Citation Impact
Citing Papers
TRP Channels as Potential Drug Targets
2017
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
2004 StandoutScience
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
ZBTB1 is a determinant of lymphoid development
2011 StandoutNobel
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL
2010 StandoutNobel
Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin
2003
Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease
2005
Therapeutic strategies for Alzheimer's disease
2002
Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed γ-Secretase Inhibitor
2004
Atopic Dermatitis
2008 Standout
Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity
2003
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
2003 Nature
Dying for a cause: invertebrate genetics takes on human neurodegeneration
2003
Uncoupled Packaging of Amyloid Precursor Protein and Presenilin 1 into Coat Protein Complex II Vesicles
2004 StandoutNobel
TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity
2006 Nature
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
2008 Standout
Dendritic cells: versatile controllers of the immune system
2007 StandoutNobel
Pathological activity of familial Alzheimer’s disease-associated mutant presenilin can be executed by six different γ-secretase complexes
2007
Trafficking and Proteolytic Processing of APP
2012
The Cancer Genome Atlas Pan-Cancer analysis project
2013 Standout
Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP
2005
Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
2009 StandoutNobel
An atomic structure of human γ-secretase
2015 Nature
Reconstitution of γ-secretase activity
2003
Presenilin-1 Regulates Intracellular Trafficking and Cell Surface Delivery of β-Amyloid Precursor Protein
2003
Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy
2007 StandoutNobel
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping γ-Secretase Activities
2003
Calcium dyshomeostasis and intracellular signalling in alzheimer's disease
2002
TANGO1 Facilitates Cargo Loading at Endoplasmic Reticulum Exit Sites
2009 StandoutNobel
Presenilin-dependent Intramembrane Proteolysis of CD44 Leads to the Liberation of Its Intracellular Domain and the Secretion of an Aβ-like Peptide
2002
Treatment of nausea and vomiting: Gaps in our knowledge
2006
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation
2004 StandoutNobel
Alzheimer's disease: treatments in discovery and development
2002
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch
2002
Chemotherapy-Induced Nausea and Vomiting
2008 Standout
Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons
2008 StandoutNobel
γ-Secretase Complex Assembly within the Early Secretory Pathway
2005
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Drosophila, the golden bug, emerges as a tool for human genetics
2005
Alzheimer's disease
2016 Standout
Loss of nicastrin elicits an apoptotic phenotype in mouse embryos
2006
PEN-2 and APH-1 Coordinately Regulate Proteolytic Processing of Presenilin 1
2003
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
2011 StandoutNobel
WormBook: the online review of Caenorhabditis elegans biology
2006 StandoutNobel
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
2002
Alzheimer's Disease
2010 Standout
The ubiquitin system: pathogenesis of human diseases and drug targeting
2004 StandoutNobel
Degradation of nicastrin involves both proteasome and lysosome
2007
Familial Alzheimer's Disease Presenilin 1 Mutations Cause Alterations in the Conformation of Presenilin and Interactions with Amyloid Precursor Protein
2005
Immature nicastrin stabilizes APH‐1 independent of PEN‐2 and presenilin: identification of nicastrin mutants that selectively interact with APH‐1
2004
Localization of presenilin–nicastrin complexes and γ‐secretase activity to the trans‐Golgi network
2003
BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions
2005
A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex
2004
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Alzheimer's Disease
2004 Standout
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
γ-Secretase Activity Is Associated with a Conformational Change of Nicastrin
2003
Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model
2004
Textpresso: An Ontology-Based Information Retrieval and Extraction System for Biological Literature
2004
Evidence That Assembly of an Active γ-Secretase Complex Occurs in the Early Compartments of the Secretory Pathway
2004
Intracellular amyloid-β in Alzheimer's disease
2007 Standout
Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex
2003
APH-1 Interacts with Mature and Immature Forms of Presenilins and Nicastrin and May Play a Role in Maturation of Presenilin·Nicastrin Complexes
2003
Nectin-1α, an Immunoglobulin-like Receptor Involved in the Formation of Synapses, Is a Substrate for Presenilin/γ-Secretase-like Cleavage
2002
Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective
2005
SEC23-SEC31 the Interface Plays Critical Role for Export of Procollagen from the Endoplasmic Reticulum
2012 StandoutNobel
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain
2003
Positive and Negative Regulation of the γ-Secretase Activity by Nicastrin in a Murine Model
2003
Molecular Mechanisms of Amyloidosis
2003 Standout
Structure and function of γ-secretase
2008
PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin
2002
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms
2006
γ-Secretase and its modulators: Twenty years and beyond
2019
Presenilin diversifies its portfolio
2007
The role of presenilin cofactors in the γ-secretase complex
2003 Nature
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Intramembrane Proteolysis
2009
The initial substrate-binding site of γ-secretase is located on presenilin near the active site
2005
γ-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation
2003
The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization
2012
Intramembrane proteolysis by presenilin and presenilin-like proteases
2003
CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer's disease amyloid β-peptide production
2005
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
2003
Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals
2003
Differential contribution of the three Aph1 genes to γ-secretase activity in vivo
2005
In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand
2003
Combining an amyloid‐beta (Aβ) cleaving enzyme inhibitor with a γ‐secretase modulator results in an additive reduction of Aβ production
2014
Fluorescence Lifetime Measurements and Biological Imaging
2010 Standout
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Presenilin-Dependent γ-Secretase on Plasma Membrane and Endosomes Is Functionally Distinct
2006
Moonlighting activity of presenilin in plants is independent of γ-secretase and evolutionarily conserved
2007
Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions
2016 Standout
Intramembrane Proteolysis: Theme and Variations
2004 Science
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Dendritic cells are specialized accessory cells along with TGF-β for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3− precursors
2007 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes
2003 StandoutScience
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Biogenesis of γ-secretase early in the secretory pathway
2007 StandoutNobel
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
Tolerogenic Dendritic Cells
2003 StandoutNobel
Amyloid Precursor Protein Associates with a Nicastrin-Dependent Docking Site on the Presenilin 1–γ-Secretase Complex in Cells Demonstrated by Fluorescence Lifetime Imaging
2003
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Works of Cara Ruble being referenced
aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation
2002
SEL‐10 interacts with presenilin 1, facilitates its ubiquitination, and alters A‐beta peptide production
2002
A cluster of novel serotonin receptor 3-like genes on human chromosome 3
2003
Pharmacological profiling of the TRPV3 channel in recombinant and native assays
2013