Standout Papers
Citation Impact
Citing Papers
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
MicroRNA-Directed Cleavage of HOXB8 mRNA
2004 Science
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
c-Met is essential for wound healing in the skin
2007
Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase
1998
Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells
2010
1 Developmental roles and clinical significance of Hedgehog signaling
2003
Notch signalling controls pancreatic cell differentiation
1999 StandoutNatureNobel
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
2001 Standout
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
2012
Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1
2001
Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest
1993
NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs
2007
The initiation of the limb bud: Growth factors, Hox genes, and retinoids
1995
Vertebrate limb development
1995
Some distal limb structures develop in mice lacking Sonic hedgehog signaling
2001
Organization of the Fugu rubripes Hox clusters: evidence for continuing evolution of vertebrate Hox complexes
1997 StandoutNobel
Maintenance of functional equivalence during paralogous Hox gene evolution
2000 StandoutNatureNobel
Ikaros DNA-Binding Proteins as Integral Components of B Cell Developmental-Stage-Specific Regulatory Circuits
2007
Fgf8 is required for outgrowth and patterning of the limbs
2000 StandoutNobel
Developmental basis of limblessness and axial patterning in snakes
1999 Nature
Homeotic genes and the evolution of arthropods and chordates
1995 Nature
Embryonic induction
1993
The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo
1989 StandoutNatureNobel
Wound repair and regeneration
2008 StandoutNature
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
2009 StandoutNobel
The world according to bedgebog
1997
Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex
1996
Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage
1995
Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
2001
Helios Is Associated with CD4 T Cells Differentiating to T Helper 2 and Follicular Helper T Cells In Vivo Independently of Foxp3 Expression
2011
Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs
1993
Predominant Interaction of Both Ikaros and Helios with the NuRD Complex in Immature Thymocytes
2007
Stem cells find their niche
2001 StandoutNature
Nerve-dependent and -independent events in blastema formation during Xenopus froglet limb regeneration
2005
Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin
1998
A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth
1995
HoxGene Expression in Limbs: Colinearity by Opposite Regulatory Controls
1999
Ikaros-Family Proteins: In Search of Molecular Functions During Lymphocyte Development
2005
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
Ptc1 and Ptc2 Transcripts Provide Distinct Readouts of Hedgehog Signaling Activity during Chick Embryogenesis
2001
Local Inhibitory Action of BMPs and Their Relationships with Activators in Feather Formation: Implications for Periodic Patterning
1998
FGF-4 and BMP-2 have opposite effects on limb growth
1993 Nature
Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing
2000
The C. elegans genome sequencing project: a beginning
1992 StandoutNatureNobel
The mouse Hoxc11 gene: genomic structure and expression pattern
1998 StandoutNobel
Ikaros Sets Thresholds for T Cell Activation and Regulates Chromosome Propagation
1999
The murine Hoxc cluster contains five neighboring AbdB-related Hox genes that show unique spatially coordinated expression in posterior embryonic subregions
1994
Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
1997
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
2007 Nature
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
1990 StandoutNatureNobel
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
2011 StandoutNature
Genetic activity along 315 kb of the Drosophila chromosome
1984
Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity
1992 Nature
Reversal of axonal pathways from rhombomere 3 correlates with extra hox expression domains
1993
Neurogenetic Dissection of Learning and Short-Term Memory in Drosophila
1988
De novo design of bioactive protein switches
2019 StandoutNatureNobel
A single type of progenitor cell maintains normal epidermis
2007 Nature
Splitting Hairs
1998
Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development
2000
The Drosophila gene torso encodes a putative receptor tyrosine kinase
1989 StandoutNatureNobel
Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb
1995 StandoutNature
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells
2002 StandoutNobel
β-catenin in Epithelial Morphogenesis: Conversion of Part of Avian Foot Scales into Feather Buds with a Mutated β-Catenin
2000
Revealing the world of RNA interference
2004 StandoutNatureNobel
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions
1994 StandoutNatureNobel
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration
1991 StandoutNatureNobel
Hoxc13 mutant mice lack external hair
1998 StandoutNobel
An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
1995 StandoutNobel
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
2000 StandoutNature
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
2007 Standout
Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle
2000
Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11
1995 StandoutNatureNobel
Manifestation of the Limb Prepattern: Limb Development in the Absence of Sonic Hedgehog Function
2001
The molecular basis of hypodactyly (Hd): a deletion in Hoxa13 leads to arrest of digital arch formation
1996
Ikaros in immune receptor signaling, lymphocyte differentiation, and function
2010
Transition of Hox expression during limb cartilage development
2002
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
1996 StandoutNature
The functions of animal microRNAs
2004 StandoutNatureNobel
Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities
2004 Standout
Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling
1999
Sonic hedgehog mediates the polarizing activity of the ZPA
1993 Standout
Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis
2006 StandoutNobel
Roles for FGF8 in the Induction, Initiation, and Maintenance of Chick Limb Development
1996
A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells
2010
A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1
1994 StandoutNatureNobel
Histone acetylation and deacetylation in yeast
2003
Synthetic protein–protein interaction domains created by shuffling Cys 2 His 2 zinc‐fingers
2006
Evolutionary conserved sequences are required for the insulation of the vertebrateHoxdcomplex in neural cells
2002
P-element transformation with period locus DNA restores rhythmicity to mutant, arrhythmic drosophila melanogaster
1984 StandoutNobel
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
Wnt-7a in feather morphogenesis: involvement of anterior-posterior asymmetry and proximal-distal elongation demonstrated with an in vitro reconstitution model
1999
Autoregulation ofShhexpression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development
2000
The effect of chromosomal position on the expression of the drosophila xanthine dehydrogenase gene
1983
P transposable elements and their use as genetic tools in drosophila
1985
Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the drosophila germ line
1983
Normal limb development in conditional mutants of Fgf4
2000 StandoutNobel
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds
1993
Involvement of FGF-8 in initiation, outgrowth and patterning of the vertebrate limb
1996
Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice
1983 Science
Function of posterior HoxD genes in the morphogenesis of the anal sphincter
1996
Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice.
1995
Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals
2005
Hox10 and Hox11 Genes Are Required to Globally Pattern the Mammalian Skeleton
2003 StandoutScienceNobel
Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning
1996
Transformation of white locus DNA in Drosophila: Dosage compensation, zeste interaction, and position effects
1984
Hoxa-13 and Hoxd-13 play a crucial role in the patterning of the limb autopod
1995
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Hox genes and mammalian development.
1997 StandoutNobel
Transformation of cultured Drosophila melanogaster cells with a dominant selectable marker.
1985
Dosage compensation in Drosophila
1986
Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector
1986 StandoutNatureNobel
Keratinocyte Stem Cells: a Commentary1
2002
Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth
1997
Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity
1996
Cell fate in the chick limb bud and relationship to gene expression
1997
Regulation of number and size of digits by posterior Hox genes: A dose-dependent mechanism with potential evolutionary implications
1997
Hox genes and morphological identity: axial versus lateral patterning in the vertebrate mesoderm
2000
A Drosophila Minute gene encodes a ribosomal protein
1985 StandoutNatureNobel
The role of segment polarity genes during early oogenesis in Drosophila
1996
Diversity, topographic differentiation, and positional memory in human fibroblasts
2002
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
1998
Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb
1997
Complex brain and behavioral functions disrupted by mutations in Drosophila
1983 StandoutNobel
The limb field mesoderm determines initial limb bud anteroposterior asymmetry and budding independent of sonic hedgehog or apical ectodermal gene expressions
1996
Retroviral infection coupled with tissue transplantation limits gene transfer in the chicken embryo.
1993
The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor
1997
Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11
1994 StandoutNobel
Extrachromosomal DNA transformation of Caenorhabditis elegans.
1985
Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene.
1993
Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo.
1993
Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos.
1993
Analysis of P transposable element functions in drosophila
1984
Extrachromosomal DNA Transformation of Caenorhabditis elegans
1985
The Mating of a Fly
1994 StandoutScienceNobel
Organizing Axes in Time and Space; 25 Years of Colinear Tinkering
2003 Science
Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome
1996 StandoutScience
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb
1996
A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene
1987 StandoutNatureNobel
Developmental Control of Cell Cycle Regulators: A Fly's Perspective
1996 Science
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
1997 StandoutScience
Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
1996 StandoutScience
Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
1984 StandoutNatureNobel
A new role for Notch and Delta in cell fate decisions: patterning the feather array
1998
Synpolydactyly phenotypes correlate with size of expansions in HOXD13 polyalanine tract
1997
A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling
2000
Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells
2011 StandoutNobel
Transformation of Cultured Drosophila melanogaster Cells with a Dominant Selectable Marker
1985
Hox genes and serial homology
1993 Nature
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.
1995
Involvement of FGF8 in initiation, outgrowth and patterning of the vertebrate limb
1996
Efficient insertion of genes into the mouse germ line via retroviral vectors.
1985
Works of Bruce Morgan being referenced
Chapter 10 Manipulating Gene Expression with Replication--Competent Retroviruses
1996
Gene Expression in thelimblessMutant: Polarized Gene Expression in the Absence of Shh and an AER
1996
Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations
1992 Nature
Differential expression of myogenic regulatory genes and Msx‐1 during dedifferentiation and redifferentiation of regenerating amphibian limbs
1995
Aiolos Regulates B Cell Activation and Maturation to Effector State
1998
Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
1997
The role of homeobox genes in limb development
1993
Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud
1994 Standout
Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors
1998
Distinct Stem Cell Populations Regenerate the Follicle and Interfollicular Epidermis
2005
Stage-Specific Effects ofSonic HedgehogExpression in the Epidermis
1998
The cloned dopa decarboxylase gene is developmentally regulated when reintegrated into the drosophila genome
1983
Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut
1995
Hox genes and growth: early and late roles in limb bud morphogenesis
1994
β-catenin signaling can initiate feather bud development
1999
Hox genes and the evolution of vertebrate axial morphology
1995
Wnt signaling maintains the hair-inducing activity of the dermal papilla
2000
BMPs mediate lateral inhibition at successive stages in feather tract development
1998
Epidermal stem cells arise from the hair follicle after wounding
2007
Analysis of Hox gene expression in the chick limb bud
1996
Histone H4 and the maintenance of genome integrity.
1995