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Citing Papers
Fission yeast Fizzy-related protein srw1p is a G 1 -specific promoter of mitotic cyclin B degradation
2000 StandoutNobel
Fission yeast CDC25 is a cell-cycle regulated protein
1990
Finishing the cell cycle: control of mitosis and cytokinesis in fission yeast
1993 StandoutNobel
The roles of Drosophila cyclins A and B in mitotic control
1990
Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene
1994 StandoutNatureNobel
Cyclin activation of p34cdc2
1990
Ordering S phase and M phase in the cell cycle
1994 StandoutNobel
Mutational analysis of the fission yeast p34cdc2 protein kinase gene
1993 StandoutNobel
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
Identification of a signal for rapid export of proteins from the nucleus
1995 StandoutNobel
A fission yeast B-type cyclin functioning early in the cell cycle
1991
roughex is a dose-dependent regulator of the second meiotic division during Drosophila spermatogenesis
1994
Cytoplasmic anchoring proteins and the control of nuclear localization
1989 StandoutNobel
Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brain
1994
Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase
1991
Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes
1991
Cloning of the mouse homologue of the yeast cell cycle control gene cdc2
1990
Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication
1990 StandoutNobel
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Involvement of p34cdc2 in establishing the dependency of S phase on mitosis
1991 StandoutNatureNobel
Cyclins of the fission yeast Schizosaccharomyces pombe
1995 StandoutNobel
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
1994 StandoutNobel
A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex
1992
The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system
1991
A Long Twentieth Century of the Cell Cycle and Beyond
2000 StandoutNobel
Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans
1991
Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase
1993
One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis
1990
Mos and the cell cycle: the molecular basis of the transformed phenotype
1993
The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae
1991
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase
1990 StandoutNatureNobel
A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase
1994
Controls of Cell Proliferation in Yeast and Animals
2007 Nobel
Cyclin is a component of maturation-promoting factor from Xenopus
1990 StandoutNobel
Isolation, characterisation and molecular cloning of new mutant alleles of the fission yeast p34 cdc2+ protein kinase gene: identification of temperature-sensitive G2-arresting alleles
1991 StandoutNobel
An essential G1 function for cyclin-like proteins in yeast
1989
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Crystal structure of cyclin-dependent kinase 2
1993 Nature
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
INH, a negative regulator of MPF, is a form of protein phosphatase 2A
1991
Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication
1989 Nature
Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycle
1991
Substrates for p34cdc2: In vivo veritas?
1990 StandoutNobel
Mitotic regulation of protein phosphatases by the fission yeast sds22 protein
1993
The mos proto‐oncogene product: Its role in oocyte maturation, metaphase arrest, and neoplastic transformation
1992
A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells
1989
The fission yeast cdc18+ gene product couples S phase to START and mitosis
1993 StandoutNobel
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
1991
Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination
1998 StandoutNatureNobel
Identification of a Gl-type cyclin puc1+ in the fission yeast Schizosaccharomyces pombe
1991 StandoutNatureNobel
A brain-specific activator of cyclin-dependent kinase 5
1994 StandoutNatureNobel
Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast
1990 StandoutNatureNobel
Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C
1990
Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor
1998
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
1989 StandoutNatureNobel
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation
1990
Cut2 proteolysis required for sister-chromatid separation in fission yeast
1996 StandoutNatureNobel
G1-specific cyclins of S. cerevisiae: Cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase
1990
tea1 and the Microtubular Cytoskeleton Are Important for Generating Global Spatial Order within the Fission Yeast Cell
1997 StandoutNobel
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2
1991
Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family
1991
Nuclear protein localization
1991
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
p25rum1 promotes proteolysis of the mitotic B-cyclin p56cdc13 during G1 of the fission yeast cell cycle
1997
Tyrosine Phosphorylation of Cdc2 Is Required for the Replication Checkpoint in Schizosaccharomyces pombe
1998
A Three-Dimensional Model of the Cdc2 Protein Kinase: Localization of Cyclin- and Suc1-Binding Regions and Phosphorylation Sites
1993
A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.
1995 StandoutNobel
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.
1993
Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.
1992
A Dominant Negative Allele of p34cdc2 Shows Altered Phosphoamino Acid Content and Sequesters p56cdc13 Cyclin
1992 StandoutNobel
Dominoes and Clocks: the Union of Two Views of the Cell Cycle
1989 Science
Cig2, a B-Type Cyclin, Promotes the Onset of S in Schizosaccharomyces pombe
1996
Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells
1992
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant.
1990
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.
1991
Block of Ca 2+ Wave and Ca 2+ Oscillation by Antibody to the Inositol 1,4,5-Trisphosphate Receptor in Fertilized Hamster Eggs
1992 StandoutScienceNobel
A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.
1996 StandoutNobel
Checkpoints and spindles
1991 StandoutNatureNobel
Green Fluorescent Protein as a Marker for Gene Expression
1994 StandoutScienceNobel
Dominant mutants identify new roles for p34cdc2 in mitosis.
1995 StandoutNobel
The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B.
1994
Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.
1991
Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.
1991
A WD Repeat Protein Controls the Cell Cycle and Differentiation by Negatively Regulating Cdc2/B-Type Cyclin Complexes
1997
Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.
1990
A mitotic role for a novel fission yeast protein kinase dsk1 with cell cycle stage dependent phosphorylation and localization.
1993
Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division.
1992
Complementation of the Mitotic Activator, p80 cdc25 , by a Human Protein-tyrosine Phosphatase
1990 StandoutScienceNobel
Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle
1990
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Differential function and expression of Saccharomyces cerevisiae B-type cyclins in mitosis and meiosis.
1993
Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.
1991
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero
1998 StandoutNobel
Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components.
1990
Correction: Identification of a Gl-type cyclin puc+ in the fission yeast Schizosaccharomyces pombe
1991 StandoutNatureNobel
Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.
1991 StandoutNobel
The role of cyclin synthesis, modification and destruction in the control of cell division
1989 StandoutNobel
Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins.
1993
Cyclin B Proteolysis and the Cyclin-dependent Kinase Inhibitor rum1p Are Required for Pheromone-induced G1Arrest in Fission Yeast
1998 StandoutNobel
The crystal structure of p13suc1, a p34cdc2-interacting cell cycle control protein.
1995 StandoutNobel
The kinetics of H1 histone kinase activation during the cell cycle of wild-type and wee mutants of the fission yeast Schizosaccharomyces pombe
1994
p13suc1 suppresses the catalytic function of p34cdc2 kinase for intermediate filament proteins, in vitro.
1992
The Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylation.
1992
Cyclin D1 is a nuclear protein required for cell cycle progression in G1.
1993
Calcium and cell cycle control
1990
Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae.
1990
Cell Cycle Control of DNA Replication by a Homologue from Human Cells of the p34 cdc2 Protein Kinase
1990 Science
B-type cyclins regulate G1 progression in fission yeast in opposition to the p25rum1 cdk inhibitor.
1996
p13suc1 of Schizosaccharomyces pombe Regulates Two Distinct Forms of the Mitotic cdc2 Kinase
1995
Visualization of centromeric and nucleolar DNA in fission yeast by fluorescence in situ hybridization
1992
A quantitative model for the cdc2 control of S phase and mitosis in fission yeast
1996 StandoutNobel
Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.
1990
The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.
1995
Control of programmed cyclin destruction in a cell-free system.
1989
The Incredible Life and Times of Biological Cells
2000 StandoutScienceNobel
A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites.
1993
Differential Function and Expression of Saccharomyces cerevisiae B-type Cyclins in Mitosis and Meiosis
1993
Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus.
1995
Nuclear localization of vertebrate cyclin a correlates with its ability to form complexes with cdk catalytic subunits
1993
The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo.
1992 StandoutNobel
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
1993 StandoutNatureNobel
Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.
1992
Cyclin A is required at two points in the human cell cycle.
1992
Mutations at sites involved in Suc1 binding inactivate Cdc2.
1991
Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle.
1994
Cyclin A and cyclin B dissociate from p34cdc2 with half-times of 4 and 15 h, respectively, regardless of the phase of the cell cycle.
1994 StandoutNobel
Cyclin B targets p34cdc2 for tyrosine phosphorylation.
1991
Two Fission Yeast B-Type Cyclins, Cig2 and Cdc13, Have Different Functions in Mitosis
1993
Cyclins A and B associate with chromatin and the polar regions of spindles, respectively, and do not undergo complete degradation at anaphase in syncytial Drosophila embryos.
1992
The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe.
1996 StandoutNobel
Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.
1992
Two fission yeast B-type cyclins, cig2 and Cdc13, have different functions in mitosis.
1993
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
The S. pombe cdc16 gene is required both for maintenance of p34cdc2 kinase activity and regulation of septum formation: a link between mitosis and cytokinesis?
1993
A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans
1994
Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae.
1992
Specific association of an M-phase kinase with isolated mitotic spindles and identification of two of its substrates as MAP4 and MAP1B.
1991
Cell cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles START-I arrest and is independent of the mating-pheromone signalling pathway.
1990
Association of p34cdc2/cyclin B complex with microtubules in starfish oocytes
1993
Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2.
1990
Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle
1994
The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.
1993
Cell cycle-regulated degradation of Xenopus cyclin B2 requires binding to p34cdc2.
1994
Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase.
1993
An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells.
1994
Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits.
1992 StandoutNobel
Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.
1991 StandoutNobel
Works of Caroline E. Alfa being referenced
Chapter 11 Antigen Localization in Fission Yeast
1993
Subcellular Localization of the p34cdc2/p63cdc13 Protein Kinase in Fission Yeast
1991
Distinct nuclear and spindle pole body populations of cyclin–cdc2 in fission yeast
1990 Nature
The fission yeast cdc2/cdc13/suc1 protein kinase: Regulation of catalytic activity and nuclear localization
1989
p63cdc13, a B-type cyclin, is associated with both the nucleolar and chromatin domains of the fission yeast nucleus.
1993
Conserved structural motifs in cyclins identified by sequence analysis
1991
Fission yeast cyclin: subcellular localisation and cell cycle regulation
1989