Citation Impact
Citing Papers
Anaesthesia, surgery, and challenges in postoperative recovery
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Long-Acting κ Opioid Antagonists Disrupt Receptor Signaling And Produce Noncompetitive Effects By Activating C-Jun N-Terminal Kinase
2007
Selective agonist binding of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) and 2S-(2α,3β,4β)-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid (kainate) receptors: a molecular modeling study
2003
Binding of an AMPA receptor potentiator ([3H]LY395153) to native and recombinant AMPA receptors1The first two authors contributed equally to this work.1
2001
Ampakines and the threefold path to cognitive enhancement
2006
Glutamate receptor ion channels
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Glutamate Receptor Ion Channels: Structure, Regulation, and Function
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Bowel Disorders
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C–C, C–O and C–N bond formation via rhodium(iii)-catalyzed oxidative C–H activation
2012 Standout
LY503430, a Novel α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Potentiator with Functional, Neuroprotective and Neurotrophic Effects in Rodent Models of Parkinson’s Disease
2003
Basic and clinical pharmacology of new motility promoting agents
2005
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Multipass membrane protein structure prediction using Rosetta
2005 StandoutNobel
Nonpeptidic ligands for peptide and protein receptors
1999
The Pictet–Spengler Reaction in Nature and in Organic Chemistry
2011 Standout
The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders
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[3H]Alvimopan binding to the μ opioid receptor: Comparative binding kinetics of opioid antagonists
2005
Therapeutic potential of β-arrestin- and G protein-biased agonists
2010 StandoutNobel
The Functional Gastrointestinal Disorders and the Rome III Process
2006 Standout
A Palladium‐Catalyzed Regiospecific Synthesis of N‐Aryl Benzimidazoles
2007
Modern Synthetic Methods for Copper‐Mediated C(aryl)O, C(aryl)N, and C(aryl)S Bond Formation
2003 Standout
Historical Overview of Chemical Library Design
2010
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Structure of the human κ-opioid receptor in complex with JDTic
2012 Nature
A new era of GPCR structural and chemical biology
2012 StandoutNobel
Alvimopan, a selective peripherally acting μ‐opioid antagonist*
2005
Lead compounds discovered from libraries
2001
Direct Imidation to Construct 1H‐Benzo[d]imidazole through PdII‐Catalyzed CH Activation Promoted by Thiourea
2009
Benzamide-Type AMPA Receptor Modulators Form Two Subfamilies with Distinct Modes of Action
2002
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Relating protein pharmacology by ligand chemistry
2007 Standout
Total synthesis of chiral biaryl natural products by asymmetric biaryl coupling
2009 Standout
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
Biaryl Phosphane Ligands in Palladium‐Catalyzed Amination
2008 Standout
Highly Diastereoselective Iron‐Mediated C(sp2)C(sp3) Cross‐Coupling Reactions between Aryl Grignard Reagents and Cyclic Iodohydrine Derivatives
2011
Recent advances in selective opioid receptor agonists and antagonists
2003
Transition‐Metal‐Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage
2009 Standout
Solid‐Phase Synthesis of Tetrahydro‐β‐carbolines and Tetrahydroisoquinolines by Stereoselective Intramolecular N‐Carbamyliminium Pictet–Spengler Reactions
2006 StandoutNobel
Asymmetric Multicomponent Reactions (AMCRs): The New Frontier
2005 Standout
Controlled Microwave Heating in Modern Organic Synthesis
2004 Standout
Selective Postoperative Inhibition of Gastrointestinal Opioid Receptors
2001
Diagnosing the decline in pharmaceutical R&D efficiency
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Synthesis and antitumour activity of trimethylsilylpropyl substituted benzimidazoles
2001
Alvimopan
2005
Multicomponent reactions for the synthesis of pyrroles
2010 Standout
PREDICT modeling and in‐silico screening for G‐protein coupled receptors
2004
Parkinson's Disease
2003 Standout
Neuropathic Pain Activates the Endogenous κ Opioid System in Mouse Spinal Cord and Induces Opioid Receptor Tolerance
2004 StandoutNobel
Heterocyclic Carbenes: Synthesis and Coordination Chemistry
2008 Standout
Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products
2010 Standout
Toward high-resolution prediction and design of transmembrane helical protein structures
2007 StandoutNobel
Iron Catalysis in Organic Synthesis
2015 Standout
Solid-Phase Intramolecular N-Acyliminium Pictet−Spengler Reactions as Crossroads to Scaffold Diversity
2004 StandoutNobel
Chemistry of Polyvalent Iodine
2008 Standout
Methodologies for Generating Solution-Phase Combinatorial Libraries
2000
Liquid-phase synthesis of 2-(alkylthio) benzimidazoles
1999
Comprehensive Survey of Combinatorial Library Synthesis: 2002
2003
Subcellular compartmentalization of 1-methyl-4-phenylpyridinium with catecholamines in adrenal medullary chromaffin vesicles may explain the lack of toxicity to adrenal chromaffin cells.
1987
Practical Methodologies for the Synthesis of Indoles
2006 Standout
Diastereomeric Salt Resolution Based Synthesis of LY503430, an AMPA (α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid) Potentiator
2005
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry
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Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
1-Substituted 4-(3-Hydroxyphenyl)piperazines Are Pure Opioid Receptor Antagonists
2010
AMPA potentiator treatment of cognitive deficits in Alzheimer disease
2007
Diastereoselective Tandem Addition−Cyclization Reactions of Unsaturated Tertiary Amines Initiated by Photochemical Electron Transfer (PET)
2000
Combinatorial Liquid-Phase Synthesis of Structurally Diverse Benzimidazole Libraries
2000
Tishchenko reactions of aldehydes promoted by diisobutylaluminum hydride and its application to the macrocyclic lactone formation
2007
Aerobic Copper-Catalyzed Organic Reactions
2013 Standout
Multiple Molecular Determinants for Allosteric Modulation of Alternatively Spliced AMPA Receptors
2003
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Cyclizations of N-Acyliminium Ions
2004 Standout
Oxidative decar☐ylation of α-amino acids: A mild and efficient method for the generation ofN-acyliminium ions
1999
Confined acids catalyze asymmetric single aldolizations of acetaldehyde enolates
2018 StandoutScienceNobel
Catalytic Asymmetric Synthesis of Unprotected β2-Amino Acids
2021 StandoutNobel
Palladium-Catalyzed Microwave-Assisted Amination of 1-Bromonaphthalenes and 5- and 8-Bromoquinolines
2003
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
2011 Standout
High-throughput combinatorial synthesis of substituted benzimidazolones
1999
A Palladium‐Catalyzed Regiospecific Synthesis of N‐Aryl Benzimidazoles
2007
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation
2000
Perylenequinone Natural Products: Total Syntheses of the Diastereomers (+)-Phleichrome and (+)-Calphostin D by Assembly of Centrochiral and Axial Chiral Fragments
2009
Two-step solution-phase synthesis of novel benzimidazoles utilizing a UDC (Ugi/de-Boc/cyclize) strategy
2001
Transition-Metal-Catalyzed Reactions in Heterocyclic Synthesis
2004 Standout
Functionalized Polymers-Emerging Versatile Tools for Solution-Phase Chemistry and Automated Parallel Synthesis
2001
Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, and Applications
2017 Standout
Rapid Microwave-Assisted Liquid-Phase Combinatorial Synthesis of 2-(Arylamino)benzimidazoles
2002
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Solar Synthesis: Prospects in Visible Light Photocatalysis
2014 StandoutScience
κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses
2003
Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses.
2003
One‐Pot Synthesis of Benzimidazo[1,2‐f]phenanthridines by Cascade Palladium‐Catalyzed N‐Arylation and Intramolecular C–H Coupling
2013
An intramolecular palladium-catalysed aryl amination reaction to produce benzimidazoles
2002
Design, Synthesis, and Investigation of Protein Kinase C Inhibitors: Total Syntheses of (+)-Calphostin D, (+)-Phleichrome, Cercosporin, and New Photoactive Perylenequinones
2009
Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist
2002
Works of Buddy E. Cantrell being referenced
Synthesis of a Series of Aryl Kainic Acid Analogs and Evaluation in Cells Stably Expressing the Kainate Receptor humGluR6
1996
Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists
1999
Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for .mu.- and .kappa.-opioid receptors
1993
3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity
1993
N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists
1998
Design and Synthesis of a Novel Series of 1,2-Disubstituted Cyclopentanes as Small, Potent Potentiators of 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic Acid (AMPA) Receptors
2002
Discovery of a Potent, Peripherally Selective trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonist for the Treatment of Gastrointestinal Motility Disorders
1994
Biarylpropylsulfonamides as Novel, Potent Potentiators of 2-Amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic Acid (AMPA) Receptors
2000
A stereoselective synthetic approach to N-alkyl-4β-methyl-5-phenylmorphans
1999
Characterization of the neurotoxic potential of m-methoxy-MPTP and the use of its N-ethyl analog as a means of avoiding exposure to a possible Parkinson-causing agent
1986
Rapid parallel synthesis applied to the optimization of a series of potent nonpeptide neuropeptide Y-1 receptor antagonists
1999
Investigation of the N-Substituent Conformation Governing Potency and μ Receptor Subtype-Selectivity in (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)- piperidine Opioid Antagonists
1998
Identification of the First trans-(3R,4R)- Dimethyl-4-(3-hydroxyphenyl)piperidine Derivative To Possess Highly Potent and Selective Opioid κ Receptor Antagonist Activity
2001
Discovery of an Opioid κ Receptor Selective Pure Antagonist from a Library of N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphans
2002
Importance of Phenolic Address Groups in Opioid Kappa Receptor Selective Antagonists
2004
Synthesis of 9β-methyl-2-alkyl-7-oxo-5-arylmorphans
1998
Synthesis and absolute configuration of LY255582, a potent opioid antagonist
1991
Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists
1998
Identification of (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a Novel Potent and Selective Opioid κ Receptor Antagonist
2003
Identification of an Opioid κ Receptor Subtype-Selective N-Substituent for (+)-(3R,4R)-Dimethyl-4-(3-hydroxyphenyl)piperidine
1998