Citation Impact
Citing Papers
TIMP-3 Binds to Sulfated Glycosaminoglycans of the Extracellular Matrix
2000
Metalloproteinases: role in breast carcinogenesis, invasion and metastasis
2000
ADAM 12-S Cleaves IGFBP-3 and IGFBP-5 and Is Inhibited by TIMP-3
2000
Matrix metalloproteinases and their inhibitors in connective tissue remodeling
1991 Standout
Construction and characterization of the soybean leaf metalloproteinase cDNA1
1997
Completion of the primary structure of the human type IV collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16
1990
Expression of the SV40 promoter in fission yeast: Identification and characterization of an AP-1-like factor
1988 StandoutNobel
The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity
1991
Cloning and Characterization of a Novel Matrix Metalloproteinase (MMP), CMMP, from Chicken Embryo Fibroblasts
1998
Post-translational Proteolytic Processing of Procollagen C-terminal Proteinase Enhancer Releases a Metalloproteinase Inhibitor
2000
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
1998 StandoutNature
Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds.
1994
TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis
1998
Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP‐3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10
1994
Zinc coordination, function, and structure of zinc enzymes and other proteins
1990
Regulation of Collagenase Gene Expression in Synovial Fibroblastsa
1990
Disruption of the cysteine-75 and zinc ion coordination is not sufficient to activate the precursor of human matrix metalloproteinase 3 (stromelysin 1)
1993
Crystal structure of globular domain of histone H5 and its implications for nucleosome binding
1993 StandoutNatureNobel
The Role of the C-terminal Domain of Human Collagenase-3 (MMP-13) in the Activation of Procollagenase-3, Substrate Specificity, and Tissue Inhibitor of Metalloproteinase Interaction
1997
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
1996 Standout
The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation
1996
Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA Library
1995
Extrinsic regulators of epithelial tumor progression: metalloproteinases
2000
Accessibility of histone H1� and its structural domains to antibody binding in extended and folded chromatin
1990
Tissue inhibitors of metalloproteinases: evolution, structure and function
2000 Standout
Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis.
1998
Crystallization and preliminary X-ray analysis of porcine synovial collagenase
1989
Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts
1990
From tadpole collagenase to a family of matrix metalloproteinases
1988
Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis
1998
Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members
1989
Identification and Characterization of Human Endometase (Matrix Metalloproteinase-26) from Endometrial Tumor
2000
Oncogene jun encodes a sequence-specific trans- activator similar to AP-1
1988 Nature
Histone H1 is located in the interior of the chromatin 30-nm filament
1994 StandoutNatureNobel
Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
1990 Standout
Novel growth regulatory factors and tumour angiogenesis
1991
The Hallmarks of Cancer
2000 Standout
Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage.
1989
Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family
1994
Localization of the Functional Domains of Human Tissue Inhibitor of Metalloproteinases-3 and the Effects of a Sorsby's Fundus Dystrophy Mutation
1998
Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model
2000
Assessment of the Role of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) during the Periovulatory Period in Female Mice Lacking a Functional TIMP-1 Gene1
1997
Stromelysin‐1: Three‐dimensional structure of the inhibited catalytic domain and of the C‐truncated proenzyme
1995
Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) has erythroid‐potentiating activity
1992
Position and orientation of the globular domain of linker histone H5 on the nucleosome
1998 StandoutNatureNobel
Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
1990 Standout
A Novel Proteolytic Cleavage Involved in Notch Signaling
2000 Standout
IκB: a Specific Inhibitor of the NF-κB Transcription Factor
1988 StandoutScienceNobel
Tissue Inhibitor of Metalloproteinase-3 Induces a Fas-associated Death Domain-dependent Type II Apoptotic Pathway
2002
Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis
2003
Identification and Characterization of a Novel Human Matrix Metalloproteinase with Unique Structural Characteristics, Chromosomal Location, and Tissue Distribution
1997
Processing of tumour necrosis factor-α precursor by metalloproteinases
1994 Nature
Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis
2001
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
2005 StandoutNature
The microenvironment of the tumour–host interface
2001 StandoutNature
Immunity, Inflammation, and Cancer
2010 Standout
Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+
1988 StandoutNobel
Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase
1995
A Novel TIMP-3 Mutation Reveals a Common Molecular Phenotype in Sorsby's Fundus Dystrophy
2000
Expression of Human Pro-Matrix Metalloproteinase 3 that Lacks the N-terminal 34 Residues in Escherichia coli: Autoactivation and Interaction with Tissue Inhibitor of Metalloproteinase 1 (TIMP-1)
1998
Temporal expression of tissue inhibitors of metalloproteinases in mouse reproductive tissues during gestation
1993
Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors
2003
Mechanisms of Matrix Degradation in Rheumatoid Arthritisa
1990
Angiotensin-converting enzyme 2 protects from severe acute lung failure
2005 StandoutNature
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor
1998
Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development.
1990
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
1990 StandoutNature
High Resolution Structure of the N-terminal Domain of Tissue Inhibitor of Metalloproteinases-2 and Characterization of Its Interaction Site with Matrix Metalloproteinase-3
1998
Degradative processes of connective tissue proteins with special emphasis on collagenolysis and bone resorption
1988
TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)
2001
The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A
1998
Production of human plasma retinol-binding protein in Escherichia coll
1993
Matrix metalloproteinase inhibition: A review of anti-tumour activity
1995
Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix
2002
Growth‐promoting activity of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) for a wide range of cells A possible new growth factor in serum
1992
Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 Å crystal structure 1 1Edited by I. Wilson
2001 Nobel
The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases
1995
Therapeutic antibody fragments with prolonged in vivo half-lives
1999
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
1995 StandoutNobel
Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate
1990
Impact energy measurement in time-of-flight mass spectrometry with cryogenic microcalorimeters
1998 StandoutNatureNobel
Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis
1988
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
1990 StandoutNatureNobel
Proteolytic activities of human fibroblast collagenase: hydrolysis of a broad range of substrates at a single active site
1990
A matrix metalloproteinase expressed on the surface of invasive tumour cells
1994 StandoutNature
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
1997 StandoutNature
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
1996 StandoutNature
Genes that mediate breast cancer metastasis to lung
2005 StandoutNature
Membrane Type 4 Matrix Metalloproteinase (MMP17) Has Tumor Necrosis Factor-α Convertase Activity but Does Not Activate Pro-MMP2
2000
Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy
1994
Phosphorylation of c-jun mediated by MAP kinases
1991 StandoutNature
A unique signature identifies a family of zinc‐dependent metallopeptidases
1989
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
The in vitro activity of ADAM‐10 is inhibited by TIMP‐1 and TIMP‐3
2000
Implantation and the placenta: key pieces of the development puzzle
1994 StandoutScience
Tissue inhibitor of metalloproteinases‐2 inhibits bFGF‐induced human microvascular endothelial cell proliferation
1993
Changing views of the role of matrix metalloproteinases in metastasis
1997
Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures
1992
Renal clearance of quantum dots
2007 StandoutNobel
Matrix Metalloproteinases
1999 Standout
Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo.
1990
Matrix Metalloproteinases: Biologic Activity and Clinical Implications
2000
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
Cell cycle-associated accumulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) in the nuclei of human gingival fibroblasts
1998
Analysis of tissue inhibitor of metalloproteinases-2 effect on pro-matrix metalloproteinase-2 activation by membrane-type 1 matrix metalloproteinase using baculovirus/insect-cell expression system
2000
Nucleotide Sequence of Yellow Fever Virus: Implications for Flavivirus Gene Expression and Evolution
1985 StandoutScienceNobel
Tissue Engineering
1993 StandoutScience
Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease
1990
Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.
1988
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
1999 StandoutScience
Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: structure and proteolysis by tetanus toxin and botulinal neurotoxins type D and F.
1994 StandoutNobel
Accessibility of the globular domain of histones H1 and H5 to antibodies upon folding of chromatin
1987
The precursor of a metalloendopeptidase from human rheumatoid synovial fibroblasts. Purification and mechanisms of activation by endopeptidases and 4-aminophenylmercuric acetate
1988
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis
1995 StandoutScience
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 Standout
Fragments of human fibroblast collagenase. Purification and characterization
1989
Structure of the human type IV collagenase gene.
1990
A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family.
1992
Purification and properties of a small latent matrix metalloproteinase of the rat uterus.
1988
Metalloproteinase inhibition and erythroid potentiation are independent activities of tissue inhibitor of metalloproteinases-1
1995
Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides
1996
The emergence of mass spectrometry in biochemical research.
1994
The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc
1996 StandoutScience
The intracellular distribution and function of the high mobility group chromosomal proteins
1985
E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.
1993 StandoutNobel
Biological Function of the Retinoblastoma Protein Requires Distinct Domains for Hyperphosphorylation and Transcription Factor Binding
1992
Making the cut: Protease-mediated regulation of angiogenesis
2006
Identification and characterization of a novel collagenase in Xenopus laevis: possible roles during frog development.
1996
Characterization of the six chicken histone H1 proteins and alignment with their respective genes.
1987
In vitro synthesis of the active tissue inhibitor of metalloproteinases encoded by a complementary DNA from virus-infected murine fibroblasts.
1988
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase
1995
Angiogenesis: Models and Modulators
1995
Hyperoxic exposure alters gene expression in the lung
1989
Selective radiolabelling and identification of a strong nucleosome binding site on the globular domain of histone H5.
1986
Some recent advances in the chemistry and biology of transforming growth factor-beta.
1987
Recognition of tau epitopes by anti-neurofilament antibodies that bind to Alzheimer neurofibrillary tangles.
1987
SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages
1989
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
1987 Standout
Bovine H10 histone subfractions contain an invariant sequence which matches histone H5 rather than H1
1981
A gene for rabbit synovial cell collagenase: member of a family of metalloproteinases that degrades the connective tissue matrix
1987
Matrix remodeling in experimental and human heart failure: a possible regulatory role for TIMP-3
2003
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1
1997 NatureNobel
Dissociation of tissue inhibitor of metalloproteinases (TIMP) from enzyme complexes yields fully active inhibitor
1989
cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.
1990
Multistage nanoparticle delivery system for deep penetration into tumor tissue
2011 StandoutNobel
Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK
1998
Interaction of Human Rheumatoid Synovial Collagenase (Matrix Metalloproteinase 1) and Stromelysin (Matrix Metalloproteinase 3) with Human α2-Macroglobulin and Chicken Ovostatin
1989
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.
1988 StandoutNobel
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
2002 StandoutScience
Phosphorylation of histone H1 through the cell cycle of Physarum polycephalum. 24 sites of phosphorylation at metaphase.
1985
Human Fibroblast Collagenase-α-Macroglobulin Interactions
1989
Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.
1989
Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase
1989
Amino acid compositions and amino-terminal sequences of the structural proteins of a flavivirus, European Tick-Borne encephalitis virus
1983
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
The collagenase gene family in humans consists of at least four members
1988
Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.
1990
High expression of 92-kD type IV collagenase (gelatinase B) in the osteoclast lineage during mouse development
1994
The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.
1990
A Cell Culture Model for T Lymphocyte Clonal Anergy
1990 StandoutScience
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases
2003 Standout
The structure of histone H1 and its location in chromatin
1980 Nature
Identification of a Stimulator of Steroid Hormone Synthesis Isolated from Testis
1995 Science
Metalloproteinase inhibitors: biological actions and therapeutic opportunities
2002
Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.
1989
Portion-mixing peptide libraries of quenched fluorogenic substrates for complete subsite mapping of endoprotease specificity.
1994 StandoutNobel
Design and Therapeutic Application of Matrix Metalloproteinase Inhibitors
1999
Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1
1994 StandoutScience
A Novel Tissue Inhibitor of Metalloproteinases-3 Mutation Reveals a Common Molecular Phenotype in Sorsby's Fundus Dystrophy
2000
Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.
1990
Binding of gelatinases A and B to type-I collagen and other matrix components
1995
12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region.
1987
Purification of the neutral proteoglycan-degrading metalloproteinase from human articular cartilage tissue and its identification as stromelysin matrix metalloproteinase-3
1989
Tissue Inhibitor of Metalloproteinase (TIMP-2)
1989
Adenovirus-Mediated Overexpression of Tissue Inhibitor of Metalloproteinase-1 Reduces Atherosclerotic Lesions in Apolipoprotein E–Deficient Mice
1999
Preferential binding of collagenase to α2‐macroglobulin in the presence of the tissue inhibitor of metalloproteinases
1986
Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production.
1994
Works of Bryan John Smith being referenced
F(ab′)2 molecules made from Escherichia coli produced Fab′ with hinge sequences conferring increased serum survival in an animal model
1998
Matrix-assisted UV-laser desorption/ionization mass spectrometric analysis of monoclonal antibodies for the determination of carbohydrate, conjugated chelator, and conjugated drug content
1991
Reciprocated matrix metalloproteinase activation: A process performed by interstitial collagenase and progelatinase A
1994
SDS Polyacrylamide Gel Electrophoresis of Proteins
2003
Chemical Cleavage of Proteins
2003
TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3
1998
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes
1987
Immunochemical studies of high mobility group non-histone chromatin proteins HMG 1 and HMG 2
1978
Conformational Studies of Histone H1o in Comparison with Histones H1 and H5
1981
Structural homology between a mammalian H1° subfraction and avian erythrocyte‐specific histone H5
1980
Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP)
1990
Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity
1985 Nature
Comparison of human stromelysin and collagenase by cloning and sequence analysis
1986
Chromatin Proteins Share Antigenic Determinants with Neurofilaments
1985
Isolation and characterisation of subfractions of nuclear protein H1°
1980