Citation Impact
Citing Papers
The final stages of spliceosome maturation require Spp2p that can interact with the DEAH box protein Prp2p and promote step 1 of splicing.
1995
Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome
2000 Nature
U1-snRNP-A protein selects a ten nucleotide consensus sequence from a degenerate RNA pool presented in various structural contexts
1991
A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein
1989
Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae.
1989
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes
1996
Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast
1995 StandoutNobel
Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors
1994 Nature
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Small nuclear rnas from budding yeasts: phylogenetic comparisons reveal extensive size variation
1989
Large-Scale Proteomic Analysis of the Human Spliceosome
2002
RNA-RNA interactions in the spliceosome: Unraveling the ties that bind
1994
Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
2000 StandoutNatureNobel
A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition
1998 StandoutNobel
Pre-mRNA splicing in yeast
1991
The signal recognition particle in S. cerevisiae
1991
The Spliceosome: Design Principles of a Dynamic RNP Machine
2009 Standout
A conserved secondary structure for telomerase RNA
1991 StandoutNobel
A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro
1990
Structure of the 30S ribosomal subunit
2000 StandoutNatureNobel
Ribozyme recognition of RNA by tertiary interactions with specific ribose 2′-OH groups
1991 NatureNobel
Defining a 5??? splice site by functional selection in the presence and absence of U1 snRNA 5??? end
2002
Two conserved domains of yeast U2 snRNA are separated by 945 nonessential nucleotides
1988
ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway
1990
A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome
1992
Composition and Functional Characterization of the Yeast Spliceosomal Penta-snRNP
2002
Compilation of tRNA sequences and sequences of tRNA genes
2004 Standout
Genetic depletion indicates a late role for U5 snRNP during in vitro spliceosome assembly
1991 StandoutNobel
Requirements for U2 snRNP addition to yeast pre-mRNA
1992 StandoutNobel
U1 snRNP-ASF/SF2 interaction and 5′ splice site recognition: characterization of required elements
1995
Yeast U1 snRNP–pre-mRNA complex formation without U1snRNA–pre-mRNA base pairing
2001 StandoutNobel
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing
2002 StandoutNatureNobel
The question remains: is the spliceosome a ribozyme?
2000
Protein functions in pre-mRNA splicing
1997
Mutations in yeast U5 snRNA alter the specificity of 5′ splice-site cleavage
1991
Assembly of the 30S subunit from Escherichia coli ribosomes occurs via two assembly domains which are initiated by S4 and S7
1988
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
Crystal Structures of Two Sm Protein Complexes and Their Implications for the Assembly of the Spliceosomal snRNPs
1999
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing
1991
A Biochemical Function for the Sm Complex
2001 StandoutNobel
A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation
1990
Antisense probing of the human U4U6 snRNP with biotinylated 2′-OMe RNA oligonucleotides
1989
Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex
1999 StandoutNobel
Comparative Biochemistry and Biophysics of Ribosomal Proteins
1991
Exon mutations uncouple 5′ splice site selection from U1 snRNA pairing
1990 StandoutNobel
An RNA Switch at the 5′ Splice Site Requires ATP and the DEAD Box Protein Prp28p
1999
Retinitis pigmentosa
2006 Standout
The Splicing Factor BBP Interacts Specifically with the Pre-mRNA Branchpoint Sequence UACUAAC
1997 StandoutNobel
Analysis of RNase-A-resistant regions of adenovirus 2 major late precursor-mRNA in splicing extracts reveals an ordered interaction of nuclear components with the substrate RNA
1987
Genetic evidence for base pairing between U2 and U6 snRNA in mammalian mRNA splicing
1991 Nature
Regulated Splicing of the Drosophila P Transposable Element Third Intron in Vitro: Somatic Repression
1990 Science
SR proteins can compensate for the loss of U1 snRNP functions in vitro.
1994
Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing
1989 StandoutNobel
Specific Alterations of U1-C Protein or U1 Small Nuclear RNA Can Eliminate the Requirement of Prp28p, an Essential DEAD Box Splicing Factor
2001
Role of poly(ADP-ribose) formation in DNA repair
1992 StandoutNatureNobel
The yeast homolog of the U1 snRNP protein 70K is encoded by the SNP1 gene
1992
Mutational analysis of the interactions between u1 small nuclear rna and pre-mrna of yeast
1989 StandoutNobel
U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites
1992
Evidence that genomic and antigenomic RNA self-cleaving elements from hepatitis delta virus have similar secondary structures
1991
The KH domain of the branchpoint sequence binding protein determines specificity for the pre-mRNA branchpoint sequence
1998 StandoutNobel
Splicing-related catalysis by protein-free snRNAs
2001 Nature
Major determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B" and their cognate RNAs
1990 Nature
Cross-Intron Bridging Interactions in the Yeast Commitment Complex Are Conserved in Mammals
1997 StandoutNobel
Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing.
1992
Targeted snRNP depletion reveals an additional role for mammalian U1 snRNP in spliceosome assembly
1990
Hierarchy for 5′ splice site preference determined in vivo
1990
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
1989 StandoutNatureNobel
Characterization of U4 and U6 interactions with the 5′ splice site using a S. cerevisiae in vitro trans-splicing system
2001
The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites
1990
Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection
1999
Mutations in U1 snRNA bypass the requirement for a cell type-specific RNA splicing factor
1993
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
Nuclear pre‐mRNA splicing in yeast
1989
Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6middle dotU5] tri-snRNP
1999
Regulation by HIV Rev depends upon recognition of splice sites
1989 StandoutNobel
Crystal structure of a hepatitis delta virus ribozyme
1998 StandoutNatureNobel
The role of the mammalian branchpoint sequence in pre-mRNA splicing.
1988
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis
2002
Who's on first? The U1 snRNP-5 splice site interaction and splicing
1991 StandoutNobel
Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint.
1993 StandoutNobel
Sequence-specific affinity selection of mammalian splicing complexes
1990
The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA
1993 Nature
Ribosomal ambiguity (ram) mutations facilitate dihydrostreptomycin binding to ribosomes
1979
Saccharomyces cerevisiae Has a U1-Like Small Nuclear RNA with Unexpected Properties
1987 Science
PRP4: a Protein of the Yeast U4/U6 Small Nuclear Ribonucleoprotein Particle
1989
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
2000 StandoutScienceNobel
Complementation by SR Proteins of Pre-mRNA Splicing Reactions Depleted of U1 snRNP
1994 Science
A functional interaction between Rev and yeast pre-mRNA is related to splicing complex formation.
1994 StandoutNobel
U1 small nuclear RNA plays a direct role in the formation of a rev-regulated human immunodeficiency virus env mRNA that remains unspliced.
1990
Unusual branch point selection in processing of human growth hormone pre-mRNA.
1988
Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase.
1985 StandoutNobel
MECHANISTIC ASPECTS OF ENZYMATIC CATALYSIS: Lessons from Comparison of RNA and Protein Enzymes
1997
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
U2 RNA from yeast is unexpectedly large and contains homology to vertebrate U4, U5, and U6 small nuclear RNAs
1986
Improved electrophoretic and immunochemical techniques for the identification and characterization of mutant proteins, applied to ribosomal protein S8 in Escherichia coli mutants
1977
Functional Modification of 16S Ribosomal RNA by Kethoxal
1972
PRE-mRNA SPLICING
1986
Determinants of the 3' splice site for self-splicing of the Tetrahymena pre-rRNA.
1988 StandoutNobel
Identification of Prp40, a Novel Essential Yeast Splicing Factor Associated with the U1 Small Nuclear Ribonucleoprotein Particle
1996
Differential nuclease sensitivity identifies tight contacts between yeast pre-mRNA and spliceosomes.
1986 StandoutNobel
An RNA conformational change between the two chemical steps of group II self-splicing.
1996
The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing
1987 Nature
Conserved amino acid residues within and outside of the N-terminal ribonucleoprotein motif of U1A small nuclear ribonucleoprotein involved in U1 RNA binding
1991
A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins.
1998 StandoutNobel
A U-rich tract enhances usage of an alternative 3′ splice site in yeast
1991
Cotranscriptional Recruitment of the U1 snRNP to Intron-Containing Genes in Yeast
2003
A U1/U4/U5 snRNP Complex Induced by a 2′- O -Methyl-Oligoribonucleotide Complementary to U5 snRNA
1996 Science
Initiator proteins for the assembly of the 50S subunit from Escherichia coli ribosomes.
1982
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery.
1991
Effects on mRNA splicing of mutations in the 3' region of the Saccharomyces cerevisiae actin intron.
1987
Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA
1987
The Yeast PRP6 Gene Encodes a U4/U6 Small Nuclear Ribonucleoprotein Particle (snRNP) Protein, and the PRP9 Gene Encodes a Protein Required for U2 snRNP Binding
1990 StandoutNobel
The U1 snRNP Base Pairs with the 5′ Splice Site within a Penta-snRNP Complex
2003
Unusual Branch Point Selection in Processing of Human Growth Hormone Pre-mRNA
1988
An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing.
1993 StandoutNobel
The primary structure of protein S5 from the small subunit of the Escherichia coli ribosome
1978
Efficient association of U2 snRNPs with pre-mRNA requires an essential U2 RNA structural element.
1991
Functional analysis of mutant Xenopus U2 snRNAs
1989
An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly
1988 Science
Genetic analysis of the role of human U1 snRNA in mRNA splicing: I. Effect of mutations in the highly conserved stem-loop I of U1.
1989
U1 snRNP can influence 3'-splice site selection as well as 5'-splice site selection.
1991 StandoutNobel
Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components.
1991 StandoutNobel
A chemical modification/interference study of yeast pre-mRNA spliceosome assembly and splicing.
1988 StandoutNobel
Identification of Proteins That Interact with Exon Sequences, Splice Sites, and the Branchpoint Sequence during Each Stage of Spliceosome Assembly
1996
Biochemical and physical characterization of an unmodified yeast phenylalanine transfer RNA transcribed in vitro.
1988
Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.
1988
Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast.
1991
Sequential recognition of the pre-mRNA branch point by U2AF65 and a novel spliceosome-associated 28-kDa protein.
1995
Universally conserved and yeast-specific U1 snRNA sequences are important but not essential for U1 snRNP function.
1990 StandoutNobel
The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
1993 StandoutNatureNobel
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
Saccharomyces cerevisiae U1 small nuclear RNA secondary structure contains both universal and yeast-specific domains.
1990 StandoutNobel
A novel role for the 3' region of introns in pre-mRNA splicing of Saccharomyces cerevisiae.
1987 StandoutNobel
Sm and Sm-like proteins belong to a large family: identification of proteins of the U6 as well as the U1, U2, U4 and U5 snRNPs.
1995
In vitro reconstitution of functional yeast U2 snRNPs.
1989
DYNAMIC RNA-RNA INTERACTIONS IN THE SPLICEOSOME
1994
Specific small nuclear RNAs are associated with yeast spliceosomes
1986 StandoutNobel
Small nuclear RNAs from Saccharomyces cerevisiae: unexpected diversity in abundance, size, and molecular complexity.
1986
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
1979 Standout
UACUAAC is the preferred branch site for mammalian mRNA splicing.
1989
Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.
1989
Effect of different mutaions in ribosomal protein S5 of Escherichia coli on translational fidelity
1975
Assembly Mapping of 30S Ribosomal Proteins from E. coli
1970 Nature
The yeast branchpoint sequence is not required for the formation of a stable U1 snRNA-pre-mRNA complex and is recognized in the absence of U2 snRNA.
1991 StandoutNobel
Three recognition events at the branch-site adenine.
1996
Yeast pre-messenger RNA splicing efficiency depends on critical spacing requirements between the branch point and 3′ splice site.
1986
Dynamic association of proteins with the pre-mRNA branch region.
1994
Interactions of Small Nuclear RNA's with Precursor Messenger RNA During in Vitro Splicing
1992 Science
Spliceosome assembly in yeast.
1987
An essential yeast snRNA with a U5-like domain is required for splicing in vivo
1987
The canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosome.
1996
Disassembly and reconstitution of signal recognition particle
1983 StandoutNobel
A U6 snRNA:pre-mRNA interaction can be rate-limiting for U1-independent splicing.
1995
Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm
1989 StandoutNobel
Structural transformations of ribosomes (dissociation, unfolding and disassembly)
1974
The Amino-Terminal Domain of Yeast U1-70K Is Necessary and Sufficient for Function
1995
The yeast splicing factor Mud13p is a commitment complex component and corresponds to CBP20, the small subunit of the nuclear cap-binding complex.
1996 StandoutNobel
Crosslinking of streptomycin to the 50S subunit of Escherichia coli with phenyldiglyoxal
1985
Splicing of Messenger RNA Precursors
1987 Science
Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation
2004 StandoutNobel
Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing.
1990
Splicing of yeast nuclear pre-mRNA in vitro requires a functional 40S spliceosome and several extrinsic factors.
1987
Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.
1990
Mode of enzyme-bound poly(ADP-ribose) synthesis and histone modification by reconstituted poly(ADP-ribose) polymerase-DNA-cellulose complex.
1981
PRP5: a helicase-like protein required for mRNA splicing in yeast.
1990
Protein components specifically associated with prespliceosome and spliceosome complexes.
1992
STRUCTURAL INSIGHTS INTO TRANSLATIONAL FIDELITY
2005 StandoutNobel
An essential snRNA from S. cerevisiae has properties predicted for U4, including interaction with a U6-like snRNA
1987
Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution.
1991
Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein
1991 Science
Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes
1986 StandoutNatureNobel
An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway.
1991
Works of C Guthrie being referenced
Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase.
1994
SPLICEOSOMAL snRNAs
1988
Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome
1999
Human U2 snRNA can function in pre-mRNA splicing in yeast
1990 Nature
Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1.
1993
Structure of intron-containing tRNA precursors. Analysis of solution conformation using chemical and enzymatic probes.
1984
Multiple roles for U6 snRNA in the splicing pathway.
1990
Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs.
1991
Activation of a cryptic TACTAAC box in the Saccharomyces cerevisiae actin intron.
1986
Nucleotide sequence of an arginine transfer ribonucleic acid from bacteriophage T4.
1977
The spliceosome is a dynamic ribonucleoprotein machine.
1996
Domains of yeast U4 spliceosomal RNA required for PRP4 protein binding, snRNP-snRNP interactions, and pre-mRNA splicing in vivo.
1990
Mutations in conserved intron sequences affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome.
1986
Electrophoretic and immunological studies on ribosomal proteins of 100 Escherichia coli revertants from streptomycin dependence
1973
Studies on the Assembly of Ribosomes in vivo
1969
Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosome.
1994
Unexpected flexibility in an evolutionarily conserved protein-RNA interaction: genetic analysis of the Sm binding site.
1990
A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis.
1992
The assembly of ribosomes
1969
A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.
1991
Architecture of the U5 small nuclear RNA.
1994
A novel role for a U5 snRNP protein in 3' splice site selection.
1995
5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements.
1988
Transcription of a yeast U6 snRNA gene requires a polymerase III promoter element in a novel position.
1990
Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing.
1992
A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation.
1987
The second catalytic step of pre-mRNA splicing.
1995
Deletion of a yeast small nuclear RNA gene impairs growth.
1985
Evidence for a Prp24 binding site in U6 snRNA and in a putative intermediate in the annealing of U6 and U4 snRNAs.
1995
An essential splicing factor, SLU7, mediates 3' splice site choice in yeast.
1992
Prp16p, Slu7p, and Prp8p interact with the 3' splice site in two distinct stages during the second catalytic step of pre-mRNA splicing.
1995
Genetic analysis of small nuclear RNAs in Saccharomyces cerevisiae: viable sextuple mutant.
1988