Standout Papers
Citation Impact
Citing Papers
Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease
2005
Interactions between APP secretases and inflammatory mediators
2008
Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
2012
Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration
2008
Microglia as a Potential Bridge between the Amyloid β‐Peptide and Tau
2004
Interleukin-1β and Glutamate Activate the NF-κB/Rel Binding Site from the Regulatory Region of the Amyloid Precursor Protein Gene in Primary Neuronal Cultures
1996
Inflammation and Alzheimer's disease
2000 Standout
Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression
1998
Apoptosis in the nervous system
2000 StandoutNature
Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release
1998
Translation of the Alzheimer Amyloid Precursor Protein mRNA Is Up-regulated by Interleukin-1 through 5′-Untranslated Region Sequences
1999
Inducible Nitric-oxide Synthase and Nitric Oxide Production in Human Fetal Astrocytes and Microglia
1997 StandoutNobel
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
1998 Standout
Reactive microgliosis
1999
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
1997 StandoutNobel
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
1994 StandoutNature
Pro-resolving lipid mediators are leads for resolution physiology
2014 StandoutNature
Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species
1998
Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease
1998
Neural mechanisms of ageing and cognitive decline
2010 Nature
Interleukin-6 in Biology and Medicine
1993
Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches
1999
Immunoregulators in the nervous system
1991
Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and β-amyloid production in cultures
1995
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Structure and mechanism of interleukin-lβ converting enzyme
1994 Nature
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
2009 StandoutNature
An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor
1996 StandoutNobel
Detection of complement alternative pathway mRNA and proteins in the Alzheimer’s disease brain
2000
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
Inflammation and Alzheimer's disease pathogenesis
1996
The biochemistry of apoptosis
2000 StandoutNature
Amyloid β-Protein and the Genetics of Alzheimer's Disease
1996
S100β protein expression in Alzheimer disease: Potential role in the pathogenesis of neuritic plaques
1994
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Structural and functional features of central nervous system lymphatic vessels
2015 StandoutNature
In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis
1996
Immune attack: the role of inflammation in Alzheimer disease
2015 Standout
Slow Degradation of Aggregates of the Alzheimer's Disease Amyloid β-Protein by Microglial Cells
1997
Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain
1998
Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology1Published on the World Wide Web on 21 October 1997.1
1998
Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
1993
Cytotoxicity of microglia
1993
Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1β or IL-1RA but increases in the associated acute phase proteins IL-6, α2-macroglobulin and C-reactive protein
1993
Microglial release of nitric oxide by the synergistic action of β-amyloid and IFN-γ
1995
A Meta-Analysis of Cytokines in Alzheimer's Disease
2010
Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits
1997
Intrathecal inflammation precedes development of Alzheimer's disease
2003
Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1
1992
Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
2007
Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide
1995
Identification of monocyte chemoattractant protein‐1 in senile plaques and reactive microglia of Alzheimer's disease
1997
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
1995 Standout
Microglial interleukin-lα expression in human head injury: Correlations with neuronal and neuritic β-amyloid precursor protein expression
1994
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease
1992
Correlation of Astrocytic S100β Expression with Dystrophic Neurites in Amyloid Plaques of Alzheimerʼs Disease
1996
Proteoglycans and the acute-phase response in Alzheimer's disease brain
1994
Alzheimer's Disease
2010 Standout
The Fas Death Factor
1995 StandoutScience
Increased Neuronal β‐Amyloid Precursor Protein Expression in Human Temporal Lobe Epilepsy: Association with Interleukin‐1α Immunoreactivity
1994
Recombinant Human Single Chain Fv Antibodies Recognizing Human Interleukin-6
1998 StandoutNobel
Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
1993
Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1
1995
The Inflammasomes
2010 Standout
Characterization of interleukin-1 production by microglia in culture
1992
A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies
1990 StandoutNature
Microglia in neurodegenerative disease
2010
The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases
1995
Elevated circulating tumor necrosis factor levels in Alzheimer's disease
1991
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Glial cell-specific mechanisms of TGF-β1 induction by IL-1 in cerebral cortex
1993
The Hallmarks of Aging
2013 Standout
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
2005 StandoutNature
Local Neuroinflammation and the Progression of Alzheimer's Disease
2002
Complement and cytokine gene expression in cultured microglia derived from postmortem human brains
1995
Cytokines and retroviruses
1992
Inhibition of death receptor signals by cellular FLIP
1997 StandoutNature
The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein
1991
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
2008 Standout
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Intracerebral Production of Tumor Necrosis Factor-α, a Local Neuroprotective Agent, in Alzheimer Disease and Vascular Dementia
1999
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1
1995
Regulation of β-amyloid precursor protein isoform mRNAs by transforming growth factor-β1 and interleukin-1β in astrocytes
1993
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Frailty in elderly people
2013 Standout
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs
1995
The molecular pathology of Alzheimer's disease
1991 Standout
Increased S100β neurotrophic activity in Alzheimer's disease temporal lobe
1992
Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS
1999
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
1995 StandoutNatureNobel
Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: Complement activation and therapeutic approaches
1996
Peripheral Inflammatory Cytokines as Biomarkers in Alzheimer’s Disease and Mild Cognitive Impairment
2007
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy
1995 StandoutScience
Serum cytokine levels in patients with Alzheimer's disease
1994
Tissue factor antigen in senile plaques of Alzheimer's disease.
1991
Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia
1997
Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.
1995
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Prevention of Vertebrate Neuronal Death by the crmA Gene
1994 Science
INFLAMMATION AND ALZHEIMERS DISEASE
2000
Apoptosis in the Pathogenesis and Treatment of Disease
1995 StandoutScience
Microglia actions in Alzheimer’s disease
2013
Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death.
1994
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Complement activation by beta-amyloid in Alzheimer disease.
1992
Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Aβ toxicity
2008
The effects of a novel NSAID on chronic neuroinflammation are age dependent☆
1999
Neuronal–Glial Interactions Mediated by Interleukin-1 Enhance Neuronal Acetylcholinesterase Activity and mRNA Expression
2000
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.
1989
Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1β Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation
1998
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
1995
Mitochondrial myopathies
1985
Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.
1993
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid.
1992
Fluorescent Sensors for Zn2+Based on a Fluorescein Platform: Synthesis, Properties and Intracellular Distribution
2001 StandoutNobel
Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation.
1998
Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis
2014
Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.
1992
Transforming growth factor beta in Alzheimer's disease
1994
Meta-analysis of age-related gene expression profiles identifies common signatures of aging
2009
Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway
2003
Complement C1q and C3 mRNA expression in the frontal cortex of Alzheimer's patients
1995
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
1996 StandoutNature
Inflammatory factors stimulate expression of group II phospholipase A2 in rat cultured astrocytes. Two distinct pathways of the gene expression
1991
Resolution of inflammation is altered in Alzheimer's disease
2014
The neural mechanisms underlying cholinergic celldeath within the basal FOREBRAIN
1998
Caspases: Enemies Within
1998 StandoutScience
Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation
1998
Mechanisms and Genes of Cellular Suicide
1995 StandoutScience
beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.
1998
Works of C.A. Araoz being referenced
Dermatomyositis: ultrastructure of abnormal mitochondria in the skeletal muscle.
1977
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
1989 Standout
Apolipoprotein D in the aging brain and in Alzheimer’s dementia
2000