Citation Impact
Citing Papers
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells
2005 StandoutScience
Merlin/ NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane
2005
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C
2003 StandoutNobel
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension
2019 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The GIT Family of ADP-ribosylation Factor GTPase-activating Proteins
2000 StandoutNobel
‘Ins and outs’ of seven-transmembrane receptor signalling to ERK
2004
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1
2001 StandoutNobel
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
2005 Standout
Inflammation and metabolic disorders
2006 StandoutNature
β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation
2002 StandoutNobel
Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor
2004 StandoutNobel
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Oxidative stress and gene regulation
2000
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Loss of Net as Repressor Leads to Constitutive Increased c-fos Transcription in Cervical Cancer Cells
2004 StandoutNobel
Phosphatidylinositol 3-Kinase Signaling Inhibits DAF-16 DNA Binding and Function via 14-3-3-dependent and 14-3-3-independent Pathways
2001 StandoutNobel
Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338
2000
Negative Regulation of ERK and Elk by Protein Kinase B Modulates c-fos Transcription
2003
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Ras Activation of the Raf Kinase: Tyrosine Kinase Recruitment of the MAP Kinase Cascade
2001
Ras - a versatile cellular switch
1998
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
1999 StandoutNobel
The Hallmarks of Cancer
2000 Standout
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
1998 StandoutNobel
Vav1 Transduces T Cell Receptor Signals to the Activation of the Ras/ERK Pathway via LAT, Sos, and RasGRP1
2004
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
2004 Standout
Protein Kinase A Blocks Raf-1 Activity by Stimulating 14-3-3 Binding and Blocking Raf-1 Interaction with Ras
2003
The Molecular and Genetic Basis of Neurological Tumours
2002
Fibronectin, integrins, and growth control
2001
Modulation of Kinase Activity and Oncogenic Properties by Alternative Splicing Reveals a Novel Regulatory Mechanism for B-Raf
1998
Phosphorylation and Functional Inactivation of TSC2 by Erk
2005 Standout
Nrk, an X-linked Protein Kinase in the Germinal Center Kinase Family, Is Required for Placental Development and Fetoplacental Induction of Labor
2011 StandoutNobel
Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
2000
A Tyrosine-phosphorylated Protein That Binds to an Important Regulatory Region on the Cool Family of p21-activated Kinase-binding Proteins
1999
MAP kinase pathways
1999
Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak
2000
Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading
1999
The RASSF1A Tumor Suppressor Activates Bax via MOAP-1
2005
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
1999
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Negative regulation of the serine/threonine kinase B-Raf by Akt
2000
TGFβ in Cancer
2008 Standout
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
2007
Different Properties of SEK1 and MKK7 in Dual Phosphorylation of Stress-induced Activated Protein Kinase SAPK/JNK in Embryonic Stem Cells
2003 StandoutNobel
Mammalian MAP kinase signalling cascades
2001 StandoutNature
Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein
2008
NF-κB Is Required for UV-Induced JNK Activation via Induction of PKCδ
2006
β-Arrestin–mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection
2007 StandoutNobel
Rho and Rac Take Center Stage
2004 Standout
New Insights into the Control of MAP Kinase Pathways
1999
AKT/PKB Signaling: Navigating the Network
2017 Standout
The Ste20 group kinases as regulators of MAP kinase cascades
2001
Systematic Mutagenesis of α-Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
2012 StandoutNobel
GIT Proteins, A Novel Family of Phosphatidylinositol 3,4,5-Trisphosphate-stimulated GTPase-activating Proteins for ARF6
2000 StandoutNobel
The Evolution of the MAP Kinase Pathways: Coduplication of Interacting Proteins Leads to New Signaling Cascades
1999
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Ras and Rho GTPases
2000
Integrins
2002 Standout
Nf1-Dependent Tumors Require a Microenvironment Containing Nf1+/−- and c-kit-Dependent Bone Marrow
2008
TAK1 Mitogen-activated Protein Kinase Kinase Kinase Is Activated by Autophosphorylation within Its Activation Loop
2000
Zinc fingers are sticking together
1998
Positive and negative regulation of Raf kinase activity and function by phosphorylation
2001
The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
2008 StandoutNobel
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
Physical Association with Ras Enhances Activation of Membrane-bound Raf (RafCAAX)
1997
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
The Stability of the G Protein-coupled Receptor-β-Arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation
2003 StandoutNobel
A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity
2008 StandoutNobel
The extended protein kinase C superfamily
1998
Biology of the p21-Activated Kinases
2003
Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt
1999 Science
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
2000
KSR stimulates Raf-1 activity in a kinase-independent manner
1997
Two distinct classes of Ran-binding sites on the nucleoporin Nup-358
1999 StandoutNobel
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
Identification of a Motif in the Carboxyl Terminus of β-Arrestin2 Responsible for Activation of JNK3
2001 StandoutNobel
Myocyte Adrenoceptor Signaling Pathways
2003 StandoutScienceNobel
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
1999 Standout
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity
2000 StandoutNobel
Semisynthesis and Folding of the Potassium Channel KcsA
2002 StandoutNobel
The Strength of Interaction at the Raf Cysteine-Rich Domain Is a Critical Determinant of Response of Raf to Ras Family Small GTPases
1999
Small Guanine Nucleotide-Binding Proteins and Myocardial Hypertrophy
2000
Insulin signal transduction through protein kinase cascades
1998
Transforming Growth Factor β Signaling via Ras in Mesenchymal Cells Requires p21-Activated Kinase 2 for Extracellular Signal-Regulated Kinase-Dependent Transcriptional Responses
2007
Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate
2004
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
2000
Negative Regulation of the Serine/Threonine Kinase B-Raf by Akt
2000
The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf
2000
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
2001 Standout
Signal Transduction through MAP Kinase Cascades
1998 Standout
Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C
1998 Science
p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts
1999
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Works of Bruce Diaz being referenced
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
1998 Nature
Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms
1998
Activation of Raf-1 Signaling by Protein Kinase C through a Mechanism Involving Raf Kinase Inhibitory Protein
2003
Hyperactivation of P21ras and the Hematopoietic-Specific Rho Gtpase, Rac2, Cooperate to Alter the Proliferation of Neurofibromin-Deficient Mast Cells in Vivo and in Vitro
2001
Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling
1997
An Intact Raf Zinc Finger Is Required for Optimal Binding to Processed Ras and for Ras-Dependent Raf Activation In Situ
1997