Standout Papers
Citation Impact
Citing Papers
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
2016 StandoutScience
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a)
2018
Base triplet stepping by the Rad51/RecA family of recombinases
2015 Science
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
Rationally engineered Cas9 nucleases with improved specificity
2015 StandoutScience
Structures of the CRISPR genome integration complex
2017 StandoutScienceNobel
Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system
2016
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
2019 StandoutNobel
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
2019 StandoutNobel
Broad Targeting Specificity during Bacterial Type III CRISPR-Cas Immunity Constrains Viral Escape
2017
Structural basis for promiscuous PAM recognition in type I–E Cascade from E. coli
2016 Nature
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
2015 Standout
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
2016 StandoutNature
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
2014 Standout
Classification and evolution of type II CRISPR-Cas systems
2014 StandoutNobel
Cas3-Derived Target DNA Degradation Fragments Fuel Primed CRISPR Adaptation
2016
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Molecular mechanisms of CRISPR–Cas spacer acquisition
2018
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
DNA Targeting by a Minimal CRISPR RNA-Guided Cascade
2016 StandoutNobel
Skeletal infections: microbial pathogenesis, immunity and clinical management
2022 Standout
Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis
2018
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
Massively parallel determination and modeling of endonuclease substrate specificity
2014 StandoutNobel
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
Conformational Control of Cascade Interference and Priming Activities in CRISPR Immunity
2016
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA
2016
Adaptation in CRISPR-Cas Systems
2016 StandoutNobel
Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?
2015
Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition
2016
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System
2017
The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit
2017
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
2016 StandoutNobel
Spacer capture and integration by a type I-F Cas1–Cas2-3 CRISPR adaptation complex
2017
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
2016 Science
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning
2015 StandoutScienceNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Evolution and Ecology of CRISPR
2016
CRISPR-Cas: biology, mechanisms and relevance
2016 StandoutNobel
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference
2014 StandoutNobel
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Simultaneous precise editing of multiple genes in human cells
2019 StandoutNobel
CRISPR-Cas: Adapting to change
2017 Science
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures
2018
Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity
2017
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Understanding the Molecular Mechanisms of the CRISPR Toolbox Using Single Molecule Approaches
2018
Works of Bryan Gibb being referenced
RPA antagonizes microhomology-mediated repair of DNA double-strand breaks
2014
DNA Sequence Alignment by Microhomology Sampling during Homologous Recombination
2015
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System
2015 StandoutNobel
Bacteriophage therapy for bone and joint infections
2021
Single-Stranded DNA Curtains for Real-Time Single-Molecule Visualization of Protein–Nucleic Acid Interactions
2012