Citation Impact
Citing Papers
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
A fluorescent probe designed for studying protein conformational change
2005 StandoutNobel
Origins of catalysis by computationally designed retroaldolase enzymes
2010 StandoutNobel
TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain
2002 StandoutNobel
Electrically monitoring DNA repair by photolyase
2005 StandoutNobel
Reactions of cysteines substituted in the amphipathic N-terminal tail of a bacterial potassium channel with hydrophilic and hydrophobic maleimides
2002
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Synthesis and utility of fluorogenic acetoxymethyl ethers
2010
Crystal Structure of a Purple Acid Phosphatase Containing a Dinuclear Fe(III)-Zn(II) Active Site
1995 Science
Kinetic Analysis of the Mechanism and Specificity of Protein-disulfide Isomerase Using Fluorescence-quenched Peptides
1998 StandoutNobel
Synthetic Inhibitors of Elastase
1994
Instability and decay of the primary structure of DNA
1993 StandoutNatureNobel
Preliminary crystallographic studies of urease from jack bean and from Klebsiella aerogenes
1992
The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli
2005 StandoutNobel
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
The specificity of chymotrypsin
1991
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Characterization of Three Components of Human Adenovirus Proteinase Activity in Vitro
1996
Ribosomal localization of translation initiation factor IF2
2003
Intrinsic motions along an enzymatic reaction trajectory
2007 Nature
An antibody VH domain with a lox‐Cre site integrated into its coding region: bacterial recombination within a single polypeptide chain
1995
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant
2011 StandoutNatureNobel
Mechanism of Fe(III) – Zn(II) Purple Acid Phosphatase Based on Crystal Structures
1996
A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus
2006
Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl .alpha.-chymotrypsin using different denaturants
1988
At the Crossroads of Chemistry and Immunology: Catalytic Antibodies
1991 Science
A DNA metalloenzyme with DNA ligase activity
1995 StandoutNatureNobel
Enolpyruvate: chemical determination as a pyruvate kinase intermediate
1991 StandoutNobel
Extremely thermostable D-glyceraldehyde-3-phosphate dehydrogenase from the eubacterium Thermotoga maritima
1990
Enriched sources of Escherichia coli replication proteins
1992
Structural Basis for Proofreading during Replication of the Escherichia coli Chromosome
2002
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
Thioflavin T Is a Fluorescent Probe of the Acetylcholinesterase Peripheral Site That Reveals Conformational Interactions between the Peripheral and Acylation Sites
2001
Catalytic promiscuity and the evolution of new enzymatic activities
1999
Site‐directed mutagenesis of Klebsiella aerogenes urease: Identification of histidine residues that appear to function in nickel ligation, substrate binding, and catalysis
1993
The structure of jack bean urease
1988
The origin of the electrostatic perturbation in acetoacetate decarboxylase
2009 Nature
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
2004 StandoutNatureNobel
Regulation of the p300 HAT domain via a novel activation loop
2004
Requirement of Carbon Dioxide for in Vitro Assembly of the Urease Nickel Metallocenter
1995 Science
The crystal structure of urease from Klebsiella aerogenes
1995 StandoutScience
The Protonic Equilibrium Accompanying the Acylation of Chymotrypsin and Subtilisin*
1966
Bimetallic catalysis by late transition metal complexes
1998 StandoutNobel
Structural patterns in globular proteins
1976 StandoutNatureNobel
Conformational changes accompanying the formation of chymotrypsin-substrate complexes. Evidence for the involvement of an N-terminal α-amino group in the activity and the conformation of the enzyme
1964
Reactivity of the essential thiol of Klebsiella aerogenes urease. Effect of pH and ligands on thiol modification
1991
Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia.
1987
Molecular orbital studies of enzyme activity: I: Charge relay system and tetrahedral intermediate in acylation of serine proteinases.
1975 StandoutNobel
Catalytic Proficiency: The Unusual Case of OMP Decarboxylase
2002
Geometric and Electronic Structure/Function Correlations in Non-Heme Iron Enzymes
1999 Standout
Three-dimensional Structure of Tosyl-α-chymotrypsin
1967 StandoutNatureNobel
Kinetics of subtilisin and thiolsubtilisin
1983
Zinc: biological functions and coordination motifs
1993
pK of the lysine amino group at the active site of acetoacetate decarboxylase
1971
Domains of Escherichia coli primase: functional activity of a 47-kDa N-terminal proteolytic fragment.
1994 StandoutNobel
Macroscopic models for studies of electrostatic interactions in proteins: limitations and applicability.
1984 StandoutNobel
Novel folded protein domains generated by combinatorial shuffling of polypeptide segments
2000 StandoutNobel
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II
1990 StandoutNatureNobel
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
1976 Standout
Molar absorptivity and A1cm1% values for proteins at selected wavelengths of the ultraviolet and visible regions. VIII
1973
Chymotrypsin
1973
Orienting DNA Helices on Gold Using Applied Electric Fields
1998
Sulfonyl Fluorides as Inhibitors of Esterases. II. Formation and Reactions of Phenylmethanesulfonyl α-Chymotrypsin*
1964
Crystallization of trimeric recombinant human tumor necrosis factor (cachectin).
1988 StandoutNobel
Extensive comparison of the substrate preferences of two subtilisins as determined with peptide substrates which are based on the principle of intramolecular quenching
1992 StandoutNobel
A retroviral Cys-Xaa2-Cys-Xaa4-His-Xaa4-Cys peptide binds metal ions: spectroscopic studies and a proposed three-dimensional structure.
1989
Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope
1997 StandoutScienceNobel
Binding of boronic acids to chymotrypsin
1974
The Mechanism of Irreversible Enzyme Inactivation at 100°C
1985 Science
Conformational equilibria in α- and δ-chymotrypsin
1972
Tryptophan Synthase: Structure and Function of the Monovalent Cation Site
2009
ARTIFICIAL LIGHT‐SENSITIVE ENZYMATIC SYSTEMS AS CHEMICAL AMPLIFIERS OF WEAK LIGHT SIGNALS
1979
Ligation of the diiron site of the hydroxylase component of methane monooxygenase. An electron nuclear double resonance study.
1992
Molecular orbital studies of enzyme activity: catalytic mechanism of serine proteinases.
1976 StandoutNobel
Photocontrol of urease-collagen membrane activity
1976
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Mechanism of the Reaction Catalyzed by Acetoacetate Decarboxylase. Importance of Lysine 116 in Determining the pKa of Active-Site Lysine 115
1996
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
2004 StandoutNobel
Chymotrypsin: Molecular and catalytic properties
1986
α-Chymotrypsin: A Case Study of Substituent Constants and Regression Analysis in Enzymic Structure—Activity Relationships
1970
Confirmation of UAG as a nonsense codon in bakers' yeast by amino acid replacements of glutamic acid 71 in iso-1-cytochrome c
1973
Site-directed mutagenesis of the active site cysteine in Klebsiella aerogenes urease.
1992
Esterase Activities of Human Carbonic Anhydrases B and C
1967 Standout
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Purification of the Azotobacter vinelandii nifV-encoded homocitrate synthase
1997
An estimate of intraproteic electrostatic fields values originated by the peptide groups in α-Chymotrypsin
1972
On the Specificity of Streptococcal Proteinase
1966 StandoutNobel
Structure of Subtilisin BPN′ at 2.5 Å Resolution
1969 Nature
Sequence of the Klebsiella aerogenes urease genes and evidence for accessory proteins facilitating nickel incorporation
1990
Physical characterization of two-iron uteroferrin. Evidence for a spin-coupled binuclear iron cluster.
1983
Enzyme millisecond conformational dynamics do not catalyze the chemical step
2009 StandoutNobel
Structure-Function Analysis of Hepatitis C Virus Envelope-CD81 Binding
2000 StandoutNobel
Purification and characterization of the nickel-containing multicomponent urease from Klebsiella aerogenes.
1987
Portion-mixing peptide libraries of quenched fluorogenic substrates for complete subsite mapping of endoprotease specificity.
1994 StandoutNobel
Binuclear Metallohydrolases
1996
Sulfonyl Fluorides as Inhibitors of Esterases. III. Identification of Serine as the Site of Sulfonylation in Phenylmethanesulfonyl α-Chymotrypsin*
1965
Mechanistic Studies on Synthetic Fe−S-Based Clusters and Their Relevance to the Action of Nitrogenases
2005 StandoutNobel
Competitive Inhibitors of Klebsiella aerogenes Urease
1989
Methylation of histidine-48 in pancreatic phospholipase A2. Role of histidine and calcium ion in the catalytic mechanism
1980
Converting Trypsin to Chymotrypsin: The Role of Surface Loops
1992 Science
Cloning and expression of various staphylococcal genes encoding urease inStaphylococcus carnosus
1991
Conjugation of DNA to Silanized Colloidal Semiconductor Nanocrystalline Quantum Dots
2002 StandoutNobel
Mössbauer studies of alkane ω-hydroxylase: Evidence for a diiron cluster in an integral-membrane enzyme
1997
Betadoublet: de novo design, synthesis, and characterization of a beta-sandwich protein.
1994
The coordination chemistry of the binuclear iron site in hemerythrin
1987
Yeast super-suppressors are altered tRNAs capable of translating a nonsense codon in vitro
1975 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Computational design of a red fluorophore ligase for site-specific protein labeling in living cells
2014 StandoutNobel
Works of Burt Zerner being referenced
Cloning and sequencing of a jack bean urease-encoding cDNA
1991
[8] Reassessment of Ellman's reagent
1983
Kinetic Evidence for the Formation of Acyl-Enzyme Intermediates in the α-Chymotrypsin-Catalyzed Hydrolyses of Specific Substrates
1964
Properties of the Fe(II)-Fe(III) derivative of red kidney bean purple phosphatase. Evidence for a binuclear zinc-iron center in the native enzyme
1988
Acetoacetate Decarboxylase. Identification of Lysine at the Active Site*
1966
Sigmoid and Bell-Shaped pH-Rate Profiles in α-Chymotrypsin-Catalyzed Hydrolyses. a Mechanistic Correlation
1963
Properties of a purple phosphatase from red kidney bean: a zinc-iron metalloenzyme
1986
The Formation of an Acyl-enzyme Intermediate in the α-Chymotrypsin-catalyzed Hydrolyses of Non-labile trans-Cinnamic Acid Esters1-3
1962
Carboxylesterases (EC 3.1.1.). The molecular weight and equivalent weight of pig liver carboxylesterase
1969
Iron-containing acid phosphatases: Comparison of the enzymes from beef spleen and pig allantoic fluid
1978
A low-molecular-weight acid phosphatase which contains iron
1973
The pH Dependence of Some α-Chymotrypsin-catalyzed Hydrolyses1-3
1962
Spectrophotometric Investigations of the Mechanism of α-Chymotrypsin-catalyzed Hydrolyses. Detection of the Acyl-enzyme Intermediate1-3
1962
Jack bean urease (EC 3.5.1.5). I. A simple dry ashing procedure for the microdetermination of trace metals in proteins. The nickel content of urease
1980
Ellman's reagent: 5,5′-dithiobis(2-nitrobenzoic acid)—a reexamination
1979
Iron-containing acid phosphatases: Characterization of the metal-ion binding site of the enzyme from pig allantoic fluid
1980
Jack Bean Urease VI. Determination of thiol and disulfide content
1983
ChemInform Abstract: JACK BEAN UREASE (EC 3.5.1.5), A METALLOENZYME, A SIMPLE BIOLOGICAL ROLE FOR NICKEL
1975
The Kinetics and Mechanism of the Hydrolysis of o-Carboxyphthalimide1
1961
Jack bean urease (EC 3.5.1.5). V. On the mechanism of action of urease on urea, formamide, acetamide, N-methylurea, and related compounds
1980
Jack bean urease (EC 3.5.1.5). IV. The molecular size and the mechanism of inhibition by hydroxamic acids. Spectrophotometric titration of enzymes with reversible inhibitors
1980
The Kinetic Consequences of the Acyl-Enzyme Mechanism for the Reactions of Specific Substrates with Chymotrypsin
1964
Evidence for a binuclear iron site in pig allantoic fluid acid phosphatase (uteroferrin)
1983
Metal Ions in Enzymes Using Ammonia or Amides
1976 Science
Purification and properties of a carboxylesterase from the liver of tiger shark (Galeocerdo cuvier)
1976
Inhibition of jack bean urease (EC 3.5.1.5) by acetohydroxamic acid and by phosphoramidate. Equivalent weight for urease
1975
Oxazolinones as enzyme acylating agents
1966
The Spectrophotometric Determination of the Operational Normality of an α-Chymotrypsin Solution
1961
Spontaneous and α-chymotrypsin-catalyzed hydrolysis of 4-cis-benzylidene-2-phenyloxazolin-5-one. Catalysis by tris(hydroxymethyl)aminomethane
1969
Jack bean urease (EC 3.5.1.5). Demonstration of a carbamoyl-transfer reaction and inhibition by hydroxamic acids
1969
Jack bean urease (EC 3.5.1.5). II. The relationship between nickel, enzymatic activity, and the "abnormal" ultraviolet spectrum. The nickel content of jack beans
1980
Recent advances in the chemistry of an old enzyme, urease
1991
Moessbauer analysis of the binuclear iron site in purple acid phosphatase from pig allantoic fluid
1989
THE INFLUENCE OF pH AND DEUTERIUM OXIDE ON THE KINETICS OF α-CHYMOTRYPSIN-CATALYZED REACTIONS1,2
1961
Iron-containing acid phosphatases: Interaction of phosphate with the enzyme from pig allantoic fluid
1982
Mössbauer and EPR study of the binuclear iron centre in purple acid phosphatase
1983
Spontaneous and enzyme-catalyzed hydrolysis of saturated oxazolinones
1969
Acetoacetate Decarboxylase. Preparation of the Enzyme*
1966
Jack bean urease (EC 3.5.1.5). III. The involvement of active-site nickel ion in inhibition by β-mercaptoethanol, phosphoramidate, and fluoride
1980
Jack bean urease (EC 3.5.1.5). A new purification and reliable rate assay
1969
Jack bean urease (EC 3.5.1.5) VIII. On the inhibition of urease by amides and esters of phosphoric acid
1986
Jack bean urease: the first nickel enzyme
1984
Jack bean urease VII. Light scattering and nickel(II) spectrum Thiolate → nickel(II) charge-transfer peaks in the spectrum of the β-mercaptoethanol-urease complex
1983
Carboxylesterases (EC 3.1.1). Purification and Titration of Chicken, Sheep, and Horse Liver Carboxylesterases
1975
Primary structure of cytochrome c from the elephant seal, Mirounga leonina
1972
The involvement of histidine in the action of liver carboxylesterases
1973
Jack bean urease (EC 3.5.1.5). Metalloenzyme. Simple biological role for nickel
1975