receptors, Partners and Regulators: From Conserved Domains to Powerful Functions
1998
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
2000
The Notch Ligands, Jagged and Delta, Are Sequentially Processed by α-Secretase and Presenilin/γ-Secretase and Release Signaling Fragments
2003
The Notch Ligands, Delta1 and Jagged2, Are Substrates for Presenilin-dependent “γ-Secretase” Cleavage
2003
NOTCH2 Mutations Cause Alagille Syndrome, a Heterogeneous Disorder of the Notch Signaling Pathway
2006 Standout
Mouse Jagged1 Physically Interacts with Notch2 and Other Notch Receptors
1999
Notch signaling regulates left–right asymmetry determination by inducingNodalexpression
2003
Regulation of αβ/γδ T Cell Lineage Commitment and Peripheral T Cell Responses by Notch/RBP-J Signaling
2004 StandoutNobel
Thicker Than Blood
2003
Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system
1997
Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development
1996
Differentiation and Diversification of Vascular Cells from Embryonic Stem Cells
2004
Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength
2001
Oncoprotein Networks
1997
The Notch signalling pathway in hair growth
1998
Differentiation of Arterial, Venous, and Lymphatic Endothelial Cells From Vascular Progenitors
2007
Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta
1995 Nature
Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis
1999 StandoutNobel
Stimulation of human epidermal differentiation by Delta–Notch signalling at the boundaries of stem-cell clusters
2000
Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells
2008
Anchoring Notch Genetics and Biochemistry
2004
The Hallmarks of Cancer
2000 Standout
Notch-1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds
1999
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
2006 StandoutNobel
Notch Activity Influences the αβ versus γδ T Cell Lineage Decision
1997
Kuz and TACE can activate Notch independent of ligand
2008
Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFβ coreceptor
2003
Notch Signaling – Constantly on the Move
2007
CADASIL: A Critical Look at a Notch Disease
2006
Inducible gene knockout of transcription factor recombination signal binding protein‐J reveals its essential role in T versus B lineage decision
2002 StandoutNobel
A role for hairy1 in regulating chick limb bud growth
2003
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Two-Photon Calcium Imaging Reveals an Odor-Evoked Map of Activity in the Fly Brain
2003 StandoutNobel
The Ins and Outs of Notch Signaling
1997
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development
2004
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
2002
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
2002
Microfibrillar Proteins MAGP-1 and MAGP-2 Induce Notch1 Extracellular Domain Dissociation and Receptor Activation
2006
Notch signalling: a simple pathway becomes complex
2006 Standout
neurogenin1 Is Essential for the Determination of Neuronal Precursors for Proximal Cranial Sensory Ganglia
1998
Notch Signaling in Vertebrate Development and Disease
1997
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
2008
CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?
2002
Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3
2008
Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5
2000 StandoutNobel
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
2000 Nature
Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development
2001
Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing drosophila wing
1995
A Chemosensory Gene Family Encoding Candidate Gustatory and Olfactory Receptors in Drosophila
2001 StandoutNobel
Ligand-Induced Signaling in the Absence of Furin Processing of Notch1
2001
A mouse model of Alagille syndrome:Notch2as a genetic modifier ofJag1haploinsufficiency
2002
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
2006 Nature
Structure/function studies of lin-12/Notch proteins
1994
Physical Interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 Receptors
2000
The many facets of Notch ligands
2008
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
1999
Bare rudiments of notch signaling: how receptor levels are regulated
2007
Spatial Representation of the Glomerular Map in the Drosophila Protocerebrum
2002 StandoutNobel
Expression of a Delta homologue in prospective neurons in the chick
1995 Nature
Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene
1996 StandoutNobel
Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells
2000
Asymmetric Expression of Notch/Delta/Serrate Is Associated with the Anterior–Posterior Axis of Feather Buds
1997
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Angiogenic Signalling Pathways
2008
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti
2001
Correlating Notch Signaling with Thymocyte Maturation
1998
Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination
1999 Standout
Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud
2005
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System
2002 StandoutNobel
Identification and mapping of human cDNAs homologous to Drosophila mutant genes through EST database searching
1996
Localisation of members of the notch system and the differentiation of vibrissa hair follicles: Receptors, ligands, and fringe modulators
2000
Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells
1995
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
1998
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Identification of High-Molecular-Weight Proteins with Multiple EGF-like Motifs by Motif-Trap Screening
1998
DNER acts as a neuron-specific Notch ligand during Bergmann glial development
2005
Implantation and the placenta: key pieces of the development puzzle
1994 StandoutScience
Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development
1996
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
1996 StandoutNature
The shortest path from the surface to the nucleus: RBP‐Jκ/Su(H) transcription factor
1996 StandoutNobel
HES and HERP families: Multiple effectors of the notch signaling pathway
2003
The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity
2001
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)
1995 StandoutNobel
Dosage-sensitive requirement for mouse Dll4 in artery development
2004
Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
2003
A Role for Abl in Notch Signaling
1998
sonic hedgehog and vascular endothelial growth factor Act Upstream of the Notch Pathway during Arterial Endothelial Differentiation
2002
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
2004 StandoutNobel
In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish
2008 StandoutScienceNobel
Notch-dependent control of myelopoiesis is regulated by fucosylation
2008
RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
2010 StandoutNobel
Directed and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells
2008 StandoutNobel
Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
1996
Dll4, a novel Notch ligand expressed in arterial endothelium
2000
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta
1995
Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling
2003
Notch signaling is essential for vascular morphogenesis in mice
2000 Standout
Regulation of Notch1 and Dll4 by Vascular Endothelial Growth Factor in Arterial Endothelial Cells: Implications for Modulating Arteriogenesis and Angiogenesis
2002
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
2000
T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells.
1996
Fringe modulation of Jagged1-induced Notch signaling requires the action of β4galactosyltransferase-1
2001
Complementary and combinatorial patterns of Notch gene family expression during early mouse development
1995
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
1999
Notch and the Skeleton
2009
Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas
2004
Notch signalling via RBP-J promotes myeloid differentiation
2000
Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation
2001
Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers
2000
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1
2000
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
2005
Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality
1999
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Regulation of intrathymic T‐cell development by Lunatic Fringe– Notch1 interactions
2006
Neural Science
2000 StandoutNobel
The Notch ligand Jagged1 is required for inner ear sensory development
2001
The roles of receptor and ligand endocytosis in regulating Notch signaling
2005
Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate.
1995
HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo
2003
Role of Glycosylation in Development
2004
DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur
2007
Genetic Analysis of Caenorhabditis elegans glp-1 Mutants Suggests Receptor Interaction or Competition
2003
Disruption of the mouse RBP-Jк gene results in early embryonic death
1995 StandoutNobel
TheO-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development
2008
Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium
2001
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development
2004
Concise Review: Notch Signaling in Stem Cell Systems
2006
Notch signaling controls multiple steps of pancreatic differentiation
2003
Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements
1997
Genes, Signals, and Lineages in Pancreas Development
2003
Conservation of the Notch signalling pathway in mammalian neurogenesis
1997 StandoutNobel
Notch Signaling
1995 Science
Functional Analysis of Hes-1 in Preadipocytes
2005
Truncated Mammalian Notch1 Activates CBF1/RBPJk-Repressed Genes by a Mechanism Resembling That of Epstein-Barr Virus EBNA2
1996
Isolation and Functional Analysis of a cDNA for Human Jagged2, a Gene Encoding a Ligand for the Notch1 Receptor
1997
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
O2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3-Kinase/AKT Signaling
2011
Notch2 Haploinsufficiency Results in Diminished B1 B Cells and a Severe Reduction in Marginal Zone B Cells
2003
RBP-L, a Transcription Factor Related to RBP-Jκ
1997 StandoutNobel
Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway
1998
Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element.
1996
Signaling Pathways in Vascular Development
2002
Conservation of neurogenic genes and mechanisms
1999
Notch Signaling: Cell Fate Control and Signal Integration in Development
1999 StandoutScience
The Notch1 receptor is cleaved constitutively by a furin-like convertase
1998
Notch Inhibits Osteoblast Differentiation and Causes Osteopenia
2008
Cell proliferation control by Notch signaling in Drosophila development
1998
Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome
2002
Notch1 is required for the coordinate segmentation of somites
1995
An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
1994 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Immobilization of Notch ligand, Delta-1, is required for induction of Notch signaling
2000
The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
1994
THE LIN-12/Notch SIGNALING PATHWAY AND ITS REGULATION
1997
Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.
1996
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
2000 StandoutScienceNobel
The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells
1998
Diversity and Pattern in the Developing Spinal Cord
1996 Science
Presenilin-1 regulates neuronal differentiation during neurogenesis
2000
Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
1999
Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation
2001
The Presenilins in Alzheimer's Disease--Proteolysis Holds the Key
1999 Science
SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function
2000
Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4
1997
Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor
2004
Morphogen gradient interpretation
2001 StandoutNatureNobel
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
2003 StandoutNobel
Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch
1995
Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2
2000
Works of C.E. Lindsell being referenced
Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
1996
Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.
2000
A secreted Delta1‐Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling
2002
Jagged: A mammalian ligand that activates notch1
1995
Jagged2: A Serrate-like Gene Expressed during Rat Embryogenesis
1996
Notch signalling pathway mediates hair cell development in mammalian cochlea
1999
Expression Patterns ofJagged, Delta1, Notch1, Notch2,andNotch3Genes Identify Ligand–Receptor Pairs That May Function in Neural Development
1996
Embryonic Lethality and Vascular Defects in Mice Lacking the Notch Ligand Jagged1
1999
Notch1 is essential for postimplantation development in mice.
1994
Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels
2001