Citation Impact
Citing Papers
Probing mucin-type O-linked glycosylation in living animals
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2004
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[17] Mechanisms of inhibition of DNA polymerases by 2′-deoxyribonucleoside 5′-triphosphate analogs
1995
Differential Discrimination of DNA Polymerases for Variants of the Non-Standard Nucleobase Pair Between Xanthosine and 2,4-Diaminopyrimidine, Two Components of an Expanded Genetic Alphabet
1996
Emtricitabine
2003
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2005
Highly Enantioselective Synthesis of 3‐Substituted Furanones by Palladium‐Catalyzed Kinetic Resolution of Unsymmetrical Allyl Acetates
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NEW SYNTHESIS OF L-FMAU FROM L-ARABINOSE
2002
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2010
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Functionally interacting telomerase RNAs in the yeast telomerase complex
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A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less
1997 Standout
Long‐term therapy with clevudine for chronic hepatitis B can be associated with myopathy characterized by depletion of mitochondrial DNA†
2009
Treatment with Indinavir, Zidovudine, and Lamivudine in Adults with Human Immunodeficiency Virus Infection and Prior Antiretroviral Therapy
1997 Standout
Emtricitabine (FTC) for the treatment of HIV infection
2004
Tuberculosis in Patients with Human Immunodeficiency Virus Infection
1999 Standout
Clinical trial: a phase II, randomized study evaluating the safety, pharmacokinetics and anti‐viral activity of clevudine for 12 weeks in patients with chronic hepatitis B
2008
A Practical Synthesis of L-FMAU from L-Arabinose
1999
3 The Medicinal Chemistry of the Azido Group
1994
DNA Polymerase δ Is Required for Human Mismatch Repair in Vitro
1997 StandoutNobel
Emtricitabine
2005
Inhibition of Epstein-Barr virus replication by a novel l-nucleoside, 2′-fluoro-5-methyl-β-l-arabinofuranosyluracil
1996
A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes
2002 StandoutNobel
Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine
2009
Clevudine myopathy in patients with chronic hepatitis B
2009
The Catalytic Asymmetric Acetalization
2013 StandoutNobel
A randomized, open-label study comparing low-dose clevudine plus adefovir combination therapy with clevudine monotherapy in naïve chronic hepatitis B patients
2014
Palladium‐Catalyzed anti‐Markovnikov Oxidation of Terminal Alkenes
2014 StandoutNobel
Emtricitabine, a New Antiretroviral Agent with Activity against HIV and Hepatitis B Virus
2005
Asymmetric synthesis and biological evaluation of .beta.-L-(2R,5S)- and .alpha.-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents
1993
A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase
2018 StandoutNobel
Treatment with Lamivudine, Zidovudine, or Both in HIV-Positive Patients with 200 to 500 CD4+ Cells per Cubic Millimeter
1995
l-Nucleoside enantiomers as antivirals drugs: A mini-review
2006
Human Immunodeficiency Virus Type-1 Reverse Transcriptase
1996
Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolution
1998
A C-nucleotide base pair: methylpseudouridine-directed incorporation of formycin triphosphate into RNA catalyzed by T7 RNA polymerase
1991
Steady‐State Pharmacokinetics of Emtricitabine and Tenofovir Disoproxil Fumarate Administered Alone and in Combination in Healthy Volunteers
2007
Understanding the unique mechanism of l-FMAU (Clevudine) against hepatitis B virus: molecular dynamics studies
2002
Conformational analysis of the complete series of 2′ and 3′ monofluorinated dideoxyuridines
1997
Stem cell-derived polarized hepatocytes
2020 StandoutNobel
Catabolic disposition of 3'-azido-2',3'-dideoxyuridine in hepatocytes with evidence of azido reduction being a general catabolic pathway of 3'-azido-2',3'-dideoxynucleosides
1992
Rapid Changes in Human Immunodeficiency Virus Type 1 RNA Load and Appearance of Drug-Resistant Virus Populations in Persons Treated with Lamivudine (3TC)
1995
Can a Ketone Be More Reactive than an Aldehyde? Catalytic Asymmetric Synthesis of Substituted Tetrahydrofurans
2018 StandoutNobel
3d Transition Metals for C–H Activation
2018 Standout
Fluorine in medicinal chemistry
2007 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
A Strategy for the Chemoselective Synthesis of O-Linked Glycopeptides with Native Sugar−Peptide Linkages
1997 StandoutNobel
C-Nucleosides: Synthetic Strategies and Biological Applications
2009
Molecular Targets for AIDS Therapy
1990 Science
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA
2006 StandoutNobel
Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.
1993
Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.
1994 StandoutNobel
Applications of Cyclic Sulfates ofvic-Diols: Synthesis of Episulfides, Olefins, and Thio Sugars
1997
Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor
1992 StandoutScience
Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine
1994
Transport, metabolism and elimination mechanisms of anti-HIV agents
1999
Comprehensive Structural Studies of 2′,3′-Difluorinated Nucleosides: Comparison of Theory, Solution, and Solid State
2008
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
A Versatile Enantioselective Strategy Towardl -C-Nucleosides: A Total Synthesis ofl -Showdomycin
1999
Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L‐FMAU, DAPD, penciclovir and lobucavir
2000
A de novo synthesis of ethyl 2-deoxy-l-ribosides
1998
Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance
1998 StandoutScience
Preparation and pyrolysis of 1-(pyrazol-5-yl)-1,2,3-triazoles and related compounds 1
1997
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
Cascade Processes of Metallo Carbenoids
1996 Standout
Infectious amplification of wild-type human immunodeficiency virus from patients' lymphocytes and modulation by reverse transcriptase inhibitors in vitro
1993
The Cation−π Interaction
1997 Standout
HIV-1 Reverse Transcriptase Can Discriminate between Two Conformationally Locked Carbocyclic AZT Triphosphate Analogues
1998
Positive Effects of Combined Antiretroviral Therapy on CD4 + T Cell Homeostasis and Function in Advanced HIV Disease
1997 StandoutScience
1-(Ethoxymethyl)-6-(Phenylselenenyl)Pyrimidines with Activity against Human Immunodeficiency Virus Types 1 and 2
1992
The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine
1993
Stereoselective Cyclopropanation Reactions
2003 Standout
Carbonic Anhydrase Inhibitors: Stacking with Phe131 Determines Active Site Binding Region of Inhibitors As Exemplified by the X-ray Crystal Structure of a Membrane-Impermeant Antitumor Sulfonamide Complexed with Isozyme II
2005
Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
1992
A Novel Phenotypic Drug Susceptibility Assay for Human Immunodeficiency Virus Type 1
2000
New Unnatural L-Nucleoside Enantiomers:From Their Stereospecific Synthesis to Their Biological Activities
1997
A Field Guide to Foldamers
2001 Standout
Chemoselective Elaboration of O-Linked Glycopeptide Mimetics by Alkylation of 3-ThioGalNAc
2001 StandoutNobel
Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89
1997
Investigating Cellular Metabolism of Synthetic Azidosugars with the Staudinger Ligation
2002 StandoutNobel
Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not.
1994
Synthesis of cyclopropane-fused dideoxycarbocyclic nucleosides structurally related to neplanocin C
1993
Recent advances in the synthesis of fluorinated nucleosides
2009
2′F-Arabinonucleic acids (2′F-ANA) — History, properties, and new frontiers
2008
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
The Chemistry of Neutron Capture Therapy
1998 Standout
A simplified procedure for the stereospecific transformation of 1,2-diols into epoxides
1992 StandoutNobel
A platelet-activating factor antagonist, RP 55778, inhibits cytokine-dependent induction of human immunodeficiency virus expression in chronically infected promonocytic cells.
1993 StandoutNobel
In Vitro Selection of Functional Nucleic Acids
1999 StandoutNobel
Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors
2004 StandoutNobel
A Stereocontrolled Total Synthesis of C-Nucleosides
1984 StandoutNobel
Metal–Organic Frameworks in Biomedicine
2011 Standout
Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns.
1995
Potential Mechanism for Sustained Antiretroviral Efficacy of AZT-3TC Combination Therapy
1995 Science
Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia
1997 StandoutScience
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids
1999
Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/ nucleotide inhibitors
2009
Comparative Total Syntheses of Turkey Ovomucoid Third Domain by Both Stepwise Solid Phase Peptide Synthesis and Native Chemical Ligation
1996
Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy
1997 StandoutScience
Catalytic Asymmetric Transacetalization
2010 StandoutNobel
Enzymatic resolution of α-acetoxyethers: A new approach to the synthesis of homochiral O,O-acetals
1999
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Boron Containing Pyrimidines, Nucleosides, and Oligonucleotides for Neutron Capture Therapy
1994
Single-Step Kinetics of HIV-1 Reverse Transcriptase Mutants Responsible for Virus Resistance to Nucleoside Inhibitors Zidovudine and 3-TC
1997
Noncompetitive Inhibition of Hepatitis B Virus Reverse Transcriptase Protein Priming and DNA Synthesis by the Nucleoside Analog Clevudine
2013
The observed inhibitory potency of 3'-azido-3'-deoxythymidine 5'-triphosphate for HIV-1 reverse transcriptase depends on the length of the poly(rA) region of the template
1992
Asymmetric Transition-Metal-Catalyzed Allylic Alkylations: Applications in Total Synthesis
2003 Standout
Crystal Structures of Zidovudine- or Lamivudine-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptases Containing Mutations at Codons 41, 184, and 215
2002
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
2012 Standout
In Vitro Susceptibilities of Wild-Type or Drug-Resistant Hepatitis B Virus to (−)-β-d -2,6-Diaminopurine Dioxolane and 2′-Fluoro-5-Methyl-β-l -Arabinofuranosyluracil
2001
Works of C. K. CHU being referenced
Antiretroviral Activity, Biochemistry, and Pharmacokinetics of 3′‐Azido‐2′,3′‐Dideoxy‐5‐Methylcytidinea
1990
Antiviral Activity of Clevudine [L–Fmau, (1–(2–Fluoro–5–Methyl–β, L–Arabinofuranosyl) Uracil)] Against Woodchuck Hepatitis Virus Replication and Gene Expression in Chronically Infected Woodchucks ( Marmota Monax )
2001
Antiviral activity of cyclopentenyl nucleosides against orthopox viruses (Smallpox, monkeypox and cowpox)
2003
Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine
1990
High-performance liquid chromatographic determination of (−)-β-d-2-aminopurine dioxolane and (−)-β-d-2-amino-6-chloropurine dioxolane, and their metabolite (−)-β-d-dioxolane guanine in monkey serum, urine and cerebrospinal fluid
1997
Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro
1994
A Stereochemical Rationale for the Activity of Anti-HIV Nucleosides
1990
Nucleosides. 104. Synthesis of 4-amino-5-(D-ribofuranosyl)pyrimidine C-nucleosides from 2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile
1977
Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.
1992
Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil
1996
Correlation between preferred sugar ring conformation and activity of nucleoside analogues against human immunodeficiency virus.
1989
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides
1993
Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus
1995
Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes
1992
Nucleosides. 100. General synthesis of pyrimidine C-5 nucleosides related to pseudouridine. Synthesis of 5-(.beta.-D-ribofuranosyl)isocytosine (pseudoisocytidine), 5-(.beta.-D-ribofuranosyl)-2-thiouracil (2-thiopseudouridine), and 5-(.beta.-D-ribofuranosyl)uracil (pseudouridine)
1976
Pharmacokinetics of 1-(2-fluoro-5-methyl-beta-L-arabinofuranosyl)uracil in woodchucks
1997
Synthesis of C-nucleoside analogs of 2',3'-dideoxycytidine, 3'-azido-2',3'-dideoxyuridine (CS-87), and 2',3'-dideoxy-2',3'-didehydrocytidine
1988
Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks
1996
General syntheses of 2',3'-dideoxynucleosides and 2',3'-didehydro-2',3'-dideoxynucleosides
1989
Ring transformation reactions of C‐nucleosides: Facile synthesis of pyrazolo[1,5‐a]pyrimidine and pyrazolo[1,5‐a]triazine C‐nucleosides
1986
Nucleosides XCIX. 2-Acetoxybenzoyl Chloride, A Reagent for the Direct Synthesis of 2,2′-Anhydro-pyrimidine Nucleosides
1976
Phosphorylation of 3'-azido-2',3'-dideoxyuridine and preferential inhibition of human and simian immunodeficiency virus reverse transcriptases by its 5'-triphosphate
1989