Standout Papers
Citation Impact
Citing Papers
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
CRISPR–Cas9 Structures and Mechanisms
2017 StandoutNobel
Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a)
2018
Crystal structure of the CRISPR RNA–guided surveillance complex from Escherichia coli
2014 Science
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9
2017 StandoutNobel
Rationally engineered Cas9 nucleases with improved specificity
2015 StandoutScience
The crystal structure of Cpf1 in complex with CRISPR RNA
2016 Nature
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
2019 StandoutNobel
RNA-Independent DNA Cleavage Activities of Cas9 and Cas12a
2017
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
2017
Directional R-Loop Formation by the CRISPR-Cas Surveillance Complex Cascade Provides Efficient Off-Target Site Rejection
2015
Structure and Engineering of Francisella novicida Cas9
2016
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1
2017
Linking CRISPR-Cas9 interference in cassava to the evolution of editing-resistant geminiviruses
2019
Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems
2015
The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a
2017
Structural basis for promiscuous PAM recognition in type I–E Cascade from E. coli
2016 Nature
Guide RNA engineering for versatile Cas9 functionality
2016
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
2016 StandoutNature
PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease
2016
Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage
2017 Nature
Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9
2017
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
2014 Standout
Classification and evolution of type II CRISPR-Cas systems
2014 StandoutNobel
Expanding the Biologist’s Toolkit with CRISPR-Cas9
2015 StandoutNobel
Development of an intein-mediated split–Cas9 system for gene therapy
2015
Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a
2017
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
RNA-based recognition and targeting: sowing the seeds of specificity
2017 StandoutNobel
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
2015
Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States
2019
Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities
2017
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity
2014
Diverse Mechanisms of CRISPR-Cas9 Inhibition by Type IIC Anti-CRISPR Proteins
2019
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
2018 Nature
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Diversity, classification and evolution of CRISPR-Cas systems
2017
Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds
2014
Temperature-Responsive Competitive Inhibition of CRISPR-Cas9
2018 StandoutNobel
Spatiotemporal allele organization by allele-specific CRISPR live-cell imaging (SNP-CLING)
2017
An Efficient Genotyping Method for Genome-modified Animals and Human Cells Generated with CRISPR/Cas9 System
2014
A decade of discovery: CRISPR functions and applications
2017
Foreign DNA capture during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells
2016 StandoutNobel
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
CRISPR-Cas immunity in prokaryotes
2015 Nature
The structural biology of CRISPR-Cas systems
2015 StandoutNobel
Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes
2015 StandoutNobel
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
2016 Standout
Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design
2015
Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch
2016 StandoutNobel
Rapid characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements
2015
Massively parallel determination and modeling of endonuclease substrate specificity
2014 StandoutNobel
Cas9 specifies functional viral targets during CRISPR–Cas adaptation
2015 Nature
Crystal Structure of Staphylococcus aureus Cas9
2015
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Unravelling the structural and mechanistic basis of CRISPR–Cas systems
2014
DNA and RNA interference mechanisms by CRISPR-Cas surveillance complexes
2015 StandoutNobel
Enhanced Specificity and Efficiency of the CRISPR/Cas9 System with Optimized sgRNA Parameters in Drosophila
2014
C2c1-sgRNA Complex Structure Reveals RNA-Guided DNA Cleavage Mechanism
2016
Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
2014
Photoactivatable CRISPR-Cas9 for optogenetic genome editing
2015
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
Bacterial CRISPR: accomplishments and prospects
2015
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
2015 Nature
Mechanism of CRISPR-RNA guided recognition of DNA targets inEscherichia coli
2015
Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex
2017
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Annotation and Classification of CRISPR-Cas Systems
2015
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
2016
Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems
2017
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity
2015 StandoutNobel
Modulating the Cascade architecture of a minimal Type I-F CRISPR-Cas system
2016
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA
2016
Characterization and Repurposing of Type I and Type II CRISPR–Cas Systems in Bacteria
2018
Engineering the Delivery System for CRISPR-Based Genome Editing
2018
A Conserved Structural Chassis for Mounting Versatile CRISPR RNA-Guided Immune Responses
2015
Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition
2016
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Small molecule–triggered Cas9 protein with improved genome-editing specificity
2015
The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit
2017
In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni
2017
Protein Engineering of Cas9 for Enhanced Function
2014
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response
2016 StandoutNobel
DNase H Activity of Neisseria meningitidis Cas9
2015
Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a
2019
Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
2016 StandoutNobel
Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage
2015
Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality
2014
Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs
2014
Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems
2015
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
2014
The Bacterial Origins of the CRISPR Genome-Editing Revolution
2015
Genome Engineering with Targetable Nucleases
2014
A prudent path forward for genomic engineering and germline gene modification
2015 StandoutScienceNobel
Performance of the Cas9 Nickase System inDrosophila melanogaster
2014
Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes
2014
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
2016 Science
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Selection of chromosomal DNA libraries using a multiplex CRISPR system
2014
Structural basis of CRISPR–SpyCas9 inhibition by an anti-CRISPR protein
2017 Nature
Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning
2015 StandoutScienceNobel
The chemistry of Cas9 and its CRISPR colleagues
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering
2016 StandoutNobel
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference
2014 StandoutNobel
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Mechanism of foreign DNA recognition by a CRISPR RNA-guided surveillance complex from Pseudomonas aeruginosa
2015
RNA-dependent RNA targeting by CRISPR-Cas9
2018 StandoutNobel
Structure Principles of CRISPR-Cas Surveillance and Effector Complexes
2015
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
Covalent Modification of Bacteriophage T4 DNA Inhibits CRISPR-Cas9
2015
Optical Control of CRISPR/Cas9 Gene Editing
2015
Cas9 function and host genome sampling in Type II-A CRISPR–Cas adaptation
2015
Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases
2019
Mechanism of duplex DNA destabilization by RNA-guided Cas9 nuclease during target interrogation
2017
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures
2018
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3
2014
Disabling Cas9 by an anti-CRISPR DNA mimic
2017 StandoutNobel
Works of Carolin Anders being referenced
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
In Vitro Enzymology of Cas9
2014
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
2014 Nature
In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA Target
2015
Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9
2016