Standout Papers
- Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen‐presenting cells (1993)
- Antibodies against the T cell receptor/CD3 complex interfere with distinct intra‐thymic cell‐cell interactions in vivo: correlation with arrest of T cell differentiation (1989)
Citation Impact
Citing Papers
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2006
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2007
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Re-establishing immunological self-tolerance in autoimmune disease
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Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
1989 Nature
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2006
Molecular and Cellular Events of T Cell Development
1989
MicroRNA-205 Maintains T Cell Development following Stress by Regulating Forkhead Box N1 and Selected Chemokines
2016
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2009 StandoutNobel
CD4 + T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion
2015
The Dendritic Cell System and its Role in Immunogenicity
1991 Standout
Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice
2014
Deletion of self-reactive T cells before entry into the thymus medulla
1988 Nature
CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood CD25+ T cells
2003
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
1995 StandoutNatureNobel
Roles for MicroRNAs in Conferring Robustness to Biological Processes
2012
A decade of AIRE
2007
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4
2005 StandoutNobel
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
1994
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Nonself-Antigens Are the Cognate Specificities of Foxp3+ Regulatory T Cells
2007
Tolerance and Autoimmunity
2001
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
1992 StandoutNatureNobel
Thymic cortical epithelial cells lack full capacity for antigen presentation
1989 Nature
Developmental regulation of MHC class II transport in mouse dendritic cells
1997 StandoutNatureNobel
Origin of regulatory T cells with known specificity for antigen
2002
Tolerance and Autoimmunity: Lessons at the Bedside of Primary Immunodeficiencies
2007
Estimating the proportion of microarray probes expressed in an RNA sample
2010
Tolerance, Danger, and the Extended Family
1994 Standout
Thymic selection revisited: how essential is it?
2003
The Cellular Mechanism of Aire Control of T Cell Tolerance
2005
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
2007
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
2006 StandoutNobel
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
2010 StandoutNobel
Inducible IL-2 production by dendritic cells revealed by global gene expression analysis
2001
Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
2006
Metazoan MicroRNAs
2018 Standout
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development
2012 StandoutNobel
Taking dendritic cells into medicine
2007 StandoutNatureNobel
In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine
1989 Nature
Acquisition of immunologic self-tolerance
1989
Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice
2017
Intraclonal competition limits the fate determination of regulatory T cells in the thymus
2009
The enemy within: keeping self-reactive T cells at bay in the periphery
2002
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Virus-induced autoantibody response to a transgenic viral antigen
1990 StandoutNatureNobel
Dendritic Cells as Antigen Presenting Cellsin Vivo
1990 StandoutNobel
Control of the Immune Response at the Level of Antigen-Presenting Cells: A Comparison of the Function of Dendritic Cells and B Lymphocytes
1989 StandoutNobel
Lymphotoxin ?, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface
1993
Thymic Dendritic Cells: Phenotype and Function
1990
Constitutive Crosspresentation of Tissue Antigens by Dendritic Cells Controls CD8+ T Cell Tolerance In Vivo
2008
Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
2005 Nature
Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance
2017
Negative selection and autoimmunity
2003
Towards an integrated view of thymopoiesis
1991
Antigen presentation to naive CD4 T cells in the lymph node
2003
Regulatory T cell development in the absence of functional Foxp3
2007
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus
1989 StandoutNobel
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
Mechanisms maintaining peripheral tolerance
2009
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Autoimmune disease: why and where it occurs
2001
Mechanisms of suppression by suppressor T cells
2005
Extrathymic positive selection of αβ T-cell precursors in nude mice
1992 StandoutNatureNobel
Aire regulates negative selection of organ-specific T cells
2003
Increased antigen presenting cell‐mediated T cell activation in mice and patients without the autoimmune regulator
2006
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Selection of regulatory T cells in the thymus
2012
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
2023 StandoutNobel
Positive and Negative Selection of T Cells
2003
Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis
2003
The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity
2015
Identity of cells that imprint H–2-restricted T-cell specificity in the thymus
1986 Nature
Sequestration From Immune CD4 + T Cells of Mycobacteria Growing in Human Macrophages
1993 StandoutScienceNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes
2004
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
1998 StandoutScienceNobel
A Nondeletional Mechanism of Thymic Self Tolerance
1989 StandoutScienceNobel
Aire
2009
miR-29ab1 Deficiency Identifies a Negative Feedback Loop Controlling Th1 Bias That Is Dysregulated in Multiple Sclerosis
2012
The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.
1992
Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma
2005 Science
The function of Ia+ dendritic cells and Ia- dendritic cell precursors in thymocyte mitogenesis to lectin and lectin plus interleukin 1.
1988
Established Human Papillomavirus Type 16-Expressing Tumors Are Effectively Eradicated Following Vaccination with Long Peptides
2002
Natural Innate and Adaptive Immunity to Cancer
2011 Standout
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
1990 StandoutScienceNobel
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
1986 StandoutNatureNobel
Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo
1997
Bone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.
1985
miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a
2015
Early Events in T-Cell Maturation
1987
Self-Reactive T Cells Selected on Thymic Cortical Epithelium Are Polyclonal and Are Pathogenic In Vivo
1999
NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner
2004 StandoutNobel
An approach to isolating T cell lines that react to antigens presented on the surface of dendritic cells
1991 StandoutNobel
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
T Cell Anergy
2003
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells
2007
Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells
2001
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.
1987
Maintenance of in Vivo Tolerance by Persistence of Antigen
1992 StandoutScienceNobel
HUMAN T CELL RESPONSES AGAINST MELANOMA
2005
The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells
1990 Science
Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection
2012
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.
1987
Tolerogenic Dendritic Cells
2003 StandoutNobel
Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.
1988
Antigen Presentation and T Cell Stimulation by Dendritic Cells
2002
Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 + T Cells
1992 StandoutScienceNobel
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
2011
Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.
1996
Presentation of a Viral T Cell Epitope Expressed in the CDR3 Region of a Self Immunoglobulin Molecule
1993 StandoutScienceNobel
Low-Dose Adenovirus Vaccine Encoding Chimeric Hepatitis B Virus Surface Antigen-Human Papillomavirus Type 16 E7 Proteins Induces Enhanced E7-Specific Antibody and Cytotoxic T-Cell Responses
2005 StandoutNobel
Medullary Thymic Epithelium: A Mosaic of Epithelial “Self”?
1998
Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins.
1990 StandoutNobel
Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.
1994
Antigen-Specific FoxP3-Transduced T-Cells Can Control Established Type 1 Diabetes
2005
Unraveling Function in the TNF Ligand and Receptor Families
1994 StandoutScienceNobel
Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1
1994 StandoutNobel
Works of Bruno Kyewski being referenced
Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism
2008
The thymic medulla: a unique microenvironment for intercellular self-antigen transfer
2009
Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues
2006
Monoclonal antibodies reactive with subsets of mouse and human thymic epithelial cells.
1988
Half‐life of antigen/major histocompatibility complex class II complexes in vivo: intra‐ and interorgan variations
1993
Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
2014
Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells
2007
Antigen presentation in the thymus for positive selection and central tolerance induction
2009
Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
2000
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor
2011
Promiscuous gene expression and central T-cell tolerance: more than meets the eye
2002
Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen‐presenting cells
1993 StandoutNobel
Thymic nurse cells: possible sites of T-cell selection
1986
Self-representation in the thymus: an extended view
2004
Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: Rescue of CD4 T cell lineage without co‐engagement of TcR/CD4 by MHC class II
1995
Taking the thymus to pieces
1992
Regulating self-tolerance by deregulating gene expression
2004
How thymic antigen presenting cells sample the body's self-antigens
2010
Highly variable expression of tissue‐restricted self‐antigens in human thymus: Implications for self‐tolerance and autoimmunity
2007
An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
2007 Nature
Presentation and intercellular transfer of self antigen within the thymic microenvironment: expression of the Eα peptide-l-Ab complex by isolated thymic stromal cells
1994
Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance
2001
Self-antigen presentation by thymic stromal cells: a subtle division of labor
2000
Bone marrow as a priming site for T-cell responses to blood-borne antigen
2003
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
2001
CD4+ helper T cells are required for resistance to a highly metastatic murine tumor
1987
Antibodies against the T cell receptor/CD3 complex interfere with distinct intra‐thymic cell‐cell interactions in vivo: correlation with arrest of T cell differentiation
1989 StandoutNobel
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
2005
Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled.
1987
Phenotype of stromal cell‐associated thymocytes in situ is compatible with selection of the T cell repertoire at an “immature” stage of thymic T cell differentiation
1987
Intrathymic presentation of circulating non-major histocompatibility complex antigens
1984 Nature
The immunocompetence of murine stromal cell-associated thymocytes.
1984
A CENTRAL ROLE FOR CENTRAL TOLERANCE
2006
Lymphoepithelial interactions in the mouse thymus: phenotypic and kinetic studies on thymic nurse cells.
1982
Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters
2004
Foxp3 + CD25 + regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage
2006
Intrathymic lymphopoiesis: stromal cell-associated proliferation of T cells is independent of lymphocyte genotype.
1984
Thymocyte rosettes: multicellular complexes of lymphocytes and bone marrow-derived stromal cells in the mouse thymus.
1982
CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium
1998
Selection of a Broad Repertoire of CD4+ T Cells in H-2Ma0/0 Mice
1997
Dynamic Changes During the Immune Response in T Cell–Antigen-presenting Cell Clusters Isolated from Lymph Nodes
2003
Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation.
1986