Standout Papers
- Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein. (1989)
- MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos (1996)
- The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos (1993)
- Correct integration of retroviral DNA in vitro (1987)
- A nucleoprotein complex mediates the integration of retroviral DNA. (1989)
Citation Impact
Citing Papers
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Wnt Gradient Formation Requires Retromer Function in Wnt-Producing Cells
2006 Science
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
2008 StandoutScienceNobel
MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4-and PAR-1-dependent phosphorylation
2008
Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation
2009 StandoutScience
A Putative Catenin–Cadherin System Mediates Morphogenesis of the Caenorhabditis elegans Embryo
1998
Distinct Populations of Primary and Secondary Effectors During RNAi in C. elegans
2006 StandoutScienceNobel
The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
1998 Nature
Processing of Viral DNA Ends Channels the HIV-1 Integration Reaction to Concerted Integration*[boxs]
2005
SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation
2014
MEX-5 and MEX-6 Function to Establish Soma/Germline Asymmetry in Early C. elegans Embryos
2000
The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans
2002
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
2003 Nature
LIN-12/Notch signaling: lessons from worms and flies
1998
C. elegans PAR Proteins Function by Mobilizing and Stabilizing Asymmetrically Localized Protein Complexes
2004
A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegans
1998
P Granules in the Germ Cells of Caenorhabditis elegans Adults Are Associated with Clusters of Nuclear Pores and Contain RNA
2000
Form of the worm:
2000
Fv1. the mouse retrovirus resistance gene
1998
Wnt Regulates Spindle Asymmetry to Generate Asymmetric Nuclear β-Catenin in C. elegans
2011
MicroRNAs
2004 Standout
How signaling between cells can orient a mitotic spindle
2011
β-catenin: a key mediator of Wnt signaling
1998
Cytokinesis in eukaryotes: a mechanistic comparison
1999
HIV DNA Integration
2012
Oncogenic potential of a C.eleganscdc25 gene is demonstrated by a gain-of-function allele
2002
RNA interference: genetic wand and genetic watchdog
2000
Wnt Signals and Frizzled Activity Orient Anterior-Posterior Axon Outgrowth in C. elegans
2006
PGL-1, a Predicted RNA-Binding Component of Germ Granules, Is Essential for Fertility in C. elegans
1998
Evidence for Direct Involvement of the Capsid Protein in HIV Infection of Nondividing Cells
2007
POP-1 and Anterior–Posterior Fate Decisions in C. elegans Embryos
1998
Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer
2005
Drosophila Wnt-1 Undergoes a Hydrophobic Modification and Is Targeted to Lipid Rafts, a Process That Requires Porcupine
2004
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
1997 StandoutNobel
Integration of the Unfolded Protein and Oxidative Stress Responses through SKN-1/Nrf
2013
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans
2000
Mammalian Ryk Is a Wnt Coreceptor Required for Stimulation of Neurite Outgrowth
2004 Nobel
Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans
2008
Asymmetric cortical and nuclear localizations of WRM-1/β-catenin during asymmetric cell division in C. elegans
2005
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
1998 StandoutNatureNobel
Getting into shape: epidermal morphogenesis in Caenorhabditis elegans embryos
2000
Genotoxicity of Retroviral Integration In Hematopoietic Cells
2006
A superfamily of membrane-bound O -acyltransferases with implications for Wnt signaling
2000
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
2000 StandoutNatureNobel
The KLHL12–Cullin-3 ubiquitin ligase negatively regulates the Wnt–β-catenin pathway by targeting Dishevelled for degradation
2006
Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells
2006
The Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in Caenorhabditis elegans
2013
HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
1991
par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
1995
Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-κB-dependent innate immune responses
2001
Identification of genes expressed in C. elegans touch receptor neurons
2002 StandoutNatureNobel
SRC-1 and Wnt Signaling Act Together to Specify Endoderm and to Control Cleavage Orientation in Early C. elegans Embryos
2002 StandoutNobel
Wnt signaling: a common theme in animal development
1997 Standout
Crystal structure of a β-catenin/Axin complex suggests a mechanism for the β-catenin destruction complex
2003
The SAD-1 Kinase Regulates Presynaptic Vesicle Clustering and Axon Termination
2001
The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo
1994
HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots
2002 Standout
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
2003
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
β-Catenin is a Nek2 substrate involved in centrosome separation
2007
Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion
2006
Wnt and calcium signaling: β-Catenin-independent pathways
2005
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
2000 StandoutNature
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
A Global Profile of Germline Gene Expression in C. elegans
2000
BTB/POZ Domain Proteins Are Putative Substrate Adaptors for Cullin 3 Ubiquitin Ligases
2003
Wnt Signals Can Function as Positional Cues in Establishing Cell Polarity
2006
C. elegans LIN-18 Is a Ryk Ortholog and Functions in Parallel to LIN-17/Frizzled in Wnt Signaling
2004
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
MX2 is an interferon-induced inhibitor of HIV-1 infection
2013 StandoutNatureNobel
Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection
1992
The immune response of Drosophila
2003 StandoutNatureNobel
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
1997 StandoutNature
Mitochondrial SKN-1/Nrf Mediates a Conserved Starvation Response
2012
Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling
2000
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans
2015
Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context
2006
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
Dynamics of a Developmental Switch: Recursive Intracellular and Intranuclear Redistribution of Caenorhabditis elegans POP-1 Parallels Wnt-Inhibited Transcriptional Repression
2002
Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo
1996
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans
2002 StandoutNobel
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
2007 StandoutNatureNobel
Integration complexes derived from HIV vectors for rapid assays in vitro
1999
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
Restriction of multiple divergent retroviruses by Lv1 and Ref1
2003
Binary specification of the embryonic lineage in Caenorhabditis elegans
1997 Nature
Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate β-Catenin-dependent Gene Expression
2006
The anaphase-promoting complex: it's not just for mitosis any more
2002
Distinct β-catenins mediate adhesion and signalling functions in C. elegans
2000 Nature
Phosphorylation by the β-Catenin/MAPK Complex Promotes 14-3-3-Mediated Nuclear Export of TCF/POP-1 in Signal-Responsive Cells in C. elegans
2004
Neurogenesis and the Cell Cycle
2003
Efflux-dependent auxin gradients establish the apical–basal axis of Arabidopsis
2003 StandoutNature
Hotspots for unselected Ty1 transposition events on yeast chromosome III are near tRNA genes and LTR sequences
1993
HIV-1 cDNA Integration: Requirement of HMG I(Y) Protein for Function of Preintegration Complexes In Vitro
1997
Geometric analysis and comparison of protein-DNA interfaces: why is there no simple code for recognition? 1 1Edited by R. Ebright
2000
The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos
1992 StandoutNobel
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
The power of the 3′ UTR: translational control and development
2003
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Revealing the world of RNA interference
2004 StandoutNatureNobel
Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis
1999
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation
2004 Nature
pop-1 Encodes an HMG box protein required for the specification of a mesoderm precursor in Early C. elegans embryos
1995
Two neurons mediate diet-restriction-induced longevity in C. elegans
2007 Nature
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans
2001
Highly preferred targets for retrovirus integration
1988
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans
2002 StandoutNobel
Pathway to Totipotency: Lessons from Germ Cells
2006
Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos
2005 StandoutNobel
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement
2009
The Survivin-like C. elegans BIR-1 Protein Acts with the Aurora-like Kinase AIR-2 to Affect Chromosomes and the Spindle Midzone
2000 StandoutNobel
MOM-4, a MAP Kinase Kinase Kinase–Related Protein, Activates WRM-1/LIT-1 Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection
2001
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
2003 Standout
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system
1998 Nature
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
An analysis of the response to gut induction in the C. elegans embryo
1995
Specification of anterior-posterior differences within the AB lineage in the C. elegans embryo: a polarising induction
1995
Capsid Is a Dominant Determinant of Retrovirus Infectivity in Nondividing Cells
2004
Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time
2017
A Genetic Analysis of the Caenorhabditis elegans Detoxification Response
2017
Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation
2007 Science
BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase
2004
Combinatorial RNA interference indicates GLH-4 can compensate for GLH-1; these two P granule components are critical for fertility in C. elegans
2000
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
2008 StandoutScienceNobel
An actin-mediated two-step mechanism is required for ventral enclosure of the C. elegans hypodermis
1997
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence
2015
Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours
2004
AIR-2: An Aurora/Ipl1-related Protein Kinase Associated with Chromosomes and Midbody Microtubules Is Required for Polar Body Extrusion and Cytokinesis in Caenorhabditis elegans Embryos
1998
Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP
2004
Genome-wide analysis of developmental and sex-regulated gene expression profiles in Caenorhabditis elegans
2000
Wnt signaling and cancer
2000 Standout
Segregation of germ granules in living Caenorhabditis elegans embryos: cell-type-specific mechanisms for cytoplasmic localisation
1996
Duels without obvious sense: counteracting inductions involved in body wall muscle development in the Caenorhabditis elegans embryo
1995
Multiple potential germ-line helicases are components of the germ-line-specific P granules of Caenorhabditis elegans
1996
Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition
1997
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
2016 StandoutNobel
The expression of the C. elegans labial-like Hox gene ceh-13 during early embryogenesis relies on cell fate and on anteroposterior cell polarity
1997
The Caenorhabditis elegans LIN-26 protein is required to specify and/or maintain all non-neuronal ectodermal cell fates
1996 StandoutNobel
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Chromosome Structure and Human Immunodeficiency Virus Type 1 cDNA Integration: Centromeric Alphoid Repeats Are a Disfavored Target
1998
Distribution of targets for avian retrovirus DNA integration in vivo.
1994
Integration of human immunodeficiency virus type 1 DNA in vitro.
1990
Transcriptionally active genome regions are preferred targets for retrovirus integration
1990
Dissection of Cell Division Processes in the One Cell Stage Caenorhabditis elegans Embryo by Mutational Analysis
1999
The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo
1998
Physical properties of the Creutzfeldt-Jakob disease agent
1989
Establishment of gut fate in the E lineage of C. elegans: the roles of lineage-dependent mechanisms and cell interactions
1993
RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
1998 StandoutNobel
Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans
2015 StandoutNobel
Integration of human immunodeficiency virus DNA: adduct interference analysis of required DNA sites.
1992
Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans
1994 StandoutNobel
The β-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development
1998
THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE
2004 Standout
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
2005
Human immunodeficiency virus integration in a cell-free system
1990
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Launching the germline in Caenorhabditis elegans: regulation of gene expression in early germ cells
1999
Simian virus 40 minichromosomes as targets for retroviral integration in vivo.
1992
ZYG-9, A Caenorhabditis elegans Protein Required for Microtubule Organization and Function, Is a Component of Meiotic and Mitotic Spindle Poles
1998
Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection.
1993
Human DNA Repair Genes
2001 StandoutScienceNobel
RNAi in C. elegans : Soaking in the Genome Sequence
1998 StandoutScienceNobel
Cell polarity in early C. elegans development
1993
The role of Axin2 in calvarial morphogenesis and craniosynostosis
2005
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
The C. elegans MEX-1 protein is present in germline blastomeres and is a P granule component
1997
The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 inCaenorhabditis elegans
2009
Early transcription inCaenorhabditis elegansembryos
1994
Human immunodeficiency virus type 1 may preferentially integrate into chromatin occupied by L1Hs repetitive elements.
1994
Disruption of the terminal base pairs of retroviral DNA during integration.
1997
Relationship between Retroviral DNA Integration and Gene Expression
2000
Reversal of Integration and DNA Splicing Mediated by Integrase of Human Immunodeficiency Virus
1992 Science
LIN-5 Is a Novel Component of the Spindle Apparatus Required for Chromosome Segregation and Cleavage Plane Specification in Caenorhabditis elegans
2000 StandoutNobel
Works of Bruce Bowerman being referenced
Wnt signalling in Caenorhabditis elegans : regulating repressors and polarizing the cytoskeleton
2000
Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell
1999
Centrosome Maturation and Mitotic Spindle Assembly in C. elegans Require SPD-5, a Protein with Multiple Coiled-Coil Domains
2002
Neddylation and Deneddylation of CUL-3 Is Required to Target MEI-1/Katanin for Degradation at the Meiosis-to-Mitosis Transition in C. elegans
2003
MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans
1999 Nature
Heads or Tails
2002
MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos
1996 StandoutNobel
Cell polarity in the early Caenorhabditis elegans embryo
1999
Dynein Modifiers in C. elegans: Light Chains Suppress Conditional Heavy Chain Mutants
2007
β-Catenin Asymmetries after All Animal/Vegetal- Oriented Cell Divisions in Platynereis dumerilii Embryos Mediate Binary Cell-Fate Specification
2007
3 Maternal Control of Pattern Formation in Early Caenorhabditis elegans Embryos
1998
Determinants of blastomere identity in the early C. elegans embryo
1995
Restriction of Mesendoderm to a Single Blastomere by the Combined Action of SKN-1 and a GSK-3β Homolog Is Mediated by MED-1 and -2 in C. elegans
2001
A new DNA-binding motif in the Skn-1 binding domain–DNA complex
1998
Wnt Signaling Polarizes an Early C. elegans Blastomere to Distinguish Endoderm from Mesoderm
1997
The Anaphase-Promoting Complex and Separin Are Required for Embryonic Anterior-Posterior Axis Formation
2002
Multiple Wnt Signaling Pathways Converge to Orient the Mitotic Spindle in Early C. elegans Embryos
2004
Asymmetric cell division: fly neuroblast meets worm zygote
2001
skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo
1992
The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase
2003 Nature
The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryos
1993 StandoutNobel
The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
1999 Nature
The Nonmuscle Myosin Regulatory Light Chain Gene mlc-4 Is Required for Cytokinesis, Anterior-Posterior Polarity, and Body Morphology during Caenorhabditis elegans Embryogenesis
1999
Metaphase to Anaphase (mat) Transition–Defective Mutants inCaenorhabditis elegans
2000
Degrade to create: developmental requirements for ubiquitin-mediated proteolysis during earlyC. elegansembryogenesis
2006
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein.
1989 StandoutNobel
Correct integration of retroviral DNA in vitro
1987 StandoutNobel
cyk-1: a C. elegans FH gene required for a late step in embryonic cytokinesis
1998
The maternal par genes and the segregation of cell fate specification activities in early Caenorhabditis elegans embryos
1997
A nucleoprotein complex mediates the integration of retroviral DNA.
1989 StandoutNobel
Time-dependent responses to glp-1-mediated inductions in early C. elegans embryos
1996
The maternal genespn-4encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in earlyC. elegansembryos
2001
Cell Polarity and the Cytoskeleton in theCaenorhabditis ElegansZygote
2003
High-Throughput Cloning of Temperature-Sensitive Caenorhabditis elegans Mutants with Adult Syncytial Germline Membrane Architecture Defects
2015
Cell interactions involved in development of the bilaterally symmetrical intestinal valve cells during embryogenesis in Caenorhabditis elegans
1992
The Promise and Perils of Wnt Signaling Through β-Catenin
2002 Science
Cytoskeletal Regulation by the Nedd8 Ubiquitin-Like Protein Modification Pathway
2002 Science
Formation of a Monomeric DNA Binding Domain by Skn-1 bZIP and Homeodomain Elements
1994 Science
Two maternal genes, apx-1 and pie-1, are required to distinguish the fates of equivalent blastomeres in the early Caenorhabditis elegans embryo
1994