Citation Impact
Citing Papers
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
2006 StandoutNobel
Genetic Analysis of Sequences in the 3′ Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication
2002
Clinical guidelines on the management of hepatitis C
2001
Selective blockade of the inhibitory Fcγ receptor (FcγRIIB) in human dendritic cells and monocytes induces a type I interferon response program
2007 StandoutNobel
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
Characterization of a canine homolog of hepatitis C virus
2011 StandoutNobel
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals
2008 StandoutNobel
Evidence for a functional RNA element in the hepatitis C virus core gene
2007 StandoutNobel
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
2016 StandoutNobel
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
To Interfere and to Anti-interfere: The Interplay Between Hepatitis C Virus and Interferon
2002
Replication of a hepatitis C virus replicon clone in mouse cells.
2006
The Spring α-Helix Coordinates Multiple Modes of HCV (Hepatitis C Virus) NS3 Helicase Action
2016 StandoutNobel
Assessment of Hepatitis C Virus Quasispecies Heterogeneity by Gel Shift Analysis: Correlation with Response to Interferon Therapy
1997
The Treatment of Chronic Viral Hepatitis
1997
Modulation of interferon expression by hepatitis c virus ns5a protein and human homeodomain protein ptx1
2003
Cell Culture Systems for Hepatitis C Virus
2013
Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity.
1998
Interferons, interferon‐like cytokines, and their receptors
2004
Hepatitis C Virus and eliminating post-transfusion hepatitis
2000 StandoutNobel
Characterization of simple and complex hepatitis C virus quasispecies by heteroduplex gel shift analysis: correlation with nucleotide sequencing
1995
Possible mechanisms of action and reasons for failure of antiviral therapy in chronic hepatitis C
1999
Pretreatment Virus Load and Multiple Amino Acid Substitutions in the Interferon Sensitivity-Determining Region Predict the Outcome of Interferon Treatment in Patients With Chronic Genotype 1B Hepatitis C Virus Infection
1997
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Variation in the hepatitis C virus NS5a region in relation to hypervariable region 1 heterogeneity during interferon treatment
1998
Hepatitis C Virus Infection
2001 Standout
How Hepatitis C Virus Counteracts the Interferon Response: The Jury Is Still out on NS5A
2001
Subcellular localization of hepatitis C viral proteins in mammalian cells
1999
Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults
2000
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Turning Hepatitis C into a Real Virus
2010 StandoutNobel
euHCVdb: the European hepatitis C virus database
2006 StandoutNobel
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Effect of interferon alfa on the dynamics of hepatitis C virus turnover in vivo
1996
Hepatitis C virus NS5A as a potential viral Bcl‐2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma
2003
Interferon sensitivity‐determining region of nonstructural region 5A of hepatitis C virus genotype 1b correlates with serum alanine aminotransferase levels in chronic infection
2005
Cultivation of hepatitis C virus in primary hepatocyte culture from patients with chronic hepatitis C results in release of high titre infectious virus
1996
Molecular virology of hepatitis C virus.
1997
Drug-Induced Hepatotoxicity
2003 Standout
Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein
1997
Molecular Mechanisms of Interferon Resistance Mediated by Viral-Directed Inhibition of PKR, the Interferon-Induced Protein Kinase
1998
Herbal hepatotoxicity: An expanding but poorly defined problem
2000
Advances in experimental systems to study hepatitis C virus in vitro and in vivo
2015
The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy
1999
Mutations in the Nonstructural Protein 5a Gene and Response to Interferon in Patients with Chronic Hepatitis C Virus 1b Infection
1996
Structural and Biological Identification of Residues on the Surface of NS3 Helicase Required for Optimal Replication of the Hepatitis C Virus
2005
Viruses and interferon: a fight for supremacy
2002
Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection
1999
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
Chapter 2 Cutting the Gordian Knot-Development and Biological Relevance of Hepatitis C Virus Cell Culture Systems
2008
Acetaminophen Induced Pancreatitis
1991
Molecular Characterization of Hepatitis C Virus
1998 StandoutNobel
Determinants for Membrane Association of the Hepatitis C Virus RNA-dependent RNA Polymerase
2001 StandoutNobel
HCV NS5A inhibits interferon-α signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines
2006
Mutations of hepatitis C virus 1b NS5A 2209–2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients
1997
Improved correlation between multiple mutations within the NS5A region and virological response in European patients chronically infected with hepatitis C virus type 1b undergoing combination therapy
1999
Analysis of Sequence Configurations of the ISDR, PKR-Binding Domain, and V3 Region as Predictors of Response to Induction Interferon-α and Ribavirin Therapy in Chronic Hepatitis C Infection
2002
Mutations in the interferon sensitivity determining region and virological response to combination therapy with pegylated-interferon alpha 2b plus ribavirin in patients with chronic hepatitis C-1b infection
2010
Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa
1997
Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)
2000
Association of Amino Acid Substitution Pattern in Core Protein of Hepatitis C Virus Genotype 1b High Viral Load and Non-Virological Response to Interferon-Ribavirin Combination Therapy
2005
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
2009 StandoutNatureNobel
Mutations in the Nonstructural 5A Gene of European Hepatitis C Virus Isolates and Response to Interferon Alfa
1997
Complete nucleotide sequence of a type 4 hepatitis C virus variant, the predominant genotype in the Middle East.
1997
Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.
1995 StandoutNobel
Characteristics of Nucleotide Substitution in the Hepatitis C Virus Genome: Constraints on Sequence Change in Coding Regions at Both Ends of the Genome
1997
Hepatitis C virus: How genetic variability affects pathobiology of disease
2011
Acute Pancreatitis
1994 Standout
VIRUSES AND THE TYPE I INTERFERON ANTIVIRAL SYSTEM: INDUCTION AND EVASION
2002
Hepatitis C virus and interferon resistance
2000
Hypersusceptibility to Vesicular Stomatitis Virus Infection in Dicer1-Deficient Mice Is Due to Impaired miR24 and miR93 Expression
2007 StandoutNobel
Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b
1997
Hepatitis C virus genetic variability: pathogenic and clinical implications
2003
Hepatitis C Virus Population Dynamics During Infection
2006
Revealing the world of RNA interference
2004 StandoutNatureNobel
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines
1996
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
2006 StandoutNature
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Long-term response to interferon alpha is unrelated to“interferon sensitivity determining region” variability in patients with chronic hepatitis C virus-1b infection
1999
Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties
2000 StandoutNobel
Characterization of the nuclear localization signal and subcellular distribution of hepatitis C virus nonstructural protein NS5A
1996
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
The NS5A Protein of Hepatitis C Virus Is a Zinc Metalloprotein
2004 StandoutNobel
A genetically humanized mouse model for hepatitis C virus infection
2011 StandoutNatureNobel
Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C
1998 Standout
Novel Insights into Hepatitis C Virus Replication and Persistence
2004
Mutations in the interferon-sensitivity determining region of hepatitis C virus and transcriptional activity of the nonstructural region 5A protein
1998
Variability of the Hepatitis C Virus Genome
1998
Expressional screening of interferon‐stimulated genes for antiviral activity against hepatitis C virus replication
2006
Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy†
2008
Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-α catalytic subunit
1997
Hepatitis C Virus non-structural 5A abrogates signal transducer and activator of transcription-1 nucleartranslocation induced by IFN-α through dephosphorylation
2007
Ser2194 Is a Highly Conserved Major Phosphorylation Site of the Hepatitis C Virus Nonstructural Protein NS5A
2000
Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance
1998
Activation and evasion of the antiviral 2???-5??? oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA
2002
Acetaminophen Hepatotoxicity in Alcoholics
1986
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling
1999
Nonstructural Protein 5A of Hepatitis C Virus Inhibits the Function of Karyopherin β3
2000
Enhancement of Hepatitis C Virus RNA Replication by Cell Culture-Adaptive Mutations
2001
Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line
1999 StandoutScience
Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation
1998
Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase
1997 StandoutNobel
Ultrastructural analysis of hepatitis C virus particles
2013 StandoutNobel
Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection
2002 Standout
Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase
2002
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
2015 StandoutNobel
Dynamics of hepatitis C virus NS5A quasispecies during interferon and ribavirin therapy in responder and non-responder patients with genotype 1b chronic hepatitis C
2005
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
2011 StandoutNobel
Antiapoptotic and Oncogenic Potentials of Hepatitis C Virus Are Linked to Interferon Resistance by Viral Repression of the PKR Protein Kinase
1999
Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A protein
2003
Efficient Initiation of HCV RNA Replication in Cell Culture
2000 StandoutScienceNobel
Statistical analysis of combined substitutions in nonstructural 5A region of hepatitis C virus and interferon response
2000
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
Interferon Resistance of Hepatitis C Virus Genotype 1b: Relationship to Nonstructural 5A Gene Quasispecies Mutations
1998
Hepatitis C Virus Heteroduplex Tracking Assay for Genotype Determination Reveals Diverging Genotype 2 Isolates in Italian Hemodialysis Patients
1998 StandoutNobel
Genetic diversity and evolution of hepatitis C virus – 15 years on
2004
Ribavirin Resistance in Hepatitis C Virus Replicon-Containing Cell Lines Conferred by Changes in the Cell Line or Mutations in the Replicon RNA
2005
Evolution of Hepatitis C Virus Quasispecies in Hypervariable Region 1 and the Putative Interferon Sensitivity-Determining Region during Interferon Therapy and Natural Infection
1998
The NS5A/NS5 Proteins of Viruses from Three Genera of the Family Flaviviridae Are Phosphorylated by Associated Serine/Threonine Kinases
1998 StandoutNobel
Response of Hepatitis C Virus to Long-Term Passage in the Presence of Alpha Interferon: Multiple Mutations and a Common Phenotype
2013 StandoutNobel
Hyperphosphorylation of the Hepatitis C Virus NS5A Protein Requires an Active NS3 Protease, NS4A, NS4B, and NS5A Encoded on the Same Polyprotein
1999
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
Viral Determinants of Resistance to Treatment in Patients with Hepatitis C
2007
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs
2002 StandoutNobel
Hepatitis C virus NS5A: tales of a promiscuous protein
2004
Identification of the Major Phosphorylation Site of the Hepatitis C Virus H Strain NS5A Protein as Serine 2321
1999 StandoutNobel
Hepatitis C Virus NS5A Physically Associates with p53 and Regulates p21/waf1 Gene Expression in a p53-Dependent Manner
2001
Mutations in Hepatitis C Virus RNAs Conferring Cell Culture Adaptation
2001
Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
2006
Effect of Alpha Interferon on the Hepatitis C Virus Replicon
2001
High-Throughput Screening of the Yeast Kinome: Identification of Human Serine/Threonine Protein Kinases That Phosphorylate the Hepatitis C Virus NS5A Protein
2004
Viral Quasispecies Evolution
2012
Hepatitis C Virus Nonstructural 5A Protein Induces Interleukin-8, Leading to Partial Inhibition of the Interferon-Induced Antiviral Response
2001
Influence of the genetic heterogeneity of the ISDR and PePHD regions of hepatitis C virus on the response to interferon therapy in chronic hepatitis C
2001
Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy
1998 StandoutScience
Mutations in the NS5A region do not predict interferon-responsiveness in American patients infected with genotype 1b hepatitis C virus
1999
Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins
2003
Prospective Characterization of Full-Length Hepatitis C Virus NS5A Quasispecies during Induction and Combination Antiviral Therapy
2000
Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator
1997
Mutations in the non-structural protein 5A gene in patients with chronic hepatitis C virus 1b infection during repeated interferon treatment
2000
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication
2004 StandoutNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Persistent and Transient Replication of Full-Length Hepatitis C Virus Genomes in Cell Culture
2002
Works of C Sato being referenced
Prevention of acetaminophen-induced hepatotoxicity by acute ethanol administration in the rat: comparison with carbon tetrachloride-induced hepatoxicity.
1981
Clinical relevance of hepatitis C virus quasispecies
1995
Analysis of Genotypes and Amino Acid Residues 2209 to 2248 of the Ns5a Region of Hepatitis C Virus in Relation to the Response to Interferon–β Therapy
1997
Introduction of NS5A mutations enables subgenomic HCV replicon derived from chimpanzee‐infectious HC‐J4 isolate to replicate efficiently in Huh‐7 cells
2004
Selection of hepatitis C virus quasispecies during interferon treatment
1996
Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.
1995
Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis
1994
Variations in the core region of hepatitis C virus genomes in patients with chronic hepatitis
1995
Autoimmune hepatitis triggered by administration of an herbal medicine.
1997