Standout Papers
Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help
2003 StandoutScienceNobel
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin
2001
Dendritic cell lineage, plasticity and cross-regulation
2001
Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2
2003 Standout
A Toll-like receptor recognizes bacterial DNA
2000 StandoutNature
Development of immunoadjuvants for immunotherapy of cancer
2001
Fast Kinetics of Exocytosis Revealed by Simultaneous Measurements of Presynaptic Capacitance and Postsynaptic Currents at a Central Synapse
2001
Human Toll-like receptor 2 mediates induction of the antimicrobial peptide human beta-defensin 2 in response to bacterial lipoprotein
2001
NODs: intracellular proteins involved in inflammation and apoptosis
2003
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity
2002
Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
2002
Toll signaling pathways in the innate immune response
2000
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
2002 Nature
A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists
1996
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Natural adjuvants: Endogenous activators of dendritic cells
1999
Ligand-specific oligomerization of T-cell receptor molecules
1997 Nature
Roles of Toll‐like receptors in innate immune responses
2001
Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex
2001
Danger signals: SOS to the immune system
2001
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
2001 Nature
Role of TLR-2 in the Activation of Nuclear Factor κB by Oxidative Stress in Cardiac Myocytes
2001
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
The apoptotic signaling pathway activated by Toll-like receptor-2
2000
Toll-like Receptor-2 Mediates Treponema Glycolipid and Lipoteichoic Acid-induced NF-κB Translocation
2001
Toll-like receptor signalling
2004 Standout
Discrimination of bacterial lipoproteins by Toll-like receptor 6
2001 Standout
CD36 is a sensor of diacylglycerides
2005 StandoutNatureNobel
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products
1999
The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A
1988
The immune response of Drosophila
2003 StandoutNatureNobel
Analysis of a Successful Immune Response against Hepatitis C Virus
1999 StandoutNobel
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
1999 Standout
Mechanism of action of an acidic transcriptional activator in vitro
1991
Intracellular vs extracellular recognition of pathogens – common concepts in mammals and flies
2002
The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling
2000
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
Activation of Macrophages by Linear (1→3)-β-d-Glucans
2002
Effects of activation-defective TBP mutations on transcription initiation in yeast
1994 StandoutNatureNobel
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Toll-like receptors: critical proteins linking innate and acquired immunity
2001 Standout
The embryonal carcinoma stem cell Ela-like activity involves a differentiation-regulated transcription factor
1990
Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway
2002 Standout
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
A genetically humanized mouse model for hepatitis C virus infection
2011 StandoutNatureNobel
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Toll-like receptors and innate immunity
2009
Human Nod1 Confers Responsiveness to Bacterial Lipopolysaccharides
2001
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
2000
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
A CRISPR/Cas system mediates bacterial innate immune evasion and virulence
2013 Nature
COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast
1995 StandoutNobel
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
2000
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
Toll-like receptors and innate immunity
2001 Standout
Toll-Like Receptors
2003 Standout
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
1999 StandoutScience
Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system.
1989
Involvement of Toll-Like Receptor 4 in Innate Immunity to Respiratory Syncytial Virus
2001
An Essential Role of the NF-κB/Toll-Like Receptor Pathway in Induction of Inflammatory and Tissue-Repair Gene Expression by Necrotic Cells
2001
Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels
1998
Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins
2002 Standout
Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex
2000
Cutting Edge: Preferentially the R-Stereoisomer of the Mycoplasmal Lipopeptide Macrophage-Activating Lipopeptide-2 Activates Immune Cells Through a Toll-Like Receptor 2- and MyD88-Dependent Signaling Pathway
2000
Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH.
1991
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
cAMP response element-binding protein is activated by Ca2+/calmodulin- as well as cAMP-dependent protein kinase.
1991 StandoutNobel
Evidence for an Accessory Protein Function for Toll-Like Receptor 1 in Anti-Bacterial Responses
2000
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible toStaphylococcus aureusInfection
2000
A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
2005 StandoutNobel
Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF
1992 StandoutNatureNobel
The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43.
1990
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity
2002
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
2005 StandoutScience
Signaling Events Induced by Lipopolysaccharide-Activated Toll-Like Receptor 2
1999
Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine Macrophages
2001
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae
1991 StandoutNobel
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
2000 Standout
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells
2000 StandoutScienceNobel
Toll-Like Receptor 2 Is Required for Innate, But Not Acquired, Host Defense to Borrelia burgdorferi
2002
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2
2000
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Colony-Stimulating Factor-1 Suppresses Responses to CpG DNA and Expression of Toll-Like Receptor 9 but Enhances Responses to Lipopolysaccharide in Murine Macrophages
2002
LIGAND RECOGNITION BY αβ T CELL RECEPTORS
1998
Immunobiology of Dendritic Cells
2000 Standout
Gene Expressions of Toll-Like Receptor 2, But Not Toll-Like Receptor 4, Is Induced by LPS and Inflammatory Cytokines in Mouse Macrophages
2000
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Flagellin, a Novel Mediator of Salmonella-Induced Epithelial Activation and Systemic Inflammation: IκBα Degradation, Induction of Nitric Oxide Synthase, Induction of Proinflammatory Mediators, and Cardiovascular Dysfunction
2001
Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors
1999 Science
Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors
2001 Science
Innate Immune Recognition
2002 Standout
Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression
2000
B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.
1994
Two Lipoproteins Extracted fromEscherichia coliK-12 LCD25 Lipopolysaccharide Are the Major Components Responsible for Toll-Like Receptor 2-Mediated Signaling
2002
Mutations in the Extracellular Domain Cause RET Loss of Function by a Dominant Negative Mechanism
1998
Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines
2002
Maturation of Human Dendritic Cells by Cell Wall Skeleton ofMycobacterium bovisBacillus Calmette-Guerin: Involvement of Toll-Like Receptors
2000
Works of Brigitte Devaux being referenced
Broad specificity of GDNF family receptors GFR?1 and GFR?2 for GDNF and NTN in neurons and transfected cells
2000
A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor
1997 Nature
Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2
1999 StandoutScience
Genomic footprinting detects factors bound to major late and IVa2 promoters in adenovirus-infected HeLa cells.
1988
T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen.
1993
Identical genomic footprints of the adenovirus EIIa promoter are detected before and after EIa induction.
1987
The abundance and in vitro DNA binding of three cellular proteins interacting with the adenovirus EIIa early promoter are not modified by the EIa gene products.
1987
The Abundance and In Vitro DNA Binding of Three Cellular Proteins Interacting with the Adenovirus Ella Early Promoter Are Not Modified by the Ela Gene Products
1987
Expression of T Cell Antigen Receptor Heterodimers in a Lipid-Linked Form
1990 Science