Standout Papers
- Conjugation in Saccharomyces cerevisiae (1988)
- Courtship in Saccharomyces cerevisiae: an early cell-cell interaction during mating. (1990)
- Courtship in S. cerevisiae: Both cell types choose mating partners by responding to the strongest pheromone signal (1990)
- Courtship in Saccharomyces cerevisiae: an Early Cell-Cell Interaction during Mating (1990)
- S. cerevisiae α pheromone receptors activate a novel signal transduction pathway for mating partner discrimination (1991)
Citation Impact
Citing Papers
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[5] Assay of yeast mating reaction
1991
[1] Getting started with yeast
1991 Standout
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1998
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2002
Saccharomyces cerevisiae mata mutant cells defective in pointed projection formation in response to α‐factor at high concentrations
1994 StandoutNobel
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Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae.
1994
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
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ADP-ribosylation Factor and Rho Proteins Mediate fMLP-dependent Activation of Phospholipase D in Human Neutrophils
1998
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1997 StandoutNatureNobel
Pheromone-induced phosphorylation of a G protein β subunit in S. cerevisiae is associated with an adaptive response to mating pheromone
1991
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Secretory Vesicle Budding from the Trans-Golgi Network Is Mediated by Phosphatidic Acid Levels
1998
High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis
2013 StandoutNobel
Signalling through the lipid products of phosphoinositide-3-OH kinase
1997 Nature
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1999 StandoutNobel
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2004 StandoutNobel
A comparative study of human GS2, its paralogues, and its rat orthologue
2007
A protein-conducting channel in the endoplasmic reticulum
1991 StandoutNobel
Rhodopsin-family receptors associate with small G proteins to activate phospholipase D
1998 Nature
A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains
1992 Nature
Identification of a Lipase-linked Cell Membrane Receptor for Pigment Epithelium-derived Factor
2006
Auxin distribution and transport during embryonic pattern formation in wheat
2001
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins
2002
Biogenesis of COPI‐coated transport vesicles
1997
ARF proteins mediate insulin-dependent activation of phospholipase D
1997
Different Domains of Mammalian ADP-ribosylation Factor 1 Mediate Interaction with Selected Target Proteins
1997
Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway
1995 Nature
A Spatial Map of Olfactory Receptor Expression in the Drosophila Antenna
1999 StandoutNobel
Local, Efflux-Dependent Auxin Gradients as a Common Module for Plant Organ Formation
2003 Standout
A regulatory hierarchy for cell specialization in yeast
1989 Nature
The role of lipid signaling in constitutive membrane traffic
1997
β-Arrestin-mediated ADP-ribosylation Factor 6 Activation and β2-Adrenergic Receptor Endocytosis
2001 StandoutNobel
Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2
1990
Structure of the Guanine Nucleotide Exchange Factor Sec7 Domain of Human Arno and Analysis of the Interaction with ARF GTPase
1998
The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy
2006
Development of cell polarity in budding yeast
1991
Getting started with yeast
2002 Standout
The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast
1991
Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the question
1992 StandoutNobel
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Membrane protein sequestering by ionic protein–lipid interactions
2011 StandoutNatureNobel
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Identification of an Insulin-regulated Lysophospholipase with Homology to Neuropathy Target Esterase
2007
Structural Basis for Activation of ARF GTPase
1998
Overexpression of fIbA, an early regulator of Aspergillus asexual sporulation, leads to activation of brIA and premature initiation of development
1994
The Arabidopsis GNOM ARF-GEF Mediates Endosomal Recycling, Auxin Transport, and Auxin-Dependent Plant Growth
2003
ARNO Is a Guanine Nucleotide Exchange Factor for ADP-ribosylation Factor 6
1998
Selection of polarized growth sites in yeast
1996
Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII Vesicle
2005 StandoutNobel
Phermone response in yeast
1990
The role of ARF and Rab GTPases in membrane transport
1999
Efflux-dependent auxin gradients establish the apical–basal axis of Arabidopsis
2003 StandoutNature
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
2007
Programmed population control by cell–cell communication and regulated killing
2004 StandoutNatureNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots
2005 StandoutNature
SEC21 is a gene required for ER to Golgi protein transport that encodes a subunit of a yeast coatomer
1992 StandoutNatureNobel
The fission yeast cdc18+ gene product couples S phase to START and mitosis
1993 StandoutNobel
Regulation of phyllotaxis by polar auxin transport
2003 Nature
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
Identification of a Gl-type cyclin puc1+ in the fission yeast Schizosaccharomyces pombe
1991 StandoutNatureNobel
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Cell polarity and morphogenesis in Saccharomyces cerevisiae
1992
FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation
1990
Signalling through phosphoinositide 3-kinases: the lipids take centre stage
1999
NEW EMBO MEMBER'S REVIEW: Apical-basal pattern formation in Arabidopsis embryogenesis
2001
G1-specific cyclins of S. cerevisiae: Cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase
1990
tea1 and the Microtubular Cytoskeleton Are Important for Generating Global Spatial Order within the Fission Yeast Cell
1997 StandoutNobel
SGV1 encodes a CDC28/cdc2-related kinase required for a Gα subunit-mediated adaptive response to pheromone in S. cerevisiae
1991
A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae
1989
BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI
2004 StandoutNobel
Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.
1989
Stoichiometry of G protein subunits affects the Saccharomyces cerevisiae mating pheromone signal transduction pathway.
1990
Partial loss-of-function alleles reveal a role forGNOMin auxin transport-related, post-embryonic development ofArabidopsis
2003
Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase
2006 Science
AKR1Encodes a Candidate Effector of the Gβγ Complex in theSaccharomyces cerevisiaePheromone Response Pathway and Contributes to Control of both Cell Shape and Signal Transduction
1996 StandoutNobel
Coupled ER to Golgi Transport Reconstituted with Purified Cytosolic Proteins
1997
Small GTP-Binding Proteins
2001 Standout
IME4, a gene that mediates MAT and nutritional control of meiosis in Saccharomyces cerevisiae.
1992
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
The Role of ADP-ribosylation Factor and Phospholipase D in Adaptor Recruitment
1997
Overproduction of the yeast STE12 protein leads to constitutive transcriptional induction.
1990
Specification of sites for polarized growth in Saccharomyces cerevisiae and the influence of external factors on site selection.
1992
Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes
1998 StandoutNobel
Interactions among the Subunits of the G Protein Involved in Saccharomyces cerevisiae Mating†
1993
Negative regulation of FAR1 at the Start of the yeast cell cycle.
1993
FAR1 is required for oriented polarization of yeast cells in response to mating pheromones.
1995
ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles
1998 StandoutNobel
ARF-GEP 100 , a guanine nucleotide-exchange protein for ADP-ribosylation factor 6
2001
The ATGL Gene Is Associated With Free Fatty Acids, Triglycerides, and Type 2 Diabetes
2006
Sec16p potentiates the action of COPII proteins to bud transport vesicles
2002 StandoutNobel
Signaling Through Scaffold, Anchoring, and Adaptor Proteins
1997 StandoutScience
Crystal structure of Sar1-GDP at 1.7 A resolution and the role of the NH2 terminus in ER export
2001
FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1.
1993
PIP2and Proteins: Interactions, Organization, and Information Flow
2002
Correction: Identification of a Gl-type cyclin puc+ in the fission yeast Schizosaccharomyces pombe
1991 StandoutNatureNobel
The ADP ribosylation factor nucleotide exchange factor ARNO promotes β-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization
2000
STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes.
1989
G protein mutations that alter the pheromone response in Saccharomyces cerevisiae.
1990
Autoinducer binding by the quorum-sensing regulator TraR increases affinity for target promoters in vitro and decreases TraR turnover rates in whole cells
1999
Significance of C-terminal cysteine modifications to the biological activity of the Saccharomyces cerevisiae a-factor mating pheromone.
1991
AFR1Promotes Polarized Apical Morphogenesis inSaccharomyces cerevisiae
1995
Effects of expression of mammalian G alpha and hybrid mammalian-yeast G alpha proteins on the yeast pheromone response signal transduction pathway.
1990
Yeast pheromone response pathway: characterization of a suppressor that restores mating to receptorless mutants.
1989
CDC36 and CDC39 are negative elements in the signal transduction pathway of yeast.
1990
IME4, a Gene That Mediates MAT and Nutritional Control of Meiosis in Saccharomyces cerevisiae
1992
Localization of endogenous ARF6 to sites of cortical actin rearrangement and involvement of ARF6 in cell spreading
1998
Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein.
1992
Regulation of postreceptor signaling in the pheromone response pathway of Saccharomyces cerevisiae.
1989
Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients.
1995 StandoutNobel
ADP-Ribosylation Factor 1 (ARF1) Regulates Recruitment of the AP-3 Adaptor Complex to Membranes
1998
Signaling by Phosphoinositide-3,4,5-Trisphosphate Through Proteins Containing Pleckstrin and Sec7 Homology Domains
1997 Science
Phosphorylation of FAR1 in response to alpha-factor: a possible requirement for cell-cycle arrest.
1992
A Synthetic Lethal Screen Identifies SLK1, a Novel Protein Kinase Homolog Implicated in Yeast Cell Morphogenesis and Cell Growth
1992
STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast.
1990
ADP-Ribosylation Factor 6 Delineates Separate Pathways Used by Endothelin 1 and Insulin for Stimulating Glucose Uptake in 3T3-L1 Adipocytes
2001
The SPA2 gene of Saccharomyces cerevisiae is important for pheromone-induced morphogenesis and efficient mating.
1990
The carboxyl terminus of Scg1, the G alpha subunit involved in yeast mating, is implicated in interactions with the pheromone receptors.
1991
Mutational Activation of the STE5 Gene Product Bypasses the Requirement for G Protein β and γ Subunits in the Yeast Pheromone Response Pathway
1994
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
1993 StandoutNatureNobel
Reconstitution of Retrograde Transport from the Golgi to the ER In Vitro
1998 StandoutNobel
Yeast Pheromone Response Pathway: Characterization of a Suppressor That Restores Mating to Receptorless Mutants
1989
Polar auxin transport — old questions and new concepts?
2002
Chromosome Aberrations and Cancer
1991 Science
Pheromone Signalling in Saccharomyces cerevisiae Requires the Small GTP-Binding Protein Cdc42p and Its Activator CDC24
1995
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Significance of C-Terminal Cysteine Modifications to the Biological Activity of the Saccharomyces cerevisiae a-Factor Mating Pheromone
1991
Control of Yeast Mating Signal Transduction by a Mammalian β 2 -adrenergic Receptor and G s α Subunit
1990 StandoutScienceNobel
A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth.
1992
Functional Expression of the Yeast α-Factor Receptor in Xenopus Oocytes
1989
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
Biosynthesis, conjugation, catabolism and homeostasis of indole-3-acetic acid in Arabidopsis thaliana
2002
Cell cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles START-I arrest and is independent of the mating-pheromone signalling pathway.
1990
Three-dimensional analysis of morphogenesis induced by mating pheromone α factor in saccharomyces cerevisiae
1989 StandoutNobel
Cell polarization directed by extracellular cues in yeast.
1994
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network
1997
Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase.
1992 StandoutNobel
Polarization of yeast cells in spatial gradients of alpha mating factor.
1993
Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway.
1994
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Polar auxin transport – old questions and new concepts?
2002
Reversible dissociation of coatomer: Functional characterization of a β/δ-coat protein subcomplex
1998
Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases.
1993
Works of Catherine Jackson being referenced
The Arf activator Gea2p and the P-type ATPase Drs2p interact at the Golgi in Saccharomyces cerevisiae
2004
Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors
2000
A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains
1996 Nature
S. cerevisiae α pheromone receptors activate a novel signal transduction pathway for mating partner discrimination
1991 StandoutNobel
Courtship in S. cerevisiae: Both cell types choose mating partners by responding to the strongest pheromone signal
1990 StandoutNobel
Nucleotide exchange on ARF mediated by yeast Geal protein
1996 Nature
Regulators and effectors of the ARF GTPases
2000
Brefeldin A Acts to Stabilize an Abortive ARF–GDP–Sec7 Domain Protein Complex
1999
Conjugation in Saccharomyces cerevisiae
1988 StandoutNobel
ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells
2005
Courtship in Saccharomyces cerevisiae: an early cell-cell interaction during mating.
1990 StandoutNobel
Microbial cell-cell interactions
1992
Courtship in Saccharomyces cerevisiae: an Early Cell-Cell Interaction during Mating
1990 StandoutNobel
The ARF exchange factors Gea1p and Gea2p regulate Golgi structure and function in yeast
2001
Controlling small guanine–nucleotide-exchange factor function through cytoplasmic RNA intramers
2001
Coordinated Polar Localization of Auxin Efflux Carrier PIN1 by GNOM ARF GEF
1999 Science