Standout Papers
Citation Impact
Citing Papers
Potent, Highly Selective, and Orally Bioavailable Gem -Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide Synthase
2010
Effective Formation of Silicone-in-Fluorocarbon-in-Water Double Emulsions: Studies on Droplet Morphology and Stability
2002
Mapping the Fluorophilicity of a Hydrophobic Pocket: Synthesis and Biological Evaluation of Tricyclic Thrombin Inhibitors Directing Fluorinated Alkyl Groups into the P Pocket
2006
Gold(I)‐Catalyzed Alkoxyhalogenation of β‐Hydroxy‐α,α‐Difluoroynones
2008
A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF⋅⋅⋅CO Interactions
2003
Fluorine as a Hydrogen‐Bond Acceptor: Experimental Evidence and Computational Calculations
2014
Straightforward One‐Pot Synthesis of Trifluoromethyl Sulfonium Salts
2006
A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKaand binding affinity and evidence for intermolecular C–F⋯CN interactions
2004
Catalysis for fluorination and trifluoromethylation
2011 StandoutNature
Introduction of Fluorine and Fluorine‐Containing Functional Groups
2013 Standout
A Weak Attractive Interaction between Organic Fluorine and an Amide Group
2004
Trifluoroacetamides from Amino Alcohols as Nucleophilic Trifluoromethylating Reagents
2003
Synthesis ofα,β-Unsaturated Amides by Olefin Cross-Metathesis
2001 StandoutNobel
The observation of a large gauche preference when 2-fluoroethylamine and 2-fluoroethanol become protonated
2004
Ortho‐Trifluoromethylation of Functionalized Aromatic Triazenes
2012
Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones
2006 StandoutNobel
Fluorine Conformational Effects in Organocatalysis: An Emerging Strategy for Molecular Design
2011
Palladium(II)‐Catalyzed Selective Monofluorination of Benzoic Acids Using a Practical Auxiliary: A Weak‐Coordination Approach
2011
Efficient 1,4-addition of α-substituted fluoro(phenylsulfonyl)methane derivatives to α,β-unsaturated compounds
2008 Nobel
Aromatic N versus aromatic F: bioisosterism discovered in RNA base pairing interactions leads to a novel class of universal base analogs
2010
Photoinduced Controlled Radical Polymerization
2010
Enantioselective α‐Fluorination of Carbonyl Compounds: Organocatalysis or Metal Catalysis?
2005
Expedient synthesis of α-substituted fluoroethenes
2012
Fluorobis(phenylsulfonyl)methane: A Fluoromethide Equivalent and Palladium‐Catalyzed Enantioselective Allylic Monofluoromethylation
2006
Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HCαCO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles
2004
Phosphoramidites: Privileged Ligands in Asymmetric Catalysis
2010 StandoutNobel
Recent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity
2015
Stereoselective Monofluoromethylation of Primary and Secondary Alcohols by Using a Fluorocarbon Nucleophile in a Mitsunobu Reaction
2007
Interactions with Aromatic Rings in Chemical and Biological Recognition
2003 Standout
A Fluorine Scan at the Catalytic Center of Thrombin: CF, COH, and COMe Bioisosterism and Fluorine Effects on pKa and log D Values
2006
The preferred all-gauche conformations in 3-fluoro-1,2-propanediol
2013
Enantioselective Formation of Stereogenic Carbon–Fluorine Centers by a Simple Catalytic Method
2005
Modern Synthetic Methods for Fluorine‐Substituted Target Molecules
2004 Standout
The Polar Hydrophobicity of Fluorinated Compounds
2004
Origin of the stability conferred upon collagen by fluorination
2009
An Unexpected and Significantly Lower Hydrogen‐Bond‐Donating Capacity of Fluorohydrins Compared to Nonfluorinated Alcohols
2012
Weak Hydrogen Bridges: A Systematic Theoretical Study on the Nature and Strength of CH⋅⋅⋅FC Interactions
2004
Fluorine in Medicinal Chemistry
2004 Standout
An overview of N-heterocyclic carbenes
2014 StandoutNature
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
2014 StandoutNobel
Room‐Temperature Nucleophilic Aromatic Fluorination: Experimental and Theoretical Studies
2006
2‐Fluoro‐1,3‐benzodithiole‐1,1,3,3‐tetraoxide: A Reagent for Nucleophilic Monofluoromethylation of Aldehydes
2010
Towards Enantioselective Nucleophilic Trifluoromethylation
2004
Olefin Metathesis Involving Ruthenium Enoic Carbene Complexes
2001 StandoutNobel
One‐Pot Synthesis of PTFEMA‐b‐PMMA‐b‐PTFEMA by Controlled Radical Polymerization with a Difunctional Initiator in Conjugation with Photoredox Catalyst of Ir(ppy)3 Under Visible Light
2013
Anion Transporters and Biological Systems
2013
Asymmetric synthesis of β-hydroxy sulfonic acids by BINAP/Ru-catalyzed hydrogenation
1999 StandoutNobel
Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions
2004
A dinuclear gold(i ) complex as a novel photoredox catalyst for light-induced atom transfer radical polymerization
2015
Fluorine in medicinal chemistry
2007 Standout
The conformation of 2-fluoroethanol — is intramolecular hydrogen bonding important?
1994
A Weak Attractive Interaction between Organic Fluorine and an Amide Group
2004
Carbon-fluorine bond formation.
2008
Fluoride ion-catalyzed generation and carbonyl addition of α-halo carbanions derived from α-halo organosilicon compounds
1988
Geometric and Electronic Structure/Function Correlations in Non-Heme Iron Enzymes
1999 Standout
Straightforward One‐Pot Synthesis of Trifluoromethyl Sulfonium Salts
2006
On the polarity of partially fluorinated methyl groups
2013
Nonaqueous Liquid Electrolytes for Lithium-Based Rechargeable Batteries
2004 Standout
A General Model for Selectivity in Olefin Cross Metathesis
2003 StandoutNobel
Ortho‐Trifluormethylierung funktionalisierter aromatischer Triazene
2012
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
New Approaches to Olefin Cross-Metathesis
1999 StandoutNobel
Ring-Closing Metathesis of Olefinic Peptides: Design, Synthesis, and Structural Characterization of Macrocyclic Helical Peptides
2001 StandoutNobel
Conversion of Supramolecular Clusters to Macromolecular Objects
1999 Science
Enantioselective Fluorination of tert-Butoxycarbonyl Lactones and Lactams Catalyzed by Chiral Pd(II)-Bisphosphine Complexes
2006
Photoinitiated atom transfer radical polymerization: Current status and future perspectives
2014
Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers
2001 StandoutScience
Direct trifluoro-methoxylation of aromatics with perfluoro-methyl-hypofluorite
2012
Enantioselective organocatalytic route to trifluoromethyl-β-amino acids using chiral bases
2007
Reactivity of a Hypervalent Iodine Trifluoromethylating Reagent toward THF: Ring Opening and Formation of Trifluoromethyl Ethers
2010
Conformational analysis. Part 28. OH⋯F hydrogen bonding and the conformation of trans-2-fluorocyclohexanol
1996
A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF⋅⋅⋅CO Interactions
2003
Copper-free click chemistry for dynamic in vivo imaging
2007 StandoutNobel
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
α-Fluoro-α-nitro(phenylsulfonyl)methane as a fluoromethyl pronucleophile: Efficient stereoselective Michael addition to chalcones
2009 Nobel
Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase
2018 StandoutNobel
Stable Carbenes
1999 Standout
Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery
2015
α-Fluorinated Ethers, Thioethers, and Amines: Anomerically Biased Species
2005
Visible‐Light‐Induced Controlled Polymerization of Hydrophilic Monomers with Ir(ppy)3 as a Photoredox Catalyst in Anisole
2014
Practical Synthesis of 1,1-Difluoro- or 1-Fluoroalkenes from 2,2,2-Trifluoroacetophenone Derivatives
2011
Fluorinated Phosphonates: Synthesis and Biomedical Application
2006
Multi-State Regulation of the Dihydrogen Phosphate Binding Affinity to a Light- and Heat-Responsive Bis-Urea Receptor
2014 StandoutNobel
Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of Ketones
2001 StandoutNobel
Synthesis of Methylene- and Alkylidenecyclopropane Derivatives
1998
Photocatalyzed Cu-Based ATRP Involving an Oxidative Quenching Mechanism under Visible Light
2015
Some influences of fluorine in bioorganic chemistry
1997
Conformational analysis. Part 22. An NMR and theoretical investigation of the gauche effect in fluoroethanols
1994
α,β,γ-Trifluoroalkanes: A Stereoselective Synthesis Placing Three Vicinal Fluorines along a Hydrocarbon Chain
2004
Monodisperse Double Emulsions Generated from a Microcapillary Device
2005 StandoutScience
Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept
2017
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
Two Dimensional Chiral Networks Emerging from the Aryl−F···H Hydrogen-Bond-Driven Self-Assembly of Partially Fluorinated Rigid Molecular Structures
2008 StandoutNobel
Enantioselective Formation of Stereogenic Carbon–Fluorine Centers by a Simple Catalytic Method
2005
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Metal-Mediated Reductive Hydrodehalogenation of Organic Halides
2002
A New Reagent for Direct Difluoromethylation
2012
Fluorobis(phenylsulfonyl)methane: A Fluoromethide Equivalent and Palladium‐Catalyzed Enantioselective Allylic Monofluoromethylation
2006
Gold(I)‐Catalyzed Alkoxyhalogenation of β‐Hydroxy‐α,α‐Difluoroynones
2008
Fluorinated Ylides and Related Compounds
1996
Reactions of ethyl bromodifluoroacetate in the presence of copper powder
2004
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Ab initiocalculation of molar volumes: Comparison with experiment and use in solvation models
1995
Reversal of the Apparent Regiospecificity of NAD(P)H-Dependent Hydride Transfer: The Properties of the Difluoromethylene Group, A Carbonyl Mimic
2003
Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions
2014
Fluorine Scan of Inhibitors of the Cysteine Protease Human Cathepsin L: Dipolar and Quadrupolar Effects in the π‐Stacking of Fluorinated Phenyl Rings on Peptide Amide Bonds
2016
Polyfluorinated Ethanes as Versatile Fluorinated C2-Building Blocks for Organic Synthesis
2015
PFAS Exposure Pathways for Humans and Wildlife: A Synthesis of Current Knowledge and Key Gaps in Understanding
2020
Fluorinated Carbonyl and Olefinic Compounds: Basic Character and Asymmetric Catalytic Reactions
2003
Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity
2010 StandoutNobel
From Bifunctional to Trifunctional (Tricomponent Nucleophile–Transition Metal–Lewis Acid) Catalysis: The Catalytic, Enantioselective α-Fluorination of Acid Chlorides
2011
Methods of preparation ofC-substituted phosphorus ylides and their application in organic synthesis
1997
Three-Membered-Ring-Based Molecular Architectures
2006
Trimethylsilyl fluorosulfonyldifluoroacetate (TFDA): a new, highly efficient difluorocarbene reagent
2004
Nucleophilic substitution of optically active 1-alkoxypolyfluoroalkyl sulfonates
1998
Important fluorinated drugs in experimental and clinical use
2002
Stereoselective Monofluoromethylation of Primary and Secondary Alcohols by Using a Fluorocarbon Nucleophile in a Mitsunobu Reaction
2007 Nobel
2‐Fluoro‐1,3‐benzodithiole‐1,1,3,3‐tetraoxide: A Reagent for Nucleophilic Monofluoromethylation of Aldehydes
2010
A Stable Four-Membered N-Heterocyclic Carbene
2004 StandoutNobel
Metabolism of Fluorine-Containing Drugs
2001
New Methodology for the Deoxygenative Difluoromethylenation of Aldehydes and Ketones; Unexpected Formation of Tetrafluorocyclopropanes
2005
Room Temperature Asymmetric Allylic Trifluoromethylation of Morita–Baylis–Hillman Carbonates
2011
The SF5‐Unit as Steric Protecting Group; Synthesis and Structure of F5SCSF3
1988
Photoinduced Electron Transfer Reactions for Macromolecular Syntheses
2016
Palladium(II)‐Catalyzed Selective Monofluorination of Benzoic Acids Using a Practical Auxiliary: A Weak‐Coordination Approach
2011
DNA-Based Asymmetric Catalysis: Sequence-Dependent Rate Acceleration and Enantioselectivity
2008 StandoutNobel
Disulfonimide-Catalyzed Asymmetric Synthesis of β3-Amino Esters Directly from N-Boc-Amino Sulfones
2013 StandoutNobel
Palladium-Catalyzed Oxidative Aryltrifluoromethylation of Activated Alkenes at Room Temperature
2011
Fluorinated Carbenes
1996
Light-Controlled Radical Polymerization: Mechanisms, Methods, and Applications
2016 Standout
Photoirradiated Atom Transfer Radical Polymerization with an Alkyl Dithiocarbamate at Ambient Temperature
2010
Radical Trifluoromethylation of Titanium Ate Enolate
2005
Metal-Catalyzed Living Radical Polymerization
2001 Standout
Photoredox Catalysis in Organic Chemistry
2016 Standout
A Novel and Highly Efficient Synthesis of gem-Difluorocyclopropanes
2000
Advances in Copper Complexes as Anticancer Agents
2013 Standout
Recent progress in the use of photoirradiation in living radical polymerization
2012
Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450 BM3 demethylases
2009 StandoutNobel
Well-controlled atom transfer radical polymerizations of acrylates using recyclable niobium complex nanoparticle as photocatalyst under visible light irradiation
2015
Cation−π Interactions in Ligand Recognition by Serotonergic (5-HT3A) and Nicotinic Acetylcholine Receptors: The Anomalous Binding Properties of Nicotine
2002
Fluorine chemistry at the millennium
2004
Photochemically Mediated Atom Transfer Radical Polymerization of Methyl Methacrylate Using ppm Amounts of Catalyst
2012
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
2013 Standout
Fluorinated organometallics: Perfluoroalkyl and functionalized perfluoroalkyl organometallic reagents in organic synthesis
1992
Anisotropy of the Induced Current Density (ACID), a General Method To Quantify and Visualize Electronic Delocalization
2005 Standout
Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability
2016
Per- and polyfluoroalkyl substances in the environment
2022 StandoutScience
Room‐Temperature Nucleophilic Aromatic Fluorination: Experimental and Theoretical Studies
2006
Quantum Mechanical Continuum Solvation Models
2005 Standout
Improved performance of lithium-ion cells with the use of fluorinated carbonate-based electrolytes
2003
The Development of L2X2RuCHR Olefin Metathesis Catalysts: An Organometallic Success Story
2000 StandoutNobel
Synthesis of CF3-Substituted Sulfoximines from Sulfonimidoyl Fluorides
2011
Visible light-induced controlled radical polymerization of methacrylates with perfluoroalkyl iodide as the initiator in conjugation with a photoredox catalyst fac-[Ir(ppy)]3
2014
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Cellulose grafting by photoinduced controlled radical polymerisation
2014
Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions
2008
Difluorophenylsulfanylmethyl Radical and Difluoromethylene Diradical Synthons: gem-Difluoromethylene Building Block
2004
Solar Synthesis: Prospects in Visible Light Photocatalysis
2014 StandoutScience
Diethyl bromodifluoromethylphosphonate: a highly efficient and environmentally benign difluorocarbene precursor
2009
Electrophilic reactions of fluorocarbons under the action of aluminum chlorofluoride, a potent Lewis acid
1996
Asymmetric Enamine Catalysis
2007 StandoutNobel
An efficient catalytic enantioselective fluorination of β-ketophosphonates using chiral palladium complexes
2005
New approaches to enantioselective fluorination: Cinchona alkaloids combinations and chiral ligands/metal complexes
2007
The Coordination Chemistry of the CF Unit in Fluorocarbons
1997
Dimanganese decacarbonyl/2-cyanoprop-2-yl-1-dithionaphthalate: toward sunlight induced RAFT polymerization of MMA
2014
ATRP with a light switch: photoinduced ATRP using a household fluorescent lamp
2014
Confinement-Controlled, Either syn- or anti-Selective Catalytic Asymmetric Mukaiyama Aldolizations of Propionaldehyde Enolsilanes
2021 StandoutNobel
Visible Light and Sunlight Photoinduced ATRP with ppm of Cu Catalyst
2012
Innate C-H trifluoromethylation of heterocycles
2011
Copper Catalyzed Cross-Coupling of Iodobenzoates with Bromozinc-difluorophosphonate
2012
Methods for the synthesis of gem-difluoromethylene compounds
1996
Redox Control of the Binding Modes of an Organic Receptor
2015 StandoutNobel
Enlightening the Mechanism of Copper Mediated PhotoRDRP via High-Resolution Mass Spectrometry
2015
Highly enantioselective fluorination reactions of β-ketoesters and β-ketophosphonates catalyzed by chiral palladium complexes
2006
Wechselwirkungen mit aromatischen Ringen in chemischen und biologischen Erkennungsprozessen
2003
Works of Bruce E. Smart being referenced
Rate of Cyclization of Perfluoro-4-Oxa-5-hexenyl Radical. Use of Tributylgermanium Hydride as an Effective H-Transfer Agent for Perfluoro-n-alkenyl Radicals
1996
Rate constants for hydrogen abstraction from alkoxides by a perfluoroalkyl radical. An oxyanion accelerated processElectronic supplementary information (ESI) available: Tables of kinetic data and plots of kinetic data. See http://www.rsc.org/suppdata/ob/b4/b405074f
2004
Rates of 1,5-Hydrogen Abstraction in 1,1,2,2-Tetrafluoro-n-pentyl and 1,1,2,2,3,3-Hexafluoro-n-pentyl Radicals
1999
Fluorocarbanion chemistry. A versatile synthesis of functionalized fluoro ketones
1986
Preface
2003
Introduction: Fluorine Chemistry
1996
Are fluorocarbon chains stiffer than hydrocarbon chains? Dynamics of end-to-end cyclization in a C8F16 segment monitored by fluorescence
1990
Fluorine substituent effects (on bioactivity)
2001 Standout
Use of Gas-Phase 1H NMR to Determine the Kinetics of Unimolecular Rearrangement of 2,2-Dichloro-1-methylenecyclopropane and the Bimolecular Dimerization of (Dichloromethylene)cyclopropane
2002
Stable perfluoroalkyl carbanion salts
1986
A Remarkable Visible Light Effect on Atom-Transfer Radical Polymerization
2000
Electronic structure and conformational analysis of 1,2-difluoroethane
1988
A New Synthesis of Fluorinated Oxetanes
1995
Conformational energies of 2-fluoroethanol and 2-fluoroacetaldehyde enol: strength of the internal hydrogen bond
1991
The [2 + 2] and [2 + 4] cycloadditions of difluoromethylenecyclopropanes
1986
Phosphine- and phosphite-mediated difluorocarbene exchange reactions of (bromodifluoromethyl)phosphonium salts. Evidence for facile dissociation of (difluoromethylene)triphenylphosphorane
1983
Molecular structure and electronic properties of CF3C.tplbond.SF3
1986
The structures and energetics of fluorine-substituted phosphonium ylides
1986
Stable trifluoromethylated allyl and heteroallyl anions: structure and dynamic properties
1986
Thermal Isomerizations of Fluorinated Spiropentanes
1981
Structures and stabilities of fluorinated carbanions. Evidence for anionic hyperconjugation
1986
Ketone perfluoro enolates: regioselective and stereoselective synthesis, unique reactivities, and electronic properties
1990
Sulfonation of acyclic fluorovinyl ethers
1977
Geometries and energies of the fluoroethylenes
1986
A novel reaction of sulfur trioxide with fluoro olefins
1976
Reactivity of Fluorinated Alkyl Radicals in Solution. Some Absolute Rates of Hydrogen-Atom Abstraction and Cyclization
1994