Citation Impact
Citing Papers
p53: puzzle and paradigm.
1996 Standout
Cell Death: The Significance of Apoptosis
1980 Standout
Bax-Deficient Mice with Lymphoid Hyperplasia and Male Germ Cell Death
1995 Science
The role of the p53 protein in the apoptotic response
1994
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
1996
Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview
1992
Inflammation and cancer
2002 StandoutNature
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
WAF1, a potential mediator of p53 tumor suppression
1993 Standout
An Olfactory Sensory Map in the Fly Brain
2000 StandoutNobel
The genetic regulation of apoptosis
1995
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
A subset of p53-deficient embryos exhibit exencephaly
1995
Tumor spectrum analysis in p53-mutant mice
1994 Standout
Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning
1993
Apoptosis in cancer therapy: Crossing the threshold
1994
Molecular regulation of apoptosis: Genetic controls on cell death
1993
From DNA damage to cell cycle arrest and suicide: a budding yeast perspective
1996
Tumor surveillance via the ARF–p53 pathway
1998
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
The p53 pathway and apoptosis
1999
Telomere states and cell fates
2000 StandoutNatureNobel
When Checkpoints Fail
1997 StandoutNobel
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
1994
Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice
1993
Apoptosis (the 1992 Frank Rose Memorial Lecture)
1993
The Hallmarks of Cancer
2000 Standout
p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes
1994 Nature
The genetics of cell cycle checkpoints
1995
Mechanisms of carcinogenesis and the mutant mouse
1996
Death-defying acts: a meeting review on apoptosis.
1993
COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective
1996
Tumor suppressor genes
1994
p53-Dependent apoptosis suppresses tumor growth and progression in vivo
1994
Cooperative tumorigenic effects of germline mutations in Rb and p53
1994
The golden age: gold nanoparticles for biomedicine
2011 Standout
DNA-templated assembly and electrode attachment of a conducting silver wire
1998 StandoutNature
Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis
1997
Apoptosis induced by γ-irradiation, but not CD4 ligation, of peripheral T lymphocytesin vivo is p53-dependent
1997
Sunburn and p53 in the onset of skin cancer
1994 StandoutNature
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation
1998
Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27
1996
Cell cycle checkpoints
1994
An evolutionary perspective on apoptosis
1994
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
Autoimmune disease. a problem of defective apoptosis
1994
Apoptosis Biochemical events and relevance to cancer chemotherapy
1992
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1995 Nature
Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli
1991
Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM
1995
p53-dependent apoptosis suppresses radiation–induced teratogenesis
1996
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo
2002
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
1993 Standout
Mismatch Repair Deficiency in Phenotypically Normal Human Cells
1995 StandoutScienceNobel
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Programmed Cell Death in Animal Development
1997 Standout
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
1995 Standout
Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?
1993
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
1994 Nature
Drug-target interactions: only the first step in the commitment to a programmed cell death?
1991
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
1994 StandoutNobel
Activation of C. elegans cell death protein CED-9 by an ammo-acid substitution in a domain conserved in Bcl-2
1994 StandoutNatureNobel
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
1995 StandoutNatureNobel
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
2009 StandoutNatureNobel
Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents
1993
Life, death, and the pursuit of apoptosis.
1996
Regulation of Proliferation-Survival Decisions during Tumor Cell Hypoxia
1998
A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity
1999
Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.
1994
DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2
2000 Science
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.
1994
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
1994
Absence of WAF1 mutations in a variety of human malignancies
1994
A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.
1999
Quality Control by DNA Repair
1999 StandoutScienceNobel
Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.
1994
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
Apoptosis in the Pathogenesis and Treatment of Disease
1995 StandoutScience
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
1994
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.
1994
Chk2/hCds1 functions as a DNA damage checkpoint in G1by stabilizing p53
2000
Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorhabditis elegans.
1994
Cancer Cell Cycles
1996 StandoutScience
Ataxia-telangiectasia and cellular responses to DNA damage.
1995
T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.
1996
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Antisense telomerase treatment: induction of two distinct pathways, apoptosis and differentiation
1998
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function
2002
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
1994
p53 and E2F-1 cooperate to mediate apoptosis.
1994
Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis
1997
A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.
1996
Mutations in the p53 and SCID genes cooperate in tumorigenesis.
1996
bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria
1994
Apoptosis and Programmed Cell Death in Immunity
1992
Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- γc-/- mice: functional inactivation of p53 in developing T cells
2004
Tissue-specific inactivation of p53 tumor suppression in the mouse.
1996
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
1995 Standout
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Growth factor modulation of p53-mediated growth arrest versus apoptosis.
1995
Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.
1996
The cancer connection
2002 StandoutNatureNobel
Expression of baculovirus P35 prevents cell death in Drosophila
1994
Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
2000 StandoutScience
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
1994 Standout
Genetic Control of Programmed Cell Death in Drosophila
1994 Science
Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice
1993 Science
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
1999
The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis
1999
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
Accumulation of wild-type p53 protein upon gamma-irradiation induces a G2 arrest-dependent immunoglobulin kappa light chain gene expression.
1995
Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System
1993 Science
Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.
1993
Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen.
1994
Dual roles of ATM in the cellular response to radiation and in cell growth control.
1996 Nobel
Human DNA Repair Genes
2001 StandoutScienceNobel
A role for E2F1 in the induction of apoptosis during thymic negative selection.
2000
Testing the Role of p53 in the Expression of Genetic Instability and Apoptosis in Ataxia-telangiectasia
1994
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
Programmed cell death by default in embryonic cells, fibroblasts, and cancer cells.
1995
Apoptosis in AIDS
1993 StandoutScienceNobel
Cytokines Inhibit p53-Mediated Apoptosis but Not p53-Mediated G1 Arrest
1995
Programmed cell death and Bcl-2 protection in the absence of a nucleus.
1994
Mechanisms and Genes of Cellular Suicide
1995 StandoutScience
Bcl-2 and the regulation of programmed cell death
1994 Standout
Works of C C Bird being referenced
Thymocyte apoptosis induced by p53-dependent and independent pathways
1993 StandoutNature
Morphological aspects of glucocorticoid‐induced cell death in human lymphoblastoid cells
1978
Kinetic and Physical Studies of Cell Death Induced By Chemotherapeutic Agents Or Hyperthermia
1986
Immunogold-silver staining: new method of immunostaining with enhanced sensitivity.
1983