Citation Impact
Citing Papers
Accelerated telomere shortening in response to life stress
2004 StandoutNobel
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
2005 StandoutScience
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
2006
Hallmarks of Cancer: The Next Generation
2011 Standout
EGFR associated expression profiles vary with breast tumor subtype
2007
Reversal of Senescence in Mouse Fibroblasts through Lentiviral Suppression of p53
2003
The DNA-damage response in human biology and disease
2009 StandoutNature
Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation
2004
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
2002 Nature
The RB and p53 pathways in cancer
2002 Standout
A view on drug resistance in cancer
2019 StandoutNature
Replicative senescence: a critical review
2004
Mechanisms of cellular senescence in human and mouse cells
2004
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
2007 StandoutNobel
Crystal structure of parallel quadruplexes from human telomeric DNA
2002 StandoutNature
Cellular senescence: when bad things happen to good cells
2007 Standout
Cell-cycle checkpoints and cancer
2004 StandoutNature
Developmental differences in the immortalization of lung fibroblasts by telomerase
2003
Reversal of human cellular senescence: roles of the p53 and p16 pathways
2003
Transformation of Different Human Breast Epithelial Cell Types Leads to Distinct Tumor Phenotypes
2007
Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells
2007
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
BRAFE600-associated senescence-like cell cycle arrest of human naevi
2005 StandoutNature
Smurf2 up-regulation activates telomere-dependent senescence
2004
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Different telomere damage signaling pathways in human and mouse cells
2002
Cellular Senescence in Cancer and Aging
2007 Standout
Living on a break: cellular senescence as a DNA-damage response
2008
Putting the stress on senescence
2001
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Catalytically active human telomerase mutants with allele-specific biological properties
2003
Involvement of the INK4a/Arf gene locus in senescence
2003
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
2012 StandoutNature
Regulation of cellular senescence by p53
2001
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
2005 Standout
Erosion of the telomeric single-strand overhang at replicative senescence
2003
Gene expression patterns associated with p53 status in breast cancer
2006
A DNA damage checkpoint response in telomere-initiated senescence
2003 StandoutNature
Molecular changes accompanying senescence and immortalization of cultured human mammary epithelial cells
2002
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
Hallmarks of senescence in carcinogenesis and cancer therapy
2004
When cells get stressed: an integrative view of cellular senescence
2004
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
Tumor suppression by Ink4a–Arf: progress and puzzles
2003
Contribution of p16INK4a to replicative senescence of human fibroblasts
2004
Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
2010 Standout
The essence of senescence: Figure 1.
2010 Standout
Cellular senescence as a tumor-protection mechanism: the essential role of counting
2001
Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype
2011
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
Telomere Length Homeostasis Is Achieved via a Switch between Telomerase- Extendible and -Nonextendible States
2004
Telomerase and Tel1p Preferentially Associate with Short Telomeres in S. cerevisiae
2007
Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence
2004
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging
2004
Historical claims and current interpretations of replicative aging
2002
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival
2011
Switching and Signaling at the Telomere
2001 StandoutNobel
Oxidative stress shortens telomeres
2002 Standout
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
2005 StandoutNature
Genes involved in senescence and immortalization
2000
Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor?
2000
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging
2007
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
A G-Quadruplex-Interactive Potent Small-Molecule Inhibitor of Telomerase Exhibiting in Vitro and in Vivo Antitumor Activity
2002
Pancreatic cancer biology and genetics
2002
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
Senescence and immortalization: role of telomeres and telomerase
2004
Molecular Regulation of Melanocyte Senescence
2002
The role of senescent cells in ageing
2014 StandoutNature
p16INK4A is a robust in vivo biomarker of cellular aging in human skin
2006
Clonal evolution in cancer
2012 StandoutNature
The Hallmarks of Aging
2013 Standout
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Telomerase: A target for cancer therapeutics
2002
Human DNA methylomes at base resolution show widespread epigenomic differences
2009 StandoutNature
Discovery and saturation analysis of cancer genes across 21 tumour types
2014 StandoutNature
Tel1p Preferentially Associates with Short Telomeres to Stimulate Their Elongation
2007
Uncoupling the Senescent Phenotype from Telomere Shortening in Hydrogen Peroxide-Treated Fibroblasts
2001
Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock
2004
Genetics and biology of pancreatic ductal adenocarcinoma
2006
The cancer genome
2009 StandoutNature
Cell senescence and cancer
2001
Haploinsufficiency of mTR results in defects in telomere elongation
2002 StandoutNobel
Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1
2002
Telomerase core components protect Candida telomeres from aberrant overhang accumulation
2007 StandoutNobel
Does a Sentinel or a Subset of Short Telomeres Determine Replicative Senescence?
2004
Regulation of Telomerase by Telomeric Proteins
2004
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
2010
Oncogenic transformation and experimental models of human cancer
2007
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
2010 Standout
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres
2006 StandoutNobel
A Perspective on Cancer Cell Metastasis
2011 StandoutScience
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
2011 StandoutScience
Telomeres: Cancer to Human Aging
2006
Whole chromosome loss is promoted by telomere dysfunction in primary cells
2010
Modification of Subtelomeric DNA
2004
Four faces of cellular senescence
2011 Standout
p16INK4a Modulates p53 in Primary Human Mammary Epithelial Cells
2006
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Normal Human Fibroblasts Are Resistant to RAS-Induced Senescence
2004
Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert
2002
The signals and pathways activating cellular senescence
2004
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Haploinsufficiency of t e lomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita
2005 StandoutNobel
How Shelterin Protects Mammalian Telomeres
2008 Standout
When cells get stressed: an integrative view of cellular senescence
2004
Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci
2003
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
A Two-Stage, p16INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status
2002
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Telomere length and heredity: Indications of paternal inheritance
2005
Loss of linker histone H1 in cellular senescence
2006
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53
2009
Human melanocyte senescence and melanoma susceptibility genes
2003
Works of Brittney‐Shea Herbert being referenced
Cell-Type-Specific Responses to Chemotherapeutics in Breast Cancer
2004
Telomerase Template Antagonist GRN163L Disrupts Telomere Maintenance, Tumor Growth, and Metastasis of Breast Cancer
2006
Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells
2003
p16INK4a inactivation is not required to immortalize human mammary epithelial cells
2002
Effects of Chemopreventive and Antitelomerase Agents on the Spontaneous Immortalization of Breast Epithelial Cells
2001
Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions
2004
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
2001
Lipid modification of GRN163, an N3′ → P5′ thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
2005
Subsenescent Telomere Lengths in Fibroblasts Immortalized by Limiting Amounts of Telomerase
2000
Novel Short Oligonucleotide Conjugates as Inhibitors of Human Telomerase
2003
Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells.
2003