Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Gating the Selectivity Filter in ClC Chloride Channels
2003 StandoutScienceNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Developmental refinement of hair cell synapses tightens the coupling of Ca 2 + influx to exocytosis
2014 StandoutNobel
First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
2019
Multidrug resistance in cancer: role of ATP–dependent transporters
2002 Standout
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Purification and Characterization of Recombinant Cystic Fibrosis Transmembrane Conductance Regulator from Chinese Hamster Ovary and Insect Cells
1995
Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)
1992
Pathogenesis of Shiga-Toxin Producing Escherichia coli
2011
Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation
1991 Nature
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons
2021
γ-Secretase: proteasome of the membrane?
2004
Presenilin 1 Regulates Epidermal Growth Factor Receptor Turnover and Signaling in the Endosomal-Lysosomal Pathway
2007
nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans
2009 StandoutNobel
Chloride channels, Golgi pH and cystic fibrosis
1992
The C. elegans Cell Corpse Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters
1998 StandoutNobel
Activation by Extracellular Nucleotides of Chloride Secretion in the Airway Epithelia of Patients with Cystic Fibrosis
1991
Iron Overload Cardiomyopathy
2010
In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
1992
Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR
1992 Nature
Disturbed structural interactions between microfilaments and tight junctions in rat hepatocytes during extrahepatic cholestasis induced by common bile duct ligation
1996
Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel
1991
Interpreting Neonatal Lethal Phenotypes in Mouse Mutants: Insights Into Gene Function and Human Diseases
2009
Balancing Acts
2004 Standout
Insulin promotes functional induction of silent synapses in differentiating rat neocortical neurons
2001
Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line.
1992
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive
1992 Nature
Nucleoside triphosphates are required to open the CFTR chloride channel
1991
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Calcium cooperativity of exocytosis as a measure of Ca2+ channel domain overlap
2011
Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.
1991
Two to Tango: Regulation of Mammalian Iron Metabolism
2010 Standout
Inactivation of the murine cftr gene abolishes cAMP-mediated but not Ca2+-mediated secretagogue-induced volume decrease in small-intestinal crypts
1993 StandoutNobel
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
A Proteomic Analysis of Lysosomal Integral Membrane Proteins Reveals the Diverse Composition of the Organelle
2004
Salmonella typhi uses CFTR to enter intestinal epithelial cells
1998 StandoutNatureNobel
Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung afterin vivointratracheal plasmid-mediated gene transfer
1992
Enzymes involved in metabolism of extracellular nucleotides and nucleosides: Functional implications and measurement of activities
2014
Haemochromatosis
2018
In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator
1991 Nature
The Human ATP-Binding Cassette (ABC) Transporter Superfamily
2001
Repeat instability as the basis for human diseases and as a potential target for therapy
2010
CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship
1993 Nature
Activation of ion transport pathways by changes in cell volume
1991
Pathogenesis and management of iron toxicity in thalassemia
2010
Cystic fibrosis: molecular biology and therapeutic implications
1992 StandoutScience
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver
2005
Multiple proteolytic systems, including the proteasome, contribute to CFTR processing
1995
Voltage-gated Calcium Channels Provide an Alternate Route for Iron Uptake in Neuronal Cell Cultures
2007
twine, a cdc25 homolog that functions in the male and female germline of drosophila
1992 StandoutNobel
CFTR: Development of high- affinity antibodies and localization in sweat gland
1991
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
2007
Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation
2006
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
2002 StandoutNatureNobel
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses
2011
Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
1993 StandoutNatureNobel
Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene
1991 Nature
Amazing chloride channels: an overview
2003
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
An Animal Model for Cystic Fibrosis Made by Gene Targeting
1992 StandoutScienceNobel
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Regulation of Plasma Membrane Recycling by CFTR
1992 Science
Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes
1991 Science
Expression cloning of an ATP receptor from mouse neuroblastoma cells.
1993 StandoutNobel
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents.
1992
Postsynaptic N -methyl- d -aspartate receptor function requires α-neurexins
2004 StandoutNobel
Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis
1992 StandoutScienceNobel
Postsynaptic Membrane Fusion and Long-Term Potentiation
1998 StandoutScienceNobel
Biochemical characterization of the cystic fibrosis transmembrane conductance regulator in normal and cystic fibrosis epithelial cells.
1992
Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity
1991 Science
The mei-P26 Gene Encodes a RING Finger B-box Coiled-Coil-NHL Protein That Regulates Seizure Susceptibility in Drosophilia
2005
Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor
1994 StandoutScienceNobel
All-or-none potentiation at CA3-CA1 synapses
1998 StandoutNobel
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Swelling-induced and depolarization-induced C1-channels in normal and cystic fibrosis epithelial cells
1991
Fast structural responses of gap junction membrane domains to AB5 toxins
2013 StandoutNobel
Cystic Fibrosis Gene Mutation in Two Sisters with Mild Disease and Normal Sweat Electrolyte Levels
1991
Bacterial Biofilms: A Common Cause of Persistent Infections
1999 StandoutScience
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
Molecular Structure and Physiological Function of Chloride Channels
2002
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Ion permeation and selectivity in ClC-type chloride channels
2001
Genome-wide comprehensive analysis of human helicases
2011
The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.
1994
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Cystic ibrosis: Molecular Biology and Therapeutic Implications
1992 Science
Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents
2021 StandoutNobel
Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.
1991
Potential of preventing Pseudomonas aeruginosa lung infections in cystic fibrosis patients: Experimental studies in animals
1996
Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily.
1991
The Pharmacology of the Ductus Arteriosus
1998
Characterization of the cystic fibrosis transmembrane conductance regulator in a colonocyte cell line.
1992
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
Regulation of Cl- channels in normal and cystic fibrosis airway epithelial cells by extracellular ATP.
1992
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2
2001 StandoutNobel
Channelling our thoughts
1991 Nature
Immunocytochemical localization of the cystic fibrosis gene product CFTR.
1991
Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2.
1991
Genome-wide comprehensive analysis of human helicases.
2011
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice.
1995 StandoutNobel
Genetic determination of exocrine pancreatic function in cystic fibrosis.
1992
Effect of Deleting the R Domain on CFTR-Generated Chloride Channels
1991 Science
ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor
2001 StandoutNobel
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
2000 StandoutScience
Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses
1999 StandoutNobel
Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (cftr): Detection of immunologically related proteins
1995
Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation inAplysiasensory neurons
2000 StandoutNobel
cAMP-inducible chloride conductance in mouse fibroblast lines stably expressing the human cystic fibrosis transmembrane conductance regulator.
1991
Works of Cameron Ackerley being referenced
L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy
2003
Cytochrome P4S0 during ontogenic developments occurrence in the ductus arteriosus and other tissues
1994
The Chloride Channel ClC-4 Co-localizes with Cystic Fibrosis Transmembrane Conductance Regulator and May Mediate Chloride Flux across the Apical Membrane of Intestinal Epithelia
2002
Nuclear and mitochondrial localization of the putative RNA helicase DHX32
2006
Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane
2003
Enhancing glioblastoma treatment using cisplatin-gold-nanoparticle conjugates and targeted delivery with magnetic resonance-guided focused ultrasound
2018
Carbon monoxide formation in the ductus arteriosus in the lamb: implications for the regulation of muscle tone
1997
Mutations in NHLRC1 cause progressive myoclonus epilepsy
2003
Septins Regulate Developmental Switching from Microdomain to Nanodomain Coupling of Ca2+ Influx to Neurotransmitter Release at a Central Synapse
2010
Altered distribution of heat shock protein 60 (Hsp60) with dysregulated expression of DHX32
2006
Retinoic acid and the cyclin dependent kinase inhibitors synergistically alter proliferation and morphology of U343 astrocytoma cells
1997
Intracellular delivery of purine nucleoside phosphorylase (PNP) fused to protein transduction domain corrects PNP deficiency in vitro
2006
Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance
1991
Recruitment of functional GABAA receptors to postsynaptic domains by insulin
1997 Nature
The structure and organization of the bile canalicular cytoskeleton with special reference to actin and actin-binding proteins
1995
Targeted inactivation of sister of P-glycoprotein gene ( spgp ) in mice results in nonprogressive but persistent intrahepatic cholestasis
2001
Defective Lung Vascular Development and Fatal Respiratory Distress in Endothelial NO Synthase-Deficient Mice
2004
Expression of the chloride channel ClC-2 in the murine small intestine epithelium
2000
Translocation of verotoxin-1 across T84 monolayers: mechanism of bacterial toxin penetration of epithelium
1997
Expanded Repeat in Canine Epilepsy
2005 Science