Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response
2015
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
Circulating microRNAs as stable blood-based markers for cancer detection
2008 Standout
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Machine learning predicts new anti-CRISPR proteins
2020 StandoutNobel
Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function
2024 StandoutNobel
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
2017
Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner
2018 StandoutNobel
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development
2010 Nature
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain
2015 StandoutNobel
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Biological functions of fucose in mammals
2017
Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma
2008
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
2010
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis
2010
Selective targeting of histone methylation
2011
Inhibition of 2-oxoglutarate dependent oxygenases
2011
RNA-based recognition and targeting: sowing the seeds of specificity
2017 StandoutNobel
Histone methylation: a dynamic mark in health, disease and inheritance
2012 Standout
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
2017 Standout
The CW domain, a new histone recognition module in chromatin proteins
2011
Pattern Recognition Receptors and Inflammation
2010 Standout
Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation
2015
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation
2010
The Human Transcription Factors
2018 Standout
Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO
2014
Histone demethylases in development and disease
2010
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
miR-155 gene: A typical multifunctional microRNA
2009
Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway
2015
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades
2011 Standout
Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
2015 Standout
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
MicroRNA-155 Suppresses Activation-Induced Cytidine Deaminase-Mediated Myc-Igh Translocation
2008
The structural biology of CRISPR-Cas systems
2015 StandoutNobel
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene
2008
Metazoan MicroRNAs
2018 Standout
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression
2010 Nature
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
2013 StandoutNobel
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
An efficient and sensitive method for preparing cDNA libraries from scarce biological samples
2014 StandoutNobel
Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial
2016 Standout
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Discovery and Characterization of Cas9 Inhibitors Disseminated across Seven Bacterial Phyla
2019
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense
2011 StandoutNobel
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
MicroRNAs in Human Cancer
2012
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
2012 StandoutNobel
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases
2009
Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
2010 Standout
Chromatin as an oxygen sensor and active player in the hypoxia response
2011
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
2010 StandoutNature
The evolution of gene regulation by transcription factors and microRNAs
2007
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2
2013 StandoutNobel
Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates
2014
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
2016 StandoutNobel
Structural studies on human 2-oxoglutarate dependent oxygenases
2010
DNA-dependent formation of transcription factor pairs alters their binding specificity
2015 Nature
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Histone and DNA Modifications in Mental Retardation
2010
The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation
2010
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
2018 Standout
Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
2011 Standout
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Impact of cytosine methylation on DNA binding specificities of human transcription factors
2017 Science
Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells
2016
Epigenetic Regulation by Histone Demethylases in Hypoxia
2015
PHF8 Targets Histone Methylation and RNA Polymerase II To Activate Transcription
2010
2-Oxoglutarate-Dependent Oxygenases
2018
Glyco-redox, a link between oxidative stress and changes of glycans: Lessons from research on glutathione, reactive oxygen and nitrogen species to glycobiology
2016
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Neoantigens in cancer immunotherapy
2015 StandoutScience
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation
2012 StandoutNobel
Prediction of enzymatic pathways by integrative pathway mapping
2018
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation
2014 StandoutNobel
Works of C.D.O. Cooper being referenced
Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases
2013
Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation
2011
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase
2009 StandoutNobel
Microrna expression distinguishes between germinal center B cell‐like and activated B cell‐like subtypes of diffuse large B cell lymphoma
2007
A prominent -hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation
2010
Structural Insights into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2
2015
Mutations in Multidomain Protein MEGF8 Identify a Carpenter Syndrome Subtype Associated with Defective Lateralization
2012
High-throughput production of human proteins for crystallization: The SGC experience
2010
Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev
2015
MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B‐cell lymphomas
2007
Crystal structure of the PHF8 Jumonji domain, an Nε‐methyl lysine demethylase
2010