Standout Papers
- The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex (2009)
- Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex (2011)
- Conformational changes in the G protein Gs induced by the β2 adrenergic receptor (2011)
- Crystal structure of the β2 adrenergic receptor–Gs protein complex (2011)
- Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer (2009)
- Structure and function of an irreversible agonist-β2 adrenoceptor complex (2011)
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor (2011)
Citation Impact
Citing Papers
Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS
2018 StandoutNobel
Crystal Structure of a Lipid G Protein–Coupled Receptor
2012 Science
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
2010 StandoutScience
Structure of an Agonist-Bound Human A 2A Adenosine Receptor
2011 Science
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Origins of coevolution between residues distant in protein 3D structures
2017 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Biased Signaling Pathways in β 2 -Adrenergic Receptor Characterized by 19 F-NMR
2012 ScienceNobel
Exploiting conformational dynamics to modulate the function of designed proteins
2023 StandoutNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Protein structure determination using metagenome sequence data
2017 StandoutScienceNobel
Crystal Structure-Based Virtual Screening for Fragment-like Ligands of the Human Histamine H 1 Receptor
2011
Assessing the utility of coevolution-based residue–residue contact predictions in a sequence- and structure-rich era
2013 StandoutNobel
Accurate computational design of multipass transmembrane proteins
2018 StandoutScienceNobel
The diverse and expanding role of mass spectrometry in structural and molecular biology
2016
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
GPCR activation mechanisms across classes and macro/microscales
2021
Protein Conformational Switches: From Nature to Design
2012
Agonist-bound structures of G protein-coupled receptors
2012
Nanobody stabilization of G protein-coupled receptor conformational states
2011 StandoutNobel
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
Nucleotide signalling during inflammation
2014 StandoutNature
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Activation and allosteric modulation of a muscarinic acetylcholine receptor
2013 NatureNobel
Recent developments in biased agonism
2013 Nobel
Computational design of G Protein-Coupled Receptor allosteric signal transductions
2019
Solution NMR studies of polytopic α-helical membrane proteins
2011
Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR
2012
Artificial membrane-like environments for in vitro studies of purified G-protein coupled receptors
2011
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor
2012 StandoutNobel
Structure-based drug screening for G-protein-coupled receptors
2012 StandoutNobel
Biotechnological applications of recombinant single-domain antibody fragments
2011
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
2011 StandoutNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Structure of the human κ-opioid receptor in complex with JDTic
2012 Nature
A new era of GPCR structural and chemical biology
2012 StandoutNobel
New amphiphiles for membrane protein structural biology
2011
Multiple ligand-specific conformations of the β2-adrenergic receptor
2011 StandoutNobel
Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study
2012 StandoutNobel
A Glimpse of Structural Biology through X-Ray Crystallography
2014
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Signaling by Sensory Receptors
2011 StandoutNobel
Chemistry and Biology of Vision
2011
Agonist-bound structure of the human P2Y12 receptor
2014 Nature
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor
2012 StandoutNobel
Structural insights into adrenergic receptor function and pharmacology
2011 StandoutNobel
Recent advances in magic angle spinning solid state NMR of membrane proteins
2014
Structure of the human histamine H1 receptor complex with doxepin
2011 Nature
A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins
2012 StandoutNobel
G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
2012 Nature
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
2013 Nature
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
The Use of GPCR Structures in Drug Design
2011
Structure and dynamics of the M3 muscarinic acetylcholine receptor
2012 StandoutNatureNobel
X-ray structure of the mammalian GIRK2–βγ G-protein complex
2013 NatureNobel
Multiplex single-molecule interaction profiling of DNA-barcoded proteins
2014 Nature
Optochemical Genetics
2011
Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing
2012
Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation
2016
GPCRdb: an information system for G protein-coupled receptors
2015
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Amphipols, Nanodiscs, and Fluorinated Surfactants: Three Nonconventional Approaches to Studying Membrane Proteins in Aqueous Solutions
2010
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Structure of the adenosine A2A receptor bound to an engineered G protein
2016 Nature
Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks
2018
Conformations of macromolecules and their complexes from heterogeneous datasets
2014
Probing Single Biomolecules in Solution Using the Anti-Brownian Electrokinetic (ABEL) Trap
2012 StandoutNobel
Activation mechanism of theβ2-adrenergic receptor
2011
Trajectories of the ribosome as a Brownian nanomachine
2014 StandoutNobel
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
2015 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Membrane Protein Structure Determination Using Crystallography and Lipidic Mesophases: Recent Advances and Successes
2012
Structure-Function of the G Protein–Coupled Receptor Superfamily
2012
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists
2017 StandoutNobel
Conformational Dynamics of Single G Protein-Coupled Receptors in Solution
2011 StandoutNobel
Single-molecule spectroscopy reveals photosynthetic LH2 complexes switch between emissive states
2013 StandoutNobel
GPCRdb: the G protein‐coupled receptor database – an introduction
2016
Emerging Targets in Photopharmacology
2016 StandoutNobel
Conserved Binding Mode of Human β2Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography
2010
Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
2015 StandoutNobel
Optochemische Genetik
2011
Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy
2012
Nanobodies: Natural Single-Domain Antibodies
2013 Standout
A G protein-coupled receptor at work: the rhodopsin model
2009
Works of Brian T. DeVree being referenced
Allosteric coupling from G protein to the agonist-binding pocket in GPCRs
2016 NatureNobel
Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer
2009 StandoutNobel
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Detection of G Protein-selective G Protein-coupled Receptor (GPCR) Conformations in Live Cells
2013
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
2011 StandoutNobel
Calcium-Dependent Ligand Binding and G-protein Signaling of Family B GPCR Parathyroid Hormone 1 Receptor Purified in Nanodiscs
2012