Citation Impact
Citing Papers
Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
2001 StandoutScience
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
AMP‐activated protein kinase: a potential player in Alzheimer’s disease
2011
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos
1995 Nature
FoxOs Function Synergistically to Promote Glucose Production
2010
Re-epithelialization and immune cell behaviour in an ex vivo human skin model
2020 Standout
Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers
2016
Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells
2002
Regulation of protein kinase cascades by protein phosphatase 2A
1999
PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo
1995 Standout
IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model
2017
Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia
2017
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
2005 Nature
The MAP kinase‐activated protein kinase 2 contains a proline‐rich SH3‐binding domain
1993
Role of AMP-activated protein kinase in mechanism of metformin action
2001 Standout
Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics
2006
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
The role of autophagy in neurodegenerative disease
2013 Standout
A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis
2013
Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B
1999
Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils
2003
The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication
1999
Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin
1997
The Drosophila Circadian Network Is a Seasonal Timer
2007 StandoutNobel
Insulin Stimulation of the Fatty Acid Synthase Promoter Is Mediated by the Phosphatidylinositol 3-Kinase Pathway
1998
Disruption of IRS-2 causes type 2 diabetes in mice
1998 Nature
Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators
2015
Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
2005
Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway
2002 StandoutNobel
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
1995 StandoutNature
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
2001
Pathogenesis of Selective Insulin Resistance in Isolated Hepatocytes
2015
Cellular survival: a play in three Akts
1999 Standout
The renaissance of GSK3
2001
The Hallmarks of Cancer
2000 Standout
The KEAP1–NRF2 System in Cancer
2017
Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway
2015
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
2002 Standout
A Tripartite Array of Transcription Factor Binding Sites Mediates cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene Transcription and Its Inhibition by Insulin
1998
Central Role for Phosphatidylinositide 3-Kinase in the Repression of Glucose-6-phosphatase Gene Transcription by Insulin
1998
Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation
2016
Assessment of the Roles of Mitogen-activated Protein Kinase, Phosphatidylinositol 3-Kinase, Protein Kinase B, and Protein Kinase C in Insulin Inhibition of cAMP-induced Phosphoenolpyruvate Carboxykinase Gene Transcription
1998
Activation of translation initiation factor eIF2B by insulin requires phosphatidyl inositol 3‐kinase
1997
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence
1998
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
2005 StandoutNature
Inactivation of Glycogen Synthase Kinase-3 by Epidermal Growth Factor Is Mediated by Mitogen-activated Protein Kinase/p90 Ribosomal Protein S6 Kinase Signaling Pathway in NIH/3T3 Cells
1995 Nobel
Mechanisms and functions of Nrf2 signaling in Drosophila
2015
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans
2015
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activationofCREB
1998
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
1994
A Role for the Segment Polarity Gene shaggy/GSK-3 in the Drosophila Circadian Clock
2001 StandoutNobel
Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase‐3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin
1998
The twentieth century struggle to decipher insulin signalling
2006
Essential Role for Protein Kinase B (PKB) in Insulin-induced Glycogen Synthase Kinase 3 Inactivation
1998
Metabolism, migration and memory in cytotoxic T cells
2011
Lithium Inhibits Glycogen Synthase Kinase-3 by Competition for Magnesium
2001
Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells
1996
Neuronal polarity: from extracellular signals to intracellular mechanisms
2007
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth
2005
Identification of okadaic acid-induced phosphorylation events by a mass spectrometry approach
2006
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
2013 Nature
CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation
1998 StandoutNobel
Specificity and mechanism of action of some commonly used protein kinase inhibitors
2000 Standout
Further evidence that the inhibition of glycogen synthase kinase‐3β by IGF‐1 is mediated by PDK1/PKB‐induced phosphorylation of Ser‐9 and not by dephosphorylation of Tyr‐216
1997
Activation of Protein Kinase B/Akt Is Sufficient to Repress the Glucocorticoid and cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene
1998
Glycogen Synthase Kinase-3β Haploinsufficiency Mimics the Behavioral and Molecular Effects of Lithium
2004
Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression
2012 Standout
Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades
1997
A role for casein kinase 2α in the Drosophila circadian clock
2002 StandoutNatureNobel
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory
1997 StandoutNobel
A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis
2006 StandoutNobel
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
2001
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Nrf2, the Master Regulator of Anti-Oxidative Responses
2017
AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
2007
REGULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE EXPRESSION
1997
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na + channels
2004 StandoutNobel
The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression
2015
Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation
1994
A molecular mechanism for the effect of lithium on development.
1996 Standout
The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf
1994
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time
2017
The role of p21ras in receptor tyrosine kinase signaling
1995
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis
2012
Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase
1995
FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.
1996
Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase
1999
Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila
2010 StandoutNobel
Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B
1999
Nrf2 Enhances Cholangiocyte Expansion in Pten-Deficient Livers
2013 Nobel
DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability
1999
NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis
2016
Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes
2019 StandoutNobel
Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase
1996 Science
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
Functional Studies of Shaggy/Glycogen Synthase Kinase 3 Phosphorylation Sites in Drosophila melanogaster
2004
FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
2011 Science
Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
2005
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
2010 Nobel
Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression
1998 StandoutNobel
A Dominant-Negative Mutant of mSOS1 Inhibits Insulin-Induced Ras Activation and Reveals Ras-Dependent and -Independent Insulin Signaling Pathways
1995
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
A resetting signal between Drosophila pacemakers synchronizes morning and evening activity
2005 StandoutNatureNobel
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia
1998 StandoutNobel
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
Reelin Signals through Phosphatidylinositol 3-Kinase and Akt To Control Cortical Development and through mTor To Regulate Dendritic Growth
2007
Aquaglyceroporin AQP9: Solute permeation and metabolic control of expression in liver
2003 StandoutNobel
Activation of protein kinase B/cAkt in hepatocytes is sufficient for the induction of expression of the gene encoding glucokinase
2000
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Insulin signal transduction through protein kinase cascades
1998
The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction
1999
A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression.
1994
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells
1994
Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase
1994
CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals
1999 Standout
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase
1996
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
1994
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1
2016
The mitogen-activated protein kinase signal transduction pathway
1993 Standout
The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2
1993
Works of Calum Sutherland being referenced
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
2010
Glycogen Synthase Kinase-3 regulates IGFBP-1 gene transcription through the Thymine-rich Insulin Response Element
2004
Distinct Priming Kinases Contribute to Differential Regulation of Collapsin Response Mediator Proteins by Glycogen Synthase Kinase-3 in Vivo
2006
Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug
2016
New connections in the regulation of PEPCK gene expression by insulin
1996
Identification of insulin‐stimulated protein kinase‐1 as the rabbit equivalent of rskmo‐2
1993
The Molecular Physiology of Hepatic Nuclear Factor 3 in the Regulation of Gluconeogenesis
2000
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
2012
Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen‐activated protein (MAP) kinase and MAP‐kinase‐activated kinases 1 and 2
1993
Obesity-Induced Insulin Resistance in Human Skeletal Muscle Is Characterised by Defective Activation of p42/p44 MAP Kinase
2013
Insulin Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression Does Not Require Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway
1996
Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin
1995
The α‐isoform of glycogen synthase kinase‐3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase‐activated protein kinase‐1 in vitro
1994
Dominant Negative Forms of Akt (Protein Kinase B) and Atypical Protein Kinase Cλ Do Not Prevent Insulin Inhibition of Phosphoenolpyruvate Carboxykinase Gene Transcription
1999
Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATPchannel activation
2004
Activation of the Ras Mitogen-activated Protein Kinase-Ribosomal Protein Kinase Pathway Is Not Required for the Repression of Phosphoenolpyruvate Carboxykinase Gene Transcription by Insulin
1998
GSK-3 Phosphorylation of the Alzheimer Epitope within Collapsin Response Mediator Proteins Regulates Axon Elongation in Primary Neurons
2004
Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression
2001
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
2000
Dissection of the protein kinase cascades involved in insulin and nerve growth factor action
1992
Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance
2008
Analysis of the Signaling Pathway Involved in the Regulation of Hexokinase II Gene Transcription by Insulin
1996
Characterization of a Protein Kinase B Inhibitor In Vitro and in Insulin-Treated Liver Cells
2007
Oxidative and Chemical Stress Mimic Insulin by Selectively Inhibiting the Expression of Phosphoenolpyruvate Carboxykinase in Hepatoma Cells
1997
Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signalling
1993
Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3
2015
Filaggrin in the frontline: role in skin barrier function and disease
2009