Standout Papers
Citation Impact
Citing Papers
The Endogenous Tryptophan Metabolite and NAD+ Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress
2013
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of T H 17 to Regulatory T Cells in HIV Disease
2010
Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form
2018
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells
2006
Mouse Mesenchymal Stem Cells Suppress Antigen-Specific TH Cell Immunity Independent of Indoleamine 2,3-Dioxygenase 1 (IDO1)
2009
Rheumatoid Factor as a Potentiator of Anti–Citrullinated Protein Antibody–Mediated Inflammation in Rheumatoid Arthritis
2014
The Indoleamine-2,3-Dioxygenase (IDO) Inhibitor 1-Methyl-D-tryptophan Upregulates IDO1 in Human Cancer Cells
2011
Controlling entropy to tune the functions of intrinsically disordered regions
2014
An exposome perspective: Early-life events and immune development in a changing world
2017
Mass Cytometry: Single Cells, Many Features
2016
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
2015
Rheumatoid arthritis
2016 Standout
Chronic inflammation in the etiology of disease across the life span
2019 Standout
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
CD4 + T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion
2015
A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans
2016
Foundation models for generalist medical artificial intelligence
2023 StandoutNature
Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis
2017
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
2011 StandoutNature
Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
2015
Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis
2008
Nanosensor Detection of an Immunoregulatory Tryptophan Influx/Kynurenine Efflux Cycle
2007
Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases
2016
TGF-β and kynurenines as the key to infectious tolerance
2009
Crystal structure of the FimD usher bound to its cognate FimC–FimH substrate
2011 Nature
Indoleamine 2,3‐dioxygenase in T‐cell tolerance and tumoral immune escape
2008
The Pathogenesis of Rheumatoid Arthritis
2011 Standout
The silent war of CMV in aging and HIV infection
2015
Nonresolving Inflammation
2010 Standout
Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis
2010
B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis
2008 Standout
Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host
2008
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Risk of drug-related mortality during periods of transition in methadone maintenance treatment: A cohort study
2011
High-performance medicine: the convergence of human and artificial intelligence
2018 Standout
Structural and energetic basis of folded-protein transport by the FimD usher
2013 StandoutNatureNobel
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
2017
The “All of Us” Research Program
2019 Standout
Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis
2006
Antigen-specific therapeutic approaches for autoimmunity
2019
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
2020 StandoutNobel
Regulatory T cells in cancer immunotherapy
2016 StandoutNobel
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
2015 Standout
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
2020 Standout
Language models are an effective representation learning technique for electronic health record data
2020
A guide to deep learning in healthcare
2018 Standout
The Solute Carrier Family 15A4 Regulates TLR9 and NOD1 Functions in the Innate Immune System and Promotes Colitis in Mice
2011
A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring
2019
The blockade of immune checkpoints in cancer immunotherapy
2012 Standout
Tryptophan degradation in autoimmune diseases
2007
Mass cytometry: blessed with the curse of dimensionality
2016
Dioxin and immune regulation
2010
Indoleamine 2,3 dioxygenase–mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen‐induced arthritis
2009
Genetics and pathogenesis of inflammatory bowel disease
2011 StandoutNature
Risk of death during and after opiate substitution treatment in primary care: prospective observational study in UK General Practice Research Database
2010
Uncomplicated Urinary Tract Infection
2012 Standout
Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies
2017 Standout
The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis
2007
Mortality risk of opioid substitution therapy with methadone versus buprenorphine: a retrospective cohort study
2015
Suppression of Th1 differentiation by tryptophan supplementation in vivo
2017
Artificial Intelligence in Cardiology
2018 Standout
A small jab – a big effect: nonspecific immunomodulation by vaccines
2013
The Promised Land of Human Immunology
2013
Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH–Oligomannose-3 Complex
2008
The Neurobiology of Multiple Sclerosis: Genes, Inflammation, and Neurodegeneration
2006
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Indoleamine 2,3-dioxygenase and tumor-induced tolerance
2007
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
2019 Standout
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
2011 StandoutNobel
Variability in the immune system: of vaccine responses and immune states
2013
Systems immunology: just getting started
2017
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
2008 Nature
A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy
2017 Nature
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
Aryl Hydrocarbon Receptor Control of Adaptive Immunity
2013
Radiomics: the bridge between medical imaging and personalized medicine
2017 Standout
The Interleukin-1 Family: Back to the Future
2013
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
2019 StandoutNobel
Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development
2015
Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding (ACCENSE)
2013
Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis
2009
Role of indoleamine 2,3-dioxygenase in health and disease
2015
Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality
2009
Regulatory T Cells and Human Disease
2020 StandoutNobel
Targeting Treg cells in cancer immunotherapy
2019 StandoutNobel
Antiadhesion Therapy for Urinary Tract Infections—A Balanced PK/PD Profile Proved To Be Key for Success
2012
Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy
2017
Kynurenine Pathway Enzymes in Dendritic Cells Initiate Tolerogenesis in the Absence of Functional IDO
2006
Evolution of the immune system in humans from infancy to old age
2015 Standout
Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells
2017
Risk of mortality on and off methadone substitution treatment in primary care: a national cohort study
2015
Machine Learning in Medicine
2019 Standout
Cytokine Storm
2020 Standout
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Selective Covalent Protein Immobilization: Strategies and Applications
2009
Mechanically Activated Integrin Switch Controls α 5 β 1 Function
2009 Science
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Serum C-Reactive Protein and Congestive Heart Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents
2017
IDO Mediates TLR9-Driven Protection from Experimental Autoimmune Diabetes
2009
Toll-Like Receptor Engagement Enhances the Immunosuppressive Properties of Human Bone Marrow-Derived Mesenchymal Stem Cells by Inducing Indoleamine-2,3-dioxygenase-1 via Interferon-β and Protein Kinase R
2009
The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation
2008
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis
2010
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Forced IDO 1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes
2014
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Evolution, human-microbe interactions, and life history plasticity
2017
Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
2010
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis
2012
Immunity to Citrullinated Proteins in Rheumatoid Arthritis
2008
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
2013 StandoutNobel
Heterogeneity of Human CD4+T Cells Against Microbes
2016
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Protein Immobilization Strategies for Protein Biochips
2007
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Works of Brian Kidd being referenced
Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite
2005 Science
Deep Patient: An Unsupervised Representation to Predict the Future of Patients from the Electronic Health Records
2016 Standout
Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines
2006
Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes
2015
Factors associated with mortality in Scottish patients receiving methadone in primary care: retrospective cohort study
2009
Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination
2008
Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis
2008
Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans
2016
Antigen microarray profiling of autoantibodies in rheumatoid arthritis
2005
γδ T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response
2012
Virus-Specific CD4+ Memory-Phenotype T Cells Are Abundant in Unexposed Adults
2013
FimH Forms Catch Bonds That Are Enhanced by Mechanical Force Due to Allosteric Regulation
2008
Unifying immunology with informatics and multiscale biology
2014
Interdomain Interaction in the FimH Adhesin of Escherichia coli Regulates the Affinity to Mannose
2007
Computation of Conformational Coupling in Allosteric Proteins
2009 StandoutNobel
Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting
2010
Apoptosis and other immune biomarkers predict influenza vaccine responsiveness
2013
A Suppressive Oligodeoxynucleotide Enhances the Efficacy of Myelin Cocktail/IL-4-Tolerizing DNA Vaccination and Treats Autoimmune Disease
2005
Cytomegalovirus infection enhances the immune response to influenza
2015
Apoptosis and other immune biomarkers predict influenza vaccine responsiveness
2013
Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization
2013