Citation Impact
Citing Papers
Immune Rejection of Mouse Tumors Expressing Mutated Self
2009 StandoutNobel
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
2013 StandoutNobel
Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma
2008
Expression of proopiomelanocortin (POMC)-derived melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) peptides in skin of basal cell carcinoma patients
1999
Subcellular Distribution of Tyrosinase and Tyrosinase-Related Protein-1: Implications for Melanosomal Biogenesis
1993
Are L-tyrosine and L-dopa hormone-like bioregulators?
1990
Germline p16 mutations in familial melanoma
1994
Protein Kinase C-β Activates Tyrosinase by Phosphorylating Serine Residues in Its Cytoplasmic Domain
1999
Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice
2009
Tyrosinase and related proteins in mammalian pigmentation
1996
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
Melanocyte Differentiation Marker gp75, the Brown Locus Protein, Can Be Regulated Independently of Tyrosinase and Pigmentation
1995
Strategies to overcome immune ignorance and tolerance
2002
Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
1995 Nature
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
2004 Standout
Immunization with DNA coding for gp100 results in CD4+ T-cell independent antitumor immunity
2000
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Instability and decay of the primary structure of DNA
1993 StandoutNatureNobel
Imaging in the era of molecular oncology
2008 StandoutNature
BRAFE600-associated senescence-like cell cycle arrest of human naevi
2005 StandoutNature
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Tumor immunity and autoimmunity induced by immunization with homologous DNA.
1998
The melanosome: membrane dynamics in black and white
2001
Cysteine Transport in Melanosomes from Murine Melanocytes
1999
The Hallmarks of Cancer
2000 Standout
Lessons from Hereditary Colorectal Cancer
1996 Standout
Proper Folding and Endoplasmic Reticulum to Golgi Transport of Tyrosinase Are Induced by Its Substrates, DOPA and Tyrosine
2001
Immunity to Cancer Through Immune Recognition of Altered Self: Studies with Melanoma
2003
CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems
2004 StandoutNobel
TRP‐1 expression correlates with eumelanogenesis in human pigment cells in culture
1993
Impact of genetic engineering on the understanding of spermatogenesis
2001
Downstream region of the human tyrosinase-related protein gene enhances its promoter activity
1992
Role of Tyrosinase as the Determinant of Pigmentation in Cultured Human Melanocytes
1993
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3
1998
The Cytoplasmic Tail of the Mouse Brown Locus Product Determines Intracellular Stability and Export from the Endoplasmic Reticulum
1998
Topically Applied Diacylglycerols Increase Pigmentation in Guinea Pig Skin
1995
Bone Remodeling
2006
Optimization of a self antigen for presentation of multiple epitopes in cancer immunity
2006
Safety and Immunogenicity of Tyrosinase DNA Vaccines in Patients with Melanoma
2007
Complete sequence and polymorphism study of the human TYRP1 gene encoding tyrosinase-related protein 1
1998
Induction of tyrosinase in human melanoma cells by l-tyrosine phosphate and cytochalasin D
1992
A Chemist's View of Melanogenesis
2003
Expression of Tyrosinase-related Protein 2/DOPAchrome Tautomerase in the Retinoblastoma
2001
Different Populations of Melanocytes Are Present in Hair Follicles and Epidermis
1996
Potent Prostaglandin A1 Analogs That Suppress Tumor Cell Growth through Induction of p21 and Reduction of Cyclin E
1998 StandoutNobel
AUTOCRINE AND PARACRINE REGULATION BY CYTOKINES AND GROWTH FACTORS IN MELANOMA
2000
Human tumor antigens for cancer vaccine development
1999
pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest
1994 StandoutNature
A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types
1994 StandoutScience
Biosynthesis and intracellular movement of the melanosomal membrane glycoprotein gp75, the human b (brown) locus product
1991
Sorting and Secretion of a Melanosome Membrane Protein, gp75/TRP1
1997
Cancer immunotherapy comes of age
2011 StandoutNature
Principles of CDK regulation
1995 StandoutNature
Atherosclerosis — An Inflammatory Disease
1999 Standout
Evidence for Distinct Membrane Traffic Pathways to Melanosomes and Lysosomes in Melanocytes
2001
Molecular basis of albinism: Mutations and polymorphisms of pigmentation genes associated with albinism
1999
Light is a dominant mouse mutation resulting in premature cell death
1992
The predominant defect in dilute melanocytes is in melanosome distribution and not cell shape, supporting a role for myosin V in melanosome transport
1997
The molecular basis of oculocutaneous albinism type 1 (OCA1): sorting failure and degradation of mutant tyrosinases results in a lack of pigmentation
2001
Human Melanocytes and Melanomas Express Novel mRNA Isoforms of the Tyrosinase-Related Protein-2/DOPAchrome Tautomerase Gene: Molecular and Functional Characterization
2000
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
1994 Nature
Aberrant pH of Melanosomes in Pink-Eyed Dilution (p) Mutant Melanocytes
2000
The Hallmarks of Aging
2013 Standout
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Assembly, Target‐Signaling and Intracellular Transport of Tyrosinase Gene Family Proteins in the Initial Stage of Melanosome Biogenesis
2000
Mechanisms of Ultraviolet Light‐Induced Pigmentation
1996
Human tyrosinase related protein‐1 (TRP‐1) does not function as a DHICA oxidase activity in contrast to murine TRP‐1
1998
KIT Expression Reveals a Population of Precursor Melanocytes in Human Skin
1996
The Menkes copper transporter is required for the activation of tyrosinase
2000
After Dopachrome?
1991
Abnormal Acidification of Melanoma Cells Induces Tyrosinase Retention in the Early Secretory Pathway
2002
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
2010 StandoutNobel
Localization to Mature Melanosomes by Virtue of Cytoplasmic Dileucine Motifs Is Required for Human OCA2 Function
2008
Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring
1999 StandoutScience
Immune response to a differentiation antigen induced by altered antigen: A study of tumor rejection and autoimmunity
1996
The depigmenting effect of ?-tocopheryl ferulate on human melanoma cells
1999
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Identification of MAGE-3 Epitopes Presented by HLA-DR Molecules to CD4+ T Lymphocytes
1999
Production of large amounts of hydrogen peroxide by human tumor cells.
1991 Standout
Induction of cellular immunity by immunization with novel hybrid peptides complexed to heat shock protein 70
2000 StandoutNobel
A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12.
1991 Nobel
A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.
1994
The Transcriptional Program in the Response of Human Fibroblasts to Serum
1999 StandoutScience
Of Flies and Fishes
1994 StandoutScienceNobel
Antioncogenes and human cancer.
1993
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
1995 StandoutNobel
Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma
1999 StandoutNobel
Integrated NY-ESO-1 antibody and CD8+T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
2011 StandoutNobel
Cancer Cell Cycles
1996 StandoutScience
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells
1997
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
1997 StandoutScience
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Lysosome-Related Organelles: A View from Immunity and Pigmentation.
2002
TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor
1992
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
2008 StandoutNobel
Pink-eyed Dilution Protein Controls the Processing of Tyrosinase
2002
A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase.
1992
Molecular basis of tyrosinase-negative oculocutaneous albinism. A single base mutation in the tyrosinase gene causing arginine to glutamine substitution at position 59.
1990
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.
1996 Standout
The retinoblastoma protein and cell cycle control
1995 Standout
Altered Trafficking of Lysosomal Proteins in Hermansky-Pudlak Syndrome Due to Mutations in the β3A Subunit of the AP-3 Adaptor
1999
The Ecology of Arsenic
2003 StandoutScience
Dendritic Cells Retrovirally Transduced with a Model Antigen Gene Are Therapeutically Effective against Established Pulmonary Metastases
1997
Homozygous deletions within 9p21-p22 identify a small critical region of chromosomal loss in human malignant mesotheliomas.
1993
Heteroclitic Immunization Induces Tumor Immunity
1998
Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism
2000
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Fc receptors are required in passive and active immunity to melanoma
1998
Enzymatic control of pigmentation in mammals
1991
Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial.
2003
Assignment of a Locus for Familial Melanoma, MLM, to Chromosome 9p13-p22
1992 Science
Structural organization of the pigment cell-specific gene located at the brown locus in mouse. Its promoter activity and alternatively spliced transcript
1991
HUMAN T CELL RESPONSES AGAINST MELANOMA
2005
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
2013 StandoutNobel
Distinct Protein Sorting and Localization to Premelanosomes, Melanosomes, and Lysosomes in Pigmented Melanocytic Cells✪
2001
Pre-Existing Immunity to Tyrosinase-Related Protein (TRP)-2, a New TRP-2 Isoform, and the NY-ESO-1 Melanoma Antigen in a Patient with a Dramatic Response to Immunotherapy
2002
Use of a cDNA microarray to analyse gene expression patterns in human cancer
1996 Standout
What controls melanogenesis?
1998
IFN Unresponsiveness in LNCaP Cells Due to the Lack of JAK1 Gene Expression
2005
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
Implicating a role for immune recognition of self in tumor rejection: passive immunization against the brown locus protein.
1995
Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes.
1996
Retinoic acid as modulator of UVB-induced melanocyte differentiation: Involvement of the melanogenic enzymes expression
1994
The chromosomal distribution of mouse odorant receptor genes.
1996 StandoutNobel
Isolation and Characterization of a Novel As(V)-Reducing Bacterium: Implications for Arsenic Mobilization and the Genus Desulfitobacterium
2001
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Coupling and Uncoupling of Tumor Immunity and Autoimmunity
1999
Frequent loss of chromosome 9 in human primary non-small cell lung cancer.
1994
Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression.
1994
Integration and Germ-Line Transmission of a Pseudotyped Retroviral Vector in Zebrafish
1994 Science
Molecular definition of a chromosome 9p21 germ-line deletion in a woman with multiple melanomas and a plexiform neurofibroma: implications for 9p tumor-suppressor gene(s).
1993
Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice
2002 StandoutNobel
A model for melanosome biogenesis based on the purification and analysis of early melanosomes
2001
Corticotropin Releasing Hormone and Proopiomelanocortin Involvement in the Cutaneous Response to Stress
2000
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
1996 StandoutScience
Localization of a putative tumor suppressor gene by using homozygous deletions in melanomas.
1994
Works of Brigitte Bouchard being referenced
Isolation and Characterization of Desulfitobacterium frappieri sp. nov., an Anaerobic Bacterium Which Reductively Dechlorinates Pentachlorophenol to 3-Chlorophenol
1996
Production and Characterization of Antibodies Against Human Tyrosinase
1994
Recognition of Autoantigens by Patients with Melanoma
1993
Assignment of the human TYRP (brown) locus to chromosome region 9p23 by nonradioactive in situ hybridization
1992
Antigens of melanocytes and melanoma
1991
Immunoreactive α‐Melanotropin as an Autocrine Effector in Human Melanoma Cells
1997
Cysteine Deprivation Promotes Eumelanogenesis in Human Melanoma Cells
1996
Prolactin: A Hormone at the Crossroads of Neuroimmunoendocrinology
1998
Analysis of prolactin-modulated gene expression profiles during the Nb2 cell cycle using differential screening techniques
2000
Molecular characterization of a human tyrosinase‐related‐protein‐2 cDNA
1994
Generation of pigmented stripes in albino mice by retroviral marking of neural crest melanoblasts
1991
Osteoblasts Are a New Target for Prolactin: Analysis of Bone Formation in Prolactin Receptor Knockout Mice**This work was supported in part by grants from Hoechst Marion Roussel, Inc.
1999
Intracellular sorting and targeting of melanosomal membrane proteins: identification of signals for sorting of the human brown locus protein, gp75.
1995
Retroviral gene transfer induced constitutive expression of interleukin- 2 or interferon-gamma in irradiated human melanoma cells
1992
Homozygous deletions within human chromosome band 9p21 in melanoma.
1992
The melanoma antigen gp75 is the human homologue of the mouse b (brown) locus gene product.
1990
Induction of pigmentation in mouse fibroblasts by expression of human tyrosinase cDNA.
1989